CN1064264C - Application of selenium-rich glossy ganoderma in medicine for treating psoriasis - Google Patents
Application of selenium-rich glossy ganoderma in medicine for treating psoriasis Download PDFInfo
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- CN1064264C CN1064264C CN 98110184 CN98110184A CN1064264C CN 1064264 C CN1064264 C CN 1064264C CN 98110184 CN98110184 CN 98110184 CN 98110184 A CN98110184 A CN 98110184A CN 1064264 C CN1064264 C CN 1064264C
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- lucid ganoderma
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Abstract
The present invention relates to an application of selenium-rich ganoderma to medicines for treating psoriasis. The selenium-rich ganoderma can increase the number of antibody-forming cells in human bodies, obviously enhance the activity of natural killer cells and increase the immune competence of organisms. In the 101 patients, the application of the selenium-rich ganoderma to medicines for treating psoriasis has 90.09% of the effective rate, 5.94% of the improvement rate and 3.96% of ineffective rate, and has the advantages of good therapeutic effect, high therapeutic effect and no toxic and side effect.
Description
The present invention relates to the application of Se-rich lucid ganoderma in the preparation medicine.
Psoriasis is commonly called as psoriasis, and its pathogenic factor it be unclear that, and Heredity theory assert that it is a disease of multifactorial inheritance.The more consistent view of medical circle thinks that it is that immunodeficiency causes at present.Till now, psoriatic therapeutic effect is all undesirable, and cure rate is low, relapse rate is high.
The purpose of this invention is to provide the application of a kind of Se-rich lucid ganoderma in the psoriatic medicine of preparation treatment, to improve the therapeutic effect of medicine.
The present invention is the application of Se-rich lucid ganoderma in the psoriatic medicine of preparation treatment, and described Se-rich lucid ganoderma is cultivated by following method and formed:
In concentration is in the sodium selenite solution of 100-300PPM, the ammonium molybdate that adds sodium selenite solution weight 0.05-0.08% respectively, the zinc sulfate of 0.01-0.05%, the calcium superphosphate of 0.5-2%, the common soil of 8-15%, mix homogeneously is made adjuvant, the Testa Tritici skin that in cotton seed hulls, adds cotton seed hulls weight 8-10%, mix homogeneously is made major ingredient, then, it is major ingredient by weight: the ratio of adjuvant=1: 1.25-1.30, with major ingredient, the adjuvant mix homogeneously, make culture medium, the plastic bag of packing into after the culture medium pH value is adjusted into 8, carry out high temperature sterilize, connect Ganderma lucidum strain after the cold, under 23-28 ℃ the temperature after 30-35 days cultivation, the shift-in mushroom producing room fruiting of preserving moisture is gathered after 15-20 days and can be got Se-rich lucid ganoderma.
Se-rich lucid ganoderma is preparing the application for the treatment of in the psoriatic medicine, can improve the therapeutic effect of medicine, and the medicine cost is low.
Further specify the present invention below.
Ganoderma is the individual calling of a specific kind of Ganoderma, and the Ganoderma Latin is called GanoolevmaLuoimw (LevssFr) Kaxt, another name Ganoderma lucidum (Leyss. Ex Fr.) Karst., red sesame.Description according to the Li Shizhen (1518-1593 A.D.) Compendium of Material Medica, functions such as the useful healthy energy of Ganoderma, tonifying liver gas, lung benefiting gas, beneficial vital essence, domestic many medical institutions are used for Ganoderma clinical, find that Ganoderma all has significant curative effect to the disease of nervous system, respiratory system, blood circulation, digestive system.Selenium can make antibody forming cell's number of animal increase, and natural killer cell activity obviously strengthens, thereby improves body's immunological function.Blood drawing chemical examination after by Se-rich lucid ganoderma white mice being fed two months, detect the variation of its immunologic function, the result is that serum coagulation antibody titre, serum lysozyme content and three indexs of hemocyte phagocytic function all are significantly higher than contrast, illustrate that Se-rich lucid ganoderma can improve body's immunological function.And to psoriatic pathogenic factor, the more consistent view of medical circle is that immunodeficiency causes.
