CN106421447B - A kind of pharmaceutical composition for controlling blood pressure and protecting blood vessel and its production and use - Google Patents
A kind of pharmaceutical composition for controlling blood pressure and protecting blood vessel and its production and use Download PDFInfo
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- CN106421447B CN106421447B CN201611193386.8A CN201611193386A CN106421447B CN 106421447 B CN106421447 B CN 106421447B CN 201611193386 A CN201611193386 A CN 201611193386A CN 106421447 B CN106421447 B CN 106421447B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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Abstract
The invention discloses a kind of pharmaceutical composition for treating hypertension, and it is the preparation being prepared by the bulk drug of following weight proportion：10 30 parts of rhizoma Gastrodiae, 10 20 parts of yncaria stem with hooks, 5 15 parts of lotus nut, 5 15 parts of radix scutellariae.Pharmaceutical composition of the present invention can effectively protect blood vessel, treat hypertension, and potential applicability in clinical practice is good.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for controlling blood pressure and protecting blood vessel and its production and use.
Background technology
High blood pressure refers under quiescent condition or in the case where taking antihypertensive drugs, arterial systolic blood pressure and/or diastole
Pressure increases (>=140/90mmHg), is increased with systemic arterial blood pressure as main feature, mainly with headache, dizzy, insomnia, agitation
Irritability, it is weak be common sympton, often with the organ functional such as fat and sugar metabolic disorder and the heart, brain, kidney and retina or device
Matter sexually revises, the systemic disease characterized by organ is remolded.At present, drug therapy is the most important treatment side of high blood pressure
Method.
Research shows that Chinese medicine has the advantage of uniqueness in the treatment of angiocardiopathy.Compared with Western medicine, traditional Chinese medicine ingredients are multiple
Miscellaneous, it plays integration of the curative effect often by multicomponent, too many levels, Mutiple Targets, and treatment myocardial ischemia disease, which has, to be treated
The features such as imitating, be active strong, side effect is low.
The content of the invention
Object of the present invention is to provide a kind of pharmaceutical composition of new treatment hypertension.
The pharmaceutical composition of present invention treatment hypertension, it is the system being prepared by the bulk drug of following weight proportion
Agent：Rhizoma Gastrodiae 10-30 parts, yncaria stem with hooks 10-20 parts, lotus nut 5-15 parts, radix scutellariae 5-15 parts.
Preferably, it is the preparation being prepared by the bulk drug of following weight proportion：20 parts of rhizoma Gastrodiae, 20 parts of yncaria stem with hooks, lotus
Sub- 10 parts of the heart, 10 parts of radix scutellariae.
Wherein, it by the medicinal powder of bulk drug, the water of bulk drug or extractive with organic solvent is active component that it, which is, plus pharmacy
The preparation that upper conventional auxiliary material or complementary composition are prepared.
Wherein, the preparation is oral formulations.
Wherein, the preparation is decoction, oral liquid, granule, capsule, powder, pill, tablet.
Present invention also offers the preparation method of foregoing pharmaceutical composition, step are as follows：
(1) bulk drug is weighed according to foregoing proportioning；
(2) medicinal powder, the water or extractive with organic solvent of bulk drug of material medicine are prepared, adds pharmaceutically conventional auxiliary material or auxiliary
Helping property composition, is produced.
Present invention also offers purposes of the foregoing pharmaceutical composition in the medicine for preparing treatment hypertension.
Present invention also offers foregoing pharmaceutical composition to prepare the purposes in treating vascular protection medicine.
Present invention also offers purposes of the foregoing pharmaceutical composition in the medicine for improving endothelial dysfunction is prepared.
The refined clear dizzy Antihypertensive Decoction of the present invention is made up of rhizoma Gastrodiae, yncaria stem with hooks, lotus nut, radix scutellariae four traditional Chinese medicine in ratio of the present invention.
