CN106387349A - Traditional Chinese medicinal feed additive for replacing antibiotics - Google Patents
Traditional Chinese medicinal feed additive for replacing antibiotics Download PDFInfo
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- CN106387349A CN106387349A CN201610841963.3A CN201610841963A CN106387349A CN 106387349 A CN106387349 A CN 106387349A CN 201610841963 A CN201610841963 A CN 201610841963A CN 106387349 A CN106387349 A CN 106387349A
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Abstract
The present invention belongs to the technical field of feed additive research and development and particularly relates to a traditional Chinese medicinal feed additive for replacing antibiotics and a preparation method thereof. The traditional Chinese medicinal feed additive for replacing antibiotics is prepared from the following components in parts by weight: 5-9 parts of radix scutellariae powder, 2-5 parts of houttuynia cordata root powder, 6-10 parts of radix zanthoxyli powder, 3-5 parts of fructus akebia powder, 3-6 parts of caulis spatholobi powder, 30-65 parts of a compound acidifying agent, 15-25 parts of a viable micro-organism preparation, 3-6 parts of astragalus polysaccharide, 3-5 parts of a compound enzyme preparation and 11-16 parts of a carrier. The traditional Chinese medicinal feed additive for replacing antibiotics has the effects of clearing heat and relieving toxins, strengthening spleen and tonifying kidneys, and promoting digestion, and is significantly enhanced in micro-organism preventing activity and suitable for replacing the antibiotics as the animal feed additive.
Description
Technical field
The invention belongs to feed additive research and development technology field, add particularly to a kind of Chinese medicine fodder of alternative antibiotic
Plus agent and preparation method thereof.
Background technology
The feed additive of existing disease-resistant growth-promoting is mainly antibiotic and chemicalses additive.Life-time service antibiosis
Element and chemical drugs species additive side effect are very big, and pathogenic microorganism on the one hand can be caused to develop immunity to drugs, and reduce Animal diseases
Prevention effect；On the other hand drug residue can be produced in meat, egg, milk and environment, thus seriously threatening health.For
This, the regulation that should be used as to limit and be phased out or disable to antibiotic and chemicalses additive for the world many countries.
Chinese herbal medicine immunity substance mass-energy enhancing human body immunity function, improves animal anti-stress, resistances against diseases, improves animal
Production performance, has the advantages that noresidue, is not likely to produce drug resistance, is the focus of animal nutrition research in recent years.According to literary composition
Offer report, the Chinese herbal medicine currently used for raw materials of feed additives has kind more than 200, and some patents of invention also disclose that various Chinese herbal medicine
The formula of feed additive, the effect of various formula and cost are also had nothing in common with each other, and also thousand change ten thousand of the preparation method of Chinese herbal medicine
Change, majority is no longer added using directly pulverizing, because direct comminuting method dosage and active constituent content are unstable.
CN103005210 B discloses a kind of pig feed additive of alternative antibiotic, by Massa Medicata Fermentata, Radix Angelicae Sinensis, the Radix Astragali, mountain
Short, bristly hair or beard, Radix Codonopsis, citric acid, lactic acid, be coated phosphoric acid, Tiny ecosystem system, yeast cell wall polysaccharide composition.CN103947907 B discloses
The pig immunity enhancement type feed additive of another kind of alternative antibiotic, by Folium Nelumbinis polysaccharide, Fructus Choerospondiatis extract, Radix Angelicae Sinensis powder, purple
Folium Perillae powder, four seasons Calomelas, Herba Glechomae powder, microbial ecological agent, garlicin, compound vitamin, composite mineral matter and carrier composition.Group
Fang Duowei enriching yin and nourishing kidney nourishing the stomach Chinese medicine, or the Chinese medicine of polysaccharide enhancing nonspecific immunity function, using effect and range of application are equal
By larger restriction.So the new prescription of exploitation is very necessary.
The present invention is exactly on this basis, proposes a kind of Chinese medicine feed additive for alternative antibiotic, it has
Efficiently, have no toxic side effect, safe, noresidue many advantages, such as, and wide material sources, low cost, the immune system to animal
Carry out across-the-board regulation, improve its resistance against diseases and immune function.
