CN106418532A - Immunity boosting and fatigue resisting capsules and preparation method thereof - Google Patents
Immunity boosting and fatigue resisting capsules and preparation method thereof Download PDFInfo
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- CN106418532A CN106418532A CN201610820729.2A CN201610820729A CN106418532A CN 106418532 A CN106418532 A CN 106418532A CN 201610820729 A CN201610820729 A CN 201610820729A CN 106418532 A CN106418532 A CN 106418532A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses immunity boosting and fatigue resisting capsules and a preparation method thereof and belongs to the technical field of health care products. Effective ingredients of the capsules comprise raw materials in parts by weight as follows: 50-60 parts of fiveleaf gynostemma herb, 30-40 parts of American ginseng, 25-35 parts of seabuckthorn fruit and 25-30 parts of Paecilomyces hepialid powder. The immunity boosting and fatigue resisting capsules are prepared from the Chinese herbal medicines as the raw materials and can effectively boost immunity and resist fatigue.
Description
Technical field
The invention belongs to health food preparation method and technical field, further relate to a kind of strengthen immunity, anti-tired
Capsule of labor and preparation method thereof.
Background technology
Developing rapidly with modern society, the pressure that people bear in study, work, life and each side such as environment is not
Disconnected increase, health status receives large effect, and the whole world has more than 1/3 crowd to be in the middle shape of health and disease at present
State, i.e. sub-health state.Being physiologically mainly shown as immunity degradation, tired weak grade is it is seen that in each age group for inferior health
Crowd.Sub-health state is continually changing development, such as can not be improved in time it is more likely that converting to morbid state.
Medical research shows, the disease of the mankind 99% is all relevant with immune system, therefore, wants prophylactic generation, keeps fit
Physique, enhance immunity is crucial.And can constantly subtract often in the crowd's body immune system function under fatigue state
Move back, how to mitigate the major issue also becoming enhance immunity with dispelling fatigue.Immunologic hypofunction simultaneously, is also easily caused body
Empty weak.Thus its most essential, most crucial problem of inferior health is human autoimmune's hypofunction, is easy to fatigue.Therefore,
Human autoimmune's function can effectively be improved and alleviate physical fatigue, be remote from inferior health, move towards the basic side of health
Method.
At present, the product of the gentle physical fatigue of strengthen immunity popular on the market is more, is roughly divided into following a few class：
Health food based on replenishing vitamins and mineral matter；Extract the health food of functional component with natural animal-plant raw material；With
Animal foremilk is the health food of raw material.More than these products based on individual event strengthen immunity or individual event alleviation physical fatigue, and
Hypoimmunity and fatiguability interknit.Human autoimmune's functional disturbance, immunity degradation occurs physical fatigue
Deng sub-health state, and it is chronically at fatigue state and can lead to immunity degradation, therefore individually adjusting a certain function is can not
Meet the needs of current sub-health population.
Content of the invention
In view of this, it is an object of the invention to provide one kind is with Chinese herbal medicine as primary raw material, the property of medicine relax, be not likely to produce resistance to
The property of medicine, it is suitable for long-term taking, not only antifatigue but also can the strengthen immunity of strengthen immunity, antifatigue capsule and its preparation side
Method, and the preparation process is simple of the application, take and carry all convenient, suitable large-scale production.
The present invention is solved the above problems by following technological means：
A kind of strengthen immunity of the present invention, antifatigue capsule, the active ingredient of described capsule includes following heavy
The raw material of amount part：Gynostemma pentaphylla 50-60 part, American Ginseng 30-40 part, sea-buckthorn 25-35 part and peacilomyce hepiahi bacterium powder 25-30 part.
Further, the active ingredient of described capsule includes the raw material of following weight portion：55 parts of gynostemma pentaphylla, American Ginseng 35
Part, 30 parts of sea-buckthorn and 28 parts of peacilomyce hepiahi bacterium powder.
A kind of strengthen immunity of the present invention, the preparation method of antifatigue capsule, comprise the following steps：
1) will be standby after sea-buckthorn, American Ginseng, gynostemma pentaphylla respectively net system；
2) by the sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla add reflux in, then plus alcohol reflux extract, extract
Twice；
3) by step 2) in extract twice filtered with 200 mesh stainless steel mesh respectively, filtrate is simultaneously used by merging filtrate
Pump is input to concentration tank, reclaims ethanol and concentrates filtrate to clear cream；
4) by step 3) clear cream that obtains and peacilomyce hepiahi bacterium powder mix to obtain mixture, and mixture is put into drying box
Carry out drying under reduced pressure, pulverize, obtain dry powder；
5) by step 4) in the dry powder that obtains with pelletizing after 80% ethanol softwood, particle is crossed successively 16 mesh sieves, 60 DEG C
Drying, 14 mesh sieve whole grains, No. 0 capsule of loading, obtain capsule.
