CN106491181B - Thrombus embolectomy device with multi-spiral structure - Google Patents

Thrombus embolectomy device with multi-spiral structure Download PDF

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Publication number
CN106491181B
CN106491181B CN201710028973.XA CN201710028973A CN106491181B CN 106491181 B CN106491181 B CN 106491181B CN 201710028973 A CN201710028973 A CN 201710028973A CN 106491181 B CN106491181 B CN 106491181B
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spiral
guide
ring
wires
thrombus
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CN201710028973.XA
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CN106491181A (en
Inventor
韩新巍
任克伟
水少锋
吴刚
任建庄
周朋利
孙奇勋
李臻
王艳丽
马波
路慧彬
毕永华
吴正阳
李亚华
张文哲
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First Affiliated Hospital of Zhengzhou University
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First Affiliated Hospital of Zhengzhou University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22031Gripping instruments, e.g. forceps, for removing or smashing calculi

Abstract

The invention relates to a thrombus thrombectomy device with a multi-spiral structure, which comprises: the device comprises a first driving piece, a second driving piece, an inner ring catheter, an outer ring catheter, a near-end marking ring, a far-end marking ring, a guide sleeve and a spiral guide wire; the spring stent on the self-expanding stent is similar to a self-expanding stent, and the adherence performance is better compared with the adherence performance of the existing self-expanding stent when the self-expanding stent is released. The structure of the spring stent contacting the inner wall of the blood vessel when released is a smooth spiral guide wire, and compared with the existing self-expanding stent, the damage to the blood vessel along the way is smaller, and the pain of a patient can be relieved to the greatest extent. The spring support can be completely released in the blood vessel, the plug can be completely taken out by the spring support when the plug is recovered, and the spiral guide wire of the spring support can be spirally contracted and folded when the plug is recovered, so that the plaque is prevented from being separated to the greatest extent. The spring support can be rapidly and naturally unfolded to fill the inner wall of the blood vessel after being released from the guide sleeve, which is equivalent to implementing a stent forming operation, can immediately recover blood flow and ensure that the intima of the blood vessel is not damaged.

Description

Thrombus embolectomy device with multi-spiral structure
Technical Field
The invention relates to the technical field of medical instruments, in particular to a thrombus thrombectomy device with a multi-spiral structure.
Background
Thrombosis is caused by the presence of certain causes, some components of the blood that circulate abnormally forming blood clots, or forming blood deposits on the inner walls or walls of the heart vessels, causing blood embolism. The thrombus is formed in tissues and organs of the whole body, is not limited to the pathological changes of myocardial infarction, deep venous thrombosis or cerebrovascular thrombosis and the like, and can be generated in blood vessels of any part in the body. The incidence rate of venous thrombosis is higher than that of arterial thrombosis, the ratio of the venous thrombosis to the arterial thrombosis can reach 4: 1, the venous thrombosis accounts for 40% -60% of a thrombosis mechanism, the incidence rate of the thrombosis of the blocked coronary artery is 15% -95%, and 90% of thrombosis is accompanied by atherosclerotic plaques. Thrombosis causes vessel occlusion, and blood flow blockage causes related vessel domination tissue ischemia, anoxia and even necrosis to generate corresponding tissue and organ dysfunction symptoms. In the early stage, anticoagulant drugs are mostly adopted for treatment, but the treatment effect is not obvious, the blood vessel recanalization rate is low, the recanalization time is long, and some patients are not suitable for thrombolytic treatment. The mechanical device thrombus removal provides a novel and efficient blood vessel recanalization treatment method for thrombus patients, the mechanical thrombus removal operation time is short, related complications are few, and the mechanical device thrombus removal method is a research hotspot in the field of thrombus treatment at present. At present, the multi-purpose thrombus removal support in the market is used for mechanical thrombus removal, and the thrombus removal support is mostly in a single-layer structure, is close to or is attached to the vascular wall for thrombus removal, and is weaker in fixing capacity of thrombus inside.
Disclosure of Invention
In order to overcome the defects, the invention aims to provide a thrombus taking device with a multi-spiral structure, which is safer and can quickly and effectively remove thrombus.