Rhizoma Gastrodiae in side, the dry tuber of orchid, there is certain soothing the liver, only convulsion and other effects.Modern pharmacology finds rhizoma Gastrodiae in rhizoma Gastrodiae
Element is principle active component, has certain effect for myocardial ischemia, thrombus, infection etc..Yncaria stem with hooks is Rubiaceae, wild gambier,
Plant yncaria stem with hooks, largeleaf gambirplant branchlet, uncaria hirsuta, the buckle stem branch of Uncaria sinensis and white yncaria stem with hooks, have The flat liver of heat-clearing, invigorate blood circulation, ceases wind
Traditional effects such as arresting convulsion.Modern pharmacology experiment shows, chemical composition contained by Uncaria genus plant have decompression, analgesia, anti-inflammatory, resist swell
A variety of effects such as knurl, calmness, anti-oxidant.Lotus nut is Nymphaeceae, Nelumbo, the green radicle among the mature seed of plant lotus,
With clearing away heart-fire, reduce phlegm and internal heat, stop blooding, puckery essence, the effect of gentle QI of five ZANG-organs.The pharmacological action of alkaloid is extensive, to cardiovascular system
With stronger activity, there is arrhythmia and antihypertensive effect.Radix scutellariae, Labiatae, Scutellaria, the root of radix scutellariae.Radix scutellariae
With it is clearing heat and detoxicating, moisten the lung and relieve the cough the effect of.Modern pharmacological research shows radix scutellariae antibacterial, antiviral, anti-inflammatory, antiallergy, resists swollen
Knurl, anti-oxidant, to liver, central nervous system, angiocarpy has protective effect.
We are used for prehypertensive or 1 grade of hypertension, calming the liver by monarch of rhizoma Gastrodiae, are aided with yncaria stem with hooks, help rhizoma Gastrodiae heat-clearing
It is calming the liver to stop the wind, help and internal heat is let out with radix scutellariae removing heat from the liver, embryo nelumbinis, so that the floating sun of liver is hiding, conscience is burning hot to drop, so as to reach
Checking exuberance of yang soothing the liver, suppress dynamic wind, blood pressure is dropped, heart and brain injury of kidney must answer.
Pharmaceutical composition of the present invention, formula is precise and appropriate, vascular remodeling can be significantly improved, so as to suppress caused by hypertension
The damage of target organ, there is obvious anti-hypertension and protection blood vessel, a kind of choosing is provided for clinical treatment hypertension
Select, application prospect is good.
The present invention is described in further details below by embodiment, but is not the limit to the present invention
System, according to the above of the present invention, according to the ordinary technical knowledge and customary means of this area, not departing from, the present invention is above-mentioned
Under the premise of basic fundamental thought, the modification, replacement or change of other diversified forms can also be made.
Brief description of the drawings
The refined clear influences of dizzy Antihypertensive Decoction and original side to rat ET-1 of Fig. 1.* compared with control group, P ＜ 0.05；# and model
Group compares, P ＜ 0.05.
The refined clear influences of dizzy Antihypertensive Decoction and original side to rat Ang- II of Fig. 2.* compared with control group, P ＜ 0.05；# and mould
Type group compares, P ＜ 0.05.
Embodiment
The preparation of the present inventor's pharmaceutical composition of embodiment 1
Rhizoma Gastrodiae 20g, yncaria stem with hooks 20g, lotus nut 10g are taken, radix scutellariae 10g, common 60g, the medicine after weighing is mixed after grinding, added
Enter 10 times of amount water (600ml) immersion 0.5h, decocting is boiled 1h, extracted 2 times altogether, filtering, merging filtrate, is concentrated under reduced pressure into thick paste, subtracts
Press dry dry 10 hours, crush, produce.
The preparation of the present inventor's pharmaceutical composition of embodiment 2
Rhizoma Gastrodiae 10g, yncaria stem with hooks 20g, lotus nut 5g are taken, radix scutellariae 15g, common 50g, the medicine after weighing is mixed after grinding, added
Enter 10 times of amount water (500ml) immersion 0.5h, decocting is boiled 1h, extracted 2 times altogether, filtering, merging filtrate, is concentrated under reduced pressure into thick paste, subtracts
Press dry dry 10 hours, crush, produce.
