CN106413748A - 用于类风湿性关节炎治疗的组合物及使用该组合物的方法 - Google Patents

用于类风湿性关节炎治疗的组合物及使用该组合物的方法 Download PDF

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Publication number
CN106413748A
CN106413748A CN201480073774.5A CN201480073774A CN106413748A CN 106413748 A CN106413748 A CN 106413748A CN 201480073774 A CN201480073774 A CN 201480073774A CN 106413748 A CN106413748 A CN 106413748A
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CN
China
Prior art keywords
weeks
treatment
sarilumab
subject
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480073774.5A
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English (en)
Chinese (zh)
Inventor
X·黄
M·詹森
V·马克斯
A·雷丁
C·范
H·范霍赫斯特拉滕
S·菲奥里
J·范阿德尔斯贝格
M·吉诺维斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
First Drugmaker Of Regenerating
Sanofi SA
Original Assignee
First Drugmaker Of Regenerating
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by First Drugmaker Of Regenerating, Sanofi SA filed Critical First Drugmaker Of Regenerating
Priority to CN202510671202.7A priority Critical patent/CN120514847A/zh
Publication of CN106413748A publication Critical patent/CN106413748A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201480073774.5A 2013-11-22 2014-11-21 用于类风湿性关节炎治疗的组合物及使用该组合物的方法 Pending CN106413748A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202510671202.7A CN120514847A (zh) 2013-11-22 2014-11-21 用于类风湿性关节炎治疗的组合物及使用该组合物的方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361907796P 2013-11-22 2013-11-22
US61/907,796 2013-11-22
US201462008787P 2014-06-06 2014-06-06
US62/008,787 2014-06-06
EP14306366.7 2014-09-05
EP14306366 2014-09-05
PCT/US2014/066856 WO2015077582A1 (en) 2013-11-22 2014-11-21 Compositions for the treatment of rheumatoid arthritis and methods of using same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202510671202.7A Division CN120514847A (zh) 2013-11-22 2014-11-21 用于类风湿性关节炎治疗的组合物及使用该组合物的方法

Publications (1)

Publication Number Publication Date
CN106413748A true CN106413748A (zh) 2017-02-15

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201480073774.5A Pending CN106413748A (zh) 2013-11-22 2014-11-21 用于类风湿性关节炎治疗的组合物及使用该组合物的方法
CN202510671202.7A Pending CN120514847A (zh) 2013-11-22 2014-11-21 用于类风湿性关节炎治疗的组合物及使用该组合物的方法

Family Applications After (1)

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CN202510671202.7A Pending CN120514847A (zh) 2013-11-22 2014-11-21 用于类风湿性关节炎治疗的组合物及使用该组合物的方法

Country Status (11)

Country Link
US (1) US20160280782A1 (enExample)
EP (2) EP3770173A1 (enExample)
JP (3) JP6657089B2 (enExample)
KR (3) KR20230155586A (enExample)
CN (2) CN106413748A (enExample)
AU (3) AU2014352801B2 (enExample)
CA (1) CA2930615C (enExample)
MX (2) MX377190B (enExample)
PL (1) PL3071230T3 (enExample)
SG (1) SG10201804000TA (enExample)
WO (1) WO2015077582A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112955222A (zh) * 2018-08-29 2021-06-11 里珍纳龙药品有限公司 用于治疗患有类风湿性关节炎的个体的方法和组合物
CN114206442A (zh) * 2019-01-31 2022-03-18 赛诺菲生物技术公司 用于治疗幼年特发性关节炎的抗il-6受体抗体
CN115667301A (zh) * 2019-06-04 2023-01-31 赛诺菲生物技术公司 治疗具有类风湿性关节炎的受试者的疼痛的组合物和方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
TWI589299B (zh) 2011-10-11 2017-07-01 再生元醫藥公司 用於治療類風濕性關節炎之組成物及其使用方法
US9943594B2 (en) 2011-10-11 2018-04-17 Sanofi Biotechnology Methods for the treatment of rheumatoid arthritis
WO2015077582A1 (en) * 2013-11-22 2015-05-28 Sanofi Biotechnology Compositions for the treatment of rheumatoid arthritis and methods of using same
KR20180073680A (ko) 2015-11-03 2018-07-02 사노피 바이오테크놀로지, 소시에떼 빠르 악씨옹 셍쁠리피에 포도막염 및 황반 부종의 치료를 위한 il6r 항체를 포함하는 조성물 및 이를 이용하는 방법
SG11201807614SA (en) * 2016-03-07 2018-10-30 Sanofi Biotechnology Compositions and methods for treating rheumatoid arthritis
EP3216461A1 (en) * 2016-03-07 2017-09-13 Sanofi Biotechnology Compositions and methods for treating rheumatoid arthritis
US12295912B2 (en) 2017-12-07 2025-05-13 Zacros Corporation Port-equipped bag and cap-equipped bag
MA55760A (fr) * 2019-04-24 2022-03-02 Regeneron Pharma Procédés de diagnostic et de traitement de la polyarthrite rhumatoïde
JP7373958B2 (ja) 2019-09-27 2023-11-06 株式会社日立製作所 分析システム及び分析方法
KR20210040735A (ko) 2019-10-05 2021-04-14 양수현 천장 수납형 빨래 건조대