Further, described step 2) sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla are added in reflux, Ran Houjia
Alcohol extract, extracts twice；It is specially：
Sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla are added in reflux, then adds 10 times amount 75% alcohol reflux afterwards
Extract, extract twice, extract 2h every time, extract the amount of alcohol adding every time identical.
Further, described step 3) in reclaim the condition of ethanol be temperature 60 C ± 5 DEG C, pressure -0.065～-
0.075Mpa.
Further, described step 3) in the clear cream that obtains be 1.30～1.35 in the density of 60 DEG C of mensure.
Further, described step 4) in the temperature inside the box be dried be 70 ± 5 DEG C, the pressure of drying under reduced pressure is -0.075～-
0.085Mpa.
Beneficial effects of the present invention are as follows：
The capsule of the present invention, need not increase the additives such as lubricant, glidant, with similar strengthen immunity or antifatigue
When health products reach effect same, the dose of health products of the present invention is less compared to other health products.
With Chinese herbal medicine as raw material, its property of medicine relaxes, is not likely to produce drug resistance the present invention, suitable long-term taking, meanwhile, this
Bright health products combine the antifatigue characteristic with strengthen immunity, user can strengthen immunity moreover it is possible to antifatigue, at one stroke two
?.
Re-dry after Chinese medical concrete mixing peacilomyce hepiahi bacterium powder in the present invention, reduces Chinese medicine viscosity, improves dry
Dry speed, decreases loss in dry run for the medicinal extract.
The preparation process is simple of the present invention, convenient production, it is suitable for large-scale production.
The ethanol extracting employing in the production technology of the present invention can recycle, and meanwhile, sea-buckthorn main component is flavones
Class material, American Ginseng and gynostemma pentaphylla main active are saponin(e, and this constituents dissolution rate in ethanol is higher, therefore selects
Ethanol is extracted for solvent, energy-saving, reduces cost.
Brief description
Fig. 1 is a kind of strengthen immunity proposed by the present invention, the process chart of the preparation method of antifatigue capsule.
Specific embodiment
The following is the specific embodiment of the present invention, technical scheme is further described, but the present invention
It is not limited in these embodiments.
A kind of strengthen immunity of the present invention, antifatigue capsule, the active ingredient of described capsule includes following heavy
The raw material of amount part：Gynostemma pentaphylla 50-60 part, American Ginseng 30-40 part, sea-buckthorn 25-35 part and peacilomyce hepiahi bacterium powder 25-30 part.
Wherein, peacilomyce hepiahi bacterium powder needs to check before use, can use after the assay was approved, and qualified standard is bat
Adenosine >=0.1% of bat Paecilomyces varioti bacterium powder.
Specifically, strengthen immunity of the present invention, antifatigue capsule, the active ingredient of described capsule includes following
The raw material of weight portion：55 parts of gynostemma pentaphylla, 35 parts of American Ginseng, 30 parts of sea-buckthorn and 28 parts of peacilomyce hepiahi bacterium powder.
Referring to the drawings 1, a kind of strengthen immunity that the present invention provides, the preparation method of antifatigue capsule, include below
Step：
1) will be standby after sea-buckthorn, American Ginseng, gynostemma pentaphylla respectively net system；
Then plus alcohol extract 2) sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla are added in reflux, extract twice；
Then plus 10 times amount 75% second specifically, the sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla are added in reflux,
Alcohol extracting, extracts twice, extracts 2h every time, is both needed to twice plus ethanol, extracts the amount of alcohol adding every time and is 10 times amount 75%
Ethanol.
3) by step 2) in extract twice filtered with 200 mesh stainless steel mesh respectively, filtrate is simultaneously used by merging filtrate
Pump is input to concentration tank, reclaims ethanol and concentrates filtrate to clear cream；
In concrete operations, reclaiming the condition requiring during ethanol is：Temperature 60 C ± 5 DEG C, pressure -0.065～-
0.075Mpa.
The clear cream obtaining is 1.30～1.35 in the density of 60 DEG C of mensure.
