CN106409102A - Bionic perfusion method of non-smooth blood vessel model used for liver perfusion - Google Patents
Bionic perfusion method of non-smooth blood vessel model used for liver perfusion Download PDFInfo
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- CN106409102A CN106409102A CN201610768974.3A CN201610768974A CN106409102A CN 106409102 A CN106409102 A CN 106409102A CN 201610768974 A CN201610768974 A CN 201610768974A CN 106409102 A CN106409102 A CN 106409102A
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Abstract
The invention provides a bionic perfusion method of a non-smooth blood vessel model used for liver perfusion. The donor perfusion cleaning process before liver transplantation is simulated by adopting the method of mathematical simulation. The method comprises the following steps that 1, the concrete size and parameters of a non-smooth blood vessel are determined according to medical image data; 2, the weight of foreign matter in the blood vessel is measured; 3, surface pressure required for impacting the foreign matter is determined according to the acquired weight of the foreign matter so that the perfusion speed can be obtained; and 4, perfusion simulation is performed by adopting the obtained perfusion speed, the blood vessel dynamic phenomenon generated in the perfusion process is observed through medical means, and the blood vessel dynamic parameters for evaluating the quality of blood vessel perfusion can be determined according to the medical data. Finally the analytical comparison of the dynamic characteristic result acquired through non-smooth blood vessel and straight vessel perfusion proves that the stability of blood vessel perfusion can be guaranteed by adopting the non-smooth blood vessel model, the donor perfusion process before liver transplantation further meets the actual situation, and thus the effective basis is provided for solving the problem of deposition of the foreign matter on the vessel wall to enhance the quality of the donor liver.
Description
Technical field
The present invention relates to a kind of Non-smooth surface vascular pattern for liver perfusion, specifically a kind of rough more
Close to the physical model of the actual liver vessel of human body, simulate infusion liquid and it is carried out with the perfusion cleaning process before liver transplantation.
Background technology
The mortality rate of hepatopathy induction is at home, whether developed regions or low developed area are all very high outward, and liver transplantation is
Treat unique effective means of End-stage liver disease at present.Liver is the crucial ring affecting orthotopic liver transplantation success rate for weight height
One of section, the preoperative cleaning (perfusion) to liver donor is the medical procedure that must operate.The direct shadow of quality of therefore vascular perfusion
Ring the success or not of operation.The several scholar's research process of vascular perfusion both at home and abroad, analyzes different vascular perfusion methods and produces
Raw different phenomenons and final effect, to find the purpose that more preferable vascular perfusion method reaches cleaning blood.Cut-off is up till now
Till, it is not a lot of for the preoperative vascular perfusion achievement in research of liver transplantation both at home and abroad.These researchs are mainly around right
Vasa recta models, its mathematical model of deriving, and carries out corresponding mechanical analyses on this basis.Under the auxiliary of medical image,
The vasokinetic characteristic obtaining during making liver perfusion more meets reality, reduces the subjective factorss in liver donor filling process
Impact to cleaning quality, is used to refer to guiding doctor and learns research work and for preparing (as the intestinal before anal-surgery before medical surgery
Cleaning, organ cleaning before organ transplantation etc.) theories integration is provided.
Content of the invention：
In order to solve the above problems, the present invention proposes a kind of bionic watering device of the Non-smooth surface vascular pattern for liver perfusion
Injecting method, this model is a kind of rough blood vessel, and blood vessel wall has foreign body, and this foreign body simulation dimension element deposition, collagen are fine
The foreign body that dimension degeneration, the reason such as endotheliocyte and myocyte necrosis cause is piled up, and is capable of the perfusion of more preferable simulated liver blood vessel
Process.
The technical solution adopted for the present invention to solve the technical problems comprises the steps：
A kind of bionical method for filling of the Non-smooth surface vascular pattern for liver perfusion, build rough closer to people
The physical model of the actual liver vessel of body, simulation infusion liquid carries out the perfusion cleaning process before liver transplantation to it, walks including following
Suddenly：
(1) concrete size and the parameter of Non-smooth surface blood vessel, is determined according to medical image data；
(2), detect the weight of vascular inner body；
(3), required surface pressure during impact foreign body is determined according to the foreign body weight obtaining, and then draw rate of flooding；
(4), it is irrigated emulating using the rate of flooding having obtained, observe generation in filling process by medical means
Vasokinetic phenomenon, and the vasokinetic feature evaluating vascular perfusion quality is determined according to medical data.
Further, flow velocity required for constant current perfusion for the rate of flooding more than drawing, when carrying out constant current vascular perfusion
Entrance velocity is constant V=0.2m/s.
Further, above-described vasokinetic feature includes irrigating flow velocity, blood vessel distortion, its dynamics
Changing Pattern is relevant with shape of blood vessel.
The solution have the advantages that：Using this model can not only before more realistic simulation liver transplantation donor filling
Note process, obtains accurate vasokinetic parameter, provides more scientific theoretical direction for clinical medicine, to blood vessel simultaneously
In wall, deposition of foreign material cleaning effect is preferable.
