CN106389234A - Anti-aging composition and cosmetic product - Google Patents
Anti-aging composition and cosmetic product Download PDFInfo
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- CN106389234A CN106389234A CN201611073792.0A CN201611073792A CN106389234A CN 106389234 A CN106389234 A CN 106389234A CN 201611073792 A CN201611073792 A CN 201611073792A CN 106389234 A CN106389234 A CN 106389234A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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Abstract
The invention relates to the technical filed of cosmetics, in particular to anti-aging composition and a cosmetic product. The anti-aging composition is prepared from poppy seed oil nanoemulsion, olive leaf extract, jujube extract and rutin. The poppy seed oil nanoemulsion is prepared by aid of the nanoemulsion forming principle, easily oxidized poppy seed oil is well protected, the bioavailability of the poppy seed oil is improved, and the compatibility of the poppy seed oil with water soluble substances is improved. By addition of the poppy seed oil nanoemulsion, absorption of the olive leaf extract, the jujube extract and the rutin is promoted, and the four components have a remarkable synergetic effect in the aspect of an anti-aging effect. The anti-aging composition prepared from the poppy seed oil nanoemulsion, the olive leaf extract, the jujube extract and the rutin as the main functional components is natural and safe, can effectively moisten skin, resist aging, remove winkles and enhance skin elasticity.
Description
Technical field
The present invention relates to cosmetic technical field, particularly to anti-ageing compositionss and cosmetics.
Background technology
Skin aging is the skin aging phenomenon being caused by natural cause or non-natural factor.Skin histology day after people's birth
Reach increasingly, function is gradually enlivened, will start to degenerate when reaching certain age, this degeneration is often unconsciously slow in people
Slow-motion row.The growth stage of skin histology typically ends at 25 years old about, and the growth of skin after this is carried out with aging simultaneously, skin
Skin elastic fiberss are gradually thicker, and after 35 years old, the aging rate of skin is accelerated, increasingly apparent.
With growth in the living standard, people are further strong to keeping the young desire of skin, but skin aging is one
Individual natural, inevitable process, therefore becomes the problem of women worry of much liking to be beautiful.The factor causing skin aging has very
Many, the such as increase at age, operating pressure, air pollution, ultraviolet injury and hormonal disappearance etc., these all can lead in vivo
Free radical increases, glycosylation end product level improves and proteasome activity reduces, thus it is dry, old to promote skin to occur
Speckle, wrinkle, the problem of aging such as lax.Select suitable cosmetics and skincare product, become people to resist the prefered method of skin aging.
On market, the cosmetics and skincare product of different brands can be found everywhere, however, most of skin care item are quick, direct in order to pursue
Effect, employ different chemical drugss as additive, some side effect due to chemical drugss cause to skin and body
Some infringements of body.Therefore, seek some from nature and there is preferable activity of fighting against senium extract or extract combination, replace
Traditional chemical drugss, as the adding ingredient of cosmetics and skincare product, are increasingly becoming trend and the trend in market.
At present, the most of anti-ageing product on market is although add various innate efficacy compositions, but because its absorbability is not good
Lead to effect unsatisfactory.Or Shi Qu hospital carries out hyaluronic acid and botulinum toxin injection, laser speckle dispelling, facelift etc., these
Mode is expensive, and risk is big.Therefore develop that a kind of absorbability is good, effect is significant, natural safe anti-ageing product have weight
The meaning wanted.
Content of the invention
In view of this, the invention provides anti-ageing compositionss and cosmetics.The natural safety of this anti-ageing compositions, anti-ageing effect
Significantly.
In order to realize foregoing invention purpose, the present invention provides technical scheme below：
The invention provides a kind of anti-ageing compositionss, by imperial Miyou nano-emulsion, Olive leaf P.E, Fructus Jujubae extract and rutin
Composition.
