CN106388974A - Aspherical artificial lens capable of completely correcting mesopic vision - Google Patents
Aspherical artificial lens capable of completely correcting mesopic vision Download PDFInfo
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- CN106388974A CN106388974A CN201611128589.9A CN201611128589A CN106388974A CN 106388974 A CN106388974 A CN 106388974A CN 201611128589 A CN201611128589 A CN 201611128589A CN 106388974 A CN106388974 A CN 106388974A
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- aspheric
- intraocular lens
- spherical aberration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1637—Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
- A61F2/164—Aspheric lenses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Ophthalmology & Optometry (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Materials For Medical Uses (AREA)
Abstract
The invention discloses an aspherical artificial lens capable of completely correcting mesopic vision. The surface shape of the front surface of an optical part of the aspherical artificial lens or the surface shape of the rear surface of the optical part is aspherical. A corneal spherical aberration range corrected by the aspherical artificial lens is -0.1 to -0.2 micron. Compared with an aspherical artificial lens sold in the market at present, the aspherical artificial lens capable of completely correcting mesopic vision is capable of completely correcting the common corneal spherical aberration of the mesopic vision; the influence of eccentricity and inclination of implantation of the artificial lens on the vision quality can be reduced, so that corresponding patients with cataract can obtain higher vision quality.
Description
Technical field
The present invention relates to a kind of new mesopic vision rectification type aspheric intraocular lens completely(IOL).Specifically,
The present invention relates to a kind of spherical aberration value is about -0.1 ~ -0.2 μm of aspheric intraocular lens, wherein correspond to a diameter of of pupil
4.5mm..
Background technology
Cataract, as the main cause leading to people's blinding, has caused the attention of more and more people, with people's age
Increase, human eye natural lens cognition gradually thickens, or even loses transmittancy, ultimately results in human eye complete Loss Of Vision work(
Energy.
Extract lighttight human lenses, implantable artificial crystalline lenses are the optimum selections recovering human eye vision, from 1949
The intraocular lenss that year Britain is made using hard PMMA material first, successfully achieve lens replacement operation, intraocular implants
Body and corresponding surgical technic have obtained swift and violent development, so far it is already possible to realize diffraction using flexible material many
Focus or even zoom IOL, and be successfully applied in clinic.
Fig. 1 is the dioptric schematic diagram of human eye, and from optical angle, human eye is by corneaaAnd crystalline lensesbTwo main
The optical system of lens composition, pupilcIt is the aperture diaphragm of whole optical system, retinadIt is imaging surface, whole system is suitable
In being immersed in liquid solution.Cornea, as topmost optical power element, assume responsibility for the focal power of eyes more than 2/3rds, brilliant
Shape body undertakes remaining 1/3rd diopters.The cornea of human eye carries certain positivity spherical aberration, and the size of its value varies with each individual,
Substantial amounts of clinical trial shows, the distribution of its spherical aberration value meets normal distribution law, and in the case of 6mm pupil, intermediate value is about
0.27 μm, when extraneous light enters human eye, under bright light environments, the pupil of human eye is less(Below 3mm), now the spherical aberration of cornea is relatively
Little, light is paraxial rays, can become gem-pure picture on the retina, and the visual condition of human eye is good, but in night vision
In the case of(Pupil 6mm about), the spherical aberration of cornea is larger, and the refractive power through CC region and marginal area for the light is bright
Aobvious difference, the refractive power of central area is weak, and the refractive power of marginal area is stronger, and the natural lens of human eye itself can be mended
Repay the positive spherical aberration that cornea brings so that the Integral ball differential of eyes is bordering on zero, therefore, no matter bright or scotopia or
At night, all there is good visual effect.
