CN105194749B - A kind of double pulsating flow pouring methods of the batch (-type) for reducing deposition of foreign material vascular wall - Google Patents
A kind of double pulsating flow pouring methods of the batch (-type) for reducing deposition of foreign material vascular wall Download PDFInfo
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- CN105194749B CN105194749B CN201510487649.5A CN201510487649A CN105194749B CN 105194749 B CN105194749 B CN 105194749B CN 201510487649 A CN201510487649 A CN 201510487649A CN 105194749 B CN105194749 B CN 105194749B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M3/00—Medical syringes, e.g. enemata; Irrigators
- A61M3/02—Enemata; Irrigators
- A61M3/0233—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs
- A61M3/025—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs supplied directly from the pressurised water source, e.g. with medicament supply
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Abstract
A kind of double pulsating flow pouring methods of the batch (-type) for reducing deposition of foreign material vascular wall, pulsation is combined with constant current, is irrigated, comprised the following steps with periodicity fluidised form intravasation：(1) weight of vascular inner body, is detected；(2) required surface pressure when, according to the foreign matter weight of acquisition determination impact foreign matter, and then draw rate of flooding；(3) the double Pulsating Flows of batch (-type), are introduced in the blood vessels, by caused vasokinetic phenomenon during medical means observation concern, and according to the vasokinetic parameter of medical data determination evaluation vascular perfusion quality.The pouring quality of vascular perfusion is finally carried out using batch (-type) Pulsating Flow according to two kinds of vasokinetic parameter comparisons, analysis, ensures the stabilization of Perfused vessel, while the situation of deposition of foreign material vascular wall is improved very well, effectively improves vascular wall cleaning.
Description
Technical field
The present invention relates to a kind of double pulsating flow pouring methods of batch (-type) for reducing deposition of foreign material vascular wall, specifically will
Pulsating Flow is combined with constant current, and the method for vascular perfusion is carried out with periodic blood fluidised form.
Background technology
Whether developed regions or low developed area are all very high at home, outside for the death rate that hepatopathy induces, and liver transfer operation is
Unique effective means for the treatment of End-stage liver disease at present.Liver donor quality height is the crucial ring for influenceing orthotopic liver transplantation success rate
One of section, the preoperative cleaning (perfusion) to liver donor is the medical procedure that must be operated.Therefore the direct shadow of quality of vascular perfusion
Ring the success or not of operation.The domestic and international several scholar's research process of vascular perfusion, analyzes different vascular perfusion method productions
Raw different phenomenons and final effect, to find the purpose that more preferable vascular perfusion method reaches cleaning blood.By the end of current
Untill, it is not both at home and abroad many for the preoperative vascular perfusion achievement in research of liver transplant.These research mainly around pair
Blood vessel models, and derives its mathematical modeling, and carry out corresponding mechanical analysis on this basis.Under the auxiliary of medical image, the phase
Hope blood cleaning more thoroughly influence of the subjective factor in liver donor filling process to cleaning quality can be reduced, for instructing
Medical research works and to prepare (cleaning intestinal before such as anal-surgery, the organ cleaning before organ transplant before medical surgery
Deng) theories integration is provided.Constant current perfusion is mainly employed for vascular perfusion, some additionally use eddy flow perfusion etc..Constant current fills
Note it is easy to operate, but due to the stability of constant current, its scouring force very little to tube wall, cause for liver donor cleaning performance not
It is fine；The eddy flow perfusion then occurred, on the one hand, make blood flow stable, reduce turbulent flow；On the other hand, it can obtain vascular wall
Washed away to smooth, deposition of the harmful substance (such as lipid) in vascular wall in reduction blood.And in recent years, someone has begun to
This turn stream principle is applied to clinical medical trial.This method is no doubt good, but operation difficulty is but very big, and cost disappears
Consumption is higher.