The information being disclosed in this background section is merely intended to increase the understanding of the general background to the present invention, and should not
Recognize when being considered or imply in any form that this information structure has been the prior art well known to persons skilled in the art.
Content of the invention
For deficiency above-mentioned present in prior art, the present invention provides a kind of Chinese medicine fodder of alternative antibiotic to add
Agent and preparation method thereof, this Chinese medicine feed additive reasonable recipe, preparation are simple, effect substantially, have no toxic side effect, have no drug resistance
And drug residue, can effective substitute antibiotics.
To achieve these goals, the present invention is to employ the following technical solutions realization：
A kind of Chinese medicine feed additive of alternative antibiotic, by being made up of following components by weight：Radix Scutellariae powder 5-9
Part, root of Herba Houttuyniae powder 2-5 part, Radix Zanthoxyli powder 6-10 part, YANGKAIKOU powder 3-5 part, Caulis Spatholobi powder 3-6 part, compound acidulant 30-65
Part, active bacteria formulation 15-25 part, astragalus polysaccharidess 3-6 part, compound enzymic preparation 3-5 part and carrier 11-16 part.
Preferably, described compound acidulant consists of the following composition by weight percentage：30% phosphoric acid, 20% Fructus Citri Limoniae
Acid, 20% Fumaric acid, 15% lactic acid, 10% propanoic acid and 5% calcium formate.
Preferably, described active bacteria formulation includes following composition：1.0×108-1.0×109The active lactic acid of CFU/g
Bacterium, 1.0 × 108-1.0×109The shitosan of CFU/g, 1.0 × 108-1.0×109The bacillus bifiduss of CFU/g, Lactobacillus,
The weight of shitosan and bacillus bifiduss is than for 3：2：1.
Preferably, described compound enzymic preparation is by weight percentage by 25% cellulase, 10% protease, 10% shallow lake
Powder enzyme, 10% seminase, 20% glucanase, 5% pectase, remaining is Fructus Hordei Germinatus powder.
Preferably, described carrier is made up of dehulled soybean meal powder, high lactose whey powder and zeolite powder, dehulled soybean meal powder,
The mass ratio 6 of high lactose whey powder and zeolite powder：2：1, dehulled soybean meal powder, high lactose whey powder and zeolite powder pulverized 60 in advance
Mesh sieve.
Present invention also offers the preparation method of the described Chinese medicine feed additive of alternative antibiotic, walk including following
Suddenly：
(1) respectively Radix Scutellariae, root of Herba Houttuyniae, Radix Zanthoxyli, YANGKAIKOU, Caulis Spatholobi roguing, chopping are processed, then use 70-
80% alcohol steep, extraction time 2-3h, temperature 70-80 DEG C, solvent materials compare 7-9：1, concentrate, more spray dried 80 mesh
Sieve, obtains Radix Scutellariae powder, root of Herba Houttuyniae powder, Radix Zanthoxyli powder, YANGKAIKOU powder, Caulis Spatholobi powder；
(2) weigh phosphoric acid, citric acid, Fumaric acid, lactic acid, propanoic acid, calcium formate by weight percentage, bored using Double helix
Shape mixer mixing 7-10min, puts into after being sufficiently mixed uniformly in baking car pallet, proceeds in heated-air circulation oven and dried,
Drying temperature is 40-45 DEG C, time 3-4h, then using broken vibrations sieving machine by the phosphoric acid dried, citric acid, Fumaric acid,
Lactic acid, propanoic acid, calcium formate are pulverized, after sieving be obtained compound acidulant standby, wherein, phosphoric acid, citric acid, Fumaric acid,
Granularity after lactic acid, propanoic acid, calcium formate are pulverized is more than 80 mesh；
(3) by weight 3：2：1 weighs Lactobacillus, shitosan and bacillus bifiduss, is sufficiently mixed, obtains active bacteria formulation；
(3) weigh by weight percentage cellulase, protease, amylase, seminase, glucanase, pectase and
Fructus Hordei Germinatus powder, is sufficiently mixed, and obtains compound enzymic preparation；
(4) dehulled soybean meal powder, high lactose whey powder and zeolite powder are pulverized respectively in advance, excessively 60 mesh sieves, and in mass ratio 6：2：1
Weigh dehulled soybean meal powder, high lactose whey powder and zeolite powder, be sufficiently mixed, obtain carrier；
(5) Radix Scutellariae powder of step (1) gained, root of Herba Houttuyniae powder, Radix Zanthoxyli powder, YANGKAIKOU are weighed by weight respectively
Powder, Caulis Spatholobi powder；The compound acidulant of step (2) gained；The active bacteria formulation of step (3) gained；The compound enzyme of step (4) gained
Preparation；The carrier of step (5) gained and astragalus polysaccharidess, are placed in three-dimensional motion mixer and are mixed, and incorporation time is 4-
5min, obtains final product the Chinese medicine feed additive of alternative antibiotic.
