CN106418487A - Enteral nutrition emulsion containing batyl alcohol and preparation method thereof - Google Patents
Enteral nutrition emulsion containing batyl alcohol and preparation method thereof Download PDFInfo
- Publication number
- CN106418487A CN106418487A CN201510471993.5A CN201510471993A CN106418487A CN 106418487 A CN106418487 A CN 106418487A CN 201510471993 A CN201510471993 A CN 201510471993A CN 106418487 A CN106418487 A CN 106418487A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- batilol
- enteral nutrition
- emulsion containing
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical compound CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 title claims abstract description 60
- 239000000839 emulsion Substances 0.000 title claims abstract description 28
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 22
- 230000035764 nutrition Effects 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- IWWCATWBROCMCW-UHFFFAOYSA-N batyl alcohol Natural products CCCCCCCCCCCCCCCCCCOC(O)CO IWWCATWBROCMCW-UHFFFAOYSA-N 0.000 title abstract 4
- 239000000843 powder Substances 0.000 claims abstract description 36
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 14
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 235000013325 dietary fiber Nutrition 0.000 claims abstract description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 33
- 229960003513 batilol Drugs 0.000 claims description 26
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 24
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 18
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 18
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 18
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 16
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 16
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 16
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 16
- 239000003921 oil Substances 0.000 claims description 12
- 235000019198 oils Nutrition 0.000 claims description 12
- CAXNYFPECZCGFK-UHFFFAOYSA-N 2-phenyl-2-pyridin-2-ylacetonitrile Chemical compound C=1C=CC=NC=1C(C#N)C1=CC=CC=C1 CAXNYFPECZCGFK-UHFFFAOYSA-N 0.000 claims description 11
- 241000209140 Triticum Species 0.000 claims description 11
- 235000021307 Triticum Nutrition 0.000 claims description 11
- 229920002494 Zein Polymers 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 11
- 239000008158 vegetable oil Substances 0.000 claims description 11
- 239000005019 zein Substances 0.000 claims description 11
- 229940093612 zein Drugs 0.000 claims description 11
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 10
- 241000222336 Ganoderma Species 0.000 claims description 10
- 239000004368 Modified starch Substances 0.000 claims description 10
- 229920000881 Modified starch Polymers 0.000 claims description 10
- 239000008346 aqueous phase Substances 0.000 claims description 10
- 239000001913 cellulose Substances 0.000 claims description 10
- 229920002678 cellulose Polymers 0.000 claims description 10
- 235000019426 modified starch Nutrition 0.000 claims description 10
- 239000012071 phase Substances 0.000 claims description 10
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 9
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 9
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 9
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 9
- ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 claims description 9
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 9
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 9
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 9
- 229930003779 Vitamin B12 Natural products 0.000 claims description 9
- 229930003471 Vitamin B2 Natural products 0.000 claims description 9
- 229930003268 Vitamin C Natural products 0.000 claims description 9
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 9
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 9
- 229960002685 biotin Drugs 0.000 claims description 9
- 239000011616 biotin Substances 0.000 claims description 9
- 235000020958 biotin Nutrition 0.000 claims description 9
- 229910052804 chromium Inorganic materials 0.000 claims description 9
- 239000011651 chromium Substances 0.000 claims description 9
- 235000012721 chromium Nutrition 0.000 claims description 9
- 229960000304 folic acid Drugs 0.000 claims description 9
- 235000019152 folic acid Nutrition 0.000 claims description 9
- 239000011724 folic acid Substances 0.000 claims description 9
- 235000019175 phylloquinone Nutrition 0.000 claims description 9
- 239000011772 phylloquinone Substances 0.000 claims description 9
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 9
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 claims description 9
- 229960001898 phytomenadione Drugs 0.000 claims description 9
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 9
- 229960002477 riboflavin Drugs 0.000 claims description 9
- 235000019155 vitamin A Nutrition 0.000 claims description 9
- 239000011719 vitamin A Substances 0.000 claims description 9
- 235000019163 vitamin B12 Nutrition 0.000 claims description 9
- 239000011715 vitamin B12 Substances 0.000 claims description 9
- 235000019164 vitamin B2 Nutrition 0.000 claims description 9
- 239000011716 vitamin B2 Substances 0.000 claims description 9
- 235000019158 vitamin B6 Nutrition 0.000 claims description 9
- 239000011726 vitamin B6 Substances 0.000 claims description 9
- 235000019154 vitamin C Nutrition 0.000 claims description 9
- 239000011718 vitamin C Substances 0.000 claims description 9
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 9
- 235000005282 vitamin D3 Nutrition 0.000 claims description 9