The purpose of the invention is realized by the following technical scheme:
the invention relates to a thrombus thrombectomy device with a multi-spiral structure, which comprises: the device comprises a first driving piece, a second driving piece, an inner ring catheter, an outer ring catheter, a near-end marking ring, a far-end marking ring, a guide sleeve and a spiral guide wire; the first driving piece is in driving connection with the outer ring guide pipe to drive the outer ring guide pipe to rotate; the inner ring catheter is arranged in the outer ring catheter and extends out of two ends, the second driving piece is in driving connection with the extending end of the inner ring catheter to drive the inner ring catheter to rotate, and the extending other end of the inner ring catheter is connected with the far-end marking ring; the near-end marking ring is axially and slidably sleeved on the outer ring catheter, a plurality of spiral guide wires extend out of the end part of the near-end marking ring, and the end parts of the spiral guide wires are connected with the far-end marking ring; be provided with on the guide pin bushing inner wall with a plurality of spiral rifling stripes of a plurality of spiral seal wire assorted, set up in a plurality of spiral rifling stripes when a plurality of spiral seal wires are compressed, stretch out the guide pin bushing when a plurality of spiral seal wires are not compressed and be even spiral setting and form spring bracket.
Further, the thrombus embolectomy device also comprises a third driving piece and a central guide wire; the central guide wire is arranged in the inner ring catheter and extends out, the third driving piece is in driving connection with one end, extending out, of the central guide wire to drive the central guide wire to vibrate, and the other end of the central guide wire is connected with the far-end marking ring.
Furthermore, the thrombus embolectomy device also comprises an eccentric pendulum bob, and the other end part of the central guide wire extends out of the distal end marking ring to be connected with the eccentric pendulum bob.
Further, a plurality of barbs pointing to the inner ring catheter are arranged on the spiral guide wires.
Furthermore, a mark for identifying the rotation direction of the spring support is arranged on the plurality of spiral guide wires.
Furthermore, a plurality of spring recovery wires are arranged on the far-end marking ring and are connected with the end parts of the spiral guide wires in a one-to-one correspondence mode.
Further, the plurality of spiral guide wires are nickel-titanium alloy memory guide wires.
Further, the first driving piece and the second driving piece respectively comprise a worm wheel, a worm and a motor; the worm wheel is sleeved on the inner ring conduit or the outer ring conduit, the motor is coaxially connected with the worm, and the worm is meshed with the worm wheel.
Further, the number of a plurality of spiral seal wires is four, is evenly distributed and sets up.
Further, the third driving member is a vibration motor.
The thrombus thrombectomy device with the multi-spiral structure provided by the invention has the following technical effects:
1. the spring stent in the device is similar to a self-expanding stent, but has better adherence performance when released compared with the existing self-expanding stent due to the spiral characteristic.
2. The structure of the spring support in the device contacting the inner wall of the blood vessel is a smooth spiral guide wire when being released, and compared with the existing self-expanding support, the damage to the blood vessel along the way is smaller, and the pain of a patient can be relieved to the maximum extent.
3. The spring support in the device can be completely released in the blood vessel, the spring support can completely remove the thrombus when being recovered, and the spiral guide wire of the spring support can be spirally contracted and folded when being recovered, so that the plaque is prevented from being separated to the maximum extent.
4. The spring support of the device can be rapidly and naturally unfolded to fill the inner wall of the blood vessel after being released from the guide sleeve, which is equivalent to implementing a stent forming operation, the blood flow can be immediately recovered, and after being released, the radial supporting force is rapidly reduced, so that the intima of the blood vessel is ensured not to be damaged.
Drawings
For ease of illustration, the present invention is described in detail by the following preferred embodiments and the accompanying drawings.
