CN106389602A - Pharmaceutical composition for treating syndromes of phlegm heat and bowel repletion of stroke and preparation method of pharmaceutical composition - Google Patents
Pharmaceutical composition for treating syndromes of phlegm heat and bowel repletion of stroke and preparation method of pharmaceutical composition Download PDFInfo
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- CN106389602A CN106389602A CN201610324630.3A CN201610324630A CN106389602A CN 106389602 A CN106389602 A CN 106389602A CN 201610324630 A CN201610324630 A CN 201610324630A CN 106389602 A CN106389602 A CN 106389602A
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Classifications
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- A—HUMAN NECESSITIES
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/708—Rheum (rhubarb)
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a pharmaceutical composition for treating syndromes of phlegm heat and bowel repletion of stroke and a preparation method of the pharmaceutical composition. The pharmaceutical composition consists of fructus trichosanthis, flos carthami, fructus aurantii immaturus, cortex magnolia officinalis, radix et rhizoma rhei and mirabilite. The pharmaceutical composition has functions of relaxing bowel, reducing phlegm, purging heat and promoting blood circulation. The pharmaceutical composition is mainly used for treating the syndromes of phlegm heat and bowel repletion of the stroke. The pharmaceutical composition has the characteristics that the pharmaceutical composition focuses on stomach and intestines, adopting the means of relaxing bowel and aiming at dispelling toxins, treating disease in upper part by managing lower and taking a drastic measure to treat the disease, and the pharmaceutical composition, on the basis of the effects of activating and descending yang and clearing stomach and viscus as well as the strength of purging, can rapidly and effectively remove toxins and evils in body, open upper and lower orifices, weed through the old to new, timely purge to preserve yin and protect healthy qi.
Description
Technical field
The present invention discloses a kind of pharmaceutical composition treating apoplexy phlegm-heat excess syndrome, the present invention further discloses a kind of
The preparation method of the pharmaceutical composition for the treatment of apoplexy phlegm-heat excess syndrome, belongs to traditional Chinese medical science pharmaceutical technology field.
Background technology
Apoplexy is due to healthy tendency virtual loss, and diet, feelings will, overstrain internal injury etc. cause qi and blood inverse disorderly, produce wind, fire, phlegm,
The stasis of blood, lead to the resistance of brain vessle-Bi symptom-complex or blood to overflow outside brain arteries and veins be basic pathogenesis, so that unexpected dusk servant, hemiplegia, dispute be crooked, speech is stuttering puckery
Or in silence, hemianesthesia be main clinical manifestation disease.FU QI being obstructed occupies critical role in apoplexy at acute stage, logical internal organs method
As one of important therapy of suffering from acute stroke, by wide clinical application, retrieval discovery has the logical internal organs of some scholars report to rush down turbid method
And the clinical practice of removing heat by catharsis expells the pathogenic heat method, but carefully analyzing its medication and find after discussing, its essence is still eliminating phlegm by purgation in the bowels.And
It is that the index that its clinical research is detected is like aobvious outmoded, reasonable in design, index mostly based on clinical curative effect analysis and summary of experience
Advanced Basic Experiment Study is rare.Clinically not yet find the pharmaceutical composition for apoplexy phlegm-heat excess syndrome at present
And preparation method.
Content of the invention
It is an object of the invention to provide a kind of pharmaceutical composition treating apoplexy phlegm-heat excess syndrome, it is efficiently used for treating
Apoplexy phlegm-heat excess syndrome disease.
The invention also discloses a kind of preparation method of the pharmaceutical composition treating apoplexy phlegm-heat excess syndrome, process is simple
Easy to operate it is adaptable to industrialized production.
A kind of compound Chinese medicinal preparation for treating apoplexy phlegm-heat excess syndrome of the present invention, by following weight ratio
The pharmaceutical preparation that Chinese medicine material is formed：
Melon withers 6-30, safflower 5-15, dried immature fruit of citron orange 5-15, bark of official magnolia 5-15, rheum officinale 3-10, saltcake 1-5.