Compared with prior art, the present invention has the advantages that：
(1) the immunity enhancement type Chinese medicine feed additive of the alternative antibiotic of the present invention, by Chinese traditional herbs and the Radix Astragali
Polysaccharide, active bacteria formulation, compound acidulant, compound enzymic preparation and carrier etc. are combined arranging in pairs or groups, by Chinese traditional herbs and other groups
The cooperative effect dividing plays to maximum, and antibacterial activity significantly increases.
(2) the immunity enhancement type Chinese medicine feed additive energy substitute antibiotics completely of the alternative antibiotic of the present invention, subtract
The problems such as few animal husbandry of puzzlement for a long time antibiotic resistance for a long time, the residual, Use out of range of medicine, simultaneously work as improving and support
Grow environment, reduce feed safety hidden danger, improve the effect such as culture benefit.
(3) the Chinese medicine feed additive preparation method of the alternative antibiotic of the present invention is simple, is added using this Chinese medicine fodder
Plus agent poultry meat mass-energy reaches nuisanceless requirement, people healthy is effectively ensured, can promote the use of.
Specific embodiment
With reference to specific embodiment, the specific embodiment of the present invention is described in detail, it is to be understood that the present invention
Protection domain do not limited by specific embodiment.
Embodiment 1：
A kind of Chinese medicine feed additive of alternative antibiotic, by being made up of following components by weight：5 parts of Radix Scutellariae powder,
2 parts of root of Herba Houttuyniae powder, 6 parts of Radix Zanthoxyli powder, 3 parts of YANGKAIKOU powder, 3 parts of Caulis Spatholobi powder, 30 parts of compound acidulant, active bacteria formulation 15
Part, 3 parts of astragalus polysaccharidess, 3 parts of compound enzymic preparation and 11 parts of carrier.
Described compound acidulant consists of the following composition by weight percentage：30% phosphoric acid, 20% citric acid, 20% prolong
Fumarate, 15% lactic acid, 10% propanoic acid and 5% calcium formate；Described active bacteria formulation includes following composition：1.0×108CFU/g
Lactobacillus, 1.0 × 108The shitosan of CFU/g, 1.0 × 108The bacillus bifiduss of CFU/g, Lactobacillus, shitosan with
The weight of bacillus bifiduss is than for 3：2：1；Described compound enzymic preparation is by weight percentage by 25% cellulase, 10% albumen
Enzyme, 10% amylase, 10% seminase, 20% glucanase, 5% pectase, remaining is Fructus Hordei Germinatus powder；Described carrier is by going
Skin bean cake powder, high lactose whey powder and zeolite powder composition, the mass ratio 6 of dehulled soybean meal powder, high lactose whey powder and zeolite powder：2：
1, dehulled soybean meal powder, high lactose whey powder and zeolite powder pulverized 60 mesh sieves in advance.
