CN106389330A - 用于递送治疗剂的方法和组合物 - Google Patents

用于递送治疗剂的方法和组合物 Download PDF

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Publication number
CN106389330A
CN106389330A CN201610672083.8A CN201610672083A CN106389330A CN 106389330 A CN106389330 A CN 106389330A CN 201610672083 A CN201610672083 A CN 201610672083A CN 106389330 A CN106389330 A CN 106389330A
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CN
China
Prior art keywords
agents
therapeutic agent
pharmaceutical composition
liquid pharmaceutical
polyethylene glycol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610672083.8A
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English (en)
Chinese (zh)
Inventor
S·吉苏拉森
J·阿普
R·戈德瑞
M·E·拉斯蒂
G·G·普拉辛斯基
M·亚兹迪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hananja ehf
University of Iceland
Ikano Therapeutics Inc
Original Assignee
Hananja ehf
University of Iceland
Intranasal Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hananja ehf, University of Iceland, Intranasal Therapeutics Inc filed Critical Hananja ehf
Publication of CN106389330A publication Critical patent/CN106389330A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/55171,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0031Rectum, anus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Otolaryngology (AREA)
  • Psychiatry (AREA)
  • Dispersion Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201610672083.8A 2007-01-19 2008-01-18 用于递送治疗剂的方法和组合物 Pending CN106389330A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IS8593 2007-01-19
IS8593/2007 2007-01-19
CN200880005593.3A CN101678112B (zh) 2007-01-19 2008-01-18 用于递送治疗剂的方法和组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200880005593.3A Division CN101678112B (zh) 2007-01-19 2008-01-18 用于递送治疗剂的方法和组合物

Publications (1)

Publication Number Publication Date
CN106389330A true CN106389330A (zh) 2017-02-15

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ID=39512543

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201610674407.1A Pending CN106420614A (zh) 2007-01-19 2008-01-18 用于递送治疗剂的方法和组合物
CN200880005593.3A Active CN101678112B (zh) 2007-01-19 2008-01-18 用于递送治疗剂的方法和组合物
CN201610672083.8A Pending CN106389330A (zh) 2007-01-19 2008-01-18 用于递送治疗剂的方法和组合物

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Application Number Title Priority Date Filing Date
CN201610674407.1A Pending CN106420614A (zh) 2007-01-19 2008-01-18 用于递送治疗剂的方法和组合物
CN200880005593.3A Active CN101678112B (zh) 2007-01-19 2008-01-18 用于递送治疗剂的方法和组合物

Country Status (11)

Country Link
EP (2) EP3150230A1 (enExample)
JP (5) JP5877939B2 (enExample)
CN (3) CN106420614A (enExample)
AU (1) AU2008206105B2 (enExample)
CA (1) CA2676010C (enExample)
DK (1) DK2121025T3 (enExample)
ES (1) ES2611995T3 (enExample)
HU (1) HUE031463T2 (enExample)
IL (1) IL199904A (enExample)
PL (1) PL2121025T3 (enExample)
WO (1) WO2008089426A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111278425A (zh) * 2017-09-11 2020-06-12 耶路撒冷希伯来大学伊萨姆研究开发有限公司 用于向脑部经鼻给药药物和用于全身作用的组合物和方法
CN111388481A (zh) * 2020-03-20 2020-07-10 浙江美华鼎昌医药科技有限公司 一种咪达唑仑和丙戊酸钠的药物组合物及其制备方法
CN113274482A (zh) * 2021-06-07 2021-08-20 穆琳 缩宫素或其衍生物在制备治疗或改善贫乳的制剂中的用途以及组合物
CN114588116A (zh) * 2020-12-04 2022-06-07 四川科瑞德制药股份有限公司 磷苯妥英钠固体组合物、冻干方法、及其用途

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GB0720716D0 (en) * 2007-10-23 2007-12-05 York Pharma Plc Novel formulation
GB2481407B (en) * 2010-06-22 2012-05-23 Special Products Ltd A rapid onset liquid midazolam composition for buccal administration
SG194927A1 (en) * 2011-05-13 2013-12-30 Euro Celtique Sa Intranasal pharmaceutical dosage forms comprising naloxone
JP2019099557A (ja) * 2017-11-28 2019-06-24 日本化薬株式会社 ベンダムスチンを含有する溶液製剤
WO2019226753A1 (en) 2018-05-25 2019-11-28 Ucb Biopharma Sprl Benzodiazepine formulations
WO2024142091A1 (en) * 2022-12-26 2024-07-04 Cipla Limited Stable aqueous injectable formulation of flucytosine
WO2025115019A1 (en) * 2023-11-30 2025-06-05 Padagis Israel Pharmaceuticals Ltd. Stable nitroglycerin formulations

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111278425A (zh) * 2017-09-11 2020-06-12 耶路撒冷希伯来大学伊萨姆研究开发有限公司 用于向脑部经鼻给药药物和用于全身作用的组合物和方法
CN111278425B (zh) * 2017-09-11 2024-06-11 耶路撒冷希伯来大学伊萨姆研究开发有限公司 用于向脑部经鼻给药药物和用于全身作用的组合物和方法
US12064508B2 (en) 2017-09-11 2024-08-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Compositions and methods for nasal administration of drugs to brain and for systemic effect
CN111388481A (zh) * 2020-03-20 2020-07-10 浙江美华鼎昌医药科技有限公司 一种咪达唑仑和丙戊酸钠的药物组合物及其制备方法
CN114588116A (zh) * 2020-12-04 2022-06-07 四川科瑞德制药股份有限公司 磷苯妥英钠固体组合物、冻干方法、及其用途
CN114588116B (zh) * 2020-12-04 2024-03-15 四川科瑞德制药股份有限公司 磷苯妥英钠固体组合物、冻干方法、及其用途
CN113274482A (zh) * 2021-06-07 2021-08-20 穆琳 缩宫素或其衍生物在制备治疗或改善贫乳的制剂中的用途以及组合物
WO2022257863A1 (zh) * 2021-06-07 2022-12-15 穆琳 缩宫素或其衍生物在制备治疗或改善贫乳的制剂中的用途以及组合物
CN113274482B (zh) * 2021-06-07 2023-09-05 穆琳 缩宫素或其衍生物在制备治疗或改善贫乳的制剂中的用途以及组合物

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JP5877939B2 (ja) 2016-03-08
PL2121025T3 (pl) 2017-09-29
CA2676010A1 (en) 2008-07-24
JP2010516696A (ja) 2010-05-20
IL199904A (en) 2014-07-31
AU2008206105B2 (en) 2014-04-03
JP2017048250A (ja) 2017-03-09
JP6084277B2 (ja) 2017-02-22
CA2676010C (en) 2016-05-17
WO2008089426A3 (en) 2009-02-12
JP2016029117A (ja) 2016-03-03
ES2611995T3 (es) 2017-05-11
CN106420614A (zh) 2017-02-22
CN101678112B (zh) 2016-08-31
WO2008089426A2 (en) 2008-07-24
JP6295314B2 (ja) 2018-03-14
AU2008206105A1 (en) 2008-07-24
DK2121025T3 (en) 2017-01-30
EP2121025B1 (en) 2016-11-02
EP3150230A1 (en) 2017-04-05
EP2121025A2 (en) 2009-11-25
JP2013231089A (ja) 2013-11-14
CN101678112A (zh) 2010-03-24
HUE031463T2 (en) 2017-07-28
JP2017155060A (ja) 2017-09-07
IL199904A0 (en) 2010-04-15

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