The content of the invention
In order to solve the above problems, the present invention proposes a kind of double pulsation purlings of batch (-type) for reducing deposition of foreign material vascular wall
Injecting method, this method are a kind of periodicity vascular perfusion method, Pulsating Flow is combined with constant current in periodicity intravasation, one
Aspect pulsation fluidised form can give one external force of foreign matter being adhered on vascular wall, work of the another aspect constant current fluidised form in inertia force
Wash away vascular wall well under, while ensureing angiogenesis micro-strain amount, reach the deposition for reducing foreign matter in vascular wall
Purpose.
The technical solution adopted for the present invention to solve the technical problems comprises the following steps：
A kind of double pulsating flow pouring methods of the batch (-type) for reducing deposition of foreign material vascular wall, are to be combined pulsation with constant current,
It is irrigated, is comprised the following steps with periodicity fluidised form intravasation：
1st, the weight of vascular inner body is detected；
Required surface pressure when the 2nd, according to the foreign matter weight of acquisition determination impact foreign matter, and then draw rate of flooding；
3rd, the double Pulsating Flows of batch (-type) are introduced in the blood vessels, pass through caused vascular dynamics during medical means observation concern
Phenomenon is learned, and the vasokinetic parameter of evaluation vascular perfusion quality is determined according to medical data.
Further, the rate of flooding drawn above is the flow velocity required for constant current perfusion, when carrying out constant current vascular perfusion
Entrance velocity is constant v=0.273 [m/s].
Further, entrance velocity needs to be irrigated according to constant current during batch (-type) noted above pair Pulsating Flow vascular perfusion
Speed carries out being equivalent to SIN function：
V=if (t>=2 [s], 0.28 [m/s] sin (2 × pi × t/1 [s])+0.28 [m/s], 0.28 [m/s])
The formula shows that porch initial flow rate is 0.28 [m/s].
Further, above-described vasokinetic parameter includes perfusion flow velocity, shearing force, blood vessel distortion amount.
The solution have the advantages that：Vascular perfusion quality during liver transplant can be improved, while is clinical medicine
More scientific theoretical direction is provided, this method combines pulsation fluidised form and constant current fluidised form, can not only reduce blood turbulent flow, Er Qieneng
It is enough to wash away vascular wall well, it is simple to operate, it is preferable to deposition of foreign material cleaning effect in vascular wall.
Brief description of the drawings
Fig. 1 is first order vessel model schematic, and middle bossing rearward is the foreign matter for being adhered to vascular wall；
Entrance velocity schematic diagram when Fig. 2 is batch (-type) pair pulsating flow pouring；
Fig. 3 is velocity of blood flow schematic diagram in constant current filling process medium vessels；
Fig. 4 is vessel inner blood flow velocity schematic diagram during the double pulsating flow pourings of batch (-type)；
Fig. 5 is constant current filling process medium vessels boundary shear stress schematic diagram；
Fig. 6 is blood vessel boundary shear stress schematic diagram during the double pulsating flow pourings of batch (-type)
Fig. 7 is constant current filling process medium vessels overall deformation schematic diagram；
Fig. 8 is the double pulsating flow pouring process blood vessel overall deformation schematic diagrames of batch (-type)
Embodiment
In order that present disclosure is easier to be clearly understood, specific embodiment and combination below according to the present invention
Accompanying drawing, the present invention is further detailed explanation, due to specific condition limit, the present invention relates to experiment using calculate
The form of machine emulation is carried out, i.e., carrying out first order vessel by finite element analysis software irrigates analogue simulation.
Invention solve its technology Integral Thought be：
(1) before orthotopic liver transplantation, during the cleaning (perfusion) to liver donor, the weight of vascular inner body is detected first；
Required surface pressure when secondly according to the foreign matter weight of acquisition determination impact foreign matter, and then draw rate of flooding；Finally in blood
The double Pulsating Flows of batch (-type) are introduced in pipe, by caused vasokinetic phenomenon during medical means observation concern, and according to
Medical data determines the vasokinetic parameter of evaluation vascular perfusion quality, shows that the double Pulsating Flows of batch (-type) can realize that blood vessel fills
Gaze at.(2) perfusion such as described foreign matter weight physical parameter can be detected and calculated by medical means.(3) rate of flooding
The impact velocity needed when being by being irrigated according to the constant current being calculated is, it is necessary to further equivalent into the double Pulsating Flows of batch (-type) by it
Rate of flooding, it is specific to irrigate the cycle and need to be determined according to the weight of foreign matter.