Itself there is positive spherical aberration in traditional sphere intraocular lenss, it, on the basis of the positive spherical aberration of cornea itself, increased
Total spherical aberration of human eye, affects postoperative visual quality.Patient therefore will be made to obtain more preferably visual effect it is necessary to reduce postoperative eye
Total spherical aberration.Aspheric intraocular lens are based on that this is theoretical and research and develop, by the aspheric design of plane of crystal so as to
There is zero spherical aberration or negative spherical aberration, so that total spherical aberration of postoperative eye remains at low levels, thus solving common sphere intraocular implants
Body in the case of big pupil, the problem that contrast declines, improve the visual capacity under half-light and night-environment.AMO company
Tecnis Z900 type intraocular lenss are the intraocular lenss that the first can produce negative spherical aberration, produce -0.27 μm of negative ball
Difference, equal with the average spherical aberration statistical data of cornea, design concept is to be completely counterbalanced by the positive spherical aberration of cornea.Alcon company sets
The aspheric intraocular lens Acrysof SN60WF of meter, after optical section, surface adopts aspheric design, can produce -0.2 μ
The negative spherical aberration of m is it is intended to keep a certain amount of positive spherical aberration for full eye, to obtain more preferable visual comfort.Bausch & lomb is public
The aspheric intraocular lens of department entitled SofPort AO and AkreosAO of release, crystal aberrationless itself, will not be to whole
Individual human eye introduces extra spherical aberration, also referred to as zero spherical aberration crystal.
However, the aspheric faceted crystal of -0.27 μm of negative spherical aberration, to crystalline lenses during implantation and postoperation recovery, exist
Bias and tilt very sensitive, even slight bias, the characteristic limited by aspheric surface crystal diffraction will disappear, because
This this crystalloid is in fact very high to the accuracy and required precision of implant surgery.Zero spherical aberration(No spherical aberration)Crystal no ball itself
Difference, or even in bias, do not introduce coma yet, therefore can effectively reduce the impact that crystal is eccentric and inclination is to image quality,
But this design there is problems that, because crystal itself does not offset the positive spherical aberration of cornea, in mesopic vision and scotopia
It will be apparent that limiting visual effect in the case of feel.
In sum, the present invention proposes a kind of new intraocular lenss, and this crystal can be completely counterbalanced by mesopic vision feelings
The spherical aberration of cornea under condition, thus human eye visual quality under bright and dark situation is substantially improved, part compensates human eye simultaneously
Cornea spherical aberration in the case of night vision, takes into account its image quality, more importantly, reduce operation implantation process in crystal inclined
The impact to image quality of the heart and inclination, it is true that human eye is in most cases, is all to be operated in bright and Crape ring
Under border, therefore, the image quality in the case of effective lifting mesopic vision, and sufficiently consider follow-up implant surgery to imaging matter
The impact of amount, provides a kind of crystal type of more balance and is necessary..
Content of the invention
Present invention aim at providing a kind of new aspheric intraocular lenss.Crystalline with presently commercially available aspheric Intraocular
Body phase ratio, the new aspheric intraocular lens of the present invention can correct the cornea spherical aberration of mesopic vision completely, makes white accordingly
Cataract patient obtains higher visual quality.
Specifically, the present invention relates to the content of following many aspects:
1st, a kind of mesopic vision rectification type aspheric intraocular lens completely, the front table of described aspheric intraocular lens optical section
The face shape on the rear surface of the face shape in face or optical section is aspheric surface it is characterised in that the ball of described aspheric intraocular lens
Between difference is -0.1 ~ -0.2 μm.
2nd, the aspheric intraocular lens according to content 1, the front surface face type of described crystal is sphere, and rear surface is
Aspheric surface.
3rd, the aspheric intraocular lens according to content 1, the front surface face type of described crystal is aspheric surface, rear surface
For sphere.
4th, the aspheric intraocular lens according to content 1, the front surface of described crystal and rear surface face type are
Aspheric surface.
