CN106474349A - A kind of promoting blood circulation polysaccharide tablet - Google Patents
A kind of promoting blood circulation polysaccharide tablet Download PDFInfo
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- CN106474349A CN106474349A CN201510530823.XA CN201510530823A CN106474349A CN 106474349 A CN106474349 A CN 106474349A CN 201510530823 A CN201510530823 A CN 201510530823A CN 106474349 A CN106474349 A CN 106474349A
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- rhizoma gastrodiae
- polysaccharide
- folium ginkgo
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Abstract
Entitled a kind of promoting blood circulation polysaccharide tablet of the present invention, belongs to technical field of food healthcare.This product mainly with Jerusalem artichoke polysaccharide as main material, with Rhizoma Gastrodiae, Folium Ginkgo or Rhizoma Gastrodiae, Folium Ginkgo active ingredient as adjuvant, and through compounding, grinding, sieve, pelletize, tabletting forms.Purpose is blood sugar lowering, blood fat reducing, brain healthy, blood circulation promoting and blood stasis dispelling, is used for health care for the middle and old aged.This product is to human body fanout free region, taking convenience.It is mainly characterized by including 50 70 parts of raw material Jerusalem artichoke polysaccharide（wt）, Rhizoma Gastrodiae powder or 20 30 parts of Rhizoma Gastrodiae extract（wt）, Folium Ginkgo or 10 20 parts of Ginkgo Biloba Extract（wt）, Folium Ginkgo solution 30 63ml, Rhizoma Gastrodiae solution 10 30ml, disintegrating agent be 57 parts of carboxymethyl starch sodium（wt）；Lubricant accounts for gross mass 0.1 0.2% for magnesium stearate（wt）；Adhesive is PVPK30 ethanol solution concentration 0.5 2.5%（wt）, 10 26 ml.Preparation process is as follows：(1), Jerusalem artichoke Polyose extraction and purification；(2), Folium Ginkgo active ingredient is extracted；(3), Rhizoma Gastrodiae active ingredient is extracted；(4) a kind of, preparation of promoting blood circulation polysaccharide tablet.
Description
Technical field
The invention belongs to a kind of nutrient and healthcare products technology category, be related to a kind of by feverfew Jerusalem artichoke tuber extract polysaccharide purified again after to obtain Jerusalem artichoke polysaccharide be raw material, a kind of Technology of the promoting blood circulation polysaccharide tablet being obtained with other supplementary product compatibilities, there is memory reinforcing, alleviate senile dementia, promoting blood circulation, the effect of blood sugar lowering, blood fat reducing.
Background technology
Jerusalem Artichoke Resource enriches, growing environment strong adaptability, easily cultivation, easily breeding, can once cultivate and harvest for many years, nature wild plant is huge many.Jerusalem artichoke fresh tuber is rich in about 15-20%（wt）Jerusalem artichoke polysaccharide, has low in calories, promotes plurality of health care functions and the excellent edibilities such as bifidus bacilluss growth, enhance immunity, can be widely used in the manufacture of functional food, medicine and health product as functional ingredient.Jerusalem artichoke polysaccharide is the nutritional supplement of food by multiple state approvals in the world, as a kind of dietary fibre complex, is formally approved.And Rhizoma Gastrodiae has regulation blood pressure, reduction blood fat, strengthen blood vessel elasticity, relaxing muscles and tendons to promote blood circulation, improves the health care of sleep, hypermnesis function, and to coronary heart diseases and angina pectoris patient outcome substantially, and the effect of there is brain healthy, headache that neurasthenia, hypertension or blood supply insufficiency are caused, dizzy effectively.Folium Ginkgo is astringed the lung, and relievings asthma, blood circulation promoting and blood stasis dispelling, pain relieving.For cough and asthma due to lung deficiency；Coronary heart disease, angina pectoriss, hyperlipidemia, anticoagulant is solid, has certain probability to improve memory.Folium Ginkgo energy blood circulation promoting, prevention of cardiovascular disease, has very strong removing free radical and antioxidation, and flavonoid glycoside in Folium Ginkgo, aminoacid and Amino acid synthesis collagen protein composition are to human body beauty treatment, suppression melanin growth, keeps skin gloss and elasticity to play no small effect.
The present invention is with Jerusalem artichoke tuber as raw material, Jerusalem artichoke polysaccharide is obtained through extraction and purification, compound with adjuvant Rhizoma Gastrodiae powder or Rhizoma Gastrodiae, Folium Ginkgo or Ginkgo Biloba Extract phase by a certain percentage again, be made for a kind of promoting blood circulation polysaccharide tablet with Jerusalem artichoke polysaccharide as main material, it has blood sugar lowering, adjust fat, brain healthy, the effect of blood circulation promoting and blood stasis dispelling, and instant, has no toxic side effect, it is suitable for industrialized production, real genus green health care food.