Imperial Miyou, also known as seed of Papaver somniferum L. powder, without the addiction composition such as morphine, is a kind of natural containing high compound nutritional composition
Rare green plantss oil.The survey report of the Institute of Science and Technology, National Food Bureau being provided according to relevant production unit, (1) is contained rich
Rich polyunsaturated fatty acid, including Palmic acid 10.7%, stearic acid 1.6%, Oleic acid 21.9%, linoleic acid 66.5%, Caulis et Folium Lini
Acid 0.8%, the propellant of these Fatty acid compositions human metabolism, and there is skin care, Exfoliating Scrub and slow down aging
Effect；(2) abundant sky heptose, D-mannoheptulose and other active polypeptide and polysaccharide are contained, and cupreol, racemization flesh
The alcohols such as alcohol and ring laudanum alcohol, the immunity making one increases substantially, anti-aging；(3) contain abundant antioxidant VE
(231mg/kg) and trace element, including selenium, magnesium, calcium, phosphorus etc., cardio-cerebrovascular can be improved from dimension ability, heart tonifying and brain strengthening；
(4) contain micro flavone and phytosterol, can strongly improve kidney power, make one to retain youthful vitality；(5) containing human body can not be certainly
Row synthesizes but necessary eight kinds of aminoacid：Leucine, isoleucine, L-Valine, Phenylalanine, Methionine, lysine, Soviet Union's ammonia
Acid and tryptophan.Imperial Miyou has blood fat reducing, inhibition thrombosis, lipid peroxidation inhibition, slow down aging, improves human immunity work(
Cytoactive, can be increased, improve skin elasticity, the good action of soft skin.
Nano-emulsion is that the one kind being spontaneously formed under suitable proportioning by water, oil, surfactant and cosurfactant is outer
See the thermodynamic stable system as clear as crystal or translucent, viscosity is low, particle diameter is between 10～100nm.Nano-emulsion is each at present
Plant the application of cosmetics, be mainly used in solubilising, slow-release controlled-release and the protection of effective ingredient, and the biology of effective ingredient can be improved
Availability and the stability of preparation, promote absorption of cosmetics etc..Compared with Traditional makeup emulsion, producing of nano-emulsion
Many clear advantages are had during cosmetic：Optical clear, nano-emulsion spontaneously forms, and has the characteristics that efficient energy-saving, stability
Relatively good, good solubilization can be had with long-term storage, the higher product of oil composition can be made, and product is no greasy
Sense, has good comfort during use, Cutaneous permeation effect is fast, and Transdermal absorption effect is good.
Olive leaf P.E is rich in oleuropein, is to maintain multi-functional dose of skin health and vigor, reactivates albumen
Enzyme body, promotes cell toxin expelling, the ager process of delaying skin cell.
Fructus Jujubae extract derives from Fructus Jujubae, and contained VC is 100 times of typical apple, and its principle active component is Semen Ziziphi Spinosae soap
Glycosides, can promote wound healing, strengthen skin antioxidation repair system, strengthening and reparation skin.
Rutin, also known as globulariacitrin, Citrin, rutin, there is the effect reducing capillary permeability and fragility,
Keep and recover the normal elasticity of blood capillary, additionally, rutin has extremely strong Absorption to ultraviolet, can be used as natural anti-
Shine agent, to reactive oxygen free radical and hydroxyl radical free radical, there is significant scavenging action simultaneously, can effectively prevent the photoaging of skin.
The present invention has after being applied in combination imperial Miyou nano-emulsion, Olive leaf P.E, Fructus Jujubae extract and rutin significantly
Anti-ageing effect, effect is better than each component and is used alone, and embodies obvious synergistic function.Said composition is applied and is making up
In product, comply with the trend of cosmetic industry, met that consumer is natural to cosmetics, green, safe and efficient demand.
Preferably, in parts by weight, this anti-ageing compositions includes：10～20 parts of imperial Miyou nano-emulsion, Folium olive extracts
0.5～3 part of thing, 1～5 part of Fructus Jujubae extract, 0.8～2.5 part of rutin.
In the embodiment that the present invention provides, in parts by weight, this anti-ageing compositions includes：Imperial Miyou nano-emulsion 20
Part, 0.5 part of Olive leaf P.E, 3 parts of Fructus Jujubae extract, 1 part of rutin.
In another embodiment that the present invention provides, in parts by weight, this anti-ageing compositions includes：Imperial Miyou nano-emulsion 10
Part, 1.6 parts of Olive leaf P.E, 5 parts of Fructus Jujubae extract, 0.8 part of rutin.
In another embodiment that the present invention provides, in parts by weight, this anti-ageing compositions includes：Imperial Miyou nano-emulsion 15
Part, 3 parts of Olive leaf P.E, 1 part of Fructus Jujubae extract, 2.5 parts of rutin.