- 239000011647 vitamin D3 Substances 0.000 claims description 9
- 229940045997 vitamin a Drugs 0.000 claims description 9
- 229940011671 vitamin b6 Drugs 0.000 claims description 9
- 229940021056 vitamin d3 Drugs 0.000 claims description 9
- 229910021380 Manganese Chloride Inorganic materials 0.000 claims description 8
- GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 claims description 8
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 8
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 8
- 229960002079 calcium pantothenate Drugs 0.000 claims description 8
- 229960004874 choline bitartrate Drugs 0.000 claims description 8
- QWJSAWXRUVVRLH-UHFFFAOYSA-M choline bitartrate Chemical compound C[N+](C)(C)CCO.OC(=O)C(O)C(O)C([O-])=O QWJSAWXRUVVRLH-UHFFFAOYSA-M 0.000 claims description 8
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 8
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 8
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 claims description 8
- 239000000395 magnesium oxide Substances 0.000 claims description 8
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 8
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 8
- 239000011565 manganese chloride Substances 0.000 claims description 8
- 235000002867 manganese chloride Nutrition 0.000 claims description 8
- 229940099607 manganese chloride Drugs 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 239000001103 potassium chloride Substances 0.000 claims description 8
- 235000011164 potassium chloride Nutrition 0.000 claims description 8
- 235000007715 potassium iodide Nutrition 0.000 claims description 8
- 239000011780 sodium chloride Substances 0.000 claims description 8
- 239000011775 sodium fluoride Substances 0.000 claims description 8
- 235000013024 sodium fluoride Nutrition 0.000 claims description 8
- 239000011684 sodium molybdate Substances 0.000 claims description 8
- 235000015393 sodium molybdate Nutrition 0.000 claims description 8
- TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 claims description 8
- 239000011781 sodium selenite Substances 0.000 claims description 8
- 235000015921 sodium selenite Nutrition 0.000 claims description 8
- 229960001471 sodium selenite Drugs 0.000 claims description 8
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 8
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 8
- 229960001763 zinc sulfate Drugs 0.000 claims description 8
- 229930003451 Vitamin B1 Natural products 0.000 claims description 5
- 229930003427 Vitamin E Natural products 0.000 claims description 5
- 229960000355 copper sulfate Drugs 0.000 claims description 5
- 238000004090 dissolution Methods 0.000 claims description 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 5
- 244000000010 microbial pathogen Species 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 229960004839 potassium iodide Drugs 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 5
- 229960000414 sodium fluoride Drugs 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 229960003495 thiamine Drugs 0.000 claims description 5
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 5
- 235000010374 vitamin B1 Nutrition 0.000 claims description 5
- 239000011691 vitamin B1 Substances 0.000 claims description 5
- 235000019165 vitamin E Nutrition 0.000 claims description 5
- 239000011709 vitamin E Substances 0.000 claims description 5
- 229940046009 vitamin E Drugs 0.000 claims description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- 210000000582 semen Anatomy 0.000 claims description 4
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- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- RNVYQYLELCKWAN-UHFFFAOYSA-N solketal Chemical compound CC1(C)OCC(CO)O1 RNVYQYLELCKWAN-UHFFFAOYSA-N 0.000 claims description 2
- 235000012424 soybean oil Nutrition 0.000 claims description 2
- 239000003549 soybean oil Substances 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims 1
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- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 8
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- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
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- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
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- 239000000460 chlorine Substances 0.000 description 1
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- 229960001231 choline Drugs 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
- 229940000351 hemocyte Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000000718 radiation-protective agent Substances 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 229940091258 selenium supplement Drugs 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to an enteral nutrition emulsion containing batyl alcohol and a preparation method thereof, and belongs to the technical field of nutrition food preparations. The product is obtained by processing batyl alcohol, ganoderma lucidum spore powder, protein, fat, carbohydrates, vitamins, microelements, dietary fibers and water according to a certain production technology. As a full-nutrition emulsion, the enteral nutrition emulsion is easy to digest and absorb and can be directly eaten by patients. Meanwhile, compared with other nutrition preparations, the effective active ingredient batyl alcohol is added, and thus the product has the effect of increasing the number of granulocytes, also has the anti-radiation effect, can prevent and treat leucopenia, can be used for treating leucopenia caused by antineoplastic drugs or radiation therapy and can also be used for treating infant agranulocytosis.