A kind of preparation method of compound Chinese medicinal preparation for treating apoplexy phlegm-heat excess syndrome of the present invention, including
Following steps:
Above Six-element, saltcake is ground into fine powder；The bark of official magnolia, rheum officinale add 4 ~ and 6 times amount 70% alcohol reflux extracts 3 times, and 0.5 hour every time,
Filtration, filtrate recycling ethanol, it is concentrated into relative density 1.20～1.25 (80 DEG C)；The dregs of a decoction add 6 together with Snakegourd Fruit, safflower, the dried immature fruit of citron orange ~
8 times amount decoctings boil 3 times, 1.0 ~ 2.0 hours every time, filtration, collecting decoction, filtration, filtrate be concentrated into relative density 1.20～
1.25（80℃）Clear cream, merge with above-mentioned alcohol medicinal extract, plus saltcake fine powder, mix and obtain final product.
【Usage and dosage】Oral.Twice a day, a 10 ~ 15g.
【Indication】For apoplexy phlegm-heat excess syndrome.
Pharmacological effect of the present invention is described as follows：
Fang Xie：Chinese medicine composition of the present invention is all because of stagnant middle Jiao of phlegm thermal resistance for apoplexy phlegm-heat excess syndrome, so that conduction function is neglected one's duty,
Ascending the clear and descending the turbid is obstructed, and because of the lung and the large intestine being interior-exteriorly related, then under lead to caused by FU QI being obstructed syndrome.At the moment, that is, with logical
Internal organs resolving sputum, clearing away heat and relieving the wind syndrome, phlegm reduction of blood circulation promoting and dispelling toxins and dredging collateralses are basic therapy.We have logical internal organs, resolving sputum, expel the heat-evil, the work(of promoting blood circulation
Effect.Snakegourd Fruit sweet and slightly bitter taste in side, cold in nature.Function clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturize laxation；Rheum officinale bitter cold, function is purged heat logical
Intestines, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow is monarch drug in a prescription altogether.Arisaema cum bile hardship micro-pungent is cool, function clearing heat and eliminating phlegm, and relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion, the salty bitter cold of saltcake,
Function purgating heat and bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat.Under the dried immature fruit of citron orange, gas disappears ruffian, and bark of official magnolia promoting the circulation of qi removes full, and four will be ministerial drug altogether.Safflower is lived
The blood stasis of blood, is adjutant, and all medicines share, and holds along losing fall stomach Qi, to recover the function of its main fall；The turbid poison of the hot phlegm in Qinghua, prevents phlegm heat
Wind transmission, wind phlegm is disturbed, and key closes all cards of coma.Although its discharge function is fierce, because side demonstrate,proves corresponding, its application kind, sample phase
, perverse trend is volt.
The present invention is the pure Chinese medicine compound preparation being developed by clinical experience side, and it has logical internal organs, resolving sputum, expels the heat-evil, and lives
Effect of blood.Cure mainly apoplexy phlegm-heat excess syndrome.Card is shown in：Acute onset, unexpected hemiplegia, dispute is crooked, speech stuttering puckery or
In silence, hemianesthesia, very then coma, with abdominal distension, constipation, have a dizzy spell, cough up phlegm or abundant expectoration, dimly red tongue or dimness, yellow tongue fur or
Yellow greasy, wiry and rolling pulse.Feature is to control in stomach and intestine, and with logical internal organs as means, for the purpose of toxin expelling, treating disease in the upper by managing the lower, take away the firewood under the cauldron, by means of logical fall
The gesture of the bright stomach internal organs of sun and rush down lower power, it is evil effectively to discharge rapidly poison in vivo, logical lower orifices and open upper orifices, push away Chen Zhixin, timely purgation to preserve yin,
Protection healthy tendency.
Curative effect proves：
（1）Diagnostic criteria
1）Western medicine diagnostic criteria：
With reference to neurology branch of Chinese Medical Association cerebrovascular disease group formulation in 2010《Chinese acute ischemic cerebral apoplexy is examined
Control guide 2010》
1. Acute onset；
2. focal neurologic impairment, minority is comprehensive neurologic impairment；
3. symptom and feature lasts are more than a few hours；
4. brain CT or MRI Cerebral hemorrhage and other pathology；
5. brain CT or MRI has a responsibility for infarct focus.
2）Tcm diagnosis standard：
Draft formulation with reference to State Administration of Traditional Chinese Medicine's encephalopathic acute disease scientific research cooperative groups《Apoplexy diagnoses efficacy assessment standard》
Formulate.
