CN106377584A - Burn gel for smearing - Google Patents
Burn gel for smearing Download PDFInfo
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- CN106377584A CN106377584A CN201610814693.7A CN201610814693A CN106377584A CN 106377584 A CN106377584 A CN 106377584A CN 201610814693 A CN201610814693 A CN 201610814693A CN 106377584 A CN106377584 A CN 106377584A
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- purified water
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- mixture
- meal
- water
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides burn gel for smearing. A formula comprises the following components of rhizoma polygoni cuspidati coarse powder, rhizoma coptidis coarse powder, borneol, glycerin, potassium sorbate, hydroxypropyl methyl cellulose and purified water. A method for preparing the burn gel for the smearing comprises the following steps of extracting a liquid medicine from the rhizoma polygoni cuspidati coarse powder and the rhizoma coptidis coarse powder by adopting water-bath reflux equipment, filtering out dregs, carrying out vacuum concentration on the liquid medicine, filtering out impurities, adding 58 percent of the purified water in the components into the liquid medicine, and uniformly concocting an obtained first mixture; adding the potassium sorbate into an extracting solution from which the impurities are filtered out to dissolve the potassium sorbate, so as to obtain a phase I; taking and mixing the hydroxypropyl methyl cellulose with the glycerin uniformly, adding an obtained second mixture into 38 percent of the purified water in the components to dissolve the obtained second mixture, and making an obtained third mixture stand for 12 hours, so as to obtain a phase II; heating the phase I to 50 DEG C, then adding the phase I into the phase II, uniformly agitating an obtained fourth mixture, adding borneol fine powder into the agitated fourth mixture, finally, adding the rest of the purified water in the components into an obtained fifth mixture, agitating uniformly and cooling an obtained sixth mixture so as to obtain the burn gel. When in use, the burn gel for the smearing is smeared at an affected part twice a day, has no side effects, has the effects of detoxifying, deswelling, reducing the generation of scars and reliving pain, and is used for promoting the quick healing of a wound surface.
Description
Technical field
The present invention relates to medicine is smeared in a kind of external application treating burn, specifically one kind is smeared and is used burn gel.
Background technology
In daily life and work, inevitably occur that burn and scald is unexpected, burn and scald can be to the skin of body local
Skin, or even entirely body damages.High temperature can make skin surface be destroyed, and the surface of a wound is typically difficult to quick reparation and local
Cusalgia sense can bring very big misery directly to patient.All of burn is required for the external curing of local, wherein various curative effects
Significant Chinese medicine proved recipe is made into multiple external preparations and clinically widely uses, and has played important function in burn treating.
Clinically relatively conventional Chinese medicine external treatment burn method is directly to be smeared with tincture, decoction etc., but these tradition smear medicine
Thing such as tincture is easy to volatilization it is necessary to repeatedly smear, and easily stimulates neoplastic skin, increases patient suffering and easily leaves scar.
Content of the invention
It is an object of the invention to solving many deficiencies that above-mentioned Chinese medicine tradition smears medicine presence, one kind is provided to smear use
Burn gel, mobility quality is uniformly semi-solid in order to have for its proterties, and gel can be formed to the surface of a wound after tending to smear out and smearing
Gluey covering, local administration easily easily absorbs.
