CN106380502A - G蛋白偶联受体5(tgr5)调节剂及其使用方法 - Google Patents
G蛋白偶联受体5(tgr5)调节剂及其使用方法 Download PDFInfo
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Classifications
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- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08169460.6 | 2008-11-19 | ||
| EP08169460 | 2008-11-19 | ||
| CN200980154703.7A CN102282157B (zh) | 2008-11-19 | 2009-11-19 | G蛋白偶联受体5(tgr5)调节剂及其使用方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980154703.7A Division CN102282157B (zh) | 2008-11-19 | 2009-11-19 | G蛋白偶联受体5(tgr5)调节剂及其使用方法 |
Publications (1)
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|---|---|
| CN106380502A true CN106380502A (zh) | 2017-02-08 |
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| CN201610680498.XA Pending CN106380502A (zh) | 2008-11-19 | 2009-11-19 | G蛋白偶联受体5(tgr5)调节剂及其使用方法 |
| CN200980154703.7A Expired - Fee Related CN102282157B (zh) | 2008-11-19 | 2009-11-19 | G蛋白偶联受体5(tgr5)调节剂及其使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980154703.7A Expired - Fee Related CN102282157B (zh) | 2008-11-19 | 2009-11-19 | G蛋白偶联受体5(tgr5)调节剂及其使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8999964B2 (https=) |
| EP (2) | EP3150620B1 (https=) |
| JP (1) | JP5639073B2 (https=) |
| CN (2) | CN106380502A (https=) |
| AU (1) | AU2009316484B2 (https=) |
| BR (1) | BRPI0921992B1 (https=) |
| CA (1) | CA2744135C (https=) |
| ES (2) | ES2774368T3 (https=) |
| IL (1) | IL212970A (https=) |
| WO (1) | WO2010059859A1 (https=) |
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| CA2798610A1 (en) | 2010-05-06 | 2011-11-10 | Bristol-Myers Squibb Company | Bicyclic heteroaryl compounds as gpr119 modulators |
| WO2012149236A1 (en) | 2011-04-28 | 2012-11-01 | Bristol-Myers Squibb Company | Novel bicyclic nitrogen containing heteroaryl tgr5 receptor modulators |
| SG11201503247UA (en) * | 2012-10-26 | 2015-06-29 | Intercept Pharmaceuticals Inc | Process for preparing bile acid derivatives |
| AU2013352288B2 (en) * | 2012-11-28 | 2017-11-23 | Intercept Pharmaceuticals, Inc. | Treatment of pulmonary disease |
| WO2014200349A1 (en) | 2013-06-13 | 2014-12-18 | Fast Forward Pharmaceutical B.V. | Cd40 signalling inhibitor and a further compound, wherein the further compound is a bile acid, a bile acid derivative, an tgr5-receptor agonist, an fxr agonist or a combination thereof, for the treatment of chronic inflammation, and the prevention of gastrointestinal cancer or fibrosis. |
| SMT202000070T1 (it) * | 2014-05-29 | 2020-03-13 | Bar Pharmaceuticals S R L | Derivati del colano per l'uso del trattamento e/o la prevenzione di malattie mediate da fxr e tgr5/gpbar1 |
| KR102546748B1 (ko) * | 2014-11-19 | 2023-06-22 | 엔제트피 유케이 리미티드 | 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-3,7-다이온 스테로이드 |
| CN107207559B (zh) * | 2014-11-19 | 2019-10-25 | Nzp英国有限公司 | 作为制备类固醇fxr调节剂的中间体的6-烷基-7-羟基-4-烯-3-酮类固醇 |
| KR102527821B1 (ko) * | 2014-11-19 | 2023-05-02 | 엔제트피 유케이 리미티드 | 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-6,7-다이온 스테로이드 |
| EA033445B1 (ru) * | 2014-11-19 | 2019-10-31 | Nzp Uk Ltd | 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr |
| EP3223823A4 (en) * | 2014-11-26 | 2018-10-17 | Enanta Pharmaceuticals, Inc. | Bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
| CN105348365A (zh) * | 2014-12-03 | 2016-02-24 | 四川百利药业有限责任公司 | 一种胆酸衍生物及其制备方法、药物组合物和用途 |
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| KR101555716B1 (ko) * | 2007-01-19 | 2015-09-25 | 인터셉트 파마슈티컬즈, 인크. | Ｔｇｒ5 조절제로서의 23-치환 담즙산 및 이의 사용 방법 |
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| JP5639073B2 (ja) | 2014-12-10 |
| ES2592452T3 (es) | 2016-11-30 |
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| EP3150620A1 (en) | 2017-04-05 |
| ES2774368T3 (es) | 2020-07-20 |
| CA2744135C (en) | 2017-07-04 |
| BRPI0921992A2 (pt) | 2018-06-05 |
| IL212970A (en) | 2017-07-31 |
| JP2012509349A (ja) | 2012-04-19 |
| US20110263555A1 (en) | 2011-10-27 |
| AU2009316484B2 (en) | 2015-04-16 |
| US8999964B2 (en) | 2015-04-07 |
| CN102282157B (zh) | 2017-02-22 |
| AU2009316484A1 (en) | 2010-05-27 |
| CA2744135A1 (en) | 2010-05-27 |
| CN102282157A (zh) | 2011-12-14 |
| EP3150620B1 (en) | 2020-01-08 |
| EP2373673B1 (en) | 2016-07-27 |
| WO2010059859A1 (en) | 2010-05-27 |
| BRPI0921992B1 (pt) | 2021-12-14 |
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