The preparation method of the described Chinese medicine feed additive of alternative antibiotic, comprises the steps：
(1) respectively Radix Scutellariae, root of Herba Houttuyniae, Radix Zanthoxyli, YANGKAIKOU, Caulis Spatholobi roguing, chopping are processed, then use 70% second
Alcohol extracts, and extraction time 2h, temperature 70 C, solvent materials compare 7：1, concentrate, more spray dried 80 mesh sieves, obtain Radix Scutellariae powder, fish
Raw meat grass roots powder, Radix Zanthoxyli powder, YANGKAIKOU powder, Caulis Spatholobi powder；
(2) weigh phosphoric acid, citric acid, Fumaric acid, lactic acid, propanoic acid, calcium formate by weight percentage, bored using Double helix
Shape mixer mixing 7min, puts into after being sufficiently mixed uniformly in baking car pallet, proceeds in heated-air circulation oven and dried, dry
Temperature is 40 DEG C, time 3h, then using broken vibrations sieving machine by the phosphoric acid dried, citric acid, Fumaric acid, lactic acid, propanoic acid,
Calcium formate is pulverized, after sieving be obtained compound acidulant standby, wherein, phosphoric acid, citric acid, Fumaric acid, lactic acid, propanoic acid,
Granularity after calcium formate is pulverized is more than 80 mesh；
(3) by weight 3：2：1 weighs Lactobacillus, shitosan and bacillus bifiduss, is sufficiently mixed, obtains active bacteria formulation；
(3) weigh by weight percentage cellulase, protease, amylase, seminase, glucanase, pectase and
Fructus Hordei Germinatus powder, is sufficiently mixed, and obtains compound enzymic preparation；
(4) dehulled soybean meal powder, high lactose whey powder and zeolite powder are pulverized respectively in advance, excessively 60 mesh sieves, and in mass ratio 6：2：1
Weigh dehulled soybean meal powder, high lactose whey powder and zeolite powder, be sufficiently mixed, obtain carrier；
(5) Radix Scutellariae powder of step (1) gained, root of Herba Houttuyniae powder, Radix Zanthoxyli powder, YANGKAIKOU are weighed by weight respectively
Powder, Caulis Spatholobi powder；The compound acidulant of step (2) gained；The active bacteria formulation of step (3) gained；The compound enzyme of step (4) gained
Preparation；The carrier of step (5) gained and astragalus polysaccharidess, are placed in three-dimensional motion mixer and are mixed, and incorporation time is
4min, obtains final product the Chinese medicine feed additive of alternative antibiotic.
Addition in animal basal diet for the Chinese medicine feed additive product of the present invention is 1000 g ton.
Embodiment 2：
A kind of Chinese medicine feed additive of alternative antibiotic, by being made up of following components by weight：9 parts of Radix Scutellariae powder,
5 parts of root of Herba Houttuyniae powder, 10 parts of Radix Zanthoxyli powder, 5 parts of YANGKAIKOU powder, 6 parts of Caulis Spatholobi powder, 65 parts of compound acidulant, active bacteria formulation 25
Part, 6 parts of astragalus polysaccharidess, 5 parts of compound enzymic preparation and 16 parts of carrier.
Described compound acidulant consists of the following composition by weight percentage：30% phosphoric acid, 20% citric acid, 20% prolong
Fumarate, 15% lactic acid, 10% propanoic acid and 5% calcium formate；Described active bacteria formulation includes following composition：1.0×109CFU/g
Lactobacillus, 1.0 × 109The shitosan of CFU/g, 1.0 × 109The bacillus bifiduss of CFU/g, Lactobacillus, shitosan with
The weight of bacillus bifiduss is than for 3：2：1；Described compound enzymic preparation is by weight percentage by 25% cellulase, 10% albumen
Enzyme, 10% amylase, 10% seminase, 20% glucanase, 5% pectase, remaining is Fructus Hordei Germinatus powder；Described carrier is by going
Skin bean cake powder, high lactose whey powder and zeolite powder composition, the mass ratio 6 of dehulled soybean meal powder, high lactose whey powder and zeolite powder：2：
1, dehulled soybean meal powder, high lactose whey powder and zeolite powder pulverized 60 mesh sieves in advance.