Preferably, in terms of weight/mass percentage composition, imperial Miyou nano-emulsion is grouped into by following group：
Its preparation method is：By surfactant and oil phase mixing, it is subsequently adding the cosurfactant containing imperial Miyou,
It is stirring evenly and then adding into water, stirring obtains imperial Miyou nano-emulsion.
Preferably, surfactant is one of tween 80, polyoxyethylene hydrogenated Oleum Ricini or two kinds.
Preferably, cosurfactant is one of propylene glycol, 1,3 butylene glycol or two kinds.
Preferably, oil phase is one or more of isopropyl myristate, Jojoba oil, Semen Tritici aestivi germ oil.
In the embodiment that the present invention provides, polyoxyethylene hydrogenated Oleum Ricini is polyoxyethylene hydrogenated Oleum Ricini 40.
Present invention also offers a kind of cosmetics, including imperial Miyou nano-emulsion, Olive leaf P.E, Fructus Jujubae extract, rutin
With adjuvant acceptable on cosmeceutical.
In the embodiment that the present invention provides, the dosage form of cosmetics is gel, acceptable auxiliary on cosmeceutical in gel
Material includes wetting agent, glycerol, thickening agent, Sensiva SC50,1,2- hexanediol, MEIGUI CHUNLU, triethanolamine and water.
Preferably, in terms of weight/mass percentage composition, in gel, each amounts of components is：
Preferably, wetting agent be ethoxy urea, ceramide, hyaluronate sodium, beta glucan, reed fragrant plant oil, sorbose
One or more of alcohol, glycine betaine or amino acid humectant.
Preferably, thickening agent is one of Carbomer, xanthan gum, alginate jelly, arabic gum or tara gum or several
Kind.
Preferably, the pH value of gel is 5～6.5.
Preferably, the preparation method of this gel comprises the steps：
Glycerol, thickening agent are mixed with 80～90 DEG C of water, homogenizing 3～5min is so as to fully swelling；
When temperature is down to 40～45 DEG C, add imperial Miyou nano-emulsion, Olive leaf P.E, Fructus Jujubae extract, rutin, moisturizing
Agent, stirs；
When temperature is down to 15～30 DEG C, add triethanolamine adjust pH be 5～6.5, be subsequently adding Sensiva SC50,
1,2- hexanediol, MEIGUI CHUNLU, stir, and obtain gel.
The invention provides anti-ageing compositionss and cosmetics.This anti-ageing compositions is extracted by imperial Miyou nano-emulsion, Folium olive
Thing, Fructus Jujubae extract and rutin composition.The present invention at least has one of following advantage：
1) present invention, by the imperial Miyou nano-emulsion of nano-emulsion formation basic theory preparation, has to oxidizable imperial Miyou well
Protective effect, improves its bioavailability, improves the compatibility of imperial Miyou and water-soluble substanceses simultaneously.
2) drive the addition of Miyou nano-emulsion, promote Olive leaf P.E, Fructus Jujubae extract, the absorption of rutin, in anti-ageing work(
4 kinds of efficacious prescriptions face component has significant synergistic function.
3) the imperial Miyou nano-emulsion of the present invention, Olive leaf P.E, 4 kinds of raw materials of Fructus Jujubae extract and rutin become for primary efficacy
Point, natural safety, can effectively skin care, anti-ageing wrinkle removal, enhancing skin elasticity.
4) even if the oil component containing high level for the gel of the present invention, still there is transparent outward appearance, good stability
With use comfort, quality is salubrious, has no the greasy feeling of ordinary emulsion cream.
Specific embodiment
The invention discloses anti-ageing compositionss and cosmetics, those skilled in the art can use for reference present disclosure, suitably change
Enter technological parameter to realize.Specifically, all similar replacements and change are aobvious for a person skilled in the art
And be clear to, they are considered as including in the present invention.The method of the present invention and application are carried out by preferred embodiment
Description, related personnel substantially can be carried out to method described herein and application in without departing from present invention, spirit and scope
Change or suitably change and combine, to realize and to apply the technology of the present invention.
In anti-ageing compositionss that the present invention provides and cosmetics, raw materials used or adjuvant all can be buied by market.
With reference to embodiment, the present invention is expanded on further：
The preparation of the anti-ageing compositionss of embodiment 1
The formula of imperial Miyou nano-emulsion is following (by weight)：
The preparation method of imperial Miyou nano-emulsion is：By surfactant and oil phase mixing, stir, be subsequently adding containing
The cosurfactant of imperial Miyou, stirs, and is finally slowly added to pure water, and is stirred continuously up to system clear.
