CN106389519A - Western medicine compound preparation for treating leukotrichia and alopecia and preparation method thereof - Google Patents

Western medicine compound preparation for treating leukotrichia and alopecia and preparation method thereof Download PDF

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CN106389519A
CN106389519A CN201611077599.4A CN201611077599A CN106389519A CN 106389519 A CN106389519 A CN 106389519A CN 201611077599 A CN201611077599 A CN 201611077599A CN 106389519 A CN106389519 A CN 106389519A
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western medicine
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alopecia
hoariness
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不公告发明人
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Zhengzhou Renhong Pharmaceutical Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/01Hydrocarbons
    • A61K31/015Hydrocarbons carbocyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • A61K31/315Zinc compounds
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    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401Proline; Derivatives thereof, e.g. captopril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/02Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A61K35/10Peat; Amber; Turf; Humus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/52Juglandaceae (Walnut family)

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Abstract

The invention discloses a western medicine compound preparation for treating leukotrichia and alopecia. The western medicine compound preparation is prepared from the following raw materials in parts by weight: 2 to 8 parts of taurine, 2 to 5 parts of zinc gluconate, 0.1 to 1 part of vitamin B, 5 to 10 parts of L-proline, 2 to 10 parts of dihydroartemisinin, 2 to 8 parts of licochalcone A, 8 to 10 parts of walnut oil, 2 to 5 parts of maltose, 20 to 40 parts of monobenzone solution, 2 to 5 parts of folic acid, 4 to 10 parts of humic acid, 0.5 to 2 parts of carotene and 1 to 2 parts of minoxidilum. The western medicine compound preparation has the advantages that white hair can gradually become black after about half a year; in addition, the skin can be white, tender and smooth after the long-time administration; the toxic and side effects of the western medicine compound preparation are small; the treatment course is short; the effect taking speed is high; the effects of clearing away heat, cooling the blood, nourishing the liver and the kidney, reinforcing qi, nourishing the blood, replenish qi and calming the nerves are achieved.