Below be the toxicity test of Se-rich lucid ganoderma to different animals.
1, white mice toxicity test
The selenic toxicity test of first, high concentration
With 50,100,150,200,250, the sodium selenite solution digestion wheat grain of 300PPM, contrast is the clear water digestion, wheat grain boils to spreading, drop removes excessive moisture, pack in the bottle, seal a mouthful back sterilization, after the cold female kind of Ganoderma inserted in the bottle, put under 23-28 ℃ the condition and cultivate, behind the full bottle of mycelia, this is and is rich in the selenic Ganoderma mycelium of high concentration, feeds the white mice at a monthly age with this mycelium, every group 10, observe the weather of white mice every day, after feeding 60 days, put to death 5 for every group, by only dissecting, observe each group situation.Feed again to the 90th day, remaining white mice is all put to death by only observing each group situation, pathological anatomy result such as following table.
Above-mentioned evidence, the Ganoderma mycelium that promptly uses the high selenium solution of 300PPM concentration to cultivate out, the white mice of feeding also is safe, whole process from test, each concentration of treatment compared with the control, every experimental observation project of white mice does not all have any difference, the macroscopic observation no change.Microscope inspection, NIP or inflammation histiocyte.
Second, the selenic toxicity test of low concentration
The Ganoderma sporophore digestion that we cultivate out with 200PPM, 300PPM sodium selenite solution is respectively got its juice and is soaked the wheat grain white mice of feeding again, and 10 every group, contrasting is that clear water soaks wheat grain.(purpose of this test is that check Se-rich lucid ganoderma sporophore has avirulence), after feeding 60 days and 90 days, put to death 5 respectively, detection method with first detects each processing project, do not find that respectively organizing white mice has any pathological changes unusual, illustrate that the Se-rich lucid ganoderma that supplies examination is the same with contrast, white mice is not had any toxicity.
2, the culture experiment of insecticide
This test is big bacterium mosquito NecempheriaSP for the insecticide of examination, and big bacterium mosquito is an insect common in the edible fungus culturing, the adult yellowish-brown, the long 5-6 millimeter of body, simple eye 2, compound eye is bigger, it is lateral 1/2 to account for head, near the trailing edge of compound eye, a front wide and rear narrow brown patch is arranged respectively, long 1.4 millimeters of feeler, the yellow all tool hairs of base portion two joints, the hair of second joint is doubly surplus than the staple length of first segment, flagellum 14 joints, brown, following Hubei Province palpus three joints, the backboard hirsutism also has the vertical band of 4 dark browns, intermediary two vertical belt lengths, be " V " font, the fore wing prosperity, long 5 millimeters of wing, wide 1.4 millimeters, hind wing is degenerated or is become balancer, abdominal part 10 joints.
Ovum: brown, like ellipse garden shape, the end point.
Larva: head is yellow, and breast and abdominal part are yellow-white, totally 12 saves, and first segment to the both sides of minor details have a dark dotted lines to connect valve, the long 1-1.3 millimeter of larva body of first hatching, mature larva 10-16 millimeter.
Pupa: the pupa of firstization is a milky, transfers to filbertly gradually, becomes dark brown after the dozens of minutes, long 5 millimeters of pupal cell.
We cultivate big bacterium mosquito in the big wide mouthed bottle of 2000ml, seal with gauze, and the Ganoderma mycelium that the sodium selenite solution of the 200PPM that feeds is cultivated contrasts and is no selenium mycelium, triplicate, and observed result is as follows.
Big bacterium mosquito biocycle
As seen from the above table, in the test of insecticide, we find with the mycelium of the 200PPM Se-rich lucid ganoderma big bacterium mosquito of feeding, the processed group comparison is according to the effect that tangible life-saving is arranged, its larval phase, prolong 6 hours, prolongs 3 hours pupa time, and the adult stage prolongs 3 hours, total prolongation 12 hours, this result with domestic and international other scholar's research selenium elements energy slow down aging is consistent.