1. primary symptom：Hemiplegia, mind dusk cover, and speech is stuttering puckery or in silence, hemiparesthesia, and dispute is crooked；
2. secondary disease：Headache, dizziness, pupil god's change, drinking-water is sent out and is choked, mesh not wink partially, incoordination.
Have more than 2 primary symptoms or 1 primary symptom, 2 diseases and more than, in conjunction with onset, inducement, premonitory symptom,
Age can make a definite diagnosis；Do not possess above-mentioned condition, also can make a definite diagnosis in conjunction with imaging examination result.
3）Apoplexy staging scale
1. acute stage：Within falling ill 2 weeks, Hitting Viscera the longest to 1 month；
2. convalescence：Fall ill 2 weeks to 6 months；
3. sequela stage：After morbidity 6 months.
4）Apoplexy disease class diagnostic criteria
Apoplexy Hitting Viscera standard：Apoplexy has god to know confused illiteracy person；Apoplexy apoplex involving the channels and collaterals standard：Apoplexy no god knows confused illiteracy person.
5）Phlegm-heat excess syndrome diagnostic criteria：
Hemiplegia, dispute is crooked, and speech is stuttering puckery or in silence, hemianesthesia, abdominal distension, dry stool or constipation, and headache and dizziness is coughed up phlegm or phlegm
Many, red tongue body, yellow and greasy fur, wiry and rolling pulse or hemiplegia side string sliding and big.
（2）Curative effect judging standard
Comprehensive therapeutic effect judges：The cardinal symptoms such as the mind for the treatment of Patients Before And After, language, extremity motor function carry out Comprehensive Assessment
（The standard formulated with reference to the 4th national cerebrovascular academic conference of nineteen ninety-five）.It is mainly subtracting of nerve function deficit score value
Few.
Nerve function deficit score value reduces calculating：[(neural work(after neurological functional deficit integration-treatment before treatment
Can defect degree integration) ÷ treatment before neurological functional deficit integration] × 100%, be expressed as a percentage.
It is almost recovered：Minimizing >=90% of neurological functional deficit integrated value, 0 grade of disability degree.
Effective：The minimizing 46-89% of neurological functional deficit integrated value, disability degree 1-3 level.
Effectively：The minimizing 18-45% of neurological functional deficit integrated value.
Invalid：The minimizing ＜ 18% of neurological functional deficit integrated value.
（3）Therapeutic effect
Clinical statisticses application T statistical theory carries out treatment recovery from illness 200 to the patient of 320 apoplexy phlegm-heat excess syndrome
（62.5%）, effective 108（33.75%）, invalid 12（3.75%）.
Chinese medicine composition of the present invention is that qi and blood is inverse disorderly, lifting imbalance, febrile disease complicated by wind, and malicious heresy diffuses disturbs key, poison heresy superinverse, poison
Damage the syndrome of brain network.There is logical internal organs, resolving sputum, the effect of expelling the heat-evil.Snakegourd Fruit sweet and slightly bitter taste in side, cold in nature.Function clearing away heat and eliminating phlegm, wide chest
Dissipating bind, moisturize laxation.Arisaema cum bile hardship micro-pungent is cool, function clearing heat and eliminating phlegm, and relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion.Rheum officinale bitter cold, function is purged heat logical intestines, cool blood
Removing toxic substances, dispelling stasis of blood and stimulating the menstrual flow.The salty bitter cold of saltcake, function purgating heat and bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat.Under the dried immature fruit of citron orange, gas disappears ruffian, bark of official magnolia promoting the circulation of qi
Except full, nitre Huang is helped to push away the power swung.All medicines share, and hold along losing fall stomach Qi, to recover the function of its main fall；The turbid poison of the hot phlegm in Qinghua, prevents
Only phlegm thermalization wind, wind phlegm is disturbed, key closes all cards of coma.Although its discharge function is fierce, because side demonstrate,proves corresponding, its application kind,
Sample phase obtains, and perverse trend is volt.