The present invention includes extracting liquid with water-bath refluxing unit, and the technical scheme being adopted is：Formulation weight ratio is as follows：
Giant knotweed meal 4.3%～4.8%, coptis meal 2.9%～3.2%, borneol 2.3%～2.5%, glycerine 14%～
14.4%th, potassium sorbate 0.26%～0.3%, hydroxypropyl methyl cellulose 3.44%～3.6%, purified water 71.2%～
72.8%,
Preparation method is as follows：
Step 1, giant knotweed meal and coptis meal are adopted water-bath refluxing unit extract after liquid, filter bits while hot, then
It is evaporated to no after alcohol taste with conventional pressure relief method for concentration, filters impurity, add purified water gross weight 58% in component
Purified water mix homogenously；
Step 2, by the above-mentioned extract filtering after impurity add potassium sorbate so as to dissolving, obtain phase I；
Step 3, take hydroxypropyl methyl cellulose to mix with glycerine, add purified water gross weight 38% in component
Purify water dissolves, stand 12 hours, obtain phase II；
Step 4, phase I of step 2 gained is heated to being slowly added to phase II of step 3 gained after 50 DEG C, stirs, then
Borneol and grinding is become fine powder to be added thereto, finally purified water remaining in component is added, be finally evenly stirred until that cooling obtains final product burning
Hinder gel.
In technique scheme：The solvent used in water-bath refluxing extraction equipment in preparation method step 1 is 65%
The ethanol of concentration, the consumption of ethanol is 10 times of giant knotweed meal and coptis meal gross weight.
The temperature that in preparation method step 1, water-bath refluxing extraction equipment adopts is 70 DEG C, and each extraction time is little for 1.5
When, extraction time is 3 times.
Compared with the Chinese medicine external medicine that the present invention is burnt with common treatment, there is significant advantage effect, this method is by three
Plant the Chinese medicine that all there is obvious therapeutic effect to burn and carry out science combination, and extracted using the extracting method of science, special
It is not to add borneol group material in formula, obvious analgesic effect can be played, be prepared into the uniform semisolid of mobility of slightly having
Affected part treatment burn smeared by gel.During use, only need to be applied directly to affected part twice daily, after smearing can on the surface of a wound shape
Become layer protecting film, both intercepted the invasion of outer germs, and medicine can have been allowed again not volatile and act on affected part, no any after smearing
Side effect, and stimulation will not be produced to neoplastic skin, can reach heat clearing and inflammation relieving, removing toxicity for detumescence, the effect of convergence pain relieving, to the surface of a wound
Play the effect of good quick reparation, thus solve many defects that existing burn smears medicine presence, have fabulous
Burn treating acts on.
Specific embodiment：
Embodiment 1：
Formulation weight ratio is as follows：
Giant knotweed meal 4.3%, coptis meal 2.9%, borneol 2.3%, glycerine 14%, potassium sorbate 0.26%, hydroxypropyl
Methylcellulose 3.44%, purified water 72.8%,
Preparation method is as follows：
Step 1, giant knotweed meal and coptis meal are adopted water-bath refluxing unit extract after liquid, filter bits while hot, then
It is evaporated to no after alcohol taste with conventional pressure relief method for concentration, filters impurity, add purified water gross weight 58% in component
Purified water mix homogenously；
Step 2, by the above-mentioned extract filtering after impurity add potassium sorbate so as to dissolving, obtain phase I；
Step 3, take hydroxypropyl methyl cellulose to mix with glycerine, add purified water gross weight 38% in component
Purify water dissolves, stand 12 hours, obtain phase II；
Step 4, phase I of step 2 gained is heated to being slowly added to phase II of step 3 gained after 50 DEG C, stirs, then
Borneol and grinding is become fine powder to be added thereto, finally purified water remaining in component is added, be finally evenly stirred until that cooling obtains final product burning
Hinder gel.
The solvent used in water-bath refluxing extraction equipment in preparation method step 1 is the ethanol of 65% concentration, ethanol
Consumption be 10 times of giant knotweed meal and coptis meal gross weight.
The temperature that in preparation method step 1, water-bath refluxing extraction equipment adopts is 70 DEG C, and each extraction time is little for 1.5
When, extraction time is 3 times.
