CN106389715A - Traditional Chinese medicine preparation for treating hemicrania - Google Patents
Traditional Chinese medicine preparation for treating hemicrania Download PDFInfo
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- CN106389715A CN106389715A CN201611110912.XA CN201611110912A CN106389715A CN 106389715 A CN106389715 A CN 106389715A CN 201611110912 A CN201611110912 A CN 201611110912A CN 106389715 A CN106389715 A CN 106389715A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention relates to a traditional Chinese medicine preparation for treating hemicrania. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 15g of aloe, 15g of frankincense, 20g of wild chrysanthemum flower, 30g of Pilea cadierei, 30g of hemlock parsley, 20g of radix bupleuri, 15g of angelica, 10g of licorice root and 4g of borneol. The preparation for treating hemicrania has obvious curative effects for hemicrania.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to one kind and treat migrainous Chinese medicine preparation.
Background technology
Also known as vascular headache, nervous headache, it is a kind of headache of repeatability outbreak to migraine, is clinical normal
The primary headache seen, is characterized in that ictal, mostly inclined side, middle severe, beating sample headache, typically continues 4～72h, can
With Nausea and vomiting, light, Sound stimulat or daily routines all can increase to have a headache, and quiet environment, rest can alleviate headache.Migraine
Belong to clinical common chronic forms angiopathy disease, it can betide any age bracket, be more common in 35-45 year between reach
To peak, incidence rate afterwards is gradually reduced with advancing age.Its sickness rate is higher, and the body of serious harm people is good for
Health.Show according to the study, people is easier brain local damage migraine patient than usual, and the attack times of its migraine are got over
Many, the region of brain damage wound can be bigger.Migraine is common clinical and frequently-occurring disease, is with the side of recurrent exerbation or bilateral
Have a headache be characterized nerve, dysfunction of blood vessel disease, have a strong impact on the daily studying and living of people.
Still not fully aware of to migrainous pathogeny and pathological molecule mechanism at present.Clinically typically adopt Ah
A department woods, indometacin, Thebe woods, piracetam etc. are treated, but Western medicine can only alleviate slight illness it is impossible to effect a radical cure the state of an illness, effective percentage
For relatively low, easily drug resistance occur, and side effect is larger.Therefore, clinical effectiveness is not notable.So, exploitation one kind is effectively controlled
Treat medicine significant.
Content of the invention
It is an object of the invention to provide one kind treats migrainous Chinese medicine preparation.
In order to realize the purpose of the present invention, the present invention provides one kind to treat migrainous Chinese medicine preparation it is characterised in that it
It is made up by following method of following bulk drugs：Weigh Aloe 15g, Olibanum 15g, Flos Chrysanthemi Indici 20g, frozen water spends 30g, Rhizoma Chuanxiong 30g,
Radix Bupleuri 20g, Radix Angelicae Sinensis 15g and 10 grams of Radix Glycyrrhizae, add 4 liters of water, heat 3 hours under conditions of backflow, filter, obtain filtrate 1,
Described filtrate 1 is concentrated into 1000 milliliters, is cooled to room temperature, add dehydrated alcohol to alcohol content to be 75 volumes %, seal room temperature
Standing 8 hours, filters, obtains filtrate 2, make described filtrate 2 be evaporated to constant weight under reduced pressure, pulverizes, and adds 150 grams of lanoline,
Borneolum Syntheticum 4g, stirs, and obtains final product.
Described is tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, ointment or decoction for preparation, preferably uses
Unguentum.
The reasonable recipe treating migrainous medicament of the present invention, evident in efficacy for migraine pain disorders.The present invention
Beneficial effect be：Be easy to instant effect, good effect, have no toxic side effect, easy to use, price low.
Specific embodiment
Further illustrate the present invention below by embodiment.It should be understood that embodiments of the invention are for illustrating
The present invention rather than limitation of the present invention.Broadly fall into the present invention according to the simple modifications that the essence of the present invention is carried out to the present invention
Claimed scope.Unless otherwise stated, the percent in the present invention is percetage by weight.
The Chinese medicine preparation of the embodiment present invention
Weigh Aloe 15g, Olibanum 15g, Flos Chrysanthemi Indici 20g, frozen water spends 30g, Rhizoma Chuanxiong 30g, Radix Bupleuri 20g, Radix Angelicae Sinensis 15g and Radix Glycyrrhizae 10
Gram, add 4 liters of water, heat 3 hours under conditions of backflow, filter, obtain filtrate 1, described filtrate 1 is concentrated into 1000 millis
Rise, be cooled to room temperature, add dehydrated alcohol to be 75 volumes % to alcohol content, closed chamber is gentle and quiet to be put 8 hours, filters, obtains filtrate
2, make described filtrate 2 be evaporated to constant weight under reduced pressure, pulverize, add 150 grams of lanoline, Borneolum Syntheticum 4g, stir, obtain final product institute
State ointment.
Therapeutic Method：Ointment using preparation in embodiment is treated, daily 2 times, soft by 10 grams every time
Unguentum is uniformly coated at the both sides temple of patient.Continuous treatment 2 weeks.