The embodiment of the double Pulsating Flow vascular perfusion methods of batch (-type) of the present invention, including following step is given below
Suddenly：
(1) first order vessel modeling, such as Fig. 1 are carried out using three-dimensional software first, intermediate projections are be adhered to vascular wall different
Thing.Then blood vessel geometrical model importing finite element analysis software is emulated.Simulation process uses two methods, and the first step should
Vascular perfusion is carried out with constant current.The vasokinetic parameter that constant current irrigates will be obtained by emulation, and perfusion matter is evaluated with this
Amount, is contrasted item.The double Pulsating Flows of second step application batch (-type) carry out vascular perfusion.Equally, identical blood vessel is irrigated with constant current
Kinetic parameter, such as velocity of blood flow, shearing force will be obtained by emulating.Finally according to two groups of vasokinetic parameters pair
Than such as Fig. 3-Fig. 8, assay carries out the pouring quality of vascular perfusion using the double Pulsating Flows of batch (-type).
(2) the blood vessel geometrical model is provided by medical imaging (CT, or MRI) data, and sets fluid as that can not press
Contracting non-newtonian fluid.Existing medical image cannot distinguish between blood flow and blood vessel, unified by vessel wall thickness in reverse engineering software
It is set to 2mm.
(3) perfusion liquid flow direction is that from left to right, foreign matter weight is 0.03g in the first order vessel in the schematic diagram.
(4) during the progress vascular perfusion using constant current, entrance velocity is 0.273 [m/s].
(5) entrance velocity expression formula when using batch (-type) double Pulsating Flow vascular perfusion for：V=if (t>=2 [s],
0.28[m/s]sin(2×pi×t/1[s])+0.28[m/s],0.28[m/s])
The formula shows that porch initial flow rate is 0.28 [m/s], time cycle t=4 [s], entrance velocity schematic diagram, such as schemes
2.The expression formula is determined according to the relation between speed virtual value and speed maximum, and speed virtual value is herein
0.273 [m/s], maximum are 0.28 [m/s].And velocity expression is provided in the form of SIN function so that batch (-type) is double
The entrance velocity curve of Pulsating Flow is Pulsating Flow.
It is respectively using vessel inner blood during constant current perfusion and the double Pulsating Flow vascular perfusions of batch (-type) shown in Fig. 3, Fig. 4
Velocity flow profile, result in two figures is contrasted, it is apparent that using the double pulsating flow pourings of batch (-type) proposed by the present invention
After method, flow velocity is obviously improved in vessel inner blood, is more beneficial for taking away the foreign matter for being adhered to vascular wall, is reached foreign matter in blood
The purpose of the deposition of tube wall.
It is distributed using the boundary shear stress of constant current perfusion and pulsation-constant current perfusion, such as Fig. 5, Fig. 6, contrasts the two methods
Shearing force distribution understand that can significantly increase wall shearing using the double pulsating flow pouring methods of batch (-type) proposed by the present invention should
Power, the bigger impulsive force of foreign matter is given, the purpose realize and reduce deposition of foreign material, washed away tube wall.
Filling process medium vessels can deform, and such as Fig. 7, Fig. 8, represent constant current perfusion and the double pulsation purlings of batch (-type) respectively
Blood vessel distortion caused by note.By contrast, filled using the double pulsating flow pouring methods of batch (-type) proposed by the present invention with constant current
Blood vessel distortion is suitable caused by note, ensure that the stability of Perfused vessel.
It should be noted that the present invention be directed to the method for filling that deposition of foreign material in liver vessel wall is taken, its purpose
It is to improve vascular perfusion quality during liver transplant, while more scientific theoretical direction is provided for clinical medicine, but not belongs to
In being directed to and treating to disease.The contents such as liver transplant and treatment described in background technology, it is intended merely to play to this
The understanding effect of the background of invention.In addition, the present invention is simple to operate, expense is low, and foreign matter elimination effect is preferable, therefore, the present invention
Embodiment here is not limited to, those skilled in the art make obvious according to the announcement of the present invention for the present invention
Improve and modification all should be within protection scope of the present invention.