Embodiment 2：
Formulation weight ratio is as follows：
Giant knotweed meal 4.5%, coptis meal 3%, borneol 2.4%, glycerine 14.2%, potassium sorbate 0.28%, hydroxypropyl
Methylcellulose 3.52%, purified water 72.1%,
Preparation method is as follows：
Step 1, giant knotweed meal and coptis meal are adopted water-bath refluxing unit extract after liquid, filter bits while hot, then
It is evaporated to no after alcohol taste with conventional pressure relief method for concentration, filters impurity, add purified water gross weight 58% in component
Purified water mix homogenously；
Step 2, by the above-mentioned extract filtering after impurity add potassium sorbate so as to dissolving, obtain phase I；
Step 3, take hydroxypropyl methyl cellulose to mix with glycerine, add purified water gross weight 38% in component
Purify water dissolves, stand 12 hours, obtain phase II；
Step 4, phase I of step 2 gained is heated to being slowly added to phase II of step 3 gained after 50 DEG C, stirs, then
Borneol and grinding is become fine powder to be added thereto, finally purified water remaining in component is added, be finally evenly stirred until that cooling obtains final product burning
Hinder gel.
The solvent used in water-bath refluxing extraction equipment in preparation method step 1 is the ethanol of 65% concentration, ethanol
Consumption be 10 times of giant knotweed meal and coptis meal gross weight.
The temperature that in preparation method step 1, water-bath refluxing extraction equipment adopts is 70 DEG C, and each extraction time is little for 1.5
When, extraction time is 3 times.
Embodiment 3：
Formulation weight ratio is as follows：
Giant knotweed meal 4.8%, coptis meal 3.2%, borneol 2.5%, glycerine 14.4%, potassium sorbate 0.3%, hydroxypropyl
Methylcellulose 3.6%, purified water 71.2%,
Preparation method is as follows：
Step 1, giant knotweed meal and coptis meal are adopted water-bath refluxing unit extract after liquid, filter bits while hot, then
It is evaporated to no after alcohol taste with conventional pressure relief method for concentration, filters impurity, add purified water gross weight 58% in component
Purified water mix homogenously；
Step 2, by the above-mentioned extract filtering after impurity add potassium sorbate so as to dissolving, obtain phase I；
Step 3, take hydroxypropyl methyl cellulose to mix with glycerine, add purified water gross weight 38% in component
Purify water dissolves, stand 12 hours, obtain phase II；
Step 4, phase I of step 2 gained is heated to being slowly added to phase II of step 3 gained after 50 DEG C, stirs, then
Borneol and grinding is become fine powder to be added thereto, finally purified water remaining in component is added, be finally evenly stirred until that cooling obtains final product burning
Hinder gel.
The solvent used in water-bath refluxing extraction equipment in preparation method step 1 is the ethanol of 65% concentration, ethanol
Consumption be 10 times of giant knotweed meal and coptis meal gross weight.
The temperature that in preparation method step 1, water-bath refluxing extraction equipment adopts is 70 DEG C, and each extraction time is little for 1.5
When, extraction time is 3 times.
This method has made simple paper by the present inventor in 2015, but in paper component and specific method and step with
Present specification is different, specially：Add borneol in this formula, expect scientific matching and reasonable preparation with other groups, can
Burn gel is allowed significantly to have analgesic effect, this is that the applicant did clinical for several times and drug study acquisition achievement later.
In the technical program, involved giant knotweed has astringing to arrest bleeding to burn wound, reduces the effect that scar produces,
The coptis has an anti-inflammatory, antibacterial anti-inflammatory, clearing heat and detoxicating effect, and borneol can play analgesic effect in burn early stage to the surface of a wound, and the later stage makes
With the prodding and itching feeling of neoplastic skin can be alleviated.
