CN106460042A - 用于个性化疼痛管理的方法与组合物 - Google Patents

用于个性化疼痛管理的方法与组合物 Download PDF

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Publication number
CN106460042A
CN106460042A CN201580021042.6A CN201580021042A CN106460042A CN 106460042 A CN106460042 A CN 106460042A CN 201580021042 A CN201580021042 A CN 201580021042A CN 106460042 A CN106460042 A CN 106460042A
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patient
risk
morphine
low
genotype
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S.萨哈西瓦姆
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MEDICAL CENTER CHILDREN HOSPITAL
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Data Mining & Analysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Bioethics (AREA)
  • Evolutionary Computation (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Artificial Intelligence (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Databases & Information Systems (AREA)
  • Software Systems (AREA)
  • Pathology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
CN201580021042.6A 2014-02-24 2015-02-23 用于个性化疼痛管理的方法与组合物 Pending CN106460042A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461943944P 2014-02-24 2014-02-24
US61/943944 2014-02-24
PCT/US2015/017134 WO2015127379A1 (en) 2014-02-24 2015-02-23 Methods and compositions for personalized pain management

Publications (1)

Publication Number Publication Date
CN106460042A true CN106460042A (zh) 2017-02-22

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US (1) US10878939B2 (enExample)
EP (1) EP3110968B1 (enExample)
JP (1) JP6581117B2 (enExample)
KR (1) KR20160123385A (enExample)
CN (1) CN106460042A (enExample)
AU (1) AU2015218692A1 (enExample)
CA (1) CA2940422A1 (enExample)
IL (1) IL247389A0 (enExample)
SG (1) SG11201607035YA (enExample)
WO (1) WO2015127379A1 (enExample)

Cited By (4)

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CN107169573A (zh) * 2017-05-05 2017-09-15 第四范式（北京）技术有限公司 利用复合机器学习模型来执行预测的方法及系统
CN108929913A (zh) * 2018-08-21 2018-12-04 潍坊德诺泰克生物科技有限公司 用于检测rs2032582的引物探针组及其应用
CN111312387A (zh) * 2020-01-16 2020-06-19 安徽医科大学第一附属医院 一种男性慢性前列腺炎/慢性盆腔痛综合征疼痛严重程度预测模型及其建立
CN115976190A (zh) * 2022-11-15 2023-04-18 苏州吉赛基因测序科技有限公司 剖宫产患者术后镇痛用药相关基因分型检测的产品及用途

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US10878939B2 (en) 2014-02-24 2020-12-29 Children's Hospital Medical Center Methods and compositions for personalized pain management
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US11618924B2 (en) 2017-01-20 2023-04-04 Children's Hospital Medical Center Methods and compositions relating to OPRM1 DNA methylation for personalized pain management
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EP3781588B1 (en) 2018-04-20 2024-10-30 Children's Hospital Medical Center Blood biomarker for eosinophilic gastrointestinal disorders
JP7078458B2 (ja) * 2018-05-30 2022-05-31 株式会社Soken 操舵角決定装置、および、自動運転車
EP3874510A4 (en) * 2018-10-31 2022-08-03 Ancestry.com DNA, LLC ESTIMATION OF PHENOTYPES USING DNA, PEDIGREE AND HISTORICAL DATA
CN109741826B (zh) * 2018-12-13 2022-09-13 华中科技大学鄂州工业技术研究院 麻醉评估决策树构建方法及设备
US12431227B2 (en) * 2018-12-28 2025-09-30 Greenway Dna Inc. Method and system for providing a personalized cannabinoid treatment regimen
US12297501B2 (en) 2019-02-25 2025-05-13 Children's Hospital Medical Center Methods for diagnosing and treating eosinophilic gastritis
EP3935581A4 (en) 2019-03-04 2022-11-30 Iocurrents, Inc. DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING
WO2021262871A1 (en) * 2020-06-25 2021-12-30 Greenway Dna Inc. Methods and systems for providing a personalized treatment regimen using cannabinoid or psychedelic compounds
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CN119662844A (zh) * 2024-12-16 2025-03-21 郑州大学第一附属医院 用于麻醉用药基因分型的复合扩增体系、检测方法及试剂盒

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107169573A (zh) * 2017-05-05 2017-09-15 第四范式（北京）技术有限公司 利用复合机器学习模型来执行预测的方法及系统
CN108929913A (zh) * 2018-08-21 2018-12-04 潍坊德诺泰克生物科技有限公司 用于检测rs2032582的引物探针组及其应用
CN111312387A (zh) * 2020-01-16 2020-06-19 安徽医科大学第一附属医院 一种男性慢性前列腺炎/慢性盆腔痛综合征疼痛严重程度预测模型及其建立
CN115976190A (zh) * 2022-11-15 2023-04-18 苏州吉赛基因测序科技有限公司 剖宫产患者术后镇痛用药相关基因分型检测的产品及用途

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KR20160123385A (ko) 2016-10-25
US20170061073A1 (en) 2017-03-02
JP2017512069A (ja) 2017-05-18
EP3110968A1 (en) 2017-01-04
CA2940422A1 (en) 2015-08-27
WO2015127379A1 (en) 2015-08-27
AU2015218692A1 (en) 2016-09-15
JP6581117B2 (ja) 2019-09-25
EP3110968B1 (en) 2019-04-17
IL247389A0 (en) 2016-11-30
US10878939B2 (en) 2020-12-29
SG11201607035YA (en) 2016-09-29

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