The formula of anti-ageing compositionss is as follows：
The preparation method of anti-ageing compositionss is：By imperial Miyou nano-emulsion of formula ratio, Olive leaf P.E, Fructus Jujubae extract,
Rutin mixes, and obtains anti-ageing compositionss.
The preparation of the anti-ageing compositionss of embodiment 2
The formula of imperial Miyou nano-emulsion is following (by weight)：
The preparation method of imperial Miyou nano-emulsion is：By surfactant and oil phase mixing, stir, be subsequently adding containing
The cosurfactant of imperial Miyou, stirs, and is finally slowly added to pure water, and is stirred continuously up to system clear.
The formula of anti-ageing compositionss is as follows：
The preparation method of anti-ageing compositionss is：By imperial Miyou nano-emulsion of formula ratio, Olive leaf P.E, Fructus Jujubae extract,
Rutin mixes, and obtains anti-ageing compositionss.
The preparation of the anti-ageing compositionss of embodiment 3
The formula of imperial Miyou nano-emulsion is following (by weight)：
The preparation method of imperial Miyou nano-emulsion is：By surfactant and oil phase mixing, stir, be subsequently adding containing
The cosurfactant of imperial Miyou, stirs, and is finally slowly added to pure water, and is stirred continuously up to system clear.
The formula of anti-ageing compositionss is as follows：
The preparation method of anti-ageing compositionss is：By imperial Miyou nano-emulsion of formula ratio, Olive leaf P.E, Fructus Jujubae extract,
Rutin mixes, and obtains anti-ageing compositionss.
The antioxidation in vitro test of the anti-ageing compositionss of test example 1
Experiment purpose：With in vitro tests, the antioxidant effect of plant extract compositionss is investigated.
Experiment material：Free radical scavenging activity is (referred to as：DPPH, Sigma company, the U.S.)；Du800 UV, visible light
Spectrophotometer (Beckman company, the U.S.)；The compositionss of preparation in embodiment 1-3, the imperial Miyou nano-emulsion in embodiment 3,
Olive leaf P.E, Fructus Jujubae extract, rutin, the concentration of preparation is 6%.
Experimental technique：Take 0.1mL sample solution, add the DPPH solution of 60 μm of ol/L of 2mL to mix, place 30min, with
Former solvent zeroising, having surveyed absorbance at 515nm is Ai；Mix mensuration absorbance with method 0.1mL solvent+2mL DPPH solution
Extremely Ac；0.1mL sample solution+2mL solvent mixes mensuration absorbance extremely Aj.Its free radical scavenging according to the following formula
Rate.
Clearance rate (%)=[1- (Ai-Aj)/Ac] × 100%
Wherein, the contribution to absorbance for the Aj response sample itself；Ai sample is to the absorption values after DPPH effect；Ac is
DPPH is originally in the absorption measuring wavelength.
Experimental result is as follows：
Table 1 plant extract compositionss oxidation resistance is tested
| Sample | Clearance rate (%) |
| Embodiment 1 compositionss | 90.2 |
| Embodiment 2 compositionss | 93.7 |
| Embodiment 3 compositionss | 92.4 |
| Imperial Miyou nano-emulsion in embodiment 3 | 41.8 |
| Olive leaf P.E | 69.5 |
| Fructus Jujubae extract | 85.7 |
| Rutin | 81.3 |
Vitro Experimental Results show, embodiment of the present invention 1-3 compositionss have preferable radical scavenging activity, clearance rate
Higher than each single dose group.
The preparation of the anti-ageing gel of embodiment 4
The formula of anti-ageing gel is following (in terms of weight/mass percentage composition)：
The preparation method of anti-ageing gel is as follows：Glycerol, thickening agent are added in 80 DEG C of hot water, homogenizing 5min so as to
Fully swelling；Treat that temperature is down to 40 DEG C, sequentially add imperial Miyou nano-emulsion, Olive leaf P.E, Fructus Jujubae extract, rutin, moisturizing
Agent, stirs；When temperature drops to room temperature, adding triethanolamine to adjust pH is 6.5, be subsequently adding Sensiva SC50,1,2-
Hexanediol, MEIGUI CHUNLU, stir.