The preparation of the present inventor's pharmaceutical composition of embodiment 3
Rhizoma Gastrodiae 30g, yncaria stem with hooks 15g, lotus nut 15g are taken, radix scutellariae 5g, common 65g, the medicine after weighing is mixed after grinding, added
Enter 10 times of amount water (650ml) immersion 0.5h, decocting is boiled 1h, extracted 2 times altogether, filtering, merging filtrate, is concentrated under reduced pressure into thick paste, subtracts
Press dry dry 10 hours, crush, produce.
Beneficial effects of the present invention are illustrated below by way of test example.
The present composition of test example 1 controls the effect of blood pressure and protection blood vessel
1 material
1.1 experimental animal
Healthy SPF levels male SHR 24, weight (200 ± 20) g；Healthy SPF levels male Wistar rat 8, body
Quality (200 ± 20) g, (credit number is provided by Shanghai Slac Experimental Animal Co., Ltd.：SCXK (Shanghai) 2012-
0002).Put in SPF levels laboratory and normally feed, constant temperature, constant humidity, 12h illumination/day, after adaptability is fed 1 week, subsequently tried
Test.
1.2 Experimental agents and main agents
Refined clear dizzy Antihypertensive Decoction raw medicinal herbs is purchased from attached third party people hospital of Fujian University of Traditional Chinese Medicine；Yellow Jackets (on
Extra large chemical reagent import and export corporation)；ET-1 rats ELISA kit, Ang II rats ELISA kit (Shanghai Xi Tang biologies
Co., Ltd).
1.3 experiment key instruments
Low speed centrifuge (Thermo companies of the U.S.)；(Shenzhen steps auspicious biologic medical electricity to automatic clinical chemistry analyzer BS-120
JIANMEI ELECTRONICS CO LTD).
2 experimental methods
2.1 medicine preparation
Medicine (refined clear dizzy Antihypertensive Decoction) of the present invention：Rhizoma Gastrodiae 1kg, yncaria stem with hooks 1kg, lotus nut 0.5kg, radix scutellariae 0.5kg are taken, altogether
3kg, the medicine after weighing is mixed after grinding, add 10 times of amount water immersion 0.5h, decocting is boiled 1h, extracted 2 times altogether, filter, closes
And filtrate, thick paste is concentrated under reduced pressure into, is dried under reduced pressure 10 hours, crushes, produces.
Clear dizzy Antihypertensive Decoction：Take Ilex Latifolia Thunb 60g, rhizoma Gastrodiae 60g, yncaria stem with hooks 60, radix scutellariae 20g, radix cyathulae 20g, raw bark of eucommia 20g, night
Rattan 60g, fresh dried rhizome of rehmannia 60g, mulberry leaf 30g are handed over, chrysanthemum 30g, is mixed the medicine after weighing after grinding, adds 10 times of amount water immersions
1h is boiled in 0.5h, decocting, is extracted 2 times altogether, filtering, merging filtrate, is concentrated under reduced pressure into thick paste, is dried under reduced pressure 10 hours, is crushed, i.e.,
.
2.2 animal packet
24 male SHR rats are randomly divided into clear dizzy Antihypertensive Decoction group (original side's group), refined clear dizzy Antihypertensive Decoction group (treatment group)
With 3 groups, every group 8 of model control group (model group)；Separately Wistar rats 8 are set as control group (blank group).All rats are equal
Raise the free diet in SPF level mouse room, 22 DEG C of constant-temperature moisture-keepings, 12h light cycle, experimentation.
2.3 medication
Refined clear dizzy Antihypertensive Decoction was given by 5.4g/kg/ days by treatment group, and original side's group gives clear dizzy drop by by 18.9g/kg/ days
Press soup.Gastric infusion, it is daily sooner or later each 1 time, continuous 7 days, it is administered 8 weeks altogether, control group and model group give normal saline.