FIG. 1 is an angle schematic view of a thrombus removal device with a multi-spiral structure according to the present invention;
FIG. 2 is a schematic view of another angle of the thrombectomy device with multiple helical structures according to the present invention;
FIG. 3 is a schematic structural diagram of a part of the structure of a thrombus removal device with a multi-spiral structure according to the present invention;
wherein the reference numerals are:
1. a first driving member; 2. a second driving member; 3. an inner race conduit; 4. an outer ring conduit; 5. a proximal marker ring; 6. a distal marker ring; 7. a guide sleeve; 8. a helical guide wire; 9. spiral rifling stripes; 10. a third driving member; 11. a central guidewire; 12. an eccentric pendulum bob; 13. a barb; 14. marking; 15. recovering the wire by the spring; 16. a worm gear; 17. a worm; 18. an electric motor.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Referring to fig. 1 to 3, a thrombus extraction device having a multi-spiral structure according to the present invention includes: the device comprises a first driving piece 1, a second driving piece 2, an inner ring catheter 3, an outer ring catheter 4, a near end marking ring 5, a far end marking ring 6, a guide sleeve 7 and a spiral guide wire 8; the first driving member 1 is in driving connection with the outer ring conduit 4 to drive the outer ring conduit 4 to rotate; the inner ring conduit 3 is arranged in the outer ring conduit 4 and extends out of two ends, the second driving piece 2 is in driving connection with one end of the inner ring conduit 3 extending out to drive the inner ring conduit 3 to rotate, and the other end of the inner ring conduit 3 extending out is connected with the far-end marking ring 6; the near-end marking ring 5 is axially and slidably sleeved on the outer ring catheter 4, a plurality of spiral guide wires 8 extend out of the end part of the near-end marking ring 5, and the end parts of the spiral guide wires 8 are connected with the far-end marking ring 6; a plurality of spiral rifling stripes 9 matched with the spiral guide wires 8 are arranged on the inner wall of the guide sleeve 7, the spiral guide wires 8 are arranged in the spiral rifling stripes 9 when being compressed, and the spiral guide wires 8 extend out of the guide sleeve 7 when not being compressed to form a spring support in an even spiral arrangement.
Preferably, the thrombus embolectomy device further comprises a third driving piece 10, a central guide wire 11; the central guide wire 11 is disposed in the inner ring catheter 3 and extends out, the third driving member 10 is in driving connection with the extended end of the central guide wire 11 to drive the central guide wire 11 to vibrate, and the other end of the central guide wire 11 is connected with the distal end marking ring 6.
Preferably, the thrombectomy device further comprises an eccentric pendulum 12, and the other end of the central guide wire 11 extends out of the distal marker ring 6 and is connected with the eccentric pendulum 12.
Preferably, a plurality of barbs 13 are provided on a plurality of the helical guide wires 8 pointing towards the inner ring catheter 3.
Preferably, a plurality of the spiral guide wires 8 are provided with marks 14 for identifying the turning direction of the spring holder.
Preferably, a plurality of spring retrieving wires 15 are arranged on the distal end marking ring 6, and the plurality of spring retrieving wires 15 are connected with the end parts of the plurality of spiral guide wires 8 in a one-to-one correspondence manner.
Preferably, the plurality of helical guide wires 8 are nitinol memory guide wires.
Preferably, the first driving member 1 and the second driving member 2 each comprise a worm wheel 16, a worm 17, a motor 18; the worm wheel 16 is sleeved on the inner ring conduit 3 or the outer ring conduit 4, the motor 18 is coaxially connected with the worm 17, and the worm 17 is meshed with the worm wheel 16.
Preferably, the number of the plurality of spiral guide wires 8 is four, and the spiral guide wires are uniformly distributed.
Preferably, the third driver 10 is a vibration motor 18.