The preparation of the anti-ageing gel of embodiment 5
The formula of anti-ageing gel is following (in terms of weight/mass percentage composition)：
The preparation method of anti-ageing gel is as follows：Glycerol, thickening agent are added in 90 DEG C of hot water, homogenizing 4min so as to
Fully swelling；Treat that temperature is down to 42 DEG C, sequentially add imperial Miyou nano-emulsion, Olive leaf P.E, Fructus Jujubae extract, rutin, moisturizing
Agent, stirs；When temperature drops to room temperature, adding triethanolamine to adjust pH is 5, be subsequently adding Sensiva SC50,1,2- oneself
Glycol, MEIGUI CHUNLU, stir.
The preparation of the anti-ageing gel of embodiment 6
The formula of anti-ageing gel is following (in terms of weight/mass percentage composition)：
The preparation method of anti-ageing gel is as follows：Glycerol, thickening agent are added in 100 DEG C of hot water, homogenizing 3min so as to
Fully swelling；Treat that temperature is down to 45 DEG C, sequentially add imperial Miyou nano-emulsion, Olive leaf P.E, Fructus Jujubae extract, rutin, moisturizing
Agent, stirs；When temperature drops to room temperature, adding triethanolamine to adjust pH is 5.8, be subsequently adding Sensiva SC50,1,2-
Hexanediol, MEIGUI CHUNLU, stir.
The preparation of the anti-ageing gel of embodiment 7
The formula of anti-ageing gel is following (in terms of weight/mass percentage composition)：
The preparation method of anti-ageing gel is as follows：Glycerol, thickening agent are added in 80 DEG C of hot water, homogenizing 5min so as to
Fully swelling；Treat that temperature is down to 40 DEG C, sequentially add imperial Miyou nano-emulsion, Olive leaf P.E, Fructus Jujubae extract, rutin, moisturizing
Agent, stirs；When temperature drops to room temperature, adding triethanolamine to adjust pH is 6.2, be subsequently adding Sensiva SC50,1,2-
Hexanediol, MEIGUI CHUNLU, stir.
The preparation of the anti-ageing gel of embodiment 8
The formula of anti-ageing gel is following (in terms of weight/mass percentage composition)：
The preparation method of anti-ageing gel is as follows：Glycerol, thickening agent are added in 90 DEG C of hot water, homogenizing 4min so as to
Fully swelling；Treat that temperature is down to 45 DEG C, sequentially add imperial Miyou nano-emulsion, Olive leaf P.E, Fructus Jujubae extract, rutin, moisturizing
Agent, stirs；When temperature drops to room temperature, adding triethanolamine to adjust pH is 6.4, be subsequently adding Sensiva SC50,1,2-
Hexanediol, MEIGUI CHUNLU, stir.
The anti-ageing gelling performance of test example 2 detects
1st, stability test
1) accelerated stability
The gel taking embodiment of the present invention 4-8 in right amount in centrifuge tube, sealing orifice, 3000rpm be centrifuged 30min, do not see
Observe float, precipitation and oil slick phenomenon, keep original outward appearance.
2) stablize stability
Take the gel of appropriate embodiment of the present invention 4-8, be respectively placed in investigation 3 months in 4,25,37,60 DEG C of environment, weekly
Sampling is observed, it is found that all keeping the outward appearance of clear under four kinds of steady-state conditionss of gel here of embodiment of the present invention 4-8,
The phenomenons such as float, precipitation and oil slick do not occur.
2nd, security test (human skin patch)
Choose 20 ages be 25-50 year between no dermatosiss allergies health volunteer, paste spot method：From conjunction
The speckle examination device of lattice, with closed patch experiment method, takes the gel drops of about 15 μ L embodiment of the present invention 4-8 to try in device in speckle, outward
It is covered on experimenter back with special adhesive tape, each experimenter pastes 50 speckles and tries device, respectively the gel of patch examination embodiment 4-8,24
Remove tested material after hour, after removal, observe dermoreaction respectively at 0.5,6,12,24,48 hours, according to《Cosmetics health is advised
Model》Middle dermoreaction grade scale records its result.
Result of the test：Human skin patch result shows that all experimenters pass through patch test, 0.5,6,12,
24th, observe dermoreaction within 48 hours, wherein 0 the untoward reaction such as skin erythema, pimple, vesicle, and the product of the present invention is described
Product use safety, non-stimulated.