The positive effect of the present invention is：By rushing down internal organs heat, drop the therapeutic effect that turbid poison can improve apoplexy, improve apoplexy and suffer from
The disturbance of consciousness of person, prevents aggravation and reduces disease damage degree；Mechanism of action one is to make that internal organs gas is unobstructed, and qi and blood is able to compress,
Network is reached with logical numbness, promotes the improvement of the diseases such as hemiplegia；Two is so that resistance is removed in hot the stagnating of phlegm of stomach and intestine, makes heresy have
Road, turbid pathogenic factor must not the superinverse mind, block qi and blood inverse disorderly, in case interior close；Three can timely purgation to preserve yin, in case the moon is robbed in interior, sun takes off in outer,
Twitch, the deterioration of a case such as floating yang.（Wang Yongyan《Distinguished veteran doctors of TCM academic thought source stream》）Treating disease in the upper by managing the lower, dredging intestines, turbid poison under rushing down,
Blocking and reversion, pulls out the important method of old complaint really Treating Stroke.Modern study finds, resolving sputum is led to internal organs and can be improved newly old generation
Thank, stabilizing blood pressure, exclude toxin, increase gastrointestinal peristalsis, adjust vegetative nerve functional disturbance, alleviate physical stress state, reduce
Intracranial pressure, alleviates suffering from acute stroke encephaledema, improves Brain circlulation etc..Clinically often because internal organs is so incensed that logical, mind turns clear, hemiplegia disease
Shape is accordingly taken a turn for the better.This method if using properly, often becomes the decisive of Prognosis in suffering from acute stroke encephaledema
Factor（Xu Shunquan《Brief talk the Chinese traditional treatment method of suffering from acute stroke encephaledema》）.Turbid poison under rushing down, Blocking and reversion pulls out old complaint.
Specific embodiment
Illustrated further the description present invention by following examples, and limit the present invention never in any form, without departing substantially from this
On the premise of bright technical solution, any change that those of ordinary skill in the art made for the present invention easily realize or
Change and fall within scope of the presently claimed invention.
Embodiment 1（Granule）
Weigh melon to wither 6g, safflower 5g, dried immature fruit of citron orange 5g, bark of official magnolia 5g, rheum officinale 3g, saltcake 1g；Saltcake is ground into fine powder；The bark of official magnolia, rheum officinale add 4
Times amount 70% alcohol reflux extracts 3 times, 0.5 hour every time, filters, filtrate recycling ethanol, is concentrated into relative density 1.20～1.25
(80℃)；The dregs of a decoction are added 6 times amount decoctings together with Snakegourd Fruit, safflower, the dried immature fruit of citron orange and boil 3 times, 1.0 hours every time, filter, collecting decoction, filter
Cross, filtrate is concentrated into relative density 1.20～1.25（80℃）Clear cream, merge with above-mentioned alcohol medicinal extract, plus saltcake fine powder, plus micro-
Powder silica gel, appropriate soluble starch, mix, plus 75% appropriate amount of ethanol, pelletize, and 80 DEG C of dryings are made particle 1000g, obtained final product.
Embodiment 2（Mixture）
Weigh melon to wither 18g, safflower 8g, dried immature fruit of citron orange 8g, bark of official magnolia 8g, rheum officinale 8g, saltcake 3g；Saltcake is ground into fine powder；The bark of official magnolia, rheum officinale add
5 times amount 70% alcohol reflux extracts 3 times, 0.5 hour every time, filtration, filtrate recycling ethanol, be concentrated into relative density 1.10～
The medicinal extract of 1.15 (80 DEG C), standby；The dregs of a decoction are added 7 times amount decoctings together with Snakegourd Fruit, safflower, the dried immature fruit of citron orange and boil 3 times, 1.5 hours every time,
Filtration, collecting decoction, filtration, filtrate is concentrated into relative density 1.10～1.15 (80 DEG C)（80℃）Clear cream, with above-mentioned alcohol leaching
Cream merges, plus saltcake fine powder, mixes, and continues reduced pressure concentration (less than 60 DEG C) to 1000ml, adds Steviosin 15g, mixes, point
Dress, obtains final product.