3, the toxicity test of rabbit
In this test, we adopt the aqueous solution digestion wheat grain of 300PPM sodium selenite, finish back bottling sterilization, Ganderma lucidum strain is inserted in cool back, when treating that left and right sides mycelia was covered with complete bottle in 30 days, with feed 10 every group of rabbit (contrast for no selenium Ganoderma mycelium) of this Se-rich lucid ganoderma mycelium, raising through half a year, the weather of two groups of rabbit does not have any difference, after dissecting, also do not find the rabbit of processed group, internal organs have any intoxicating phenomenon, be as good as with contrast, show liver, kidney and other internal organs also NIP tissue or abnormal cell after testing.This test explanation, 300PPM contains the selenium mycelium to the rabbit avirulence.(female rabbit farrowing of an existing processed group recently, growth is normal)
Below be that Se-rich lucid ganoderma is to improving the test for examination animal immune function.
This test is adopted and is measured serum coagulation antibody titre, serum lysozyme content, and the method for phagocytic activity of leukocytes in the blood detects Se-rich lucid ganoderma to the influence for examination animal immune function.The serum lysozyme Determination on content is the angle from humoral immunization, and the mensuration of phagocytic activity of leukocytes in the blood is from the cellular immunization angle, supplies the examination animal in the variation aspect the immunologic mechanism from these two aspect researchs.
This test is soaked the wheat grain white mice of feeding with the digestion liquid of the Se-rich lucid ganoderma of 200PPM, 300PPM, and contrasting is that clear water soaks wheat grain.Get one the monthly age white mice feed and carried out the detection of following index in two months.
(1) serum lysozyme content.Testing result sees the following form.
Serum lysozyme content
(2) phagocytic activity of leukocytes.Testing result sees the following form.
Blood hemocyte phagocytic function
The result of last the exterior and the interior shows that no matter be the Ganoderma that 200PPM or 300PPM selenium concentration are cultivated out, processed group has evident difference than matched group, this explanation, and Se-rich lucid ganoderma can obviously improve the non-specific immunity for the examination animal.
(3) in order to detect Se-rich lucid ganoderma to the influence for examination animal specific immune function, this test checks Se-rich lucid ganoderma to the function for examination animal specific humoral immunity with the method for serum coagulation antibody titre.Testing result sees the following form.
Serum coagulation antibody titer determination numerical value
From last table, we can find out obviously that the serum coagulation antibody titre of processed group and matched group has significant difference, illustrate that Se-rich lucid ganoderma can promote body's immunological function.
It below is 101 routine patients' clinical therapeutic efficacy.
101 routine psoriatics all are that outpatient service is diagnosed as psoriasis vulgaris, male's 42 examples wherein, and women's 59 examples, the age is at 13-57 between year, the shortest 7 days of the course of disease, the longest 20 years.Skin lesion type: coin shape 25 examples, map shape 30 examples, drop shape 46 examples.By stages: resting stages 46 example, carry out phases 55 example.Just send out person's 24 examples, the person's of appearing again 77 examples.Recurrence in winter and patient's 75 examples, with irrelevant person's 15 examples in season, fall ill and recidivist's 11 examples summer, the whole body person of glowing 80 examples, circumscribed 21 examples.
The instructions about how to take medicine of Se-rich lucid ganoderma:
One kilogram of Se-rich lucid ganoderma took in 20 days, every days 50 gram, 1.2 kilograms of waters steam in marmite and endure to 0.4 kilogram, take after the cold, add 1.2 kilograms in water again, endure after 0.8 kilogram for second time, with two times Ganoderma scrub water affected parts that decoct, once a day, 20 days course of treatment.After finishing each course of treatment, check once, observe therapeutic effect, and have a blood test, physiological and biochemical index such as intestinal routine, liver function, the detection index of not finding any routine patient among the 101 routine patients is unusual, and the patient that accepts for medical treatment of this 101 example, does not find that in the medication process example has any side effect.
Curative effect determinate standard:
(according to the Recognized Standards of document specifies)
(1) clinical recovery: skin lesion disappears fully, leaves temporary pigmentation and the pigment speckle that comes off, and subjective symptoms disappears.
(2) produce effects: skin lesion disappears more than 50%, and subjective symptoms disappears.