Description
Technical field
The present invention relates to a kind of Enteral Nutrition Emulsion containing batilol and preparation method thereof..
Background technology
Leukocyte is the hemocyte that a class has core.The blood cell number of normal person is 4000-10000/UL (microlitre), and under time different daily functional statuses different with body, leukocyte number in blood has and changes in a big way.When every microlitre more than 10000, referred to as leukocytosiss;And every microlitre when being less than 4000, then referred to as leukopenia.Body occurs leukocytosiss when having inflammation (i.e. inflammation);Leukopenia can have heritability, familial, acquired etc..Wherein acquired occupy the majority.Medicine, lonizing radiation, infection, toxin etc. all can make granulocytopenia, and medicine causer is most common.Medication is avoided to be intended to the leukopenia avoiding producing because of medicine.
Batilol, the batiolum extracting from shark liver, is leukocyte increasing and antiradiation drug, the granulocytopenia causing for a variety of causes.Batilol is contained more in the hemopoietic system of people, it is probably a kind of internal Hemopoietic factor, there is the effect increasing granulocyte quantity, in addition with anti-radiation effect, leukopenia can be prevented and treated, it is clinically used for because of the leukopenia that caused with antineoplastic agent and radiotherapy it can also be used to children's agranulocytosis.Should every weekly check leukocyte count during treating.For leukopenia, prevent leukopenia it can also be used to anemia and children's agranulocytosis.
Content of the invention
The present invention relates to a kind of Enteral Nutrition Emulsion containing batilol and preparation method thereof, belong to the technical field of nutraceutical preparation.This product is processed through certain production technology by batilol, Ganoderma spore powder, protein, fat, carbohydrate, vitamin, trace element, dietary fiber and water.The Enteral Nutrition Emulsion that the present invention provides can be directly used for patients as a kind of full nutrition emulsion it is easy to digest and assimilate.Simultaneously, compared to other nutritional preparations, this product with the addition of this effective active component of batilol, there is the effect increasing granulocyte quantity, in addition with anti-radiation effect, leukopenia can be prevented and treated, can be used for because of the leukopenia that caused with antineoplastic agent and radiotherapy it can also be used to children's agranulocytosis.
A kind of formula of Enteral Nutrition Emulsion containing batilol of the present invention is as follows：In mass，By Zein powder 25-50 g，Soya bean protein powder 25-55g，Wheat protein powder 25-55g，Batilol 15-150mg，Ganoderma spore powder 3-20g，Vegetable oil 27-39 g，Glycerol 10-17 g，Dietary fiber 19.2-29.8 g，Oligosaccharide 15-26 g，Potassium 1.22-1.54g，Chlorine 0.66-1.48g，Fluorine 1.2-2.0 mg，Iodine 0.10-0.19mg，Sodium 0.67-1.05mg，Calcium 480-1045 mg，Magnesium 176-372mg，Phosphorus 400-708mg，Ferrum 8.4-15.6mg，Zinc 8.42-15.96mg，Copper 0.88-1.79mg，Manganese 0.9-4.1mg，Chromium 225-376 μ g，Molybdenum 80-110 μ g，Selenium 56-84 μ g，Biotin 78-105 μ g，Vitamin K1 49-133 μ g，Vitamin B6 1.18-2.89mg，Pantothenic acid 3.58-7.96mg，Folic Acid 0.24-4.76mg，Vitamin A 0.62-1.26mg，Vitamin e1 9.6-59.2 mg，Vitamin C 90-804mg，VB11 .03-2.50 mg，Vitamin B2 1.3-3.2mg，Choline 214-398mg，Nicotiamide 9.1-17.3mg，Vitamin B12 2.1-4.9 μ g，Vitamin D3 4.2-8.8 μ g and water 1000ml composition.
Described egg albumen powder is to be that soya bean protein powder, wheat protein powder and Zein powder mix by egg albumen powder.
Described vegetable oil is one or more of soybean oil, Semen Maydis oil, Oleum Brassicae campestriss and Oleum Arachidis hypogaeae semen mixture.
Described oligosaccharide is one of Oligomeric maltose and oligofructose or two kinds of mixture.
Described dietary fiber is made up of cellulose and modified starch.
Described batilol is that glycerol and condensation of acetone are generated solketal ether, then is etherified with octadecanol-p- tosylate, obtains 1,2- isopropylidene -3- batiolum, after generate through hydrolysis.