The preparation method of the described Chinese medicine feed additive of alternative antibiotic, comprises the steps：
(1) respectively Radix Scutellariae, root of Herba Houttuyniae, Radix Zanthoxyli, YANGKAIKOU, Caulis Spatholobi roguing, chopping are processed, then use 80% second
Alcohol extracts, and extraction time 3h, 80 DEG C of temperature, solvent materials compare 9：1, concentrate, more spray dried 80 mesh sieves, obtain Radix Scutellariae powder, fish
Raw meat grass roots powder, Radix Zanthoxyli powder, YANGKAIKOU powder, Caulis Spatholobi powder；
(2) weigh phosphoric acid, citric acid, Fumaric acid, lactic acid, propanoic acid, calcium formate by weight percentage, bored using Double helix
Shape mixer mixing 10min, puts into after being sufficiently mixed uniformly in baking car pallet, proceeds in heated-air circulation oven and dried, dry
Dry temperature is 45 DEG C, time 4h, then using broken vibrations sieving machine by the phosphoric acid dried, citric acid, Fumaric acid, lactic acid, third
Acid, calcium formate pulverized, after sieving be obtained compound acidulant standby, wherein, phosphoric acid, citric acid, Fumaric acid, lactic acid, third
Granularity after acid, calcium formate are pulverized is more than 80 mesh；
(3) by weight 3：2：1 weighs Lactobacillus, shitosan and bacillus bifiduss, is sufficiently mixed, obtains active bacteria formulation；
(3) weigh by weight percentage cellulase, protease, amylase, seminase, glucanase, pectase and
Fructus Hordei Germinatus powder, is sufficiently mixed, and obtains compound enzymic preparation；
(4) dehulled soybean meal powder, high lactose whey powder and zeolite powder are pulverized respectively in advance, excessively 60 mesh sieves, and in mass ratio 6：2：1
Weigh dehulled soybean meal powder, high lactose whey powder and zeolite powder, be sufficiently mixed, obtain carrier；
(5) Radix Scutellariae powder of step (1) gained, root of Herba Houttuyniae powder, Radix Zanthoxyli powder, YANGKAIKOU are weighed by weight respectively
Powder, Caulis Spatholobi powder；The compound acidulant of step (2) gained；The active bacteria formulation of step (3) gained；The compound enzyme of step (4) gained
Preparation；The carrier of step (5) gained and astragalus polysaccharidess, are placed in three-dimensional motion mixer and are mixed, and incorporation time is
5min, obtains final product the Chinese medicine feed additive of alternative antibiotic.
Addition in animal basal diet for the Chinese medicine feed additive product of the present invention is 1300 g ton.
Embodiment 3：
A kind of Chinese medicine feed additive of alternative antibiotic, by being made up of following components by weight：7 parts of Radix Scutellariae powder,
4 parts of root of Herba Houttuyniae powder, 8 parts of Radix Zanthoxyli powder, 4 parts of YANGKAIKOU powder, 5 parts of Caulis Spatholobi powder, 50 parts of compound acidulant, active bacteria formulation 20
Part, 4 parts of astragalus polysaccharidess, 4 parts of compound enzymic preparation and 13 parts of carrier.
Described compound acidulant consists of the following composition by weight percentage：30% phosphoric acid, 20% citric acid, 20% prolong
Fumarate, 15% lactic acid, 10% propanoic acid and 5% calcium formate；Described active bacteria formulation includes following composition：5.0×108CFU/g
Lactobacillus, 5.0 × 108The shitosan of CFU/g, 5.0 × 108The bacillus bifiduss of CFU/g, Lactobacillus, shitosan with
The weight of bacillus bifiduss is than for 3：2：1；Described compound enzymic preparation is by weight percentage by 25% cellulase, 10% albumen
Enzyme, 10% amylase, 10% seminase, 20% glucanase, 5% pectase, remaining is Fructus Hordei Germinatus powder；Described carrier is by going
Skin bean cake powder, high lactose whey powder and zeolite powder composition, the mass ratio 6 of dehulled soybean meal powder, high lactose whey powder and zeolite powder：2：
1, dehulled soybean meal powder, high lactose whey powder and zeolite powder pulverized 60 mesh sieves in advance.