4) by step 3) after the clear cream that obtains and the mixing of peacilomyce hepiahi bacterium powder mixture, mixture is put into drying
Case carries out drying under reduced pressure, and the mixture after drying under reduced pressure is pulverized, and obtains dry powder；
Wherein, the temperature inside the box is dried and is 70 ± 5 DEG C, the pressure of drying under reduced pressure is -0.075-0.085Mpa.
5) by step 4) in the dry powder that obtains with pelletizing after 80% ethanol softwood, particle is crossed successively 16 mesh sieves, 60 DEG C
Drying, 14 mesh sieve whole grains, No. 0 capsule of loading, obtain capsule.
The formula of the application and technique productions health product capsule out, easy to carry, the additive of no auxiliary, adopt
Chinese herbal medicine, has no drug resistance, and is suitable for most of crowds and uses, can strengthen immunity, also can be antifatigue.And process is simple, condition
Require wide in range, be easily controlled production process.
Embodiment 1
A kind of strengthen immunity, antifatigue capsule, the active ingredient of described capsule includes the raw material of following weight portion：Twist
Blue 50 parts of stock, 30 parts of American Ginseng, 25 parts of sea-buckthorn and 25 parts of peacilomyce hepiahi bacterium powder.
A kind of above-mentioned strengthen immunity, the preparation method of antifatigue capsule, comprise the following steps：
1) will be standby after sea-buckthorn, American Ginseng, gynostemma pentaphylla respectively net system；
Then plus alcohol extract 2) sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla are added in reflux, extract twice；
Then plus 10 times amount 75% second specifically, the sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla are added in reflux,
Alcohol extracting, extracts twice, extracts 2h every time, is both needed to twice plus ethanol, extracts the amount of alcohol adding every time and is 10 times amount 75%
Ethanol.
3) by step 2) in extract twice filtered with 200 mesh stainless steel mesh respectively, filtrate is simultaneously used by merging filtrate
Pump is input to concentration tank, reclaims ethanol and concentrates filtrate to clear cream；
In concrete operations, reclaiming the condition requiring during ethanol is：55 DEG C of temperature, pressure -0.065Mpa.
The clear cream obtaining is 1.30 in the density of 60 DEG C of mensure.
4) by step 3) after the clear cream that obtains and the mixing of peacilomyce hepiahi bacterium powder mixture, mixture is put into drying
Case carries out drying under reduced pressure, and the mixture after drying under reduced pressure is pulverized, and obtains dry powder；
Wherein, peacilomyce hepiahi bacterium powder needs to test before use, can use after the assay was approved, and bat moth is intended blue or green
Adenosine >=0.1% of mould bacterium powder.
Wherein, the temperature inside the box is dried and is 65 DEG C, the pressure of drying under reduced pressure is -0.075Mpa.
5) by step 4) in the dry powder that obtains with pelletizing after 80% ethanol softwood, particle is crossed successively 16 mesh sieves, 60 DEG C
Drying, 14 mesh sieve whole grains, No. 0 capsule of loading, obtain capsule.
The formula of the application and technique productions health product capsule out, easy to carry, capsule is easy to use, no auxiliary
The additive helping, using Chinese herbal medicine, has no drug resistance, and is suitable for most of crowds and uses, can strengthen immunity, also can be antifatigue.
And process is simple, condition require wide in range, be easily controlled production process.
Embodiment 2
A kind of strengthen immunity, antifatigue capsule, the active ingredient of described capsule includes the raw material of following weight portion：Twist
Blue 52 parts of stock, 33 parts of American Ginseng, 27 parts of sea-buckthorn and 26 parts of peacilomyce hepiahi bacterium powder.
A kind of above-mentioned strengthen immunity, the preparation method of antifatigue capsule, comprise the following steps：
1) will be standby after sea-buckthorn, American Ginseng, gynostemma pentaphylla respectively net system；
Then plus alcohol extract 2) sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla are added in reflux, extract twice；
Then plus 10 times amount 75% second specifically, the sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla are added in reflux,
Alcohol extracting, extracts twice, extracts 2h every time, is both needed to twice plus ethanol, extracts the amount of alcohol adding every time and is 10 times amount 75%
Ethanol.
3) by step 2) in extract twice filtered with 200 mesh stainless steel mesh respectively, filtrate is simultaneously used by merging filtrate
Pump is input to concentration tank, reclaims ethanol and concentrates filtrate to clear cream；
In concrete operations, reclaiming the condition requiring during ethanol is：58 DEG C of temperature, pressure -0.067Mpa.