Description

A kind of treat compound Western medicine preparation of hoariness and alopecia and preparation method thereof
Technical field
The present invention relates to a kind of Western medicine preparation field, specifically a kind of compound Western medicine preparation treating hoariness and alopecia.
Background technology
Alopecia is the phenomenon of epilation, have physiological and pathologic point.Physiologic alopecia finger is sent out and is normally come off. Pathologic alopecia refers to abnormal or excessive the coming off of hair.Constantly increase the quickening with rhythm of life, environment with social pressures Continuous deterioration, and the eating habit of bad diet, also grow with each passing day with our non-health, inferior health, China de- Send out patient to get more and more.
The cardinal symptom of alopecia is that hair is greasy, as polished, also have shrivelled send out fluffy, lack gloss, have faint yellow Scales of skin that peel off set is difficult de-, or the canescence scales of skin that peel off is flown upward, if conscious itch male pattern baldness, mainly front and overhead, forehead Hairline is up moved with temples, the hair sparse at front and top, turns yellow, and deliquescing makes a piece of baldness in volume top or some fine hair eventually; Female alopecia portion overhead, hair becomes sparse, but will not completely sheet of come off.
General alopecia is divided into two kinds of fundamental types, the permanent alopecia causing because hair follicle is impaired, and because hair follicle is short The time impaired temporary alopecia causing, the male sex that permanent alopecia is common is bald, and in some European countries, the male sex's is bald Rate is up to 40%.The hair loss process of permanent alopecia (i.e. male pattern alopecia) gradually produces, during beginning, the head of head frons The obvious retraction of hair side edge, overhead exiguous human hair;Then progressively develop, finally can develop into only remaining back of head, head both sides one Circle thin hair, its main cause has three:Inherent cause, the shortage of male sex hormone or imbalance in blood circulation;It is too obese, In addition, the scar that multiple dermatosis or skin damage stay, born hair depauperation, and chemical substance or physical cause pair The grievous injury that hair follicle causes all can cause permanent alopecia.Temporary alopecia is often caused by obtaining the disease having a high fever , but, according to X-ray, take in metal (such as thallium, tin and arsenic) or take in drugs, malnutritive, some skin diseases with inflammation, slowly Property deeline, and endocrinopathy etc. also can cause temporary alopecia.
The method of existing hair growth is mainly using the method taking Chinese medicine, but adopts treatment by Chinese herbs not only curative effect Long, DeGrain;And taste bad, a lot of people can adhere to, and therefore a lot of patients select the method for hair dyeing to be covered White hair, but contain substantial amounts of chemical composition in hair dye, human body is caused with very big harm.Therefore, the present invention provides one Kind curative effect is short, features good taste, toxic and side effect are little, lower-cost compound Western medicine preparation.
Content of the invention
It is an object of the invention to provide a kind of compound Western medicine preparation treating hoariness and alopecia, to solve above-mentioned background technology The problem of middle proposition.
For achieving the above object, the present invention provides following technical scheme:
A kind of compound Western medicine preparation treating hoariness and alopecia, including the raw material of following parts by weight:Taurine 2-8 part, Portugal Grape saccharic acid zinc 2-5 part, Cobastab 0.1-1 part, L-PROLINE 5-10 part, dihydroartemisinine 2-10 part, licochalcone A 2-8 Part, walnut oil 8-10 part, maltose 2-5 part, monobenzone solution 20-40 part, folic acid 2-5 part, humic acid 4-10 part, carrot Plain 0.5-2 part, minoxidilum 1-2 part.
As the further scheme of the present invention:Raw material including following parts by weight:5 parts of taurine, zinc gluconate 3 Part, 0.3 part of Cobastab, 8 parts of L-PROLINE, 5 parts of dihydroartemisinine, 6 parts of licochalcone A, 8 parts of walnut oil, maltose 4 Part, 25 parts of monobenzone solution, 3 parts of folic acid, 6 parts of humic acid, 0.8 part of carrotene, 1.5 parts of minoxidilum.
A kind of preparation method of the compound Western medicine preparation treating hoariness and alopecia, preparation method is:
(1) weigh each raw material, standby;
(2) maltose is put in 120-250 DEG C of walnut oil, stirring mixing 0.5-1min;
(3) by taurine, zinc gluconate, Cobastab, L-PROLINE, dihydroartemisinine, minoxidilum, carrotene respectively Grind into powder, is then placed in soaking 1-2h in monobenzone solution, and uses ultrasonication 3-5min;
