CN106475157B - A kind of paper base micro-fluid chip wax crayon device and its application - Google Patents
A kind of paper base micro-fluid chip wax crayon device and its application Download PDFInfo
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- CN106475157B CN106475157B CN201610865092.9A CN201610865092A CN106475157B CN 106475157 B CN106475157 B CN 106475157B CN 201610865092 A CN201610865092 A CN 201610865092A CN 106475157 B CN106475157 B CN 106475157B
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- Prior art keywords
- paraffin
- paper base
- pen core
- fluid chip
- coating
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
Abstract
A kind of paper base micro-fluid chip wax crayon device disclosed by the invention, belongs to paper base care diagnostic equipment technical field.Including paraffin pen core, in paraffin pen core outer cladding metal-coating, and heater strip is wound on the metal-coating.The device is by heater strip heating paraffin wax pen core, so that paraffin melts in pen core and flows out pen tip can smoothly write out paraffin pattern formation microfluidic channel on paper base.It is avoided during this using additional warm table, only needs a step that can complete so that preparing microfluidic channel on paper base.The apparatus structure is simple, and design is rationally, easily operated, easy to carry, low in cost.
Description
Technical field
The invention belongs to paper base care diagnostic equipment technical fields, are specifically related to a kind of paper base micro-fluid chip wax crayon dress
It sets.
Background technique
In recent years, scientists have developed the micro-fluid chip based on paper and are widely used in care diagnostic detection, example
Such as human health, the fields such as environmental monitoring and food safety.Compared with conventional micro fluidic chip, paper base micro-fluid chip tool
Have it is easy to operate, inexpensive, environmental-friendly, be easy to get, be disposable, it is soft flexibly etc. advantages.Particularly, more due to paper
Pore structure, flowing of the liquid on paper depend on the capillarity in hole, thus paper base micro-fluid chip do not need it is external additional
Pump is to drive liquid to flow, further such that the operation of paper base micro-fluid chip becomes simply, to be more suitably applied to care diagnostic
Field.
The preparation of paper base micro-fluid chip is be unable to do without prepares the flowing that microfluidic channel is used to guide liquid on paper.At present
The method for being used to prepare paper base micro-fluid chip is broadly divided into two classes, chemical preparation process and physical preparation method.Chemistry system
Preparation Method includes photoetching process, etching method, plasma processing etc..These methods need to use more expensive chemical reagent, with
And large-scale Laboratory Instruments, and required step is various, therefore cost of manufacture is relatively high, and being chemically treated may be right
The performance of hard copy body damages.Therefore, chemical preparation process gradually fades out the people visual field instead physics preparation side
Method.Physical preparation method includes patterning method, and seal method, paraffin print process etc., compared with chemical method, these preparation methods are not required to
Expensive chemical reagent and large-scale instrument are wanted, and preparation step greatly simplifies, therefore physical preparation method is widely applied at present
In preparing paper base micro-fluid chip.In physical preparation method, due to paraffin have it is at low cost, be easy to get, low melting point, environment
The advantages that friendly, therefore the preparation method based on paraffin is especially extensive, including the method printed with paraffin printer, paraffin
The method of infiltration, and connect the method write straight with solid wax.But these methods all have the defects that it is certain, such as: stone
Wax printer is expensive, and the method operation requirement of paraffin infiltration is very high, and the method precision that solid paraffin pen is write is very low.And this
A little methods all include two steps: first, paraffin is printed on paper；Second, paraffin is made by the method that warm table heats
Melt infiltration paper, forms channel.Infiltration of the liquid paraffin inside paper during this, since melting point of paraffin wax is low, after melting
It is difficult to control thoroughly.
Summary of the invention
In order to overcome the problems of the above-mentioned prior art, the purpose of the present invention is to provide a kind of paper base micro-fluid chips
Wax crayon device and its application, the apparatus structure is simple, and design is rationally, easily operated, easy to carry, low in cost.
The present invention is to be achieved through the following technical solutions:
A kind of paper base micro-fluid chip wax crayon device, including paraffin pen core, in paraffin pen core outer cladding metal-coating, and
Heater strip is wound on the metal-coating.
Thermal insulation protection set is additionally provided with outside the wax crayon device, the tip part of pen of paraffin pen core stretches out thermal insulation protection and covers bottom
Portion.
Heater strip is wound in outside metal-coating in the shape of a spiral.
The screw pitch for being wrapped in the heater strip of metal outer is identical.
The invention also discloses application of the above-mentioned paper base micro-fluid chip wax crayon device in preparation microfluidic channel.