The clear cream obtaining is 1.32 in the density of 60 DEG C of mensure.
4) by step 3) after the clear cream that obtains and the mixing of peacilomyce hepiahi bacterium powder mixture, mixture is put into drying
Case carries out drying under reduced pressure, and the mixture after drying under reduced pressure is pulverized, and obtains dry powder；
Wherein, peacilomyce hepiahi bacterium powder needs to test before use, can use after the assay was approved, and bat moth is intended blue or green
Adenosine >=0.1% of mould bacterium powder.
Wherein, the temperature inside the box is dried and is 68 DEG C, the pressure of drying under reduced pressure is -0.077Mpa.
5) by step 4) in the dry powder that obtains with pelletizing after 80% ethanol softwood, particle is crossed successively 16 mesh sieves, 60 DEG C
Drying, 14 mesh sieve whole grains, No. 0 capsule of loading, obtain capsule.
The formula of the application and technique productions health product capsule out, easy to carry, capsule is easy to use, no auxiliary
The additive helping, using Chinese herbal medicine, has no drug resistance, and is suitable for most of crowds and uses, can strengthen immunity, also can be antifatigue.
And process is simple, condition require wide in range, temperature, pressure etc. are easily controlled.
Embodiment 3
A kind of strengthen immunity, antifatigue capsule, the active ingredient of described capsule includes the raw material of following weight portion：Twist
Blue 55 parts of stock, 35 parts of American Ginseng, 30 parts of sea-buckthorn and 28 parts of peacilomyce hepiahi bacterium powder.
A kind of above-mentioned strengthen immunity, the preparation method of antifatigue capsule, comprise the following steps：
1) will be standby after sea-buckthorn, American Ginseng, gynostemma pentaphylla respectively net system；
Then plus alcohol extract 2) sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla are added in reflux, extract twice；
Then plus 10 times amount 75% second specifically, the sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla are added in reflux,
Alcohol extracting, extracts twice, extracts 2h every time, is both needed to twice plus ethanol, extracts the amount of alcohol adding every time and is 10 times amount 75%
Ethanol.
3) by step 2) in extract twice filtered with 200 mesh stainless steel mesh respectively, filtrate is simultaneously used by merging filtrate
Pump is input to concentration tank, reclaims ethanol and concentrates filtrate to clear cream；
In concrete operations, reclaiming the condition requiring during ethanol is：Temperature 60 C, pressure -0.070Mpa.
The clear cream obtaining is 1.33 in the density of 60 DEG C of mensure.
4) by step 3) after the clear cream that obtains and the mixing of peacilomyce hepiahi bacterium powder mixture, mixture is put into drying
Case carries out drying under reduced pressure, and the mixture after drying under reduced pressure is pulverized, and obtains dry powder；
Wherein, peacilomyce hepiahi bacterium powder needs to test before use, can use after the assay was approved, and bat moth is intended blue or green
Adenosine >=0.1% of mould bacterium powder.
Wherein, the temperature inside the box is dried and is 70 DEG C, the pressure of drying under reduced pressure is -0.080Mpa.
5) by step 4) in the dry powder that obtains with pelletizing after 80% ethanol softwood, particle is crossed successively 16 mesh sieves, 60 DEG C
Drying, 14 mesh sieve whole grains, No. 0 capsule of loading, obtain capsule.
The formula of the application and technique productions health product capsule out, easy to carry, capsule is easy to use, no auxiliary
The additive helping, using Chinese herbal medicine, has no drug resistance, and is suitable for most of crowds and uses, can strengthen immunity, also can be antifatigue.
And process is simple, condition require wide in range, temperature, pressure etc. are easily controlled.
Embodiment 4
A kind of strengthen immunity, antifatigue capsule, the active ingredient of described capsule includes the raw material of following weight portion：Twist
Blue 58 parts of stock, 38 parts of American Ginseng, 31 parts of sea-buckthorn and 29 parts of peacilomyce hepiahi bacterium powder.
A kind of above-mentioned strengthen immunity, the preparation method of antifatigue capsule, comprise the following steps：
1) will be standby after sea-buckthorn, American Ginseng, gynostemma pentaphylla respectively net system；
Then plus alcohol extract 2) sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla are added in reflux, extract twice；
Then plus 10 times amount 75% second specifically, the sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla are added in reflux,
Alcohol extracting, extracts twice, extracts 2h every time, is both needed to twice plus ethanol, extracts the amount of alcohol adding every time and is 10 times amount 75%
Ethanol.