3rd, measure of merit
1) test of skin percutaneous loss moisture
Choose health volunteer 30, the age in 25-50, test site room temperature (25 ± 1) DEG C, relative humidity (40 ±
5) % enters test environment it is desirable to tester shifts to an earlier date 30min.Tester's inboard arm labelling tested person region (4cm ×
4cm), same arm can simultaneously the multiple region of labelling (interval 1cm), the equal random distribution of test sample.First test each test zone
Blank value, then test specimens press (2.0 ± 0.1) mg/cm2Consumption carry out single and smear, adopt moisture of skin to dissipate after smearing
Commit a breach of etiquette measurement respectively 0,1,2, the tested region of 4h and blank region through transepidermal water windage (TEWL), each region according to
According to parallel assay 5 times, any sample is not as smeared in blank region.Result is as shown in table 2.
The moisture of skin windage (%) of table 2 different time (h)
As shown in Table 2, skin TEWL can be significantly reduced using the anti-ageing gel of the present invention, there is moisturizing, slow down
The effect of skin aging.
2) skin elasticity test
Choose 100 women, the age 25-50 year between, be randomly divided into 5 groups, cleaning face after, take the appropriate present invention
Anti-ageing gel is applied to face, and flicking absorbs, and the daily morning and evening, respectively using once, using skin elasticity tester, surveys respectively
Try to test for the 1st, 2,4 weeks the skin elasticity index R2 (in test process negative pressure constant for 450mbar) in left cheekbone portion, take user to survey
Test result meansigma methodss.The skin elasticity exponential quantity of the 30min with after test zone cleaning is as initial value.Index explanation：Skin elasticity
Index R2, closer to 1, illustrates that the elasticity of skin is better.Result of the test is as follows：
The skin elasticity index R2 of table 3 different cycles (w)
| Test specimens | 0w | 1w | 2w | 4w |
| Embodiment 4 | 0.6301 | 0.6839 | 0.7401 | 0.8417 |
| Embodiment 5 | 0.6275 | 0.6741 | 0.7247 | 0.8154 |
| Embodiment 6 | 0.6582 | 0.7153 | 0.7603 | 0.8522 |
| Embodiment 7 | 0.6629 | 0.7026 | 0.7539 | 0.8372 |
| Embodiment 8 | 0.6580 | 0.6941 | 0.7510 | 0.8471 |
As shown in Table 3, the anti-ageing facial film of the present invention can improve skin elasticity, reduces the generation of skin lines and wrinkle, tool
There is Antiageing effect.
3) test of skin mean roughness
Choose 100 women, the age 25-50 year between, be randomly divided into 5 groups, cleaning face after, take the appropriate present invention
Anti-ageing gel is applied to face, and flicking absorbs, and the daily morning and evening, test was carried out 4 times altogether, respectively initial value respectively using once
After using anti-ageing gel 1 week, 2 weeks, 4 weeks, same time experimenter will smear position and clean, using MicroSkinII weekly
Multi-functional skin mirror image analysis system measures the skin mean roughness of left eye angular region, and result is as shown in table 4.
The skin mean roughness of table 4 different cycles (w)
| Test specimens | 0 | 1 | 2 | 4 |
| Embodiment 4 | 24.79 | 22.58 | 20.41 | 18.63 |
| Embodiment 5 | 24.61 | 22.47 | 20.49 | 18.70 |
| Embodiment 6 | 24.75 | 22.53 | 20.56 | 18.82 |
| Embodiment 7 | 24.58 | 22.39 | 20.45 | 18.66 |
| Embodiment 8 | 24.64 | 22.50 | 20.63 | 18.79 |
As shown in Table 4, the anti-ageing gel of the present invention can effectively reduce skin mean roughness, life-time service, can reach and dispel
The effect of wrinkle, makes skin more smooth, recovers young state.
The above is only the preferred embodiment of the present invention it is noted that ordinary skill people for the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of anti-ageing compositionss are it is characterised in that by imperial Miyou nano-emulsion, Olive leaf P.E, Fructus Jujubae extract and rutin group
Become.
2. it is characterised in that in parts by weight, described anti-ageing compositionss include anti-ageing compositionss according to claim 1：
10～20 parts of imperial Miyou nano-emulsion, 0.5～3 part of Olive leaf P.E, 1～5 part of Fructus Jujubae extract, 0.8～2.5 part of rutin.