Brief description
Fig. 1 is Non-smooth surface vascular pattern schematic diagram, and middle bossing is the foreign body adhering to blood vessel wall；
Fig. 2 is Vasa recta model schematic, and middle bossing is the foreign body adhering to blood vessel wall；
Fig. 3 is entrance velocity schematic diagram during Non-smooth surface vascular perfusion；
Fig. 4 is entrance velocity schematic diagram during Vasa recta perfusion；
Fig. 5 is blood vessel bulk deformation schematic diagram during Non-smooth surface vascular perfusion；
Fig. 6 is blood vessel bulk deformation schematic diagram during Vasa recta perfusion.
Specific embodiment
In order that present disclosure is easier to be clearly understood, the specific embodiment below according to the present invention simultaneously combines
Accompanying drawing, the present invention is further detailed explanation, due to specific condition limit, the present invention relates to experiment using calculate
The form of machine emulation is carried out, and carries out Non-smooth surface vascular perfusion analogue simulation by finite element analysis software.
Invention solve its technology Integral Thought be：
(1), before orthotopic liver transplantation, during the cleaning (perfusion) to liver donor, determined non-first according to medical image data
The concrete size of smooth blood vessel and parameter；Next detects the weight of vascular inner body；Then determined according to the foreign body weight obtaining
Required surface pressure during impact foreign body, and then draw constant current rate of flooding；Finally filled using the rate of flooding having obtained
Note emulation, observes, by medical means, the vasokinetic phenomenon producing in filling process, and is evaluated according to medical data determination
The vasokinetic parameter of vascular perfusion quality, shows that Non-smooth surface blood vessel carries out the feasibility of constant current perfusion.(2) described Non-smooth surface
The concrete size of blood vessel and parameter etc. all can be detected by medical means and calculate.(3) perfusion such as described foreign body weight physical parameter
All can be detected by medical means and calculate.
Of the present invention liver Non-smooth surface blood vessel is given below carry out emulating the specific embodiment of perfusion, is imitated using mathematics
Genuine method simulates the donor perfusion cleaning process before liver transplantation, comprises the following steps：
(1) Non-smooth surface blood vessel and Vasa recta modeling, such as Fig. 1 and Fig. 2 are carried out initially with three-dimensional software, intermediate projections are viscous
Invest the foreign body of blood vessel wall.Then blood vessel geometric model importing finite element analysis software is emulated.Simulation process adopts two
The method of kind, first step application Vasa recta is irrigated.The vasokinetic parameter of perfusion will be obtained by emulation, and to be commented with this
Valency pouring quality, is contrasted item.Second step application Non-smooth surface blood vessel is irrigated.Equally, irrigate identical blood with Vasa recta
Pipe kinetic parameter, such as perfusion flow velocity, blood vessel bulk deformation etc. will be obtained by emulation.Finally according to two groups of vascular dynamics
Learn parameter comparison, such as Fig. 3-Fig. 6, the dynamicss that assay is irrigated, this vasokinetic using Non-smooth surface blood vessel
Characteristic includes irrigating flow velocity, blood vessel bulk deformation, and the Changing Pattern of its dynamics is relevant with shape of blood vessel.
(2) described blood vessel geometric model is provided by medical imaging (CT, or MRI) data, and sets fluid as pressing
Contracting non-Newtonian fluid.Two kinds of vascular pattern parameters are as follows：Length of vessel is 20mm, and gateway interior diameter is 4mm, gateway
Overall diameter is 6mm, and blood vessel wall thickness is 1mm, and foreign body radius is 2mm.
(3) in described schematic diagram, infusion liquid flow direction is from left to right, and in described first order vessel, foreign body weight is 0.03g.
(4) described when being irrigated using Non-smooth surface blood vessel and Vasa recta, entrance velocity is 0.2 [m/s].
It is respectively intra-arterial infusion flow velocity during being irrigated using Non-smooth surface blood vessel and Vasa recta shown in Fig. 3, Fig. 4
Distribution, two in figure results is contrasted it is apparent that the perfusion flow velocity under two kinds of vascular patterns presents different dividing
Cloth rule, after Non-smooth surface vascular perfusion proposed by the present invention, intra-arterial infusion flow velocity is distributed changing with shape of blood vessel
Become and change, and the flow velocity of blood vessel wall recess is significantly greater than high spot flow velocity, and flow velocity is different from blood vessel wall
Vasa recta irrigates the result that flow velocity goes to zero, and is more beneficial for taking away the foreign body adhering to blood vessel wall, reaches removing foreign body in blood
The purpose of tube wall deposition.
It is distributed using the blood vessel bulk deformation that Non-smooth surface blood vessel and Vasa recta are carried out, such as Fig. 5, Fig. 6, by contrast,
Perfusion deformation under two kinds of vascular patterns presents the different regularities of distribution, using Non-smooth surface vascular perfusion proposed by the present invention
Afterwards, blood vessel distortion distribution changes with the change of shape of blood vessel, and is produced using Non-smooth surface vascular perfusion proposed by the present invention
Maximum distortion be approximately Vasa recta perfusion produce maximum distortion 8/1000ths, fully ensured that the stability of Perfused vessel.