3) by step 2) in extract twice filtered with 200 mesh stainless steel mesh respectively, filtrate is simultaneously used by merging filtrate
Pump is input to concentration tank, reclaims ethanol and concentrates filtrate to clear cream；
In concrete operations, reclaiming the condition requiring during ethanol is：63 DEG C of temperature, pressure -0.072Mpa.
The clear cream obtaining is 1.30 in the density of 60 DEG C of mensure.
4) by step 3) after the clear cream that obtains and the mixing of peacilomyce hepiahi bacterium powder mixture, mixture is put into drying
Case carries out drying under reduced pressure, and the mixture after drying under reduced pressure is pulverized, and obtains dry powder；
Wherein, peacilomyce hepiahi bacterium powder needs to test before use, can use after the assay was approved, and bat moth is intended blue or green
Adenosine >=0.1% of mould bacterium powder.
Wherein, the temperature inside the box is dried and is 73 DEG C, the pressure of drying under reduced pressure is -0.083Mpa.
5) by step 4) in the dry powder that obtains with pelletizing after 80% ethanol softwood, particle is crossed successively 16 mesh sieves, 60 DEG C
Drying, 14 mesh sieve whole grains, No. 0 capsule of loading, obtain capsule.
The formula of the application and technique productions health product capsule out, easy to carry, capsule is easy to use, no auxiliary
The additive helping, using Chinese herbal medicine, has no drug resistance, and is suitable for most of crowds and uses, can strengthen immunity, also can be antifatigue.
And process is simple, condition require wide in range, temperature, pressure etc. are easily controlled.
Embodiment 5
A kind of strengthen immunity, antifatigue capsule, the active ingredient of described capsule includes the raw material of following weight portion：Twist
Blue 60 parts of stock, 40 parts of American Ginseng, 35 parts of sea-buckthorn and 30 parts of peacilomyce hepiahi bacterium powder.
A kind of above-mentioned strengthen immunity, the preparation method of antifatigue capsule, comprise the following steps：
1) will be standby after sea-buckthorn, American Ginseng, gynostemma pentaphylla respectively net system；
Then plus alcohol extract 2) sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla are added in reflux, extract twice；
Then plus 10 times amount 75% second specifically, the sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla are added in reflux,
Alcohol extracting, extracts twice, extracts 2h every time, is both needed to twice plus ethanol, extracts the amount of alcohol adding every time and is 10 times amount 75%
Ethanol.
3) by step 2) in extract twice filtered with 200 mesh stainless steel mesh respectively, filtrate is simultaneously used by merging filtrate
Pump is input to concentration tank, reclaims ethanol and concentrates filtrate to clear cream；
In concrete operations, reclaiming the condition requiring during ethanol is：65 DEG C of temperature, pressure -0.075Mpa.
The clear cream obtaining is 1.35 in the density of 60 DEG C of mensure.
4) by step 3) after the clear cream that obtains and the mixing of peacilomyce hepiahi bacterium powder mixture, mixture is put into drying
Case carries out drying under reduced pressure, and the mixture after drying under reduced pressure is pulverized, and obtains dry powder；
Wherein, peacilomyce hepiahi bacterium powder needs to test before use, can use after the assay was approved, and bat moth is intended blue or green
Adenosine >=0.1% of mould bacterium powder.
Wherein, the temperature inside the box is dried and is 75 DEG C, the pressure of drying under reduced pressure is -0.085Mpa.
5) by step 4) in the dry powder that obtains with pelletizing after 80% ethanol softwood, particle is crossed successively 16 mesh sieves, 60 DEG C
Drying, 14 mesh sieve whole grains, No. 0 capsule of loading, obtain capsule.
The formula of the application and technique productions health product capsule out, easy to carry, capsule is easy to use, no auxiliary
The additive helping, using Chinese herbal medicine, has no drug resistance, and is suitable for most of crowds and uses, can strengthen immunity, also can be antifatigue.
And process is simple, condition require wide in range, temperature, pressure etc. are easily controlled.
Raw material components analysis in the present invention：
Peacilomyce hepiahi bacterium powder：It is separating obtained Cordyceps Militaris Paecilomyces hepiali chen from fresh aweto
Through Submerged fermentation, separate, be dried, pulverize the product made.