The preparation method of the described Chinese medicine feed additive of alternative antibiotic, comprises the steps：
(1) respectively Radix Scutellariae, root of Herba Houttuyniae, Radix Zanthoxyli, YANGKAIKOU, Caulis Spatholobi roguing, chopping are processed, then use 75% second
Alcohol extracts, and extraction time 2.5h, 75 DEG C of temperature, solvent materials compare 8：1, concentrate, more spray dried 80 mesh sieves, obtain Radix Scutellariae powder,
Root of Herba Houttuyniae powder, Radix Zanthoxyli powder, YANGKAIKOU powder, Caulis Spatholobi powder；
(2) weigh phosphoric acid, citric acid, Fumaric acid, lactic acid, propanoic acid, calcium formate by weight percentage, bored using Double helix
Shape mixer mixing 8min, puts into after being sufficiently mixed uniformly in baking car pallet, proceeds in heated-air circulation oven and dried, dry
Temperature is 43 DEG C, time 3.5h, then using broken vibrations sieving machine by the phosphoric acid dried, citric acid, Fumaric acid, lactic acid, third
Acid, calcium formate pulverized, after sieving be obtained compound acidulant standby, wherein, phosphoric acid, citric acid, Fumaric acid, lactic acid, third
Granularity after acid, calcium formate are pulverized is more than 80 mesh；
(3) by weight 3：2：1 weighs Lactobacillus, shitosan and bacillus bifiduss, is sufficiently mixed, obtains active bacteria formulation；
(3) weigh by weight percentage cellulase, protease, amylase, seminase, glucanase, pectase and
Fructus Hordei Germinatus powder, is sufficiently mixed, and obtains compound enzymic preparation；
(4) dehulled soybean meal powder, high lactose whey powder and zeolite powder are pulverized respectively in advance, excessively 60 mesh sieves, and in mass ratio 6：2：1
Weigh dehulled soybean meal powder, high lactose whey powder and zeolite powder, be sufficiently mixed, obtain carrier；
(5) Radix Scutellariae powder of step (1) gained, root of Herba Houttuyniae powder, Radix Zanthoxyli powder, YANGKAIKOU are weighed by weight respectively
Powder, Caulis Spatholobi powder；The compound acidulant of step (2) gained；The active bacteria formulation of step (3) gained；The compound enzyme of step (4) gained
Preparation；The carrier of step (5) gained and astragalus polysaccharidess, are placed in three-dimensional motion mixer and are mixed, and incorporation time is
4.5min, obtains final product the Chinese medicine feed additive of alternative antibiotic.
Addition in animal basal diet for the Chinese medicine feed additive product of the present invention is 1800 g ton.
Embodiment 4：The Chinese medicine feed additive of the alternative antibiotic of the present invention controls curative effect to chicken infection Salmonella
Really
Method：Choose 1 age in days Sanhuang chicken 500 from Nanning City chicken farm, be randomly divided into 5 groups, every group 100.It is divided into
Matched group, the Chinese medicine feed additive 1-3 group of alternative antibiotic of embodiment 1-3 preparation, antibiotic group.With chicken source Salmonella
Bacterium C79-1 infect 1 time (feeding 0.1mL, about 108Viable bacteria), feed product of the present invention after 5h, the alternative antibiotic of each embodiment
Chinese medicine feed additive addition in feedstuff presses explanation in above-described embodiment 1-3；Antibiotic is erythromycin, and addition is by base
1800 g ton feedings in plinth daily ration.Continuous nursing 30 days.Statistics chicken death number, after death takes out spleen to not dead Ji Chu
And thymus, calculate index and spleen index and thymus index.
The test result to Salmonella infection chicken for the Chinese medicine feed additive of the alternative antibiotic of table 1 present invention
As shown in table 1, knowable to table 1 analysis, the Chinese medicine feed additive pair of the alternative antibiotic of embodiment 1-3 preparation
Caused by Salmonella, chicken infection all has good control action, no dead generation, and its Thymus and spleen index has relatively compareed significantly
Improve.Illustrate that the Chinese medicine feed additive of the alternative antibiotic of the present invention has the therapeutic effect of antibiotic and improves chicken immune
The effect of power.
Embodiment 5：The Chinese medicine feed additive of the alternative antibiotic of the present invention controls curative effect to pig ehec infection
Really
Method：Choose Luchuan pig 500 in 10-20 age in days from Nanning City pig farm, be randomly divided into 5 groups, every group 100
Head.Be grouped into matched group, embodiment 1-3 preparation alternative antibiotic Chinese medicine feed additive test 1-3 group, sulphuric acid card that
Mycin antibiotic group.Use escherichia coli O301Infection (feeding 5mL/ days, about 109Viable bacteria) 5 days, the alternative antibiotic of each test group
Chinese medicine feed additive in feedstuff addition press explanation in above-described embodiment 1-3；Antibiotic is kanamycin sulfate, is raising
In material, addition presses 1800 g ton of institute's feed material.Continuous use 3 days.Observe pig situation：Symptom disappearance, diet and spiritual shape
It is to cure that condition recovers normal；Diarrhoea status mitigation, appetite switch to well effective；Diarrhoea status do not mitigate or increase, appetite does not take a turn for the better
For invalid.