3. anti-ageing compositionss according to claim 1 and 2 are it is characterised in that in terms of weight/mass percentage composition, described imperial Miyou
Nano-emulsion is grouped into by following group：
Its preparation method is：By surfactant and oil phase mixing, it is subsequently adding the cosurfactant containing imperial Miyou, stirs
Mix and uniformly add water afterwards, stirring obtains described imperial Miyou nano-emulsion.
4. anti-ageing compositionss according to claim 3 are it is characterised in that described surfactant is tween 80, polyoxy second
One of alkene castor oil hydrogenated or two kinds；Described cosurfactant is one of propylene glycol, 1,3 butylene glycol or two kinds；
Described oil phase is one or more of isopropyl myristate, Jojoba oil, Semen Tritici aestivi germ oil.
5. a kind of cosmetics are it is characterised in that include imperial Miyou nano-emulsion, Olive leaf P.E, Fructus Jujubae extract, rutin and cosmetic
Acceptable adjuvant in conduct and learning.
6. cosmetics according to claim 5 are it is characterised in that the dosage form of described cosmetics is gel, in described gel
On cosmeceutical, to include wetting agent, glycerol, thickening agent, Sensiva SC50,1,2- hexanediol, Flos Rosae Rugosae pure for acceptable adjuvant
Dew, triethanolamine and water.
7. cosmetics according to claim 6 are it is characterised in that in terms of weight/mass percentage composition, each component in described gel
Consumption is：
8. the cosmetics according to claim 6 or 7 it is characterised in that described wetting agent be ethoxy urea, ceramide,
One or more of hyaluronate sodium, beta glucan, reed fragrant plant oil, Sorbitol, glycine betaine or amino acid humectant；Described increasing
Thick dose is one or more of Carbomer, xanthan gum, alginate jelly, arabic gum or tara gum.
9. the cosmetics according to any one of claim 6 to 8 are it is characterised in that the pH value of described gel is 5～6.5.
10. the cosmetics according to any one of claim 6 to 8 are it is characterised in that the preparation method of described gel includes
Following steps：
Glycerol, thickening agent are mixed with 80～90 DEG C of water, homogenizing 3～5min is so as to fully swelling；
When temperature is down to 40～45 DEG C, add imperial Miyou nano-emulsion, Olive leaf P.E, Fructus Jujubae extract, rutin, wetting agent,
Stir；
When temperature is down to 15～30 DEG C, add triethanolamine adjust pH be 5～6.5, be subsequently adding Sensiva SC50,1,2-
Hexanediol, MEIGUI CHUNLU, stir, and obtain gel.
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| CN201611073792.0A CN106389234B (en) | 2016-11-29 | 2016-11-29 | Anti-ageing composition and cosmetics |
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| CN107496215A (en) * | 2017-10-10 | 2017-12-22 | 西北师范大学 | A kind of natural lip gloss of Fruity type and preparation method |
| CN110680760A (en) * | 2019-10-18 | 2020-01-14 | 广州睿森生物科技有限公司 | Composition containing composite peptide nanoemulsion and application of composition in preparation of cosmetics |
| CN113101256A (en) * | 2021-05-12 | 2021-07-13 | 山东福瑞达生物股份有限公司 | Anti-aging repair nanoemulsion and application thereof |
| CN115778857A (en) * | 2022-12-20 | 2023-03-14 | 水羊化妆品制造有限公司 | Composite vegetable oil nano emulsion with nourishing and anti-aging effects, and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107496215A (en) * | 2017-10-10 | 2017-12-22 | 西北师范大学 | A kind of natural lip gloss of Fruity type and preparation method |
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| CN110680760B (en) * | 2019-10-18 | 2022-04-05 | 广州睿森生物科技有限公司 | Composition containing composite peptide nanoemulsion and application of composition in preparation of cosmetics |
| CN113101256A (en) * | 2021-05-12 | 2021-07-13 | 山东福瑞达生物股份有限公司 | Anti-aging repair nanoemulsion and application thereof |
| CN113101256B (en) * | 2021-05-12 | 2022-12-02 | 山东福瑞达生物股份有限公司 | Anti-aging repair nanoemulsion and application thereof |
| CN115778857A (en) * | 2022-12-20 | 2023-03-14 | 水羊化妆品制造有限公司 | Composite vegetable oil nano emulsion with nourishing and anti-aging effects, and preparation method and application thereof |
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| Publication number | Publication date |
|---|---|
| CN106389234B (en) | 2019-05-17 |
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