American Ginseng：Sweet, slight bitter, cool in nature, the thoughts of returning home, lung, kidney channel, there is boosting qi and nourishing yin, effect of clearing heat and promoting fluid, for gas
Empty yin deficiency, abnormal heat are tired of the symptoms such as tired, cough and asthma phlegm blood, Heat Diabetes and dryness of the mouth and throat.
Sea-buckthorn：Taste is sour, puckery, warm in nature, returns spleen, stomach, lung, the heart channel of Hang-Shaoyin, has reinforcing spleen to promote digestion, effect of promoting blood circulation to remove blood stasis.For spleen
Empty deficiency of food, dyspeptic abdominalgia, chest impediment and cardialgia, blood stasis closed, fall flutter the stasis of blood swell etc. symptom.Vitamins, flavonoids is contained in sea-buckthorn
The composition such as compound, Seabuckthorn Oil and aliphatic acid, protein and amino acid and trace element.
Gynostemma pentaphylla：Bitter, micro-sweet, cold in nature, return lung, spleen, kidney channel, have clearing heat and detoxicating, cough-relieving apophlegmatic, supplementing qi and nourishing yin, prolong
Slow old and feeble effect, vexed for chest diaphragm ruffian, phlegm hinders blood stasis, palpitation, dizziness and headache, forgetful tinnitus, unconsciously sweat and tire, high fat of blood
Disease, simple obesity, old cough.
The present invention, based on Traditional Chinese Medicine theory, chooses the Chinese medicine of " replenish qi to invigorate the spleen, kidney tonifying benefit lung ", the modern fermentation of collocation
Technology product peacilomyce hepiahi bacterium powder, makes and has bifunctional health food.
The present invention in process of production, during traditional Chinese medicine extraction dried process, select mix with peacilomyce hepiahi bacterium powder after again
It is dried, reduces Chinese medicine viscosity, improve rate of drying.
The particle obtaining in the present invention, mobility is strong, and additive-free, auxiliary material adds.Existing pure Chinese medicine is extracted cream powder and is made
For the capsule of Contents Fill, mobility is poor, and viscosity is high, hygroscopicity is strong, needs in process of production to add lubricant or helps
Stream agent, such as magnesium stearate, silica etc., or need to add auxiliary material：Starch etc., because the addition of auxiliary material, will reach expected effect
Really, dose will increase.And some capsules are directly pulverized into capsule with Chinese medicine, its absorption is poor, dose big it has not been convenient to.
The capsule that the present invention obtains can strengthen immunity, and can be antifatigue.In prior art, popular enhancing on the market
The product of the gentle physical fatigue of immunity is more, is roughly divided into following a few class：Guarantor based on replenishing vitamins and mineral matter
Health food；Extract the health food of functional component with natural animal-plant raw material；Health food with animal foremilk as raw material.These
Product is how based on individual event strengthen immunity or individual event alleviation physical fatigue, and hypoimmunity and fatiguability are to interknit
's.
Carry out following animal experiment with the product obtaining in embodiment 1：
Test example 1 strengthen immunity functional test
1 experimental animal selects
Cleaning grade male Balb/c mouse, body weight 18g～22g.Sichuan University's West China Experimental Animal Center provides the (quality certification
Number：SCXK (river) 2,009 09.) practical barrier level Animal House (credit number：The management of laboratory animal committee of Sichuan Province SYXK
(river) 2009-011) raise.
2 dosage choice and test method
Animal is bought back, is divided into 0.27g/kg.bw group, 0.53g/kg.bw group and 0.80g/kg.bw group by random packet principle
And blank control group.By lymphopoiesis ability, toes swelling, serum hemolysin generation, antibody-producting cell detection
And NK cytoactive detection carries out functional evaluation.
3 result of the tests
The impact of 3.1 pairs of mouse cell immunologic functions
Table 1 cell immunization experiments result
From table 1, each dosage group toes swelling difference is above control group, and through variance analysis, high dose group is (i.e.
0.80g/kg.bw group) there is significant difference (P ＜ 0.05) compared with control group, show that product of the present invention has promotion mouse slow
The effect of hair style allergy；In mtt assay, each dosage group optical density difference is above control group, through variance analysis, high dose
Group (i.e. 0.80g/kg.bw group) has significant difference (P ＜ 0.05) compared with control group, shows that product of the present invention has promotion
The lymphopoiesis of mouse and the effect of conversion capability.
The impact of 3.2 pairs of mouse humoral immunes
Table 2 humoral immunity experimental result
From table 2, each dosage group serum hemolysin is above control group；In antibody-producting cell detection, each dosage group
Antibody-producting cell number is above control group, and there was no significant difference with control group for each dosage group.