Experimental example
Diagnostic criteria
(1) diagnosis meets in the migrainous classification of International Headache association in 2004 and diagnosis Migraine without aura and has elder generation
The migrainous diagnostic criteria of million types：A, meet at least 5 times of b-d item outbreaks；(untreated or treatment are no for b, Headache attacks
Effect) continue 4～72 hours；C, at least following in 2 headache features (Unilateral；Pulsation；In or severe pain
Bitterly；Daily routines can increase to avoid sort of activity when having a headache or having a headache)；At least (dislike with following l item during d, headache
The heart or vomiting；Photophobia and phonophobia；Can not be owing to Other diseases)；E, age≤50 year old of first attack；F, signature know the inside story same
Meaning book.
Exclusion standard：(1) age<18 years old or>70 years old；(2) hypertension, cerebrovas-cularaccident, cerebral tumor etc. are organic
Headache caused by pathological changes, cervical spondylosiss, infectious disease, other primary headaches such as cluster pain, tension-type headache and various
Secondary headache；(3) the severe primary diseases such as liver, kidney, hemopoietic system are merged；(4) gravid woman, bleeding and clotting obstacle
Person, malignant tumor patient；(5) severe psychiatric class Disease；(6) there is spoken language and write communication disorder；(7) can not or not
It is ready to coordinate investigator.
48 migraineurs, wherein each 24 of men and women are accepted in selection for medical treatment, age 27-49 year, average 34 years old.Meet above-mentioned
Diagnostic criteria.Ointment using preparation in embodiment is treated, daily 2 times, every time will be uniform for 10 grams of ointment
Be coated at the both sides temple of patient.Continuous treatment 2 weeks.
Curative effect determinate standard
With reference to Ministry of Health of the People's Republic of China《New Chinese medicine guideline of clinical investigations》With《Neurological》Draft curative effect mark
Accurate.Clinical recovery：Headache and simultaneous phenomenon disappear；Effective：Pain intensity and simultaneous phenomenon substantially mitigate, and attack times reduce,
Persistent period reduces more than 2/3；Effectively：Headache has mitigated, and outbreak extends interval time, and the persistent period reduces more than 1/3；
Invalid：Pain is no obvious to be changed or increases, and attack times increase, and duration extension is.
Headache degree standard：Using visual analogue scaleies (VAS) scoring, 0～10 minute mark chi.No headache：For 0
Point；Mild headache：Headache does not affect daily routines (1≤fraction ＜ 4)；Moderate pain：Headache impact daily routines, work
With study (4≤fraction ＜ 7)；Severe is had a headache：Because headache must bed lead to work or learn (7≤fraction ＜ 10).
Result
Through treatment, find in 48 patients, clinical cure 29, effective 12, effective 7.Do not occur over the course for the treatment of
Significantly adverse events.
Claims (1)
1. one kind treats migrainous Chinese medicine preparation it is characterised in that it is made up by following method of following bulk drugs：Weigh
Aloe 15g, Olibanum 15g, Flos Chrysanthemi Indici 20g, frozen water spends 30g, Rhizoma Chuanxiong 30g, Radix Bupleuri 20g, Radix Angelicae Sinensis 15g and 10 grams of Radix Glycyrrhizae, adds 4
Rise water, heat 3 hours under conditions of backflow, filter, obtain filtrate 1, described filtrate 1 is concentrated into 1000 milliliters, is cooled to
Room temperature, adds dehydrated alcohol to be 75 volumes % to alcohol content, closed chamber is gentle and quiet to be put 8 hours, filters, obtains filtrate 2, make described filter
Liquid 2 is evaporated to constant weight under reduced pressure, pulverizes, and adds 150 grams of lanoline, Borneolum Syntheticum 4g, stirs, obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611110912.XA CN106389715A (en) | 2016-12-06 | 2016-12-06 | Traditional Chinese medicine preparation for treating hemicrania |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611110912.XA CN106389715A (en) | 2016-12-06 | 2016-12-06 | Traditional Chinese medicine preparation for treating hemicrania |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106389715A true CN106389715A (en) | 2017-02-15 |
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ID=58084021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611110912.XA Pending CN106389715A (en) | 2016-12-06 | 2016-12-06 | Traditional Chinese medicine preparation for treating hemicrania |
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| Country | Link |
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| CN (1) | CN106389715A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105055924A (en) * | 2015-09-21 | 2015-11-18 | 南京正亮医药科技有限公司 | Medicine preparation used for treating migraine |
-
2016
- 2016-12-06 CN CN201611110912.XA patent/CN106389715A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105055924A (en) * | 2015-09-21 | 2015-11-18 | 南京正亮医药科技有限公司 | Medicine preparation used for treating migraine |
Non-Patent Citations (1)
| Title |
|---|
| 张俊莉主编: "《腰腿痛简易疗法》", 31 March 2013, 西安交通大学出版社 * |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170215 |
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| WD01 | Invention patent application deemed withdrawn after publication |