When preparing microfluidic channel, by being powered to heater strip, paraffin pen core is heated, when heating temperature reaches stone
When wax fusing point, paraffin pen core can write microfluidic channel on paper base.
The paper base is filter paper or nitrocellulose filter.
Compared with prior art, the invention has the following beneficial technical effects:
A kind of paper base micro-fluid chip wax crayon device disclosed by the invention, including paraffin pen core, in paraffin pen core outer cladding
Metal-coating, and heater strip is wound on the metal-coating.The device is by heater strip heating paraffin wax pen core, so that paraffin exists
Paraffin pattern formation microfluidic channel can smoothly be write out on paper base by melting in pen core and flowing out pen tip.It is avoided during this
Using additional warm table, only need a step that can complete so that preparing microfluidic channel on paper base.The apparatus structure is simple, if
Meter is rationally, easily operated, easy to carry, low in cost.
Detailed description of the invention
Fig. 1 is paper base micro-fluid chip wax crayon apparatus structure schematic diagram of the invention；
Fig. 2 and Fig. 3 is that embodiment 1 utilizes the device of the invention to write paraffin pattern on filter paper and nitrocellulose filter；
Fig. 4 and Fig. 5 is that embodiment 2 makes microfluidic channel using the device of the invention on nitrocellulose filter.
Specific embodiment
Below with reference to specific embodiment, the present invention is described in further detail, it is described be explanation of the invention and
It is not to limit.
Referring to Fig. 1, paper base micro-fluid chip wax crayon device of the invention, including paraffin pen core 1, due to paraffin pen core 1
Material is plastics, and heating is easy to happen plastic deformation, is not easy to write, thus in 1 outer cladding metal-coating 2 of paraffin pen core, gold
Belong to housing 2 and paraffin pen core 1 is fitted close.It is wound with heater strip 3 on the metal-coating 2, it is by metal-coating 2 that heat is equal
It is so even that be transferred at paraffin pen core 1.
Preferably, in order to which operator facilitates writing in use and operator is protected not scalded during heating
Wound, therefore devise thermal insulation protection set 4 and separate heater strip 3 with the external world, the tip part of pen of paraffin pen core 1 stretches out thermal insulation protection set
4 bottoms.
Preferably, heater strip is wound in outside metal-coating in the shape of a spiral.In order to be heated evenly, it is wrapped in metal outer
The screw pitch of heater strip is identical.
The operation principle of the present invention is that:
Before assembling, common ball pen is cleaned up and be packed into paraffin, prepares paraffin pen core 1.By paraffin pen
After core 1, metal-coating 2, heater strip 3 and thermal insulation protection set 4 shown in Fig. 1 according to assembling, it is powered to heater strip 3, so that plus
Heated filament 3 gives paraffin pen core 1 to heat, and after 1 temperature of paraffin pen core reaches paraffin melting point, can submitting a written statement to a higher authority in paper, to write out microfluid logical
Road.
Embodiment 1 writes paraffin pattern using apparatus of the present invention on paper
Paraffin is packed into the refill for ball-point pen cleaned up by the present embodiment, and heater strip 3 carries out paraffin pen core 1 after being powered
Heating, when temperature reaches paraffin melting point, is just submitted a written statement to a higher authority in different paper using the device and writes out paraffin pattern, be illustrated in figure 2
It submits a written statement to a higher authority the paraffin pattern write out in filter paper, Fig. 3 show the paraffin pattern write out on nitrocellulose filter.Introduce herein this two
Kind paper is because the substrate of most paper base micro-fluid chips is all based on filter paper or nitrocellulose filter.Therefore it demonstrates
The device can prepare microfluidic channel on different paper.
Embodiment 2 makes microfluidic channel using the device on nitrocellulose filter
The present embodiment production method and embodiment 1 are consistent, have write different shape by ruler on nitrocellulose filter
Microfluidic channel, and pigment solution is instilled in channel, liquid can be successfully fixed on by paraffin channel as the result is shown
In channel, as shown in figure 4, demonstrating the feasibility of the paper base microfluidic channel of device preparation.
Further, the microfluidic channel shape convenient for detecting immediately is prepared for using the device, as shown in Figure 5.Equally
Ground, paper base micro-fluid chip can be good at limiting flowing of the liquid on paper, therefore can be applied to care diagnostic field.
Claims (7)
1. a kind of paper base micro-fluid chip wax crayon device, which is characterized in that including paraffin pen core (1), in paraffin pen core (1) outsourcing
It covers metal-coating (2), metal-coating (2) and paraffin pen core (1) are fitted close, and are wound with heating on the metal-coating (2)
Silk (3).