The therapeutic effect to coli-infection pig for the Chinese medicine feed additive of the alternative antibiotic of table 2 present invention
As shown in table 2, the Chinese medicine feed additive of the alternative antibiotic of embodiment 1-3 preparation is to pig caused by escherichia coli
Infection all has good control action, and obvious effective rate is 96-100%, and cure rate is 58-86%.Illustrate of the present invention alternative
The Chinese medicine feed additive of antibiotic has the vicarious function of antibiotic to pig ehec infection.
The description of the aforementioned specific illustrative embodiment to the present invention illustrate that and illustration purpose.These descriptions
It is not wishing to limit the invention to disclosed precise forms, and it will be apparent that according to above-mentioned teaching, can much be changed
And change.The purpose of selecting and describing the exemplary embodiment is that explaining that the certain principles of the present invention and its reality should
With so that those skilled in the art be capable of and utilize the present invention various different exemplary and
Various different selections and change.The scope of the present invention is intended to be limited by claims and its equivalents.
Claims (6)
1. a kind of Chinese medicine feed additive of alternative antibiotic is it is characterised in that by being made up of following components by weight：Yellow
A kind of reed mentioned in ancient books powder 5-9 part, root of Herba Houttuyniae powder 2-5 part, Radix Zanthoxyli powder 6-10 part, YANGKAIKOU powder 3-5 part, Caulis Spatholobi powder 3-6 part, compound acidifying
Agent 30-65 part, active bacteria formulation 15-25 part, astragalus polysaccharidess 3-6 part, compound enzymic preparation 3-5 part and carrier 11-16 part.
2. the Chinese medicine feed additive of alternative antibiotic according to claim 1 is it is characterised in that described Compound-acid
Agent consists of the following composition by weight percentage：30% phosphoric acid, 20% citric acid, 20% Fumaric acid, 15% lactic acid, 10%
Propanoic acid and 5% calcium formate.
3. the Chinese medicine feed additive of alternative antibiotic according to claim 1 is it is characterised in that described viable bacteria system
Agent includes following composition：1.0×108-1.0×109The Lactobacillus of CFU/g, 1.0 × 108-1.0×109The shell of CFU/g gathers
Sugar, 1.0 × 108-1.0×109The bacillus bifiduss of CFU/g, the weight of Lactobacillus, shitosan and bacillus bifiduss is than for 3：2：
1.
4. the Chinese medicine feed additive of alternative antibiotic according to claim 1 is it is characterised in that described compound enzyme
Preparation is by weight percentage by 25% cellulase, 10% protease, 10% amylase, 10% seminase, 20% glucosan
Enzyme, 5% pectase, remaining is Fructus Hordei Germinatus powder.
5. alternative antibiotic according to claim 1 Chinese medicine feed additive it is characterised in that described carrier by
Dehulled soybean meal powder, high lactose whey powder and zeolite powder composition, the mass ratio 6 of dehulled soybean meal powder, high lactose whey powder and zeolite powder：
2：1, dehulled soybean meal powder, high lactose whey powder and zeolite powder pulverized 60 mesh sieves in advance.