Content of the invention
The present invention is by extracting to Jerusalem artichoke tuber, purification obtains Jerusalem artichoke polysaccharide, then with Rhizoma Gastrodiae powder or Rhizoma Gastrodiae, Folium Ginkgo or Ginkgo Biloba Extract is compatible is made for for a kind of oral promoting blood circulation polysaccharide tablet.It is new pollution-free food health preparation with Jerusalem artichoke polysaccharide as main material that this product clearly proposes, without harmful substance.It is characterized in that the 50-70% of polysaccharide containing Jerusalem artichoke（wt）, other prescription material contents are 30-50%（wt）.
The present invention is the new medicinal preparation of feature edible health care product, and its dosage form is the chewable tablet that can be administered orally, and has brain healthy, slow down aging, the multiple efficacies such as blood circulation promoting and blood stasis dispelling, reduction blood glucose, blood fat reducing.
Specific embodiment
Example 1～example 3：
(1) operating process
1). Jerusalem artichoke Polyose extraction and purification：Choose Directly Dried in Shadow or the Jerusalem artichoke block of low-temperature air-drying storage or piece carries out pulverizing granulating or powder A 100-200 part (wt)；Obtain Jerusalem artichoke polysaccharide extraction liquid using water extraction or supersound extraction, more concentrated Jerusalem artichoke polysaccharide concentrated solution B 770-850 part (wt)；And by adding natural clarifying agent ZTC1+1A component C 0.6-1.2% part (wt), B component D 1.2-2.4% part (wt) purification；And with 90% (wt) ethanol precipitate with ethanol, white Jerusalem artichoke polysaccharide F 35-43 part (wt), wherein polyoses content G 93.3-99.2% (wt) are obtained.
2). the extraction of Folium Ginkgo active ingredient：Take 100 parts of (wt) ginkgo leaf powders of M, respectively at 1000 parts of (wt) water of N, 800 parts (wt) 45% (wt) ethanol, 500 parts of (wt) 70-85% (wt) ethanol, concentrate after extracting E 1-3 hour at 60-90 DEG C of T respectively, merge concentrated solution and obtain Folium Ginkgo active ingredient extract, treated prepared Folium Ginkgo active ingredient extract and Folium Ginkgo solution.
3). the extraction of Rhizoma Gastrodiae active ingredient：Take 100 parts of (wt) Rhizoma Gastrodiae powders of R, in solid-liquid ratio Y 1：20-1：In the water of 30 (wt), at 80-105 DEG C of P, extract 3 times respectively, after time V 0.5-1.5 hour, united extraction liquid is concentrated, and concentrated solution must measure U 430-480ml, treated prepared Rhizoma Gastrodiae active ingredient extract and Rhizoma Gastrodiae solution.
4). a kind of preparation of promoting blood circulation polysaccharide tablet：
Formula material, adjuvant, recipe ratio, preparation method, formulation principle is as follows：
Raw material, ratio of adjuvant：Jerusalem artichoke polysaccharide H 50-70 part (wt), Rhizoma Gastrodiae powder or Rhizoma Gastrodiae extract J 20-30 part (wt), Folium Ginkgo or Folium Ginkgo active ingredient extract K 10-20 part (wt), Folium Ginkgo solution L 30-50ml (volume), Rhizoma Gastrodiae solution Q 10-15ml (volume).Disintegrating agent is carboxymethyl starch sodium S 5-7 part (wt)；Lubricant accounts for gross mass X 0.1-0.2% (wt) for magnesium stearate；Adhesive is PVPK30 ethanol solution concentration 0.5-2.5% (wt), Z 20-26ml.
Preparation method：Ground 120 mesh sieves are standby respectively to take raw material and each mass fraction of adjuvant in proportion；It is placed on mix homogeneously in mixer with the equivalent interior addition that progressively increases, then Deca adhesive and Folium Ginkgo solution, Rhizoma Gastrodiae solution make soft material by a certain percentage；Soft material is placed in granulation machine 16 mesh sieves excessively and makes granule, be dried under low temperature；By dried granule through 40 mesh sieve granulate intrinsic pressure 100 in tablet machine.The standard preparation that product meets 2010 editions States Pharmacopoeia specifications after testing requires.
Formulation principle：
Jerusalem artichoke polysaccharide -- playing the role of reduce blood glucose promotion sugar decomposition to make superfluous sugar transition is heat, improves body fat balance.