The concrete preparation process of described nutrition emulsion is as follows：
（1）Material mixes：Zein powder by formula ratio, wheat protein powder, soya bean protein powder, batilol, Ganoderma spore powder, sodium chloride, potassium chloride, Calcium Carbonate, magnesium oxide, ferric phrophosphate, zinc sulfate, copper sulfate, manganese chloride, potassium iodide, sodium fluoride, Chlorizate chromium, sodium molybdate, sodium selenite, cellulose, modified starch, choline bitartrate, vitamin A, vitamin D3, Vitamin E, vitamin K1, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, nicotiamide, biotin, calcium pantothenate and Folic Acid under nitrogen protection mixed dissolution or be dispersed in formula ratio 50-65 DEG C of water in obtain aqueous phase；By the glycerol of formula ratio, vegetable oil, under the conditions of 60-70 DEG C, mix homogeneously obtains oil phase；Aqueous phase and oil phase are carried out heating the emulsion that microwave stirring is mixed to get stable and uniform.
（2）Sterilizing：The emulsion mixing is sterilized at 90-120 DEG C 5-10 minute, is cooled to 45-50 DEG C immediately, after being slowly cooled to room temperature, in 1-4 DEG C of cold preservation after killing pathogenic microorganism.
It is an advantage of the current invention that：This product contains saccharide, fat, protein, vitamin, inorganic salt and the big nutrient of dietary fiber seven, is a kind of full nutrition emulsion, and material used is all from natural, green health.Simultaneously, compare other nutritional preparations, this product with the addition of this effective active component of batilol, there is the effect increasing granulocyte quantity, in addition with anti-radiation effect, leukopenia can be prevented and treated, can be used for because of the leukopenia that caused with antineoplastic agent and radiotherapy it can also be used to children's agranulocytosis.
G, mg, μ g, the ml using in the present invention represent gram respectively, milligram, microgram, milliliter.
Specific embodiment
Embodiment 1
In terms of quality grams，Take Zein powder 25g，Wheat protein powder 30g，Soya bean protein powder 30g，Batilol 35mg，Ganoderma spore powder 10g，Oligosaccharide 18.3，Sodium chloride 0.4g，Potassium chloride 1.8g，Calcium Carbonate 0.7g，Magnesium oxide 0.4g，Ferric phrophosphate 53.4mg，Zinc sulfate 37.5mg，Copper sulfate 3.6mg，Manganese chloride 9.3mg，Potassium iodide 0.2mg，Sodium fluoride 3.7mg，Chlorizate chromium 1.3mg，Sodium molybdate 0.2mg，Sodium selenite 0.2mg，Choline bitartrate 0.9g，Vitamin A 0.98mg，Vitamin D3 5.5 μ g，Vitamin E2 3.7mg，Vitamin K1 79 μ g，VB11 .6mg，Vitamin B2 1.8mg，Vitamin B6 1.87mg，Vitamin B12 2.6 μ g，Vitamin C 580mg，Nicotiamide 10.6mg，Biotin 99 μ g，Calcium pantothenate 5.7mg，Folic Acid 2.9mg，Cellulose 9.8g，Modified starch 12.1g，Vegetable oil 28.4g，Glycerol 14.2g and water 1000ml.
Production process is as follows：Zein powder by formula ratio, soya bean protein powder, wheat protein powder, batilol, Ganoderma spore powder, oligosaccharide, sodium chloride, potassium chloride, Calcium Carbonate, magnesium oxide, ferric phrophosphate, zinc sulfate, copper sulfate, manganese chloride, potassium iodide, sodium fluoride, Chlorizate chromium, sodium molybdate, sodium selenite, cellulose, modified starch, choline bitartrate, vitamin A, vitamin D3, Vitamin E, vitamin K1, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, nicotiamide, biotin, calcium pantothenate and Folic Acid under nitrogen protection mixed dissolution or be dispersed in formula ratio 60 DEG C of water in obtain aqueous phase；By the glycerol of formula ratio, vegetable oil, at a temperature of 60 DEG C, mix homogeneously obtains oil phase；Aqueous phase and oil phase are carried out, at 87 DEG C, the emulsion that microwave stirring is mixed to get stable and uniform.After canned for the emulsion mixing, sterilize 5 minutes at 120 DEG C, after being cooled to room temperature immediately under nitrogen environment again after killing pathogenic microorganism, in 4 DEG C of cold preservations.Physical and chemical index after product preserves one month under this condition is shown in Table 1.
