CN106377453B - Morinda citrifolia extract emulsion and preparation method and application thereof - Google Patents

Morinda citrifolia extract emulsion and preparation method and application thereof Download PDF

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CN106377453B
CN106377453B CN201610781630.6A CN201610781630A CN106377453B CN 106377453 B CN106377453 B CN 106377453B CN 201610781630 A CN201610781630 A CN 201610781630A CN 106377453 B CN106377453 B CN 106377453B
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noni
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extract emulsion
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郑超
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Hainan Normal University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

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Abstract

The invention provides noni extract emulsion and a preparation method and application thereof, and the noni extract emulsion comprises, by weight, 0.1-15% of noni extract, 1-15% of surfactant, 0.1-2% of ethanol and the balance of water. The noni extract emulsion is obtained by the following steps: adding fresh noni fruit into ethanol water solution containing surfactant, stirring, extracting completely, and filtering to obtain noni fruit extract emulsion. The invention also provides application of the noni extract emulsion in preparing cosmetics or skin care products, and the noni extract emulsion has strong free radical clearing capability and good whitening and skin care effects.

Description

Morinda citrifolia extract emulsion and preparation method and application thereof
Technical Field
The invention relates to the technical field of cosmetics or skin care products, in particular to noni extract emulsion, a preparation method thereof and application thereof in cosmetics or skin care products.
Background
Noni (Noni), also known as morinda citrifolia, FOLIUM JAPONICA, and the like, belongs to the genus Morinda of the family Rubiaceae. The plant is mainly distributed in islands of the south pacific, such as the philippines, australia, etc. At present, China is mainly distributed in heat zone areas such as Hainan area, Xisha islands and the like, and large-scale planting is carried out. Noni has strong functional characteristics, and roots, stems, leaves, flowers and fruits can be used as medicines. Yellow or red dye is obtained from root for dyeing clothes, and the fruit is edible and used as food-grade health product. Noni has been used as a food or pharmaceutical product for over 2000 years by the boysenia in the islands of the south pacific ocean. Noni has attracted the attention of food and drug researchers as a new medicinal plant in the world, and about 200 compounds mainly comprising anthraquinone, flavone, coumarin, glucoside, triterpenes and the like are separated and identified from noni, wherein the effective active ingredients of the noni are scopolia, rutin, ursolic acid and tannin. Furthermore, noni is rich in unsaturated fatty acids, vitamins, minerals, antioxidants, rare elements and proxeronine, Xeronine converting enzyme, etc. Noni has stronger antioxidant function, and the antioxidant capacity of noni is stronger than that of common antioxidants, including vitamin C, grape seed powder, pycnogenol and the like. Currently, the research on the biological activity of noni mainly focuses on the antibacterial, tumor prevention, free radical removal, oxidation resistance and other functional characteristics. The antioxidant effect of the noni is higher than that of a large number of antioxidants, the noni is even higher than that of grape seeds by 30 percent, the noni can effectively eliminate free radicals and enhance the function of the immune system, and amino acids, vitamins, trace elements and sugar esters in the noni can regulate the immune system of the organism, resist diseases and prevent infection. Because of its unique functional properties, noni is now one of the best-selling health products worldwide, the demand for noni in the market is increasing at a rate of 50% per year, and the government is also increasing the development and development of noni. Through retrieval, the application of the noni extract emulsion in whitening cosmetics or skin care products is not reported.
Disclosure of Invention
Therefore, the invention aims to provide a noni extract emulsion, a preparation method thereof and application of the noni extract emulsion in cosmetics or skin care products.
The technical scheme of the invention is realized as follows:
a noni extract emulsion comprises, by weight, 0.1-15% of noni extract, 1-15% of surfactant, 0.1-2% of ethanol, and the balance water.
Further, the surfactant includes an ionic surfactant and a nonionic surfactant.
Further, the ionic surfactant comprises at least one of sodium dodecyl benzene sulfonate, octadecyl trimethyl ammonium chloride, hexadecyl trimethyl ammonium chloride or distearyl hydroxyethyl methyl ammonium methyl sulfate.
Further, the nonionic surfactant comprises at least one of coconut fatty acid monoethanolamide, coconut fatty acid diethanolamide, C8-12 alkyl glycoside, C12-16 alkyl glycoside or C10-14 alkyl glycoside.
A preparation method of noni fruit extract emulsion comprises the following steps:
adding fresh noni fruit into ethanol water solution containing surfactant, stirring, extracting completely, and filtering to obtain noni fruit extract emulsion.
Furthermore, the addition amount of the noni is 150-200 g and the addition amount of the surfactant is 4-10 g in each 100mL of ethanol aqueous solution.
Furthermore, the mass fraction of ethanol in the ethanol water solution is 10-75%.