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013053751A1 (en) * 2011-10-11 2013-04-18 Sanofi Compositions for the treatment of rheumatoid arthritis and methods of using same

Family Cites Families (5)

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US6629949B1 (en) 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6659982B2 (en) 2000-05-08 2003-12-09 Sterling Medivations, Inc. Micro infusion drug delivery device
US8080248B2 (en) * 2006-06-02 2011-12-20 Regeneron Pharmaceuticals, Inc. Method of treating rheumatoid arthritis with an IL-6R antibody
ES2799439T3 (es) * 2013-11-22 2020-12-17 Sanofi Biotechnology Composiciones para el tratamiento de la artritis reumatoide y métodos de uso de las mismas
WO2015077582A1 (en) * 2013-11-22 2015-05-28 Sanofi Biotechnology Compositions for the treatment of rheumatoid arthritis and methods of using same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013053751A1 (en) * 2011-10-11 2013-04-18 Sanofi Compositions for the treatment of rheumatoid arthritis and methods of using same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "NCT01061736 on 2013_11_07：clinicaltrials.gov archive", 《HTTP://CLINICALTRIALS.GOV/ARCHIVE/NCT01061736/2013_11_07》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112955222A (zh) * 2018-08-29 2021-06-11 里珍纳龙药品有限公司 用于治疗患有类风湿性关节炎的个体的方法和组合物
CN114206442A (zh) * 2019-01-31 2022-03-18 赛诺菲生物技术公司 用于治疗幼年特发性关节炎的抗il-6受体抗体
CN115667301A (zh) * 2019-06-04 2023-01-31 赛诺菲生物技术公司 治疗具有类风湿性关节炎的受试者的疼痛的组合物和方法

Also Published As

Publication number Publication date
AU2024204881A1 (en) 2024-08-15
CA2930615A1 (en) 2015-05-28
EP3770173A1 (en) 2021-01-27
CN120514847A (zh) 2025-08-22
SG10201804000TA (en) 2018-07-30
JP2022033891A (ja) 2022-03-02
KR20220056254A (ko) 2022-05-04
KR20160079121A (ko) 2016-07-05
AU2020223706A1 (en) 2020-09-10
JP6657089B2 (ja) 2020-03-04
MX2020011993A (es) 2021-01-29
US20160280782A1 (en) 2016-09-29
MX2016006595A (es) 2016-09-06
EP3071230A1 (en) 2016-09-28
KR20230155586A (ko) 2023-11-10
AU2020223706B2 (en) 2024-04-18
MX377190B (es) 2025-03-07
CA2930615C (en) 2023-04-04
AU2014352801B2 (en) 2020-05-28
EP3071230B1 (en) 2020-04-08
JP2016539125A (ja) 2016-12-15
WO2015077582A1 (en) 2015-05-28
AU2014352801A1 (en) 2016-06-23
PL3071230T3 (pl) 2020-09-21
JP2024026223A (ja) 2024-02-28

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SE01 Entry into force of request for substantive examination
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Application publication date: 20170215