6. the preparation method of the Chinese medicine feed additive according to the arbitrary described alternative antibiotic of claim 1-5, its feature
It is, comprise the steps：
(1) respectively Radix Scutellariae, root of Herba Houttuyniae, Radix Zanthoxyli, YANGKAIKOU, Caulis Spatholobi roguing, chopping are processed, then use 70-80% second
Alcohol extracts, and extraction time 2-3h, temperature 70-80 DEG C, solvent materials compare 7-9：1, concentrate, more spray dried 80 mesh sieves, obtain yellow
A kind of reed mentioned in ancient books powder, root of Herba Houttuyniae powder, Radix Zanthoxyli powder, YANGKAIKOU powder, Caulis Spatholobi powder；
(2) weigh phosphoric acid, citric acid, Fumaric acid, lactic acid, propanoic acid, calcium formate by weight percentage, mixed using Double helix taper
Conjunction machine mixing 7-10min, puts into after being sufficiently mixed uniformly in baking car pallet, proceeds in heated-air circulation oven and dried, dry
Temperature is 40-45 DEG C, time 3-4h, then using broken vibrations sieving machine by the phosphoric acid dried, citric acid, Fumaric acid, lactic acid,
Propanoic acid, calcium formate are pulverized, after sieving be obtained compound acidulant standby, wherein, phosphoric acid, citric acid, Fumaric acid, lactic acid,
Granularity after propanoic acid, calcium formate are pulverized is more than 80 mesh；
(3) by weight 3：2：1 weighs Lactobacillus, shitosan and bacillus bifiduss, is sufficiently mixed, obtains active bacteria formulation；
(3) cellulase, protease, amylase, seminase, glucanase, pectase and Fructus Hordei Germinatus are weighed by weight percentage
Powder, is sufficiently mixed, and obtains compound enzymic preparation；
(4) dehulled soybean meal powder, high lactose whey powder and zeolite powder are pulverized respectively in advance, excessively 60 mesh sieves, and in mass ratio 6：2：1 weighs
Dehulled soybean meal powder, high lactose whey powder and zeolite powder, are sufficiently mixed, obtain carrier；
(5) Radix Scutellariae powder of step (1) gained, root of Herba Houttuyniae powder, Radix Zanthoxyli powder, YANGKAIKOU powder, chicken are weighed by weight respectively
Caulis seu Radix Schisandrae Henryi powder；The compound acidulant of step (2) gained；The active bacteria formulation of step (3) gained；The compound enzymic preparation of step (4) gained；
The carrier of step (5) gained and astragalus polysaccharidess, are placed in three-dimensional motion mixer and are mixed, and incorporation time is 4-5min,
Obtain final product the Chinese medicine feed additive of alternative antibiotic.
Priority Applications (1)
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| CN201610841963.3A CN106387349A (en) | 2016-09-22 | 2016-09-22 | Traditional Chinese medicinal feed additive for replacing antibiotics |
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| CN201610841963.3A CN106387349A (en) | 2016-09-22 | 2016-09-22 | Traditional Chinese medicinal feed additive for replacing antibiotics |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111802512A (en) * | 2020-07-30 | 2020-10-23 | 曹东 | Traditional Chinese medicine type biological feed additive and preparation method thereof |
| CN115160448A (en) * | 2022-07-07 | 2022-10-11 | 溯玄(上海)生物技术有限公司 | Hierarchical polysaccharide and application of whitening and skin-whitening cosmetics |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104000014A (en) * | 2014-05-19 | 2014-08-27 | 华南理工大学 | Feed additive capable of replacing antibiotics as well as preparation method and application of feed additive |
| CN104431337A (en) * | 2014-12-31 | 2015-03-25 | 曲靖双胞胎饲料有限公司 | Pig feed additive promoting growth and improving immunity |
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2016
- 2016-09-22 CN CN201610841963.3A patent/CN106387349A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104000014A (en) * | 2014-05-19 | 2014-08-27 | 华南理工大学 | Feed additive capable of replacing antibiotics as well as preparation method and application of feed additive |
| CN104431337A (en) * | 2014-12-31 | 2015-03-25 | 曲靖双胞胎饲料有限公司 | Pig feed additive promoting growth and improving immunity |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111802512A (en) * | 2020-07-30 | 2020-10-23 | 曹东 | Traditional Chinese medicine type biological feed additive and preparation method thereof |
| CN115160448A (en) * | 2022-07-07 | 2022-10-11 | 溯玄(上海)生物技术有限公司 | Hierarchical polysaccharide and application of whitening and skin-whitening cosmetics |
| CN115160448B (en) * | 2022-07-07 | 2023-08-25 | 广州梵之容化妆品有限公司 | Graded polysaccharide and application thereof in whitening and preparing whitening cosmetics |
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Application publication date: 20170215 |