It should be noted that the present invention be directed to vascular pattern during liver perfusion before liver transplantation, its objective is
Obtain the dynamicss with more directive significance in liver vessel filling process, reduce the shadow that subjective factorss irrigate to liver donor
Ringing, thus improving vascular perfusion quality during liver transplantation, providing more scientific theoretical direction for clinical medicine simultaneously, but simultaneously
Non- belong to the diagnosis to disease and treatment.The content such as the liver transplantation described in background technology and treatment, is intended merely to play
Understanding effect to the background of the present invention.In addition, the present invention is simple to operate, expense is low, and vasokinetic characteristic more they tends to reality,
Therefore, the invention is not restricted to embodiment here, those skilled in the art, according to the announcement of the present invention, make for the present invention
Conspicuously improved and modification all should be within protection scope of the present invention.
It will be clear that the invention is not restricted to embodiment here, those skilled in the art according to the announcement of the present invention,
All should be within protection scope of the present invention by the conspicuously improved and modification that present inventive concept is made.
Claims (3)
1. a kind of bionical method for filling of the Non-smooth surface vascular pattern for liver perfusion is it is characterised in that build uneven
The physical model closer to the actual liver vessel of human body, simulation infusion liquid the perfusion cleaning process before liver transplantation is carried out to it,
Comprise the following steps：
(1) concrete size and the parameter of Non-smooth surface blood vessel, is determined according to medical image data；
(2), detect the weight of vascular inner body；
(3), required surface pressure during impact foreign body is determined according to the foreign body weight obtaining, and then draw constant current rate of flooding；
(4), it is irrigated emulating using the rate of flooding having obtained, observe, by medical means, the blood vessel producing in filling process
Dynamic phenomena, and the vasokinetic characteristic evaluating vascular perfusion quality is determined according to medical data.
2. the bionical method for filling of the Non-smooth surface vascular pattern for liver perfusion according to claim 1, its feature exists
In, flow velocity required for constant current perfusion for the rate of flooding drawing, carrying out entrance velocity during constant current vascular perfusion is constant V=
0.2m/s.
3. the bionical method for filling of the Non-smooth surface vascular pattern for liver perfusion according to claim 1, its feature exists
In described vasokinetic characteristic includes irrigating flow velocity, blood vessel bulk deformation, the Changing Pattern of its dynamics and blood vessel
Shape is relevant.
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| CN201610768974.3A CN106409102A (en) | 2016-08-30 | 2016-08-30 | Bionic perfusion method of non-smooth blood vessel model used for liver perfusion |
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| CN201610768974.3A CN106409102A (en) | 2016-08-30 | 2016-08-30 | Bionic perfusion method of non-smooth blood vessel model used for liver perfusion |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203646395U (en) * | 2013-12-19 | 2014-06-18 | 中国人民解放军第二炮兵总医院 | Arterial perfusion device for in-vitro tissues |
| US20140207008A1 (en) * | 2011-08-20 | 2014-07-24 | Volcano Corporation | Devices, Systems, and Methods for Visually Depicting a Vessel and Evaluating Treatment Options |
| CN105194749A (en) * | 2015-08-10 | 2015-12-30 | 天津理工大学 | Intermittent type double pulsatile flow perfusion method for reducing foreign matter deposition on blood vessel walls |
| CN105561425A (en) * | 2015-12-16 | 2016-05-11 | 天津理工大学 | 1/3 time intermittent single pulsating flow perfusion method capable of reducing foreign matters deposited on vascular wall |
-
2016
- 2016-08-30 CN CN201610768974.3A patent/CN106409102A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140207008A1 (en) * | 2011-08-20 | 2014-07-24 | Volcano Corporation | Devices, Systems, and Methods for Visually Depicting a Vessel and Evaluating Treatment Options |
| CN203646395U (en) * | 2013-12-19 | 2014-06-18 | 中国人民解放军第二炮兵总医院 | Arterial perfusion device for in-vitro tissues |
| CN105194749A (en) * | 2015-08-10 | 2015-12-30 | 天津理工大学 | Intermittent type double pulsatile flow perfusion method for reducing foreign matter deposition on blood vessel walls |
| CN105561425A (en) * | 2015-12-16 | 2016-05-11 | 天津理工大学 | 1/3 time intermittent single pulsating flow perfusion method capable of reducing foreign matters deposited on vascular wall |
Non-Patent Citations (2)
| Title |
|---|
| E.S.DI MARTINO等: "Fluid-structure interaction within realistic three-dimensional models of the aneurysmatic aorta as a guidance to assess the risk of rupture of the aneurysm", 《MEDICAL ENGINEERING&PHYSICS》 * |
| 刘军等: "简易肝血管模型灌注过程中的流体动力学行为初探", 《生物医学工程学杂志》 * |
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