Rhizoma Gastrodiae -- suppressing liver-YANG, dispelling wind and removing obstruction in the collateral, improving eyesight hypermnesis, it is clinically used for improving the health care of sleep, oxygen supplement, brain-nourishing intelligence-benefiting etc..
Folium Ginkgo -- reduce cholesterol levels in blood of human body, prevent arteriosclerosis.Increase vascular permeability and elasticity and reduce blood pressure, have preferable antihypertensive effect.Eliminate the deposition composition in blood vessel wall, it is possible to decrease triglyceride, hence it is evident that reduction blood fat level, reduces the sickness rate of middle-aged and elderly people coronary heart disease.Evident in efficacy to diseases such as senile dementia, brain injury sequela, cerebral thrombosiss.
(2) process control parameters
(1) symbol in describing is parameter code name, and design parameter numerical value and preparation are the results detailed in following table.
Example 4～example 6：
(1) operating process
1). the extraction and purification of Jerusalem artichoke polysaccharide：The Jerusalem artichoke granule for the treatment of excess syndrome example 1～example 3, using water extraction Jerusalem artichoke polysaccharide, water consumption Q 260-300 part (wt), 80-90 DEG C of water extraction temperature R, constant temperature time S 30-40min；Scarvenger natural clarifying agent ZTC1+1 component A adds 45-55 DEG C of temperature H, constant temperature return time J 30-45min, and natural clarifying agent ZTC1+1 B component adds 50-65 DEG C of temperature N；Constant temperature return time P 30-45min.
2). the extraction of Folium Ginkgo active ingredient：Take 300 parts of ginkgo leaf powder M (wt), in 60% (wt) ethanol E 1500ml, at 60-70 DEG C of temperature A, extraction time B 2 hours respectively, extract 3 times, united extraction liquid, and be concentrated to give Folium Ginkgo active ingredient extraction concentrat, treated prepared Ginkgo Biloba Extract and Folium Ginkgo solution.
3). the extraction of Rhizoma Gastrodiae active ingredient：Take 200 parts of (wt) Rhizoma Gastrodiae powders of C, in solid-liquid ratio D 1：20-1：In the water of 30 (wt), at 90-105 DEG C of temperature U, extract 3 times respectively, after time Y 1-3 hour, united extraction liquid is concentrated, and concentrated solution must measure X 460-495ml, treated prepared Rhizoma Gastrodiae active ingredient extract and Rhizoma Gastrodiae solution.
4). a kind of preparation of promoting blood circulation polysaccharide tablet：
Preparation method, formulation principle are with example 1～example 3.
Raw material, ratio of adjuvant：Jerusalem artichoke polysaccharide T 55-65 part (wt), Rhizoma Gastrodiae powder or Rhizoma Gastrodiae extract V 20-25 part (wt), Folium Ginkgo or Folium Ginkgo active ingredient extract W 15-20 part (wt), Folium Ginkgo solution L 40-63ml, Rhizoma Gastrodiae solution Z 20-30ml.Disintegrating agent is 5 parts of carboxymethyl starch sodium F (wt)；Lubricant accounts for gross mass G 0.1-0.2% (wt) for magnesium stearate；Adhesive is PVPK30 ethanol solution, concentration 0.5-2.5% (wt), K 10-20ml.The standard preparation that product meets 2010 editions States Pharmacopoeia specifications after testing requires.
(2) procedure parameter
(1) symbol in is parameter code name, and design parameter numerical value and preparation are the results detailed in following table.
The standard preparation that product meets 2010 editions States Pharmacopoeia specifications after testing requires.
Claims (13)
1. a kind of preparation method of promoting blood circulation polysaccharide tablet, is made up of the following step：
1）. Jerusalem artichoke Polyose extraction and purification：Choose Directly Dried in Shadow or the Jerusalem artichoke block of low-temperature air-drying storage or piece carries out pulverizing granulating or powder 100-200 part（wt）；Obtain Jerusalem artichoke polysaccharide extraction liquid using water extraction or supersound extraction, more concentrated Jerusalem artichoke polysaccharide concentrated solution 770-850 part（wt）；And by adding natural clarifying agent ZTC1+1 component A 0.6-1.2% part（wt）, B component 1.2-2.4% part（wt）Purification；And with 90%（wt）Ethanol precipitate with ethanol, is obtained white Jerusalem artichoke polysaccharide 35-43 part（wt）, wherein polyoses content 93.3-99.2%（wt）.
2. the extraction of Folium Ginkgo active ingredient：Take 100-300 part（Wt) ginkgo leaf powder, respectively at 1000 parts（Wt) water, 800-1500 part（Wt) 45-60% ethanol（Wt), 500 parts（Wt) 85% ethanol（Wt), extract respectively at 60-90 DEG C and concentrate after 1-3 hour, merge concentrated solution and obtain Folium Ginkgo active ingredient concentrate, treated Folium Ginkgo active ingredient extract and Folium Ginkgo solution.