(4) folic acid, humic acid, licochalcone A are put in step (2) gains, stir 10-30min, be subsequently adding Step (3) gains, continue stirring 10-30min, and use ultrasonication 5-10min, get product.
As the present invention further scheme:Described step (2) puts into maltose in 180 DEG C of walnut oil, stirring Mixing 0.6min.
As the present invention further scheme:Folic acid, humic acid, licochalcone A are put into step by described step (4) (2) in gains, stir 15min, be subsequently adding step (3) gains, continue stirring 20min, and use ultrasonication 8min, Get product.
Compared with prior art, the invention has the beneficial effects as follows:
This compound Western medicine preparation passes through raw material and compounds to play synergy, can time about half a year, make white hair by Gradual change is black;And long-term taking can make whitening skin, delicacy, smooth;This compound Western medicine preparation toxic and side effect is little, and curative effect is short, sees Effect is fast, has the effect of clearing heat and cooling blood, nourishing liver and kidney, nourishing qi and blood, invigorating qi for tranquilization.
Specific embodiment
With reference to specific embodiment, the technical scheme of this patent is described in more detail.
Embodiment 1
A kind of compound Western medicine preparation treating hoariness and alopecia, including the raw material of following parts by weight:2 parts of taurine, grape 2 parts of saccharic acid zinc, 0.1 part of Cobastab, 5 parts of L-PROLINE, 2 parts of dihydroartemisinine, 2 parts of licochalcone A, 8 parts of walnut oil, 2 parts of maltose, 20 parts of monobenzone solution, 2 parts of folic acid, 4 parts of humic acid, 0.5 part of carrotene, 1 part of minoxidilum.
A kind of preparation method of the compound Western medicine preparation treating hoariness and alopecia, preparation method is:
(1) weigh each raw material, standby;
(2) maltose is put in 120 DEG C of walnut oil, stirring mixing 0.5min;
(3) by taurine, zinc gluconate, Cobastab, L-PROLINE, dihydroartemisinine, minoxidilum, carrotene respectively Grind into powder, is then placed in soaking 1h in monobenzone solution, and uses ultrasonication 3min;
(4) folic acid, humic acid, licochalcone A are put in step (2) gains, stir 10min, be subsequently adding step Suddenly (3) gains, continue stirring 10min, and use ultrasonication 5min, get product.
Embodiment 2
A kind of compound Western medicine preparation treating hoariness and alopecia, including the raw material of following parts by weight:8 parts of taurine, grape 5 parts of saccharic acid zinc, 1 part of Cobastab, 10 parts of L-PROLINE, 10 parts of dihydroartemisinine, 8 parts of licochalcone A, 10 parts of walnut oil, 5 parts of maltose, 40 parts of monobenzone solution, 5 parts of folic acid, 10 parts of humic acid, 2 parts of carrotene, 2 parts of minoxidilum.
A kind of preparation method of the compound Western medicine preparation treating hoariness and alopecia, preparation method is:
(1) weigh each raw material, standby;
(2) maltose is put in 250 DEG C of walnut oil, stirring mixing 1min;
(3) by taurine, zinc gluconate, Cobastab, L-PROLINE, dihydroartemisinine, minoxidilum, carrotene respectively Grind into powder, is then placed in soaking 2h in monobenzone solution, and uses ultrasonication 5min;
(4) folic acid, humic acid, licochalcone A are put in step (2) gains, stir 30min, be subsequently adding step Suddenly (3) gains, continue stirring 30min, and use ultrasonication 10min, get product.
Embodiment 3
A kind of compound Western medicine preparation treating hoariness and alopecia, including the raw material of following parts by weight:5 parts of taurine, grape 3 parts of saccharic acid zinc, 0.3 part of Cobastab, 8 parts of L-PROLINE, 5 parts of dihydroartemisinine, 6 parts of licochalcone A, 8 parts of walnut oil, 4 parts of maltose, 25 parts of monobenzone solution, 3 parts of folic acid, 6 parts of humic acid, 0.8 part of carrotene, 1.5 parts of minoxidilum.
A kind of preparation method of the compound Western medicine preparation treating hoariness and alopecia, preparation method is:
(1) weigh each raw material, standby;
(2) maltose is put in 180 DEG C of walnut oil, stirring mixing 0.6min;
(3) by taurine, zinc gluconate, Cobastab, L-PROLINE, dihydroartemisinine, minoxidilum, carrotene respectively Grind into powder, is then placed in soaking 1.5h in monobenzone solution, and uses ultrasonication 4min;
(4) folic acid, humic acid, licochalcone A are put in step (2) gains, stir 15min, be subsequently adding step Suddenly (3) gains, continue stirring 20min, and use ultrasonication 8min, get product.
Comparative example 1
A kind of compound Western medicine preparation treating hoariness and alopecia, including the raw material of following parts by weight:5 parts of taurine, grape 3 parts of saccharic acid zinc, 0.3 part of Cobastab, 8 parts of L-PROLINE, 6 parts of licochalcone A, 8 parts of walnut oil, 4 parts of maltose, Monot 25 parts of benzene ancestor's solution, 3 parts of folic acid, 6 parts of humic acid, 0.8 part of carrotene, 1.5 parts of minoxidilum.
