CN106459979B - 用于结合补体组分3蛋白的核酸化合物 - Google Patents

用于结合补体组分3蛋白的核酸化合物 Download PDF

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CN106459979B
CN106459979B CN201580028344.6A CN201580028344A CN106459979B CN 106459979 B CN106459979 B CN 106459979B CN 201580028344 A CN201580028344 A CN 201580028344A CN 106459979 B CN106459979 B CN 106459979B
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aptamer
protein
seq
deoxyuridine
nucleotides
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CN106459979A (zh
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丹尼尔·W·德罗莱
张弛
丹尼尔·J·奥康奈尔
沙希·古普塔
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Private Placement Protein Body Operation Co ltd
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Somalogic Inc
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CN201580028344.6A 2014-05-30 2015-05-29 用于结合补体组分3蛋白的核酸化合物 Expired - Fee Related CN106459979B (zh)

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US201462005300P 2014-05-30 2014-05-30
US62/005,300 2014-05-30
PCT/US2015/033355 WO2015184372A1 (en) 2014-05-30 2015-05-29 Nucleic acid compounds for binding to complement component 3 protein

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US (2) US11466275B2 (enExample)
EP (1) EP3149173B1 (enExample)
JP (1) JP6824041B2 (enExample)
CN (2) CN106459979B (enExample)
CA (1) CA2949246C (enExample)
ES (1) ES2664179T3 (enExample)
NO (1) NO2718257T3 (enExample)
WO (1) WO2015184372A1 (enExample)

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
ES3013534T3 (en) * 2016-07-01 2025-04-14 Somalogic Operating Co Inc Oligonucleotides comprising modified nucleosides
US12202848B2 (en) * 2019-10-18 2025-01-21 Fujifilm Wako Pure Chemical Corporation Phosphoramidite activator

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101374965A (zh) * 2006-01-17 2009-02-25 私募蛋白质体公司 测试样品的多元化分析

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US6395888B1 (en) 1996-02-01 2002-05-28 Gilead Sciences, Inc. High affinity nucleic acid ligands of complement system proteins
US6140490A (en) 1996-02-01 2000-10-31 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of complement system proteins
AU2994997A (en) * 1996-05-07 1997-11-26 T Cell Sciences, Inc. Aptamers for complement protein c3b
US20020082227A1 (en) * 1999-09-30 2002-06-27 Scott Henry Use of oligonucleotides for inhibition of complement activation
US20030219801A1 (en) * 2002-03-06 2003-11-27 Affymetrix, Inc. Aptamer base technique for ligand identification
US7947447B2 (en) * 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US8975026B2 (en) * 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
US8927509B2 (en) * 2008-05-20 2015-01-06 The Research Foundation Of State University Of New York Aptamer modulators of complement protein C3 and biologically active proteolytic products thereof
EP2558586B1 (en) 2010-04-12 2016-10-12 Somalogic, Inc. APTAMERS TO ß-NGF AND THEIR USE IN TREATING ß-NGF MEDIATED DISEASES AND DISORDERS
ES2629183T3 (es) * 2011-03-10 2017-08-07 Somalogic, Inc. Aptámeros para diagnóstico de Clostridium difficile
CN104220453B (zh) 2012-04-03 2018-03-09 诺沃姆德治疗公司 人源化的嵌合抗因子c3抗体及其用途
US10975393B2 (en) * 2016-08-24 2021-04-13 Sangamo Therapeutics, Inc. Engineered target specific nucleases
PH12022550056A1 (en) * 2019-07-11 2023-04-12 Memorial Sloan Kettering Cancer Center Dll3-targeting antibodies and uses thereof

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
CN101374965A (zh) * 2006-01-17 2009-02-25 私募蛋白质体公司 测试样品的多元化分析

Non-Patent Citations (2)

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Title
Commandeering a biological pathway using aptamer-derived molecular adaptors;Prabhat等;《Nucleic Acids Research》;20100106;第38卷(第7期);第2页左栏2-3段、最后两段及第3页左栏第3段 *
核酸适体的筛选制备及分析应用;刘腾飞等;《生物技术通报》;20131231;第39-48页 *

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ES2664179T3 (es) 2018-04-18
JP6824041B2 (ja) 2021-02-03
CN106459979A (zh) 2017-02-22
CN110643610A (zh) 2020-01-03
US20230093170A1 (en) 2023-03-23
US20170166895A1 (en) 2017-06-15
CA2949246A1 (en) 2015-12-03
EP3149173A1 (en) 2017-04-05
WO2015184372A1 (en) 2015-12-03
NO2718257T3 (enExample) 2018-04-14
US11466275B2 (en) 2022-10-11
EP3149173B1 (en) 2018-02-07
CA2949246C (en) 2023-06-27
JP2017517261A (ja) 2017-06-29

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