5th, the aspheric intraocular lens according to content 1 are it is characterised in that described aspheric face type is in two dimension
Rectangular coordinate system plane(YZ)On curve meet following aspheric curve expression formula:
Wherein Z (y) is the expression formula of the curve in YZ plane for the aspheric surface of artificial lens optic, and c is optical section
The inverse of sphere curvature radius, Q is aspheric quadratic surface constant, and y is for any point on described curve away from axis of abscissas(Z)
Vertical dimension, A2i be aspheric surface high order term coefficient.
6th, the aspheric intraocular lens according to content 1, wherein constant Q<0.
7th, the aspheric intraocular lens according to content 1, the face type of crystal can be linear according to aspheric surface expression formula
Combined section is determined.
8th, the aspheric intraocular lens according to claim 5 are it is characterised in that described aspheric Intraocular is crystalline
Body is by under ophthalmic state(35o)Refractive index is the PMMA in the range of 1.49-1.54(Polymethyl methacrylate)Or hydrophobicity
Acrylate or hydrophilic acrylate, make and described aspheric intraocular lens diopter -10D-35D model
In enclosing.
9th, the intraocular lenss according to content 1, the spherical aberration value of described intraocular lenss is set at medium size pupil
Natural human lens identical level in the range of hole.
Brief description:
Fig. 1:Liou-Brennan model eye.
Fig. 2:The spherical aberration of cornea and the relation of pupil diameter.
Fig. 3:In the case of vision improvement(Corresponding pupil diameter 3mm), the hydrophilic acrylate material intraocular lenss of 20D
Modulation transfer function (MTF) curve.
Fig. 4:In the case of vision improvement(Corresponding pupil diameter 3mm), the hydrophobic acrylic acid ester material intraocular lenss of 20D
Modulation transfer function (MTF) curve.
Fig. 5:In the case of mesopic vision(Corresponding pupil diameter 4.5mm), hydrophilic acrylate's material of 20D is manually brilliant
Shape body modulation transfer function (MTF) curve.
Fig. 6:In the case of mesopic vision(Corresponding pupil diameter 4.5mm), hydrophobic acrylic acid's ester material of 20D is manually brilliant
Shape body modulation transfer function (MTF) curve.
Fig. 7:In the case of scotopic vision(Corresponding pupil diameter 6mm), the hydrophilic acrylate material intraocular lenss of 20D
Modulation transfer function (MTF) curve.
Fig. 8:In the case of scotopic vision(Corresponding pupil diameter 6mm), the hydrophobic acrylic acid ester material intraocular lenss of 20D
Modulation transfer function (MTF) curve.
Specific embodiment:
Specific examples below is only intended to the present invention is further explained, but the invention is not limited in following
Specific embodiments.Any change on the basis of these embodiments, as long as meet spirit and the scope of the present invention, all
By in the covering scope falling into patent of the present invention.
What Fig. 1 was given is the simplification eye model of Liou and Brennan proposition in 1997, this model closely true people
The anatomical structure of eye, keeps optical characteristics and the aberration characteristics of human eye simultaneously, and this model eye includes aspheric corneaa, gradient
Refractive index crystalline lensesbAnd retinac, incident ray enters cornea from infinity to be approximately parallel to optical axis, then through crystalline
Body, finally converges on the retina of human eye, due to due to cornea spherical aberration, longer near the ray traveling optical paths of pupil center, phase
The focal power answered is less, and shorter near the ray traveling optical paths of pupil edge, corresponding focal power is larger, in the light ratio of pupil center
Relatively, rim ray is intersected with optical axis first, the spherical aberration of therefore cornea be on the occasion of.The intraocular lenss of sphere due to its to center and
The refractive nature of rim ray is similar with cornea, and therefore, the overall spherical aberration of human eye will add up, and causes in middle vision and scotopic vision
In the case of, image quality is very poor, and aspheric intraocular lens, due to being fully compensated or partly compensating cornea spherical aberration, make one
The overall spherical aberration of eye is maintained at a relatively low level of ratio, thus ensure that the vision under middle vision and scotopic vision lighting condition
Quality.