A kind of preparation method of the compound Western medicine preparation treating hoariness and alopecia, preparation method is:
(1) weigh each raw material, standby;
(2) maltose is put in 180 DEG C of walnut oil, stirring mixing 0.6min;
(3) by taurine, zinc gluconate, Cobastab, L-PROLINE, minoxidilum, carrotene grind into powder respectively, It is then placed in soaking 1.5h in monobenzone solution, and use ultrasonication 4min;
(4) folic acid, humic acid, licochalcone A are put in step (2) gains, stir 15min, be subsequently adding step Suddenly (3) gains, continue stirring 20min, and use ultrasonication 8min, get product.
Comparative example 2
A kind of compound Western medicine preparation treating hoariness and alopecia, including the raw material of following parts by weight:5 parts of taurine, grape 3 parts of saccharic acid zinc, 0.3 part of Cobastab, 8 parts of L-PROLINE, 5 parts of dihydroartemisinine, 8 parts of walnut oil, 4 parts of maltose, Monot's benzene 25 parts of solution of ancestor, 3 parts of folic acid, 6 parts of humic acid, 0.8 part of carrotene, 1.5 parts of minoxidilum.
A kind of preparation method of the compound Western medicine preparation treating hoariness and alopecia, preparation method is:
(1) weigh each raw material, standby;
(2) maltose is put in 180 DEG C of walnut oil, stirring mixing 0.6min;
(3) by taurine, zinc gluconate, Cobastab, L-PROLINE, dihydroartemisinine, minoxidilum, carrotene respectively Grind into powder, is then placed in soaking 1.5h in monobenzone solution, and uses ultrasonication 4min;
(4) folic acid, humic acid are put in step (2) gains, stir 15min, be subsequently adding step (3) gains, Continue stirring 20min, and use ultrasonication 8min, get product.
Probe into embodiment 1-3 and the curative effect of compound Western medicine preparation that comparative example 1-2 is made.
Wherein, embodiment 1 is not added with dihydroartemisinine, and embodiment 2 is not added with licochalcone A.
Clinical data:
White hair patient:Man 300, female 200;The oldest person 65 years old, age reckling 20 years old;Medical history elder 30 Year, the shortest person 1 year, the application present invention treats the compound Western medicine preparation clinical treatment of hoariness and alopecia, observes clinical efficacy.
Treatment method:
White hair patient is divided into 5 groups, i.e. 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 1 group of comparative example, comparative example 2 Group, every group 100,1 group of embodiment is administered orally the compound Western medicine preparation of embodiment 1 preparation daily, and 2 groups of embodiment is administered orally daily to be implemented The compound Western medicine preparation of example 2 preparation, 3 groups of embodiment is administered orally the compound Western medicine preparation of embodiment 3 preparation daily, and 1 group of comparative example is every The compound Western medicine preparation of day oral contrast example 1 preparation, the compound Western medicine preparation of 2 groups of comparative example daily oral contrast example 2 preparation, one Day twice, each 10-20g, sooner or later each once take within 1 hour after meal, be within two months 1 course for the treatment of, treat 3 courses for the treatment of.
Criterion of therapeutical effect:
Recovery from illness:Patient reaches more than 4/5ths blackening hair.
Take a turn for the better:/ 3rd blackening hair, body function is improved, and skin becomes more smooth.
Effectively:/ 5th blackening hair, body function is improved, and skin becomes more smooth.
Invalid:Unchanged before and after treatment.
Treatment results see table:
The curative effect of the compound Western medicine preparation that table embodiment 1-3 and comparative example 1-2 are made
Project Number of cases/example Recovery from illness/example Improvement/example Effectively/example Invalid/example Efficient/%
1 group of embodiment 100 50 25 24 1 99
2 groups of embodiment 100 52 23 23 2 98
3 groups of embodiment 100 55 26 19 0 100
1 group of comparative example 100 11 15 34 40 60
2 groups of comparative example 100 10 13 35 42 58
By upper table as can be seen that embodiment 1-3 there occurs collaborative work by adding dihydroartemisinine and licochalcone A With, can time about half a year, make white hair gradually blackening;Long-term taking can make whitening skin, delicacy, smooth, the secondary work of poison With little, curative effect is short, instant effect, has the effect of clearing heat and cooling blood, nourishing liver and kidney, nourishing qi and blood, invigorating qi for tranquilization.
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment party Formula, in the ken that one skilled in the relevant art possesses, can also be on the premise of without departing from this patent objective Make a variety of changes.