Embodiment 2
In terms of quality grams，Take Zein powder 35g，Wheat protein powder 40g，Soya bean protein powder 40g，Batilol 55mg，Ganoderma spore powder 15g，Oligosaccharide 18.3，Sodium chloride 0.4g，Potassium chloride 1.8g，Calcium Carbonate 0.7g，Magnesium oxide 0.4g，Ferric phrophosphate 53.4mg，Zinc sulfate 37.5mg，Copper sulfate 3.6mg，Manganese chloride 9.3mg，Potassium iodide 0.2mg，Sodium fluoride 3.7mg，Chlorizate chromium 1.3mg，Sodium molybdate 0.2mg，Sodium selenite 0.2mg，Choline bitartrate 0.9g，Vitamin A 0.98mg，Vitamin D3 5.5 μ g，Vitamin E2 3.7mg，Vitamin K1 79 μ g，VB11 .6mg，Vitamin B2 1.8mg，Vitamin B6 1.87mg，Vitamin B12 2.6 μ g，Vitamin C 580mg，Nicotiamide 10.6mg，Biotin 99 μ g，Calcium pantothenate 5.7mg，Folic Acid 2.9mg，Cellulose 8.7g，Modified starch 11.3g，Vegetable oil 29.7g，Glycerol 16.8g and water 1000ml.
Production process is as follows：Zein powder by formula ratio, soya bean protein powder, wheat protein powder, batilol, Ganoderma spore powder, oligosaccharide, sodium chloride, potassium chloride, Calcium Carbonate, magnesium oxide, ferric phrophosphate, zinc sulfate, copper sulfate, manganese chloride, potassium iodide, sodium fluoride, Chlorizate chromium, sodium molybdate, sodium selenite, cellulose, modified starch, choline bitartrate, vitamin A, vitamin D3, Vitamin E, vitamin K1, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, nicotiamide, biotin, calcium pantothenate and Folic Acid under nitrogen protection mixed dissolution or be dispersed in formula ratio 60 DEG C of water in obtain aqueous phase；By the glycerol of formula ratio, vegetable oil, at a temperature of 60 DEG C, mix homogeneously obtains oil phase；Aqueous phase and oil phase are carried out, at 83 DEG C, the emulsion that microwave stirring is mixed to get stable and uniform.After canned for the emulsion mixing, sterilize 5 minutes at 120 DEG C, after being cooled to room temperature immediately under nitrogen environment again after killing pathogenic microorganism, in 4 DEG C of cold preservations.Physical and chemical index after product preserves one month under this condition is shown in Table 1.
Embodiment 3
In terms of quality grams，Take Zein powder 50g，Wheat protein powder 55g，Soya bean protein powder 40g，Batilol 100mg，Ganoderma spore powder 20g，Oligosaccharide 20.7，Sodium chloride 0.4g，Potassium chloride 1.8g，Calcium Carbonate 0.7g，Magnesium oxide 0.4g，Ferric phrophosphate 53.4mg，Zinc sulfate 37.5mg，Copper sulfate 3.6mg，Manganese chloride 9.3mg，Potassium iodide 0.2mg，Sodium fluoride 3.7mg，Chlorizate chromium 1.3mg，Sodium molybdate 0.2mg，Sodium selenite 0.2mg，Choline bitartrate 0.9g，Vitamin A 0.98mg，Vitamin D3 5.5 μ g，Vitamin E2 3.7mg，Vitamin K1 79 μ g，VB11 .6mg，Vitamin B2 1.8mg，Vitamin B6 1.87mg，Vitamin B12 2.6 μ g，Vitamin C 580mg，Nicotiamide 10.6mg，Biotin 99 μ g，Calcium pantothenate 5.7mg，Folic Acid 2.9mg，Cellulose 11.2g，Modified starch 8.5g，Vegetable oil 29.7g，Glycerol 15.2g and water 1000ml.