Further, the stirring speed is 250-350 r/min, the stirring temperature is 70-80 ℃, and the stirring time is 1-10 hours.
Further, filtering by using a 100-400-mesh sieve.
The invention also provides application of the noni extract emulsion in preparing cosmetics or skin care products.
Compared with the prior art, the invention has the beneficial effects that:
the preparation process of the noni extract emulsion provided by the invention is simple to operate, the formed emulsion has a protection effect on components with whitening and skin-care functions in noni, so that the components are not easily oxidized, and the obtained emulsion can be directly applied to whitening and skin-care in the cosmetic industry, so that the intermediate steps are simplified, therefore, the preparation process is more efficient, practical and environment-friendly, and the cost is correspondingly reduced. The noni extract emulsion obtained by the invention has good improvement effect on the aspect of skin whitening and nursing.
Detailed Description
For clear and complete description of the technical solutions in the present invention, it is obvious that the inventor combines the embodiments to describe, but the following embodiments describe only some embodiments of the present invention, not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A noni extract emulsion is obtained by the following steps: dissolving 2g of octadecyl trimethyl ammonium chloride and 2.2g of coconut oil fatty acid monoethanolamide in 100mL of ethanol water solution, wherein the mass fraction of ethanol is 10%; chopping 180g of fresh noni fruits, adding the chopped noni fruits into the ethanol water solution, stirring at the stirring speed of 250r/min and the stirring temperature of 70 ℃ for 1h, standing for 3h, fully extracting, and filtering through a 100-400-mesh sieve to obtain the noni fruit extract emulsion 1.
Example 2
A noni extract emulsion is obtained by the following steps: dissolving 1g of hexadecyl trimethyl ammonium chloride and 4.4g of coconut oil fatty acid diethanol amide in 100mL of ethanol water solution, wherein the mass fraction of ethanol is 35%; chopping 180g of fresh noni fruits, adding the chopped noni fruits into the ethanol water solution, stirring at the stirring speed of 300r/min and the stirring temperature of 75 ℃ for 8 hours, standing for 2 hours, fully extracting, and filtering through a 100-400-mesh sieve to obtain the noni fruit extract emulsion 2.
Example 3
A noni extract emulsion is obtained by the following steps: 4g of distearyl hydroxyethyl methyl ammonium sulfate and 1g C8-12 alkyl glucoside are dissolved in 100mL of ethanol water solution, and the mass fraction of ethanol is 70%; chopping 180g of fresh noni fruits, adding the chopped noni fruits into the ethanol water solution, stirring at the stirring speed of 350r/min and the stirring temperature of 78 for 5 hours, standing for 2 hours, fully extracting, and filtering through a 100-400-mesh sieve to obtain the noni fruit extract emulsion 3.
Example 4
A noni extract emulsion is obtained by the following steps: dissolving 3.8g of sodium dodecyl benzene sulfonate and 4.4g C10-14 alkyl glycoside in 100mL of ethanol water solution, wherein the mass fraction of ethanol is 20%; chopping 180g of fresh noni fruits, adding into the ethanol water solution, stirring at the stirring speed of 250r/min and the stirring temperature of 80 ℃ for 10h, standing for 1h, fully extracting, and filtering through a 100-400-mesh sieve to obtain the noni fruit extract emulsion 4.
Example 5
A noni extract emulsion is obtained by the following steps: dissolving 3.8g of sodium dodecyl benzene sulfonate and 4.4g C10-14 alkyl glycoside in 100mL of ethanol water solution, wherein the mass fraction of ethanol is 20%; chopping 150g of fresh noni fruits, adding into the ethanol water solution, stirring at the stirring speed of 250r/min and the stirring temperature of 80 ℃ for 10h, standing for 1h, fully extracting, and filtering through a 100-400-mesh sieve to obtain the noni fruit extract emulsion 5.
Example 6
A noni extract emulsion is obtained by the following steps: dissolving 3.8g of sodium dodecyl benzene sulfonate and 4.4g C10-14 alkyl glycoside in 100mL of ethanol water solution, wherein the mass fraction of ethanol is 20%; cutting 200g of fresh noni fruits, adding the cut noni fruits into the ethanol water solution, stirring at the stirring speed of 250r/min and the stirring temperature of 80 ℃ for 10 hours, standing for 1 hour, fully extracting, and filtering through a 100-400-mesh sieve to obtain the noni fruit extract emulsion 6.
Example 7
A noni extract emulsion is obtained by the following steps: 2g of sodium dodecyl benzene sulfonate and 2g C10-14 alkyl glycoside are dissolved in 100mL of ethanol water solution, wherein the mass fraction of ethanol is 20%; chopping 180g of fresh noni fruits, adding the chopped noni fruits into the ethanol water solution, stirring at the stirring speed of 250r/min and the stirring temperature of 80 ℃ for 10 hours, standing for 1 hour, fully extracting, and filtering through a 100-400-mesh sieve to obtain the noni fruit extract emulsion 7.
Example 8
A noni extract emulsion is obtained by the following steps: dissolving 5g of sodium dodecyl benzene sulfonate and 5g C10-14 alkyl glucoside in 100mL of ethanol water solution, wherein the mass fraction of ethanol is 20%; chopping 180g of fresh noni fruits, adding into the ethanol water solution, stirring at the stirring speed of 250r/min and the stirring temperature of 80 ℃ for 10h, standing for 1h, fully extracting, and filtering through a 100-400-mesh sieve to obtain the noni fruit extract emulsion 8.
Comparative example 1