2.4 collection of specimens
Animal first carries out the adaptation of 1 week by a definite date, continuous treatment 8 weeks in Fujian University of Traditional Chinese Medicine's Experimental Animal Center.Rat
Fasting, free water give intraperitoneal injection of anesthesia after 24 hours, with 1% yellow Jackets with 40mg/ml dosage, treat that rat lies
, human body is soft, shows and anaesthetizes successfully.After the completion of anesthesia, cut through belly median line rapidly, be fixed on mouse platform after rat anesthesia
On, cut off skin and peritonaeum, show abdominal aorta, syringe is slowly drawn blood, be added dropwise anti-coagulants, 4 DEG C stand 2h after 3000rpm from
Heart 10min, upper strata pale yellow transparent blood plasma is extracted, -20 DEG C save backup, blood plasma ET-1 to be detected, Ang II contents.
2.6 blood ET-1, Ang II are detected
Take a blood sample 2ml, in injecting tube, mixes, and 4 DEG C stand 3000rpm centrifugation 10min after 2h, separated plasma, put -20 DEG C
Refrigerator in preserve.Make sample be placed in room temperature before measure again to melt, 4 DEG C again, 3000r/min centrifugation 5min, take supernatant, automatically
Biochemical instruments determine ET-1 and Ang II, are strictly operated by respective kit specification.
2.7 statistical analysis
Experimental data is with mean+SDRepresent, with the software analysis of SPSS 18, compare between multigroup mean and adopt
Examined with one-way analysis of variance, P<0.05 be considered as it is statistically significant.
3 results
3.1 refined clear influences of the dizzy Antihypertensive Decoction to rat plasma ET-1
SHR rats are after treatment in 8 weeks, original side group average blood plasma 154.81 ± 10.80ng/mL of ET-1, and treatment group is average
437.97 ± 15.54ng/mL of blood plasma 126.74 ± 5.60ng/mL of ET-1, model group average blood plasma ET-1, two groups of differences have system
Meter learns meaning (P<0.05).As a result show, clear dizzy Antihypertensive Decoction can substantially reduce SHR rat plasmas ET-1 levels, and of the invention
Refined clear dizzy Antihypertensive Decoction is better than original side, sees Fig. 1.
3.2 refined clear influences of the dizzy Antihypertensive Decoction to rat plasma Ang II
SHR rats are after treatment in 8 weeks, original side group average blood plasma Ang 62.33 ± 4.97ng/mL of II, and treatment group is average
Plasma A ng 32.98 ± 4.94ng/mL of II, model group 156.99 ± 8.34ng/mL of average blood plasma Ang II, two groups of differences have
Statistical significance (P<0.05).As a result showing, clear dizzy Antihypertensive Decoction can substantially reduce SHR rat plasma Ang II levels, and originally
The refined clear dizzy Antihypertensive Decoction of invention is better than original side, sees Fig. 2.
4 discuss
As " endothelial injuries-hypertension-cardiovascular event " initiation factor of chain and the vascular endothelial cell of carrier
(vascular endothelial cell, VEC), is played an important role in hypertension incidence.Therefore, protect intravascular
Chrotoplast function is to prevent and treat the key link of high blood pressure.VEC as internal maximum endocrine organ has powerful point
Function is secreted, vasoactive substances can be secreted, the vascular relaxing factor of endothelium-derived mainly includes nitric oxide, forefront ring
Element etc.；The vasoconstrictive factor of endothelium-derived mainly includes endothelin -1, Angiotensin II (Ang II), adjusts blood vessel jointly
The systolic and diastolic function of wall and the propagation of smooth muscle, migration etc.；Hypertension is one of initiating agent of vascular endothelial cell damage, is caused
The damage aggravation of endothelial cell, the significant material of some damages such as Endothelin is engendered in this evolution process.Therefore,
Blood plasma ET-1, Ang II are reduced, it is the main treatment for evaluating drug for hypertension to improve the endothelial dysfunction in hypertension process
Imitate one of index.
Aforementioned result shows that medicine of the present invention Antihypertensive Decoction dizzy clearly can significantly reduce blood plasma ET-1 and Ang II, so as to improve
Endothelial dysfunction in hypertension process.Moreover, compared with clear dizzy Antihypertensive Decoction, the refined clear dizzy Antihypertensive Decoction of medicine of the present invention to
In the case that pharmaceutical quantities reduce, effect is excellent all the better.