Specifically, an inner ring catheter 3 is sleeved inside an outer ring catheter 4 in the device, a central guide wire 11 is sleeved inside the inner ring catheter 3, the head end of the outer ring catheter 4 is coaxially connected with a worm wheel 16 through a sliding key, the outer ring catheter 4 can axially and freely slide on the worm wheel 16, the worm wheel 16 is meshed with a worm 17, the worm 17 is coaxially and fixedly connected with a motor 18, the head end of the outer ring catheter 4 extends out of the inner ring catheter 3, the head end of the inner ring catheter 3 is coaxially and slidably connected with the worm wheel 16, the inner ring catheter 3 can axially and freely slide on the worm wheel 16, the worm wheel 16 is meshed with the worm 17, the worm 17 is coaxially and fixedly connected with the motor 18, the head end of the inner ring catheter 3 extends out of the central guide wire 11, the central guide wire 11 is coaxially and fixedly connected with a vibration motor, a near end marking ring 5 is coaxially sleeved on the, the left side surface of a near-end mark ring 5 is uniformly distributed and extended with a spring support consisting of 4 spiral nickel-titanium alloy memory guide wires in a circumferential manner, each spiral nickel-titanium alloy memory guide wire in the spring support is uniformly distributed with marks 14 and barbs 13, the head and tail parts of two opposite spiral nickel-titanium alloy memory guide wires are respectively provided with two marks 14, the head and tail parts of the other two opposite spiral nickel-titanium alloy memory guide wires are respectively provided with one mark 14 so as to distinguish and confirm the rotation condition of the spring support, each barb 13 on each spiral nickel-titanium alloy memory guide wire points to the direction of a central guide wire 11, a guide sleeve 7 is sleeved on the outer side of each spiral nickel-titanium alloy memory guide wire, the inner part of the guide sleeve 7 is hollow, the inner wall of the guide sleeve 7 is uniformly distributed with a plurality of spiral rifling stripes 9, the inner circumferential diameter of the guide sleeve 7 is smaller than the diameter of a spiral, when the spring support is separated from the guide sleeve 7, the spring support is in a natural extension state, the right side of the near-end marking ring 5 is connected into the outer ring catheter 4, the left side of the near-end marking ring is communicated with the inner ring catheter 3, the tail end of the inner ring catheter 3 is coaxially and fixedly connected with the far-end marking ring 6, 4 spring recovery wires 15 are uniformly distributed and extended on the circumference of the right side of the far-end marking ring 6, the other end of each spring recovery wire 15 is connected with the part, close to the tail end, of the spiral nickel-titanium alloy memory guide wire of the corresponding spring support, the far-end marking ring 6 extends out of the central guide wire 11 close to the outer side, the central guide wire 11 is eccentrically connected with the eccentric.
The spring support composed of the first 4 spiral nickel-titanium alloy memory guide wires is completely contracted in the guide sleeve 7, when the spring support needs to work, the guide sleeve 7 is stretched into the position of a blood vessel thrombus, the motor 18 in the first driving part 1 is turned on, the motor 18 rotates to drive the worm 17 to rotate, the worm 17 drives the worm wheel 16 to rotate because the worm 17 is meshed with the worm wheel 16, the worm wheel 16 rotates to drive the outer ring catheter 4 to rotate, the outer ring catheter 4 rotates to drive the spiral nickel-titanium alloy memory guide wire to rotate, because the inner wall of the guide sleeve 7 is provided with a plurality of spiral rifling stripes 9 which are uniformly distributed, the spiral nickel-titanium alloy memory guide wire can rotate out of the guide sleeve 7 along the track of the spiral rifling stripes 9 when rotating, the head end of the outer ring catheter 4 can axially move relative to the far end relative to the worm wheel 16 to slide, the vibration motor is turned, the eccentric pendulum bob 12 rotates to form eccentric vibration to drive the spring support to vibrate integrally, at the moment, the spring support consisting of the spiral nickel-titanium alloy memory guide wire drives the guide tube guide wire to rotate and push forwards to separate from the guide sleeve 7 and vibrate, the barb 13 can catch more thrombus in the vibration process of the spring support, the spring support continuously pushes forwards until the thrombus is completely wrapped, the motor 18 and the vibrating motor in the first driving part 1 are closed, the motor 18 in the second driving part 2 is opened, the motor 18 drives the worm 17 to rotate, the worm 17 drives the worm wheel 16 to rotate, the worm wheel 16 drives the inner ring guide tube 3 to rotate, the inner ring guide tube 3 drives the far end marking ring 6 to rotate clockwise, and because the near end marking ring 5 and the outer ring guide tube 4 do not rotate, the spring recovery wire 15 drives one end of the spring support to rotate, one end of the spring support rotates, so that the spiral diameter of the spiral nickel-, the diameter diminishes, because the length of nickel titanium alloy memory seal wire is fixed, so spiral nickel titanium alloy memory seal wire spiral diameter reduces, make the distance between near-end mark ring 5 and distal end mark ring 6 increase, inner circle pipe 3 takes place axial displacement for worm wheel 16 and slides to the tip, push into guide pin bushing 7 with the tip small part spiral nickel titanium alloy memory seal wire simultaneously, spring holder tightly wraps up the thrombus this moment firmly, barb 13 vibrates simultaneously rotatory tightening and catches on more thrombus, when the spiral diameter of spring holder contracts to minimum, close vibrating motor and the motor 18 in the second driving piece 2, reverse start motor 18, spiral nickel titanium alloy memory seal wire rotates along guide pin bushing 7 inner wall spiral rifling stripe 9 and retrieves to guide pin bushing 7 inside this moment. After the spring support is completely recovered to the interior of the guide sleeve 7, the motor 18 is turned off, and the device is taken out.