Fig. 2 is the statistical distribution relation curve of the spherical aberration of eye cornea, because the distribution presence of eye cornea spherical aberration is poor
The opposite sex, meets normal distribution law, and the cornea spherical aberration value of vast majority of people is 0.27 μm about it should be noted that this statistics
Spherical aberration value is measurement in the case of 6mm pupil size.
Fig. 3 is under vision improvement environment(3mm pupil diameter), using three kinds of different types of intraocular lenss(20D's is hydrophilic
Property acrylate material)The optical property of the human eye obtaining, uses modulation transfer function (MTF)(MTF)To characterize the imaging matter of optical system
Amount, gives the relation between every millimeter of demand pairs in modulation degree and image, is the most comprehensive during all Performance of Optical System judge
Criterion.Under bright light environments, three kinds of crystal(Zero spherical aberration, sphere and middle vision aspheric surface)It is attained by being similar to diffraction pole
The image quality of limit, the aspheric intraocular lens image quality that this patent is given is best.
Fig. 4 is under vision improvement environment(3mm pupil diameter), using three kinds of different types of intraocular lenss(20D's is hydrophobic
Property acrylate material)The optical property of the human eye obtaining, under bright light environments, three kinds of crystal(Zero spherical aberration, sphere and in regard
Feel aspheric surface)It is attained by being similar to the image quality of diffraction limit, equally, the aspheric intraocular lens that this patent is given become
As quality is best.
Fig. 5 is under mesopic vision environment(4.5mm pupil diameter), using three kinds of different types of intraocular lenss(20D's
Hydrophilic acrylate's material)The optical property of the human eye obtaining, under mesopic vision, the aspheric Intraocular that this patent is given is brilliant
, close to diffraction limit, 100 lines are right/MTF of mm position is more than 0.7 for shape body image quality, and zero spherical aberration crystal is not dribbled due to itself
Difference, so image quality is placed in the middle, sphere crystal also will introduce larger spherical aberration due to itself, and after the superposition of cornea spherical aberration, enters one
Step increased the spherical aberration value of whole system so that its image quality is worst.
Fig. 6 is under mesopic vision environment(4.5mm pupil diameter), using three kinds of different types of intraocular lenss(20D's
Hydrophobic acrylic acid's ester material)The optical property of the human eye obtaining, under mesopic vision, the aspheric Intraocular that this patent is given is brilliant
, close to diffraction limit, 100 lines are right/MTF of mm position is more than 0.7 for shape body image quality, and zero spherical aberration crystal is not dribbled due to itself
Difference, image quality is placed in the middle, and under this aperture, sphere crystal also will introduce larger spherical aberration due to itself, and the superposition of cornea spherical aberration
Afterwards, further increase the spherical aberration value of whole system so that its image quality is worst.
Fig. 7 is under scotopic vision environment(6mm pupil diameter), using three kinds of different types of intraocular lenss(20D's is hydrophilic
Property acrylate material)The optical property of the human eye obtaining, under scotopic vision, the aspheric intraocular lens that this patent is given become
As quality is declined slightly, 100 lines are right/and the MTF of mm position still can be more than 0.5, because the aspheric faceted crystal that this patent proposes is complete
Entirely correct the human eye spherical aberration value in the case of mesopic vision, in the case of big pupil, whole human eye remains certain spherical aberration value,
The depth of focus of system in the case of not affecting visual quality, can be increased, zero spherical aberration crystal, because itself is without spherical aberration, is imaged matter
Amount is placed in the middle, and sphere crystal, under this aperture, because itself also will introduce very big spherical aberration, is therefore compared to mesopic vision environment
Under, its image quality further deteriorates.