Embodiment 3
Melon withers 30g, safflower 15g, dried immature fruit of citron orange 15g, bark of official magnolia 15g, rheum officinale 10g, saltcake 5g；Saltcake is ground into fine powder；The bark of official magnolia, rheum officinale add
6 times amount 70% alcohol reflux extracts 3 times, 0.5 hour every time, filtration, filtrate recycling ethanol, be concentrated into relative density 1.10～
The medicinal extract of 1.15 (80 DEG C), standby；The dregs of a decoction are added 8 times amount decoctings together with Snakegourd Fruit, safflower, the dried immature fruit of citron orange and boil 3 times, 2.0 hours every time,
Filtration, collecting decoction, filtration, filtrate is concentrated into relative density 1.10～1.15 (80 DEG C)（80℃）Clear cream, with above-mentioned alcohol leaching
Cream merges, plus saltcake fine powder, mixes, and continues reduced pressure concentration (less than 60 DEG C) to 1000ml, adds Steviosin 15g, mixes, point
Dress, obtains final product.
Further illustrate the medical effect of the present invention by following model case：
Case 1：
Patient Korea Spro, female, 55 years old, because right side limb activity is unfavorable, is admitted to hospital with speech for stuttering puckery 11 days.See when being admitted to hospital：Right side limbs
Activity is unfavorable, and speech is stuttering puckery, and diet is general, and night sleeps still, and urine is normal, and stool does not go on the 3rd.NC：Consciousness is clear
Chu, complete motor aphasia, general intelligence of surveying is mismatched, and bilateral isocoria, with circle, reflects sensitive, diameter 3mm to light, and eyeball is right
Side abduction is not complete, and bilateral volume line and nasolabial groove etc. are deep symmetrical, can not loll, 0 grade of right upper extremity muscular strength, 2 grades of right lower extremity muscular strength, left side
5 grades of myodynamia, both limbs Muscle tensility is normal, and both limbs tendon reflex symmetrically exists, and the both limbs pain sense of heat and tuning fork shake
Cooperation is owed in kinaesthesia inspection, and double babinski signs are positive, and meningeal irritation sign is negative.Cranial Computed Tomography shows：1）Subcortical arteriosclerotic encephalopathy.2）
The multiple lacunar infarction of bilateral.3）Left side thalamus hemorrhage, absorbs phase, amount of bleeding about 10ml.While Primary Care, give
The embodiment of the present invention 1 composition oral.2 times a day, a 10g.Through treatment, conditions of patients takes a turn for the better, and right side limb activity is unfavorable
Take a turn for the better, the stuttering puckery improvement of speech, diet is general, and night sleeps still, and two is just normal.BP：120/70mmHg.NC：Consciousness
Clear, incomplete motion aphasia, general intelligence of surveying is mismatched, and bilateral isocoria, with circle, reflects sensitive, diameter 3mm, eye to light
On the right side of ball, abduction is not complete, and bilateral volume line and nasolabial groove etc. are deep symmetrical, and loll right avertence, 0 grade of right upper extremity muscular strength, 2 grades of right lower extremity muscular strength,
5 grades of left limb muscular strength, both limbs Muscle tensility is normal, and both limbs tendon reflex symmetrically exists, the both limbs pain sense of heat and sound
Cooperation is owed in fork vibration sense inspection, and double babinski signs are positive, and meningeal irritation sign is negative.Dark tongue quality, tongue is greasy in vain, veins string.
Case 2：
Car, man, 55 years old, because right side limb activity is unfavorable, aphasia was admitted to hospital for 21 days.See when being admitted to hospital：Right side limb activity is not
Profit, aphasia, diet, night sleep can, occasionally have an aconuresis, stool is dry, 3-4 day a line.NC：Clear consciousness,
Dysarthrosis, general intelligence of surveying can not coordinate, and bilateral isocoria, with circle, diameter 3mm, reflects sensitive, eyeball all directions to light
Activity freely, no nystagmus, bilateral volume line symmetrically waits deep, and right side nasolabial groove shoals, and tongue stretches slightly right avertence, and 3 grades of right side upper extremity strength is right
3 grades of side lower-limb muscular strength, right side four limbs Muscle tensility, right side biceps jerk, triceps reflex, oar hyporeflexia, right side limb
Body tendon reflex weakens.The four limbs pain sensation and tuning fork vibration feel are had a medical check-up and are mismatched, and right side babinski sign is positive, and meningeal irritation sign is negative.Tongue