The impact of 3.3 pairs of NK cells in mice activity
Table 3 NK cells in mice determination of activity result
As seen from the above table, each dosage group is compared respectively at control group, its NK cytoactive rate obviously higher than control group, and
Through variance analysis, each dosage group and control group all have more significant sex differernce (P ＜ 0.01).Illustrate product of the present invention to NK cell
Activity has obvious facilitation.
To sum up, product of the present invention can improve mouse delayed allergy ability, promotes the lymphopoiesis of mouse
And conversion；And each dosage group all can remarkably promote NK cytoactive, according to《Health food inspection and assessment technique specification》Right
The criterion of strengthen immunity health food understands, the capsule that the present invention provides has the function of strengthen immunity.
Test example 2 anti-fatigue effect is tested
1st, experimental animal selects
SPF level male ICR mouse, body weight 18g～22g.Chengdu Da Shuo bio tech ltd provides (quality certification number：
SCXK (river) 2,008 24.) use barrier level Animal House (credit number：The management of laboratory animal committee of Sichuan Province SYXK
(river) 20011-011) raise.
2nd, dosage choice and test method
Animal is bought back, is divided into 267mg/kg.bw group, 533mg/kg.bw group and 800m g/kg.bw by random packet principle
Group and blank control group.Measured by swimming with a load attached to the body experiment, blood lactase acid, hepatic glycogen content measures and carries out functional evaluation.
3rd, result of the test
3.1 walking weight load measure
Table 4 mice burden swimming timing result
As can be seen from Table 4, each dosage group mice burden swimming time is above control group, wherein 267mg/kg.bw agent
The amount group mice burden swimming time is considerably longer than blank control group (P ＜ 0.01).
3.2 mouse Serum lactic acid contents measure
Table 5 mouse Serum lactic acid content measurement result
As can be seen from Table 5 swim after 20min measure mouse blood lactase acid value compared with control group, each dosage group all under
Fall, cuts 533mg/kg.bw dosage group blood lactase acid TG-AUC and is less than blank control group, and there were significant differences (P ＜ 0.01).
3.3 mouse hepatic glycogen contents measure
Table 6 mouse hepatic glycogen content measurement result
Each dosage group hepatic glycogen content is all remarkably higher than blank control group as can be seen from Table 6, and there were significant differences (P ＜
0.01).
To sum up, product of the present invention can extend the mice burden swimming time hence it is evident that increasing mouse hepatic glycogen quantity, reducing fortune
After dynamic, blood lactase acid generates, according to《Health food inspection and assessment technique specification》To the judgement mark alleviating physical fatigue health food
Will definitely know, the capsule that the present invention provides has function of relieving physical fatigue.
In the same manner, to the present invention, other embodiments and proportioning are tested, and effect is with embodiment 1.
The pharmacology of the present invention is explained as follows：
The traditional Chinese medical science thinks that gas, blood, yin, yang are the necessary four big basic elements of human body, is the main foundation of passive protective physical fitness, puts down
Chang Ruoneng constantly supplements, then can lift immunity, alleviate physical fatigue.The spleen being the foundation of acquired constitution, source of generating QI and blood, main muscle,
Four limbs, main transporting and transforming nutrients from foodstuff is precise and tiny and water is wet, the dysfunction of the spleen in transport, then the biochemical weary source of qi and blood, lucid yang failing to raise, failure in sending down turbid yin, limb muscle
Lose support, therefore see have aches in the limbs powerless.The kidney being the origin of congenital constitution, the root of healthy tendency, determines the power of native endowment, is related to the Sheng of healthy tendency
Decline.The essence of kidney Tibetan, after metaplasia vigour, excites and promotes human physiological activity, is the motive power of life.The lung is concerned with QI of the whole body, because
Whether the respiratory function of this lung perfects, and directly affects the generation of pectoral qi, also contributes to the generation of the gas of whole body.Weigh as can be seen here
Depending on " replenish qi to invigorate the spleen, kidney tonifying benefit lung ", while so that qi and blood is filled, function is not fully exerted, and can improve exempting from of body
Epidemic disease function, resisting fatigue, have strong physique.