2. paper base micro-fluid chip wax crayon device according to claim 1, which is characterized in that outside the wax crayon device also
Equipped with thermal insulation protection set (4), the tip part of pen of paraffin pen core (1) stretches out thermal insulation protection set (4) bottom.
3. paper base micro-fluid chip wax crayon device according to claim 1, which is characterized in that heater strip (3) is in the shape of a spiral
It is external to be wound in metal-coating (2).
4. paper base micro-fluid chip wax crayon device according to claim 3, which is characterized in that be wrapped in metal-coating (2)
Heater strip (3) screw pitch it is identical.
5. paper base micro-fluid chip wax crayon device described in any one of Claims 1 to 4 is in preparation microfluidic channel
Using.
6. application according to claim 5, which is characterized in that when preparation microfluidic channel, by logical to heater strip (3)
Electricity heats paraffin pen core (1), and when heating temperature reaches paraffin melting point, paraffin pen core (1) can be write on paper base
Microfluidic channel.
7. application according to claim 6, which is characterized in that the paper base is filter paper or nitrocellulose filter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610865092.9A CN106475157B (en) | 2016-09-29 | 2016-09-29 | A kind of paper base micro-fluid chip wax crayon device and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610865092.9A CN106475157B (en) | 2016-09-29 | 2016-09-29 | A kind of paper base micro-fluid chip wax crayon device and its application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106475157A CN106475157A (en) | 2017-03-08 |
| CN106475157B true CN106475157B (en) | 2019-03-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610865092.9A Active CN106475157B (en) | 2016-09-29 | 2016-09-29 | A kind of paper base micro-fluid chip wax crayon device and its application |
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| CN113198554A (en) * | 2021-05-14 | 2021-08-03 | 广州大学 | Method for manufacturing micro-fluidic chip formed rapidly on chip |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10020826A1 (en) * | 2000-04-28 | 2001-10-31 | Gert Schlueter | Method and device for filtering a liquid sample, in particular for obtaining medical preparations |
| CN103191794A (en) * | 2013-03-12 | 2013-07-10 | 西安交通大学 | Sample-adding pen and sample-adding method and application thereof |
| CN103203257A (en) * | 2013-03-12 | 2013-07-17 | 西安交通大学 | Method for manufacturing paper micro-fluidic chip |
| CN203264745U (en) * | 2013-03-12 | 2013-11-06 | 西安交通大学 | Sampling pen |
| CN103657748A (en) * | 2012-09-25 | 2014-03-26 | 中国科学院理化技术研究所 | Printing type paper microfluid chip and manufacture method thereof |
| CN204576542U (en) * | 2015-04-17 | 2015-08-19 | 浙江海洋学院 | A kind of can the pen of typing fingerprint |
-
2016
- 2016-09-29 CN CN201610865092.9A patent/CN106475157B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10020826A1 (en) * | 2000-04-28 | 2001-10-31 | Gert Schlueter | Method and device for filtering a liquid sample, in particular for obtaining medical preparations |
| CN103657748A (en) * | 2012-09-25 | 2014-03-26 | 中国科学院理化技术研究所 | Printing type paper microfluid chip and manufacture method thereof |
| CN103191794A (en) * | 2013-03-12 | 2013-07-10 | 西安交通大学 | Sample-adding pen and sample-adding method and application thereof |
| CN103203257A (en) * | 2013-03-12 | 2013-07-17 | 西安交通大学 | Method for manufacturing paper micro-fluidic chip |
| CN203264745U (en) * | 2013-03-12 | 2013-11-06 | 西安交通大学 | Sampling pen |
| CN204576542U (en) * | 2015-04-17 | 2015-08-19 | 浙江海洋学院 | A kind of can the pen of typing fingerprint |
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| Publication number | Publication date |
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| CN106475157A (en) | 2017-03-08 |
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Effective date of registration: 20210508 Address after: 215129 South half of 2nd floor, building 3, 599 Taishan Road, high tech Zone, Suzhou City, Jiangsu Province Patentee after: Huicheng Zhilian Industrial Technology Service (Suzhou) Co.,Ltd. Address before: Beilin District Xianning West Road 710049, Shaanxi city of Xi'an province No. 28 Patentee before: XI'AN JIAOTONG University |
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Effective date of registration: 20211009 Address after: 215129 South half of floor 2, building 3, No. 599, Taishan Road, high tech Zone, Suzhou, Jiangsu Province Patentee after: Suzhou DianAn Biotechnology Co.,Ltd. Address before: 215129 South half of 2nd floor, building 3, 599 Taishan Road, high tech Zone, Suzhou City, Jiangsu Province Patentee before: Huicheng Zhilian Industrial Technology Service (Suzhou) Co.,Ltd. |
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