Deep red red, yellow and greasy fur, wiry and rolling pulse.Cranial Computed Tomography（Yongji county hospital, 2011-12-23, piece number 11843）Prompting：Left side cerebral hemorrhage absorbs
Phase changes, remaining blood volume about 18ml about.While Primary Care, give the embodiment of the present invention 2 composition oral.2 times a day,
10g.Through treatment, the unfavorable improvement of limb activity on the right side of patient；Aphasia improves earlier above, and diet and night sleep still, occasionally have
Aconuresis, stool is normal.BP：125/75mmHg.Thorax is symmetrical, and double lung percussions are in hyperresonant note, and auscultation two pulmonary respiration sound is thick, not
Hear and dry and wet sound.Heart percussion heart circle is little, auscultation heart rate：75 beats/min, rule is whole, and each auscultatory valve areas is not heard and pathologic
Noise.NC：Clear consciousness, dysarthrosis, general intelligence of surveying can not coordinate, and bilateral isocoria is with circle, diameter
3mm, reflects sensitive to light, eyeball all directions activity freely, no nystagmus, bilateral volume line symmetrically waits deep, and right side nasolabial groove shoals,
Tongue is stretched and is omited right avertence, 4 grades of right side upper extremity strength, 4 grades of right side lower-limb muscular strength, right side four limbs Muscle tensility, right side biceps jerk,
Triceps reflex, oar hyporeflexia, right side limbs tendon reflex weakens.The four limbs pain sensation and tuning fork vibration feel are had a medical check-up and are mismatched, right
Side babinski sign is positive, and meningeal irritation sign is negative.Tongue is red, and tongue is greasy, veins string.
Case 3：
Patient Piao certain, female, 73 years old, because of weak 1 day of double lower limb energy, through outpatient service, institute is taken in " cerebral hemorrhage ".Existing disease：Double lower limb is lived
Power is weak, dizzy, rear waist zonesthesia.Still, frequently, stool does not go enuresis nocturna on the 5th for diet, sleep.NC：Consciousness is clear
Chu, language is fluent, generally surveys memory, computing power, judgment normally, and bilateral isocoria is with circle, diameter 3mm, light reflex spirit
Quick, eyeball all directions activity freely, no nystagmus, bilateral nasolabial groove symmetrically waits deep, lolls inclined, 5 grades of double upper extremity strength, double lower limb
3 grades of muscular strength, both limbs Muscle tensility is normal, and the bilateral bicipital muscle of arm, triceps tendon reflective symmetry exist, and double lower limb patellar tendon is anti-
Penetrate, Achilles jerk weakens, the four limbs pain sensation, tuning fork vibration sense symmetrically exist, right side babinski sign probable positive, meningeal irritation sign is cloudy
Property.Head CT：The other white matter of brain density diffusivity of bilateral telocoele, symmetry lower, obscurity boundary, crude.Both sides corona radiata, half ovum
Circle center is multiple focal and point sheet density lowers shadow, and obscurity boundary owes clear.One irregular high density shadow, border are arranged at right top
Clearly, localized cerebral sickle increase in density.Print is examined：Both sides corona radiata area, centrum ovale patients with multiple lacunar infarct；Left side top
Consider subdural hemorrhage at cerebral hemorrhage cerebral falx.While Primary Care, give the embodiment of the present invention 3 composition oral.
2 times a day, a 10g.Through treatment, patient no dizziness, headache, still feel that rear waist is uncomfortable, no obvious zonesthesia, pharyngeal discomfort
It is clearly better, no cough, expectoration, still, enuresis nocturna frequency, stool are capable for diet, sleep.BP：145/80mmHg, pharyngeal nothing is substantially filled
Blood, tonsillotome no enlargement, heart and lung auscultation is without exception.NC：Clear consciousness, language is fluent, generally surveys memory, calculating
Power, judgment are normal, and, with circle, diameter 3mm, light reflex is sensitive for bilateral isocoria, eyeball all directions activity freely, anophthalmia
Shake, bilateral nasolabial groove symmetrically waits deeply, lolls not inclined.4 grades of right upper extremity muscular strength, 5 grades of remaining myodynamia, Muscle tensility is normal, the bilateral upper arm
Biceps, triceps tendon reflective symmetry exist, and double lower limb knee jerk, Achilles jerk weaken, and left lower extremity acupuncture feel, tactile subtract
Move back, tuning fork vibration sense, joint position feel symmetrical and exist, right side babinski sign is positive, and meningeal irritation sign is negative.Red tongue body, tongue is white, arteries and veins
Sliding.