Claims (4)
- A kind of 1. double pulsating flow pouring methods of the batch (-type) for reducing deposition of foreign material vascular wall, it is characterised in that：Imitated using computer Genuine form is carried out, i.e., carrying out first order vessel by finite element analysis software irrigates analogue simulation, and pulsation is combined with constant current, It is irrigated, is comprised the following steps with periodicity fluidised form intravasation：(1) weight of vascular inner body, is detected；(2) required surface pressure when, according to the foreign matter weight of acquisition determination impact foreign matter, and then draw rate of flooding；(3) the double Pulsating Flows of batch (-type), are introduced in the blood vessels, pass through caused vasokinetic during medical means observation concern Phenomenon, and according to the vasokinetic parameter of medical data determination evaluation vascular perfusion quality.
- 2. the double pulsating flow pouring methods of the batch (-type) for reducing deposition of foreign material vascular wall according to claim 1, its feature exist In：The rate of flooding drawn is the flow velocity required for constant current perfusion, and it is constant v=to carry out entrance velocity during constant current vascular perfusion 0.273m/s。
- 3. the double pulsating flow pouring methods of the batch (-type) for reducing deposition of foreign material vascular wall according to claim 1, its feature exist In：Entrance velocity needs to be carried out being equivalent to sinusoidal letter according to constant current rate of flooding during Pulsating Flow vascular perfusion double using batch (-type) Number：V=if (t ＞=2s, 0.28m/s × sin (2 × pi × t/ [1s])+0.28m/s, 0.28m/s),The formula shows that porch initial flow rate is v=0.28m/s.
- 4. the double pulsating flow pouring methods of the batch (-type) for reducing deposition of foreign material vascular wall according to claim 1, its feature exist In：Described vasokinetic parameter includes perfusion flow velocity, shearing force, blood vessel distortion amount.
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| CN201510487649.5A CN105194749B (en) | 2015-08-10 | 2015-08-10 | A kind of double pulsating flow pouring methods of the batch (-type) for reducing deposition of foreign material vascular wall |
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| CN106409102A (en) * | 2016-08-30 | 2017-02-15 | 天津理工大学 | Bionic perfusion method of non-smooth blood vessel model used for liver perfusion |
| CN106388936A (en) * | 2016-12-05 | 2017-02-15 | 天津理工大学 | Bionic perfusion method for branch blood vessel model for liver perfusion |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203646395U (en) * | 2013-12-19 | 2014-06-18 | 中国人民解放军第二炮兵总医院 | Arterial perfusion device for in-vitro tissues |
| CN103886796A (en) * | 2014-03-13 | 2014-06-25 | 西安交通大学 | Organ perfusion system for surgery simulation trainers |
| CN104036107A (en) * | 2013-03-04 | 2014-09-10 | 西门子公司 | Determining Functional Severity of Stenosis |
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| US9339348B2 (en) * | 2011-08-20 | 2016-05-17 | Imperial Colege of Science, Technology and Medicine | Devices, systems, and methods for assessing a vessel |
| JP5747007B2 (en) * | 2012-09-12 | 2015-07-08 | 富士フイルム株式会社 | MEDICAL IMAGE DISPLAY DEVICE, MEDICAL IMAGE DISPLAY METHOD, AND MEDICAL IMAGE DISPLAY PROGRAM |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104036107A (en) * | 2013-03-04 | 2014-09-10 | 西门子公司 | Determining Functional Severity of Stenosis |
| CN203646395U (en) * | 2013-12-19 | 2014-06-18 | 中国人民解放军第二炮兵总医院 | Arterial perfusion device for in-vitro tissues |
| CN103886796A (en) * | 2014-03-13 | 2014-06-25 | 西安交通大学 | Organ perfusion system for surgery simulation trainers |
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Granted publication date: 20180123 Termination date: 20200810 |