The device has the following advantages:
1. adopt two or two more than spiral nickel titanium alloy memory seal wire spiral of each other of circumference evenly distributed to constitute spring bracket and set up the thrombus and get, choose helical structure for use because helical structure can effectual shrink and expand, can the furthest in parcel thrombus when expanding, can fasten the thrombus of parcel firm during the shrink to the condition that the thrombus leaked outward appears.
2. The barbs 13 pointing to the spiral center line are uniformly distributed on the spiral circumference inside the spring support and used for grabbing thrombus, and the thrombus can be grabbed powerfully in the thrombus grabbing process, so that the thrombus is not easy to fall off.
3. The worm wheel 16 is connected with the outer ring guide pipe 4 in a sliding key mode, when the spring support is released, the outer ring guide pipe 4 moves axially relative to the worm wheel 16 in the distal direction, the worm wheel 16 is connected with the inner ring guide pipe 3 in a sliding key mode, and when the spring support is contracted, the inner ring guide pipe 3 moves axially relative to the worm wheel 16 in the head end direction.
4. The axes of the near-end marking ring 5 and the far-end marking ring 6 are both hollow, the inner ring catheter 3 is arranged between the near-end marking ring 5 and the far-end marking ring 6 for connection, the near-end marking ring 5 does not rotate, and the far-end marking ring 6 rotates to pull the spring support through the spring recovery wire 15 to enable the spiral diameter of the spring support to contract.
5. The outer ring catheter 4, the inner ring catheter 3 and the central guide wire 11 are respectively driven by a motor, a series of operations such as propulsion, spiral shrinkage, vibration hook hanging and the like can be realized in a grading manner, and the phenomenon of incomplete thrombus removal is avoided.
6. The tail end of seal wire is connected with eccentric pendulum 12, and center seal wire 11 drives eccentric pendulum 12 and makes eccentric rotation when vibrating motor starts, arouses spring bracket vibration for barb 13 can snatch more thrombi at the in-process of vibration, avoids omitting.
7. The inner wall of the inner hole of the guide sleeve 7 adopts a design of a plurality of spiral rifling stripes distributed on the circumference, and the spiral nickel-titanium alloy memory guide wire stably pushes and contracts outwards at a constant speed along with the track of the internal thread of the guide sleeve 7 in the rotation process.
8. After the spring support breaks away from the thrombus wrapped by the increase of the spiral diameter of the guide sleeve 7, the spiral diameter is reduced during contraction, the length of the spring support is extended towards two sides, and the head end part of the spring support can independently return to the interior of the guide sleeve 7, so that the later process of reversely rotating and retracting the guide sleeve 7 can be smoothly carried out.
9. The spiral nickel-titanium alloy memory guide wire of the spring stent is similar to a self-expanding stent, but has better adherence performance when being released compared with the existing self-expanding stent because of the spiral characteristic.
10. The spiral nickel-titanium alloy memory guide wire is a round and smooth spiral memory guide wire in the structure contacting the inner wall of the blood vessel when being released, and compared with the existing self-expanding stent, the injury to the blood vessel along the way is smaller, and the pain of a patient can be relieved to the greatest extent.