To sum up, pharmaceutical composition (refined clear dizzy Antihypertensive Decoction) of the present invention has the work for the endothelial dysfunction that improves significantly
With, there is good vascular protection to act on, hypertension can be treated, and compared with clear dizzy decompression Tangyuan County side, medicine of the present invention
Refined clear dizzy Antihypertensive Decoction is in the case where dosage reduces, and effect is excellent all the better, and application prospect is good.
Claims (9)
- A kind of 1. pharmaceutical composition for treating hypertension, it is characterised in that：It is by following weight proportion bulk drug prepare and Into preparation：Rhizoma Gastrodiae 10-30 parts, yncaria stem with hooks 10-20 parts, lotus nut 5-15 parts, radix scutellariae 5-15 parts.
- 2. pharmaceutical composition according to claim 1, it is characterised in that：It is the bulk drug preparation by following weight proportion The preparation formed：20 parts of rhizoma Gastrodiae, 20 parts of yncaria stem with hooks, 10 parts of lotus nut, 10 parts of radix scutellariae.
- 3. pharmaceutical composition according to claim 1 or 2, it is characterised in that：It is medicinal powder, the bulk drug by bulk drug Water or extractive with organic solvent are active component, the preparation being prepared plus pharmaceutically conventional auxiliary material or complementary composition.
- 4. pharmaceutical composition according to claim 3, it is characterised in that：The preparation is oral formulations.
- 5. pharmaceutical composition according to claim 4, it is characterised in that：The preparation be decoction, oral liquid, granule, Capsule, powder, pill, tablet.
- 6. the preparation method of claim 1-5 any one described pharmaceutical compositions, it is characterised in that：Step is as follows：(1) bulk drug is weighed according to the proportioning of claim 1 or 2；(2) medicinal powder of preparing raw material medicine, the water of bulk drug or extractive with organic solvent, pharmaceutically conventional auxiliary material or auxiliary are added Property composition, is produced.
- 7. purposes of the claim 1-6 any one described pharmaceutical composition in the medicine for preparing treatment hypertension.
- 8. claim 1-6 any one described pharmaceutical composition is preparing the purposes in treating vascular protection medicine.
- 9. use of the claim 1-6 any one described pharmaceutical composition in the medicine for improving blood vessel endothelium dysfunction is prepared On the way.
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| CN107744571B (en) * | 2017-10-20 | 2020-10-13 | 福建中医药大学 | Pharmaceutical composition for improving vascular endothelial dysfunction and preparation method and application thereof |
| CN108403956B (en) * | 2018-05-30 | 2021-03-12 | 福建中医药大学 | New application of pharmaceutical composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1686458A (en) * | 2005-05-13 | 2005-10-26 | 成都九芝堂金鼎药业有限公司 | Chinese medicinal composition, its preparation method and use |
| WO2007006203A1 (en) * | 2005-07-07 | 2007-01-18 | Shirong Duan | A capsule formulation for treating hypertension and coronary heart disease and process for preparation thereof |
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| CN1923241B (en) * | 2005-08-31 | 2010-04-28 | 海南四环医药有限公司 | Medicine composition containing epimedium extract, uncaria extract, and gastrodine, and its preparation and use |
| CN102727762B (en) * | 2012-07-16 | 2016-03-23 | 中国药科大学 | There is in Chinese medicine for lowering blood pressure the Related Component compatibility of vasodilator effect |
| CN104825848A (en) * | 2015-05-11 | 2015-08-12 | 柳州贵族酒业有限公司 | Health wine for prevention and treatment of hypertension and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1686458A (en) * | 2005-05-13 | 2005-10-26 | 成都九芝堂金鼎药业有限公司 | Chinese medicinal composition, its preparation method and use |
| WO2007006203A1 (en) * | 2005-07-07 | 2007-01-18 | Shirong Duan | A capsule formulation for treating hypertension and coronary heart disease and process for preparation thereof |
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