Case 4：
Patient's week certain, man, 56 years old, this is suffered from, and left limb activity was unfavorable, speech takes in institute by outpatient service with " apoplexy " in stuttering puckery 7 days.Both
Past high blood pressure medical history 30 years, blood pressure is up to 240/140mmHg.See when being admitted to hospital that patient's left limb activity is unfavorable, speech is stuttering
Puckery, occasionally have dizziness, diet can, it is poor that night sleeps, and urine is normal, 2-3 day 1 row of defecating.It is admitted to hospital and look into：BP：180/90mmHg（After medication）.
NC：Clear consciousness, dysarthrosis, general intelligence of surveying is normal, the same circle of bilateral isocoria, and diameter about 3mm is anti-to light
Penetrate sensitive, the motion of eyeball all directions is normal, bilateral volume line symmetrically waits deeply, and left side nasolabial groove shoals, and loll left avertence, left side upper limbs flesh
4 grades of power, lower-limb muscular strength 4+ level, both limbs Muscle tensility is normal, and both limbs tendon reflex symmetrically exists, both limbs tuning fork vibration
Feel and the pain sensation symmetrically exists, bilateral babinski sign is positive, meningeal irritation sign is negative.Tongue body is big, and matter is dark red, yellow and greasy fur, wiry and rolling pulse.Suffer from
Person's head CT is returned：The other white matter of brain density symmetry of bilateral telocoele, diffusivity lower, and border is crude, right side thalamus and bilateral
Basal ganglia, corona radiata area, the multiple focal density of centrum ovale lower shadow, edge blurry.IMA8-9 aspect is shown in similar round stove
Property increase in density shadow, border is substantially clear, diameter about 8cm, and periphery density shows slightly attenuating.It is broadening that brain ditch splits pond form.Impression is examined
Disconnected：1）Subcortical arteriosclerotic encephalopathy；2）The multiple lacunar infarction of bilateral；3）Encephalatrophy；4）Consider pontine hemorrhage.Give
The embodiment of the present invention 2 composition oral.2 times a day, a 10g.Through treatment, after patient discharge, left limb activity is unfavorable to be had
Taken a turn for the better, the stuttering puckery mitigation of speech, rare dizziness, dry cough, diet can, night sleep poor, two is just normal.BP：176/100mmHg.Nerve
Systems inspection：Clear consciousness, dysarthrosis, general intelligence of surveying is normal, and bilateral isocoria, with circle, diameter about 3mm, reflects spirit to light
Quick, the motion of eyeball all directions is normal, and bilateral volume line symmetrically waits deeply, and left side nasolabial groove shoals, and loll left avertence, left side upper extremity strength 4+
Level, lower-limb muscular strength 5- level, both limbs Muscle tensility is normal, and both limbs tendon reflex symmetrically exists, and both limbs tuning fork vibration is felt
And the pain sensation symmetrically exists, bilateral babinski sign is positive, and meningeal irritation sign is negative.Tongue body is big, and matter is red, and tongue is greasy, veins string.
Claims (2)
1. a kind of compound Chinese medicinal preparation for treating apoplexy phlegm-heat excess syndrome is it is characterised in that be by following raw material by weight
Portion rate is made：
Melon withers 6-30, safflower 5-15, dried immature fruit of citron orange 5-15, bark of official magnolia 5-15, rheum officinale 3-10, saltcake 1-5.
2. a kind of preparation method of the compound Chinese medicinal preparation for treating apoplexy phlegm-heat excess syndrome as claimed in claim 1,
Comprise the following steps:Above Six-element, saltcake is ground into fine powder；The bark of official magnolia, rheum officinale add 4 ~ and 6 times amount 70% alcohol reflux extracts 3 times, often
Secondary 0.5 hour, filtration, filtrate recycling ethanol, it is concentrated into relative density 1.20～1.25 (80 DEG C)；The dregs of a decoction and Snakegourd Fruit, safflower, trifoliate orange
Real Jia 6 together ~ 8 times amount decoctings boil 3 times, 1.0 ~ 2.0 hours every time, filtration, collecting decoction, filter, filtrate is concentrated into relatively close
Degree 1.20～1.25（80℃）Clear cream, merge with above-mentioned alcohol medicinal extract, plus saltcake fine powder, mix and obtain final product.
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Application publication date: 20170215 |