Claims (3)
1. one kind is smeared and is used burn gel, including with water-bath refluxing unit extract liquid it is characterised in that：
Formulation weight ratio is as follows：
Giant knotweed meal 4.3%～4.8%, coptis meal 2.9%～3.2%, borneol 2.3%～2.5%, glycerine 14%～
14.4%th, potassium sorbate 0.26%～0.3%, hydroxypropyl methyl cellulose 3.44%～3.6%, purified water 71.2%～
72.8%,
Preparation method is as follows：
Step 1, giant knotweed meal and coptis meal are adopted water-bath refluxing unit extract after liquid, filter bits while hot, then with biography
System reduced pressure concentration method is evaporated to no after alcohol taste, filters impurity, adds the purifying of the purified water gross weight 58% in component
Water concocting is uniform；
Step 2, by the above-mentioned extract filtering after impurity add potassium sorbate so as to dissolving, obtain phase I；
Step 3, take hydroxypropyl methyl cellulose to mix with glycerine, add the purifying of the purified water gross weight 38% in component
Water dissolves, stand 12 hours, obtain phase II；
Step 4, phase I of step 2 gained is heated to being slowly added to phase II of step 3 gained after 50 DEG C, stirs, then by ice
Slice lapping becomes fine powder to be added thereto, and finally adds purified water remaining in component, is finally evenly stirred until that cooling obtains final product burn solidifying
Glue.
2. according to claim 1 smear with burn gel it is characterised in that：Water-bath backflow in preparation method step 1
Solvent used in extraction equipment is the ethanol of 65% concentration, and the consumption of ethanol is giant knotweed meal and coptis meal gross weight
10 times.
3. according to claim 1 smear with burn gel it is characterised in that：In preparation method step 1, water-bath backflow carries
The temperature that taking equipment adopts is 70 DEG C, and each extraction time is 1.5 hours, and extraction time is 3 times.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610814693.7A CN106377584A (en) | 2016-08-31 | 2016-08-31 | Burn gel for smearing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610814693.7A CN106377584A (en) | 2016-08-31 | 2016-08-31 | Burn gel for smearing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106377584A true CN106377584A (en) | 2017-02-08 |
Family
ID=57935456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610814693.7A Pending CN106377584A (en) | 2016-08-31 | 2016-08-31 | Burn gel for smearing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106377584A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106963808A (en) * | 2017-05-26 | 2017-07-21 | 威海美迪森医疗器械有限公司 | A kind of burn-scald medicine compositions and its preparation method and application |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230439A (en) * | 2013-04-28 | 2013-08-07 | 华南理工大学 | Elegant jessamine sustained-release membrane and preparation method thereof |
| CN103251679A (en) * | 2013-05-16 | 2013-08-21 | 施敬东 | Refreshing massage gel and preparation method thereof |
| CN104013729A (en) * | 2014-06-20 | 2014-09-03 | 安徽安科余良卿药业有限公司 | Arthralgia relieving gel and preparation method thereof |
| CN105213298A (en) * | 2015-10-16 | 2016-01-06 | 天津榕丰科技有限公司 | A kind of oral care gels and preparation method thereof |
-
2016
- 2016-08-31 CN CN201610814693.7A patent/CN106377584A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230439A (en) * | 2013-04-28 | 2013-08-07 | 华南理工大学 | Elegant jessamine sustained-release membrane and preparation method thereof |
| CN103251679A (en) * | 2013-05-16 | 2013-08-21 | 施敬东 | Refreshing massage gel and preparation method thereof |
| CN104013729A (en) * | 2014-06-20 | 2014-09-03 | 安徽安科余良卿药业有限公司 | Arthralgia relieving gel and preparation method thereof |
| CN105213298A (en) * | 2015-10-16 | 2016-01-06 | 天津榕丰科技有限公司 | A kind of oral care gels and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 侯桂芝等: ""冰片对激光烧伤创面的镇痛及抗炎作用"", 《中国药学杂志》 * |
| 杨君等: ""虎黄烧伤凝胶剂的制备及质量控制"", 《中国医药导报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106963808A (en) * | 2017-05-26 | 2017-07-21 | 威海美迪森医疗器械有限公司 | A kind of burn-scald medicine compositions and its preparation method and application |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170208 |
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| RJ01 | Rejection of invention patent application after publication |