Fig. 8 is under scotopic vision environment(6mm pupil diameter), using three kinds of different types of intraocular lenss(20D's is hydrophobic
Property acrylate material)The optical property of the human eye obtaining, in the same manner, under scotopic vision, the aspheric Intraocular that this patent is given is brilliant
Shape body image quality is declined slightly, and 100 lines are right/MTF of mm position still can be more than 0.5, zero spherical aberration crystal due to itself without
Spherical aberration, image quality is placed in the middle, and sphere crystal, under this aperture, because itself also will introduce very big spherical aberration, is therefore compared to
Under mesopic vision environment, its image quality is worst.
Claims (12)
1. a kind of mesopic vision rectification type aspheric intraocular lens completely, the front table of described aspheric intraocular lens optical section
The face shape on the rear surface of the face shape in face or optical section is aspheric surface it is characterised in that the ball of described aspheric intraocular lens
Between difference range is -0.1 ~ -0.2 μm, to substituting natural human eye lenticular aspheric surface face type intraocular lenss, simplifying people
Optical modeling in eye model, corrects the cornea spherical aberration of mesopic vision completely, and keeps the specific optical function of human eye, regards bright
Feel and mesopic vision area is respectively provided with optimal image quality.
2. aspheric intraocular lens according to claim 1, the front surface face type of described crystal is sphere, and rear surface is
Aspheric surface.
3. aspheric intraocular lens according to claim 1, the front surface face type of described crystal is aspheric surface, rear surface
For sphere.
4. aspheric intraocular lens according to claim 1, the front surface of described crystal and rear surface face type are
Aspheric surface.
5. the aspheric intraocular lens according to claim 1 are it is characterised in that described aspheric face type is in two dimension
Rectangular coordinate system plane(YZ)On curve meet following aspheric curve expression formula:
WhereinZ(y)Aspheric surface for artificial lens optic existsYZThe expression formula of the curve in plane,cFor optical section
The inverse of sphere curvature radius,QFor aspheric quadratic surface constant,yFor any point on described curve away from axis of abscissas(Z)
Vertical dimension,A 2i For aspheric surface high order term coefficient.
6. aspheric intraocular lens according to claim 1, wherein constant Q<0.
7. aspheric intraocular lens according to claim 1, the face type of crystal can be linear according to aspheric surface expression formula
Combined section is determined.
8. intraocular lenss according to claim 1, can suitably reduce surgical effect and the caused crystal that heals is inclined
The decline of the image quality that the heart leads to.
9. intraocular lenss according to claim 1, can suitably reduce surgical effect and the caused crystal that heals inclines
The decline of the image quality tiltedly leading to.
10. the aspheric intraocular lens according to claim 5 are it is characterised in that described aspheric intraocular lens
By under ophthalmic state(35o)Refractive index is the PMMA in the range of 1.49-1.54(Polymethyl methacrylate)Or hydrophobicity third
Olefin(e) acid ester or hydrophilic acrylate, make and described aspheric intraocular lens diopter -10D-35D scope
Interior.
11. intraocular lenss according to claim 1, the spherical aberration value of described intraocular lenss is set at medium size pupil
Natural human lens identical level in the range of hole.
12. according to aspheric intraocular lens in any one of the preceding claims wherein it is characterised in that described aspheric dough figurine
Work crystalline lenses are single type intraocular lenss or three-member type intraocular lenss.
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Cited By (2)
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CN112043459A (en) * | 2019-06-07 | 2020-12-08 | 伏普提卡有限公司 | Intraocular lens and method for optimizing focal depth and peripheral image quality of field of vision |
CN112494175A (en) * | 2020-11-25 | 2021-03-16 | 杭州爱晶伦科技有限公司 | Posterior chamber type aspheric intraocular lens with lens |
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CN112043459A (en) * | 2019-06-07 | 2020-12-08 | 伏普提卡有限公司 | Intraocular lens and method for optimizing focal depth and peripheral image quality of field of vision |
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CN112494175A (en) * | 2020-11-25 | 2021-03-16 | 杭州爱晶伦科技有限公司 | Posterior chamber type aspheric intraocular lens with lens |
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