3. the extraction of Rhizoma Gastrodiae active ingredient：Take 100-200 part（Wt) Rhizoma Gastrodiae powder, in solid-liquid ratio 1：20-1：30（Wt, in water), at 80-105 DEG C, extract 3 times respectively, time 0.5-3 hour, united extraction liquid is concentrated, and concentrated solution must measure 430-495ml, treated prepared Rhizoma Gastrodiae active ingredient extract and Rhizoma Gastrodiae solution.
4. a kind of preparation of promoting blood circulation polysaccharide tablet：
Take Jerusalem artichoke polysaccharide 50-70 part in proportion（wt）, Rhizoma Gastrodiae powder or Rhizoma Gastrodiae extract 20-30 part（wt）, Folium Ginkgo or Folium Ginkgo active ingredient extract 10-20 part（wt）, Folium Ginkgo solution 30-63ml, Rhizoma Gastrodiae solution 10-30ml.
5. disintegrating agent is carboxymethyl starch sodium 5-7 part（wt）；Lubricant accounts for gross mass 0.1-0.2% for magnesium stearate（wt）；Adhesive is PVPK30 ethanol solution concentration 0.5-2.5%（wt）, 10-26 ml.
6. will be standby to solid material and adjuvant each mass fraction ground 120 mesh sieves of difference；It is placed on mix homogeneously in mixer with the equivalent interior addition that progressively increases, then Deca adhesive and Folium Ginkgo solution, Rhizoma Gastrodiae solution make soft material by a certain percentage；Soft material is placed in granulation machine 16 mesh sieves excessively and makes granule, be dried under low temperature；By dried granule through 40 mesh sieve granulate tablettings in tablet machine.
7. a kind of preparation method of promoting blood circulation polysaccharide tablet according to claim 1, can obtain Jerusalem artichoke polysaccharide using water extraction, through natural clarifying agent ZTC1+1 A, B component purification from the tuber of plant Jerusalem artichoke.
8. a kind of preparation method of promoting blood circulation polysaccharide tablet according to claim 1, can be respectively adopted the active ingredient in water extraction and the ethanol extraction Folium Ginkgo of variable concentrations from plant Ginkgo biloba leaf, and respectively obtain extract and solution.
9. a kind of preparation method of promoting blood circulation polysaccharide tablet according to claim 1, can obtain extract and the solution of Rhizoma Gastrodiae active ingredient by water extraction from plant Rhizoma Gastrodiae.
10. the preparation method of a kind of promoting blood circulation polysaccharide tablet according to claim 1, its compound formulation formula is by Jerusalem artichoke polysaccharide, Rhizoma Gastrodiae powder or Rhizoma Gastrodiae active ingredient extract and solution, the supplementary product compatibility such as ginkgo leaf powder or Folium Ginkgo active ingredient extract and solution, then form through pelletizing press sheet.
A kind of 11. preparation methoies of promoting blood circulation polysaccharide tablet according to claim 1, a kind of promoting blood circulation polysaccharide tablet is by Jerusalem artichoke polysaccharide 50-70 part（wt）, Rhizoma Gastrodiae powder or Rhizoma Gastrodiae extract 20-30 part（wt）, Folium Ginkgo or Folium Ginkgo active ingredient extract 10-20 part（wt）, Folium Ginkgo solution 30-63ml, Rhizoma Gastrodiae solution 10-30ml, adhesive 10-26 ml composition chewable tablet.
12. its there are the multiple efficacies such as blood sugar lowering, blood fat reducing, brain healthy, blood circulation promoting and blood stasis dispelling, can be used for person in middle and old age, diabeticss health care is used.
13. its product preparation production process no waste mine produce, raw materials used be also all medicine-food two-purpose or state food health care approval used article, this product actually green health care good merchantable brand.
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| CN104522460A (en) * | 2014-11-27 | 2015-04-22 | 高铭鸿 | Jerusalem artichoke polysaccharide tablets beneficial for brain |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104522460A (en) * | 2014-11-27 | 2015-04-22 | 高铭鸿 | Jerusalem artichoke polysaccharide tablets beneficial for brain |
Non-Patent Citations (2)
| Title |
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| 吴清: "《230种中药颗粒剂和胶囊剂制备关键技术》", 31 January 2008 * |
| 王昌涛等: "《化妆品植物添加剂的开发与应用》", 30 April 2013 * |
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Application publication date: 20170308 |
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