(3) take a turn for the better: skin lesion disappears more than 20%, and colour-darkening is thin out, the squama attenuation, and subjective symptoms alleviates.
(4) invalid: skin lesion disappears below 20% or does not have any improvement, and subjective symptoms does not have improvement.
According to above-mentioned standard, the psoriatic's that this problem is accepted for medical treatment therapeutic effect is as follows:
41 examples of fully recovering, cure rate 40.59%, produce effects 50 examples, obvious effective rate is 49.5%, adds up to total effective rate 90.09%, and improvement rate is 5.94%, and inefficiency is 3.96%.In 41 examples of clinical recovery, the shortest 20 days of the course of treatment, the longest 80 days.This test explanation, the intractable case long to the course of disease extends the period of treatment and can improve the effective percentage of treatment.
Case 1: Zhao * *, the woman, 27 years old, the patient is long tinea since 16 years old, through curing in many ways, ineffective eventually, and after taking some treatment tinea medicine, the side effect of digestive system is obvious, as undesired etc. with diarrhoea, liver function test, after take Se-rich lucid ganoderma after three courses of treatment, the not recurrence in 2 years of now fully recovering.Case 2: slowly * *, the man, 26 years old, the patient was covered with pimple shape or coin shape skin lesion from top to bottom, and all day is unbearably scratchy, only takes two courses of treatment of Se-rich lucid ganoderma, not recurrence in a year so far.Case 3: Cui * *, man, 41 years old, suffer from psoriasis for many years, because of it is the driver, so along with wheel has changeed many hospitals, lose effect always, take Se-rich lucid ganoderma after, the good results are evident, his characteristics are, in therapeutic process, all must take every day, otherwise scratchyly feel bad, as long as took the same day, this day do not itch with regard to brisk.This patient is drug withdrawal six wheat harvesting periods now, do not see recurrence.
Claims (1)
1, the application of Se-rich lucid ganoderma in the psoriatic medicine of preparation treatment, it is characterized in that, described Se-rich lucid ganoderma is cultivated by following method and formed: in concentration is in the sodium selenite solution of 100-300PPM, the ammonium molybdate that adds sodium selenite solution weight 0.05-0.08% respectively, the zinc sulfate of 0.01-0.05%, the calcium superphosphate of 0.5-2%, the common soil of 8-15%, mix homogeneously is made adjuvant, the Testa Tritici skin that in cotton seed hulls, adds cotton seed hulls weight 8-10%, mix homogeneously is made major ingredient, then, it is major ingredient by weight: the ratio of adjuvant=1: 1.25-1.30, with major ingredient, the adjuvant mix homogeneously is made culture medium, the plastic bag of packing into after the culture medium pH value is adjusted into 8, carry out high temperature sterilize, connect Ganderma lucidum strain after the cold, under 23-28 ℃ the temperature after 30-35 days cultivation, the shift-in mushroom producing room fruiting of preserving moisture is gathered after 15-20 days and can be got Se-rich lucid ganoderma.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98110184 CN1064264C (en) | 1998-04-28 | 1998-04-28 | Application of selenium-rich glossy ganoderma in medicine for treating psoriasis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 98110184 CN1064264C (en) | 1998-04-28 | 1998-04-28 | Application of selenium-rich glossy ganoderma in medicine for treating psoriasis |
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| CN1233482A CN1233482A (en) | 1999-11-03 |
| CN1064264C true CN1064264C (en) | 2001-04-11 |
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| CN 98110184 Expired - Fee Related CN1064264C (en) | 1998-04-28 | 1998-04-28 | Application of selenium-rich glossy ganoderma in medicine for treating psoriasis |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| NZ552027A (en) * | 2004-08-02 | 2009-10-30 | Sami Labs Ltd | Compositions and methods for the management of hyperproliferative dermatological conditions |
| CN107853077A (en) * | 2017-12-05 | 2018-03-30 | 罗成喜 | A kind of solid Se-rich lucid ganoderma culture medium and its method for producing ganoderma lucidum |
| BR112023023657A2 (en) * | 2021-05-11 | 2024-01-30 | Shaochi Hsin | USE OF A PHARMACEUTICAL COMPOSITION |
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