A noni extract emulsion is obtained by the following steps: dissolving 3.8g of sodium dodecyl benzene sulfonate and 4.4g C10-14 alkyl glycoside in 100mL of ethanol water solution, wherein the mass fraction of ethanol is 20%; chopping 220g of fresh noni fruits, adding the chopped noni fruits into the ethanol water solution, stirring at the stirring speed of 250r/min and the stirring temperature of 80 ℃ for 10 hours, standing for 1 hour, fully extracting, and filtering through a 100-400-mesh sieve to obtain the noni fruit extract emulsion 9.
The components of the noni extract emulsions obtained in examples 1 to 8 and comparative example 1 are shown in table 1:
TABLE 1
Figure BDA0001106433840000051
The noni fruit extract emulsion components obtained in examples 1 to 4 show that the ethanol content in the emulsion is significantly increased when the stirring temperature is lower than the boiling point of ethanol (78.3 ℃), the ethanol content in the emulsion is significantly decreased when the stirring temperature is higher than the boiling point of ethanol, and the extraction rate of the noni fruit raw material in example 4 is higher. The emulsion components of the noni fruit extracts obtained in examples 4 to 6 and comparative example 1 show that the content of the noni fruit extract in the emulsion increases with the addition amount of the noni fruit raw material.
ABTS free radical scavenging Capacity assay
ABTS was used in this experiment to determine the free radical clearance. Preparing a mixed solution of ABTS with the concentration of 7mmol/L and potassium persulfate with the concentration of 2.45mmol/L, standing for 10-16 h at room temperature in a dark place, and diluting with water to ensure that the light absorption value of the mixed solution at 734nm is 0.7 +/-0.02 (marked as A)0) Adding 1mL of the samples of examples 1 to 8 and comparative example 1 and 1.5mL of ABTS working solution into an ABTS working solution test tube; the blank group uses distilled water to replace the sample solution; the control group used distilled water instead of ABTS working solution. The above groups were left at room temperature in the dark for 1h, and the absorbance (denoted as A) was measured at 734nm, with ascorbic acid as a positive control.
Clearance (%) ═ a0-A)/A0*100％。
The results of determination of the clearance in the ABTS radical scavenging ability assay of the emulsions obtained in examples 1 to 8 and comparative example 1 are shown in table 3:
TABLE 3
Figure BDA0001106433840000061
As can be seen from the graphs, the emulsions obtained in examples 1 to 8 have better radical scavenging ability, and particularly, the emulsion in example 4 has the best radical scavenging ability when the mass fraction of the morinda citrifolia extract in the emulsion is 10% and the mass fraction of the surfactant is 8%. It is shown that the emulsions obtained in examples 1 to 8 have a protective effect on whitening and skin-caring ingredients in noni fruits, so that they are not easily oxidized.
Whitening Activity test
The potato extract contains tyrosinase, wherein the tyrosinase is an oxidoreductase, the tyrosinase can promote L-tyrosine to generate melanin by oxidation, and in the process of forming the melanin by the tyrosine, the tyrosinase can promote L-tyrosine to generate L-dopa and further act to enable the L-dopa to form bakinone, and the dopinone finally generates the melanin.
The calculation formula of the inhibition rate is as follows: [1- (T2-T1)/(C2-C1) ] 100%
C1 is the absorbance value of the mixture of the buffer solution and the potato extract, C2 is the absorbance value of the mixture of the buffer solution, the potato extract and tyrosine, and C2, measured with C1 as a reference, is C2-C1, which represents the absorbance value of the melanin produced after subtracting the absorbance of the potato extract. T1 is the absorbance value of the mixture of the emulsion sample, the potato extract and the buffer solution, T2 is the absorbance value of the mixture of the emulsion sample, the buffer solution, the potato extract and tyrosine, and T2-T1 was obtained by measuring the absorbance value of T2 with reference to T1, which represents the absorbance value of melanin after the inhibition of the sample, with the influence of the absorbance of the sample and the potato extract being deducted. The results of the inhibition rate of the emulsions obtained in examples 1 to 8 and comparative example 1 in the whitening activity test are shown in table 2:
TABLE 2
Figure BDA0001106433840000062
The results of the above test on the inhibition rate show that the emulsions obtained in examples 1 to 8 all have a high inhibition rate and can be used for skin whitening, and particularly, in example 4, when the mass fraction of the noni fruit extract in the emulsion is 10% and the mass fraction of the surfactant is 8%, the whitening effect of the emulsion is the best. The inhibition ratios of example 4, example 7 and example 8 show that the compounding ratio of the surfactant is also important for the whitening effect of the emulsion, and when the content is 8%, the protective effect on the components having the whitening and skin-care effects in noni fruits is better. Meanwhile, the inhibition ratio of comparative example 1 was significantly reduced, indicating that the whitening effect was better not as the content of the morinda citrifolia extract was more.
In conclusion, the noni extract emulsion provided by the invention has remarkable free radical scavenging capacity and whitening and skin-care effects, the preparation method is simple and easy to operate, the requirements on equipment and instruments are not high, and the production cost is low