Production process is as follows：Zein powder by formula ratio, soya bean protein powder, wheat protein powder, batilol, Ganoderma spore powder, oligosaccharide, sodium chloride, potassium chloride, Calcium Carbonate, magnesium oxide, ferric phrophosphate, zinc sulfate, copper sulfate, manganese chloride, potassium iodide, sodium fluoride, Chlorizate chromium, sodium molybdate, sodium selenite, cellulose, modified starch, choline bitartrate, vitamin A, vitamin D3, Vitamin E, vitamin K1, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, nicotiamide, biotin, calcium pantothenate and Folic Acid under nitrogen protection mixed dissolution or be dispersed in formula ratio 60 DEG C of water in obtain aqueous phase；By the glycerol of formula ratio, vegetable oil, at a temperature of 60 DEG C, mix homogeneously obtains oil phase；Aqueous phase and oil phase are carried out, at 83 DEG C, the emulsion that microwave stirring is mixed to get stable and uniform.After canned for the emulsion mixing, sterilize 8 minutes at 110 DEG C, after being cooled to room temperature immediately under nitrogen environment again after killing pathogenic microorganism, in 4 DEG C of cold preservations.Physical and chemical index after product preserves one month under this condition see table：
Claims (6)
1. a kind of Enteral Nutrition Emulsion containing batilol it is characterised in that：In this product of 1000ml, in mass, comprise following nutritional labeling：
.
2. as claimed in claim 1 a kind of Enteral Nutrition Emulsion containing batilol it is characterised in that：Egg albumen powder is that soya bean protein powder, wheat protein powder and Zein powder mix.
3. as claimed in claim 1 a kind of Enteral Nutrition Emulsion containing batilol it is characterised in that：Vegetable oil is one or more of soybean oil, Semen Maydis oil, Oleum Brassicae campestriss and Oleum Arachidis hypogaeae semen mixture.
4. as claimed in claim 1 a kind of Enteral Nutrition Emulsion containing batilol it is characterised in that：Batilol is that glycerol and condensation of acetone are generated solketal ether, then is etherified with octadecanol-p- tosylate, obtains 1,2- isopropylidene -3- batiolum, after generate through hydrolysis.
5. as claimed in claim 1 a kind of Enteral Nutrition Emulsion containing batilol it is characterised in that：Dietary fiber is made up of cellulose and modified starch.
6. as claimed in claim 1 a kind of Enteral Nutrition Emulsion containing batilol it is characterised in that：It is characterized in that：Concrete preparation process is as follows：
（1）Material mixes：By the Zein powder of formula ratio, wheat protein powder, soya bean protein powder, batilol, Ganoderma spore powder, sodium chloride, potassium chloride, Calcium Carbonate, magnesium oxide, ferric phrophosphate, zinc sulfate, copper sulfate, manganese chloride, potassium iodide,
Sodium fluoride, Chlorizate chromium, sodium molybdate, sodium selenite; cellulose, modified starch, choline bitartrate; vitamin A, vitamin D3, Vitamin E; vitamin K1, vitamin B1, vitamin B2; vitamin B6, vitamin B12, vitamin C; nicotiamide, biotin, calcium pantothenate and Folic Acid under nitrogen protection mixed dissolution or be dispersed in formula ratio 50-65 DEG C of water in obtain aqueous phase；By the glycerol of formula ratio, vegetable oil, under the conditions of 60-70 DEG C, mix homogeneously obtains oil phase；Aqueous phase and oil phase are carried out heating the emulsion that microwave stirring is mixed to get stable and uniform；
（2）Sterilizing：The emulsion mixing is sterilized at 90-120 DEG C 5-10 minute, is cooled to 45-50 DEG C immediately, after being slowly cooled to room temperature, in 1-4 DEG C of cold preservation after killing pathogenic microorganism.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101889669A (en) * | 2010-06-24 | 2010-11-24 | 华瑞制药有限公司 | Eternal nutrition emulsion and preparation method thereof |
| CN103392969A (en) * | 2013-07-28 | 2013-11-20 | 吉林大学 | Enteral nutritional emulsion containing lecithin, and preparation method thereof |
-
2015
- 2015-08-05 CN CN201510471993.5A patent/CN106418487A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101889669A (en) * | 2010-06-24 | 2010-11-24 | 华瑞制药有限公司 | Eternal nutrition emulsion and preparation method thereof |
| CN103392969A (en) * | 2013-07-28 | 2013-11-20 | 吉林大学 | Enteral nutritional emulsion containing lecithin, and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 徐志巧等: "《实用肿瘤临床药物手册》", 30 June 2013, 中国医药科技出版社 * |
| 蓝太富: "《临床实用药物手册：临床用药知识最新读本》", 31 August 2006, 四川科学技术出版社 * |
| 陈国良等: "《灵芝治百病》", 30 September 2014, 上海科学技术文献出版社 * |
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