The capsule of the present invention from cooking culture and traditional Chinese medical science traditional theory, with Chinese herbal medicine as raw material, in conjunction with theory of traditional Chinese medical science,
According to hypoimmunity and fatigue produce mechanism, to replenish qi to invigorate the spleen, kidney tonifying benefit lung as the rules for the treatment of, from nourishing lung and kidney, secret lean
The peacilomyce hepiahi bacterium powder of gas, is equipped with the American Ginseng of boosting qi and nourishing yin, clearing heat and promoting fluid, and the monarch and his subjects share, not only kidney tonifying benefit lung but also tonifying Qi
Yin-nourishing, reaches benefit and not dry, and with mending, kidney essense fills Sheng to lung kidney simultaneously, and lung qi fills, vigour is sufficient and make energetic.Sea-buckthorn is good for
Spleen helps digestion, promoting blood circulation to remove blood stasis；Gynostemma pentaphylla supplementing qi and nourishing yin, anti-aging.Apply the gas of sea-buckthorn temperature compensation spleen and lung in side, help west with gynostemma pentaphylla
American ginseng supplementing qi and nourishing yin, clearing heat and promoting fluid, altogether for adjutant in side.Above four tastes share, kidney tonifying, beneficial lung, promote the production of body fluid, invigorating the spleen, make internal organs group
Knit sufficiently moistened foster.
Finally illustrate, above example only in order to technical scheme to be described and unrestricted, although with reference to relatively
Good embodiment has been described in detail to the present invention, it will be understood by those within the art that, can be to the skill of the present invention
Art scheme is modified or equivalent, the objective without deviating from technical solution of the present invention and scope, and it all should be covered at this
In the middle of the right of invention.
Claims (7)
1. a kind of strengthen immunity, antifatigue capsule it is characterised in that：The active ingredient of described capsule includes following weight portion
Raw material：Gynostemma pentaphylla 50-60 part, American Ginseng 30-40 part, sea-buckthorn 25-35 part and peacilomyce hepiahi bacterium powder 25-30 part.
2. a kind of strengthen immunity according to claim 1, antifatigue capsule it is characterised in that：The having of described capsule
Effect composition includes the raw material of following weight portion：55 parts of gynostemma pentaphylla, 35 parts of American Ginseng, 30 parts of sea-buckthorn and peacilomyce hepiahi bacterium powder 28
Part.
3. a kind of strengthen immunity as claimed in claim 1 or 2, antifatigue capsule preparation method it is characterised in that：Bag
Include following steps：
1) will be standby after sea-buckthorn, American Ginseng, gynostemma pentaphylla respectively net system；
Then plus alcohol extract 2) sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla are added in reflux, extract twice；
3) by step 2) in extract twice filtered with 200 mesh stainless steel mesh respectively, merging filtrate is simultaneously defeated by filter pump
Enter to concentration tank, reclaim ethanol and concentrate filtrate to clear cream；
4) by step 3) clear cream that obtains and peacilomyce hepiahi bacterium powder mix to obtain mixture, and mixture is put into drying box and carries out
Drying under reduced pressure, pulverizes, obtains dry powder；
5) by step 4) in the dry powder that obtains with pelletizing after 80% ethanol softwood, particle is crossed successively 16 mesh sieves, 60 DEG C of dryings,
14 mesh sieve whole grains, No. 0 capsule of loading, obtain capsule.
4. a kind of strengthen immunity according to claim 3, antifatigue capsule preparation method it is characterised in that：Institute
State step 2) sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla are added in reflux, then plus alcohol extract, extract twice；Tool
Body is：
By the sea-buckthorn after net system, American Ginseng, gynostemma pentaphylla add reflux in, then plus 10 times amount 75% alcohol reflux extract,
Extract twice, extract 2h every time, extract the amount of alcohol adding every time identical.
5. a kind of strengthen immunity according to claim 3, antifatigue capsule preparation method it is characterised in that：Institute
State step 3) in reclaim ethanol condition be temperature 60 C ± 5 DEG C, pressure -0.065～-0.075Mpa.
6. a kind of strengthen immunity according to claim 3, antifatigue capsule preparation method it is characterised in that：Institute
State step 3) in the clear cream that obtains be 1.30～1.35 in the density of 60 DEG C of mensure.
7. a kind of strengthen immunity according to claim 3, antifatigue capsule preparation method it is characterised in that：Institute
State step 4) in the temperature inside the box be dried be 70 ± 5 DEG C, the pressure of drying under reduced pressure is -0.075～-0.085Mpa.
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| CN111820415A (en) * | 2020-09-02 | 2020-10-27 | 延寿县鼎鑫生物工程有限公司 | Hard capsule with immunity enhancing and health care functions and preparation method thereof |
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