Claims (5)

1. a kind of compound Western medicine preparation treating hoariness and alopecia is it is characterised in that include the raw material of following parts by weight:Taurine 2-8 part, zinc gluconate 2-5 part, Cobastab 0.1-1 part, L-PROLINE 5-10 part, dihydroartemisinine 2-10 part, Radix Glycyrrhizae are looked into You are ketone A 2-8 part, walnut oil 8-10 part, maltose 2-5 part, monobenzone solution 20-40 part, folic acid 2-5 part, humic acid 4-10 Part, carrotene 0.5-2 part, minoxidilum 1-2 part.
2. the compound Western medicine preparation for the treatment of hoariness and alopecia according to claim 1 is it is characterised in that include following weight portion The raw material of number:5 parts of taurine, 3 parts of zinc gluconate, 0.3 part of Cobastab, 8 parts of L-PROLINE, 5 parts of dihydroartemisinine, Radix Glycyrrhizae 6 parts of chalcone A, 8 parts of walnut oil, 4 parts of maltose, 25 parts of monobenzone solution, 3 parts of folic acid, 6 parts of humic acid, carrotene 0.8 Part, 1.5 parts of minoxidilum.
3. a kind of preparation method of the described compound Western medicine preparation for the treatment of hoariness and alopecia as arbitrary in claim 1-2, its feature It is, preparation method is:
(1) weigh each raw material, standby;
(2) maltose is put in 120-250 DEG C of walnut oil, stirring mixing 0.5-1min;
(3) taurine, zinc gluconate, Cobastab, L-PROLINE, dihydroartemisinine, minoxidilum, carrotene are ground respectively Become powder, be then placed in soaking 1-2h in monobenzone solution, and use ultrasonication 3-5min;
(4) folic acid, humic acid, licochalcone A are put in step (2) gains, stir 10-30min, be subsequently adding step (3) gains, continue stirring 10-30min, and use ultrasonication 5-10min, get product.
4. the preparation method of the compound Western medicine preparation for the treatment of hoariness and alopecia according to claim 3 is it is characterised in that described Step (2) puts into maltose in 180 DEG C of walnut oil, stirring mixing 0.6min.
5. the preparation method of the compound Western medicine preparation for the treatment of hoariness and alopecia according to claim 3 is it is characterised in that described Step (4) puts into folic acid, humic acid, licochalcone A in step (2) gains, stirs 15min, is subsequently adding step (3) Gains, continue stirring 20min, and use ultrasonication 8min, get product.
CN201611077599.4A 2016-11-30 2016-11-30 Western medicine compound preparation for treating leukotrichia and alopecia and preparation method thereof Pending CN106389519A (en)

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US20070036742A1 (en) * 2005-08-09 2007-02-15 Access Business Group International Llc Methods and compositions for modulating hair growth or regrowth
US20070196289A1 (en) * 2003-09-12 2007-08-23 Beiersdorf Ag Use Of Licochalcone A Or Of An Extract Of Licochalcone A From Radix Glycyrrhizae Inflatae Against Skin Aging
CN101684132A (en) * 2008-09-25 2010-03-31 唐毅 Production method and application of humic acid and fulvic acid extracted from humus and organic salts of mineral compounds thereof
CN102359913A (en) * 2011-08-29 2012-02-22 南车南京浦镇车辆有限公司 Hydrostatic test device for air spring bases
CN103720752A (en) * 2012-10-15 2014-04-16 马振友 External preparation used for promoting hair growth and nourishing hair, and preparation method thereof

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