11. The spring support can be completely released in the blood vessel, the spiral nickel-titanium alloy memory guide wire can be completely withdrawn by spiral contraction during recovery, and the spiral nickel-titanium alloy memory guide wire of the spring support can be spirally contracted and folded during recovery, so that the plaque is prevented from being separated to the maximum extent.
12. The spiral nickel-titanium alloy memory guide wire can be rapidly and naturally unfolded to fill the inner wall of the blood vessel after being released from the guide sleeve 7, which is equivalent to implementing a stent forming operation, the blood flow can be recovered immediately, and after the release, the radial supporting force is rapidly reduced, so that the intima of the blood vessel is ensured not to be damaged.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.

Claims (10)

1. A thrombus extraction device with a multi-spiral structure, which is characterized by comprising: the device comprises a first driving piece, a second driving piece, an inner ring catheter, an outer ring catheter, a near-end marking ring, a far-end marking ring, a guide sleeve and a spiral guide wire; the first driving piece is in driving connection with the outer ring guide pipe to drive the outer ring guide pipe to rotate; the inner ring guide pipe is arranged in the outer ring guide pipe and extends out of two ends, the second driving piece is in driving connection with the extending end of the inner ring guide pipe to drive the inner ring guide pipe to rotate, and the extending other end of the inner ring guide pipe is connected with the far-end marking ring; the near-end marking ring is sleeved on the outer ring catheter, a plurality of spiral guide wires extend out of the end part of the near-end marking ring, the spiral guide wires penetrate through the guide sleeve, and the end parts of the spiral guide wires are connected with the far-end marking ring; the spiral guide wire compression device is characterized in that a plurality of spiral rifling stripes matched with the plurality of spiral guide wires are arranged on the inner wall of the guide sleeve, the plurality of spiral guide wires are arranged in the plurality of spiral rifling stripes when being compressed, and the plurality of spiral guide wires extend out of the guide sleeve to form a spring support in a uniform spiral arrangement when not being compressed.
2. A thrombus embolectomy device with a multi-spiral structure according to claim 1, wherein the thrombus embolectomy device further comprises a third driving member, a central guide wire; the central guide wire is arranged in the inner ring catheter and extends out, the third driving piece is in driving connection with one end, extending out, of the central guide wire to drive the central guide wire to vibrate, and the other end of the central guide wire is connected with the far-end marking ring.
3. A thrombectomy device according to claim 2, wherein the thrombectomy device further comprises an eccentric weight, and the other end of the central guide wire extends out of the distal marker ring and is connected to the eccentric weight.
4. A thrombectomy device according to claim 1, wherein multiple barbs are provided on multiple spiral wires pointing towards the inner catheter.
5. A thrombus extraction device with a multi-spiral structure according to claim 1, wherein a plurality of spiral guide wires are provided with a mark for identifying the spiral direction of the spring support.
6. A thrombus extraction device with a multi-spiral structure according to claim 1, wherein a plurality of spring retrieval wires are arranged on the distal marker ring, and the plurality of spring retrieval wires are connected with the ends of the plurality of spiral guide wires in a one-to-one correspondence.
7. A thrombectomy device according to claim 1, wherein said helical wires are nitinol memory wires.
8. A thrombus embolectomy device with a multi-spiral structure according to claim 1, wherein the first driving member and the second driving member each comprise a worm gear, a worm, and a motor; the worm wheel is sleeved on the inner ring guide pipe or the outer ring guide pipe, the motor is coaxially connected with the worm, and the worm is meshed with the worm wheel.
9. A thrombus extraction device with a multi-spiral structure according to claim 1, wherein the number of the spiral guide wires is four, and the spiral guide wires are uniformly distributed.
10. A thrombus embolectomy device with a multi-spiral structure according to claim 2, wherein the third driving member is a vibration motor.
CN201710028973.XA 2017-01-16 2017-01-16 Thrombus embolectomy device with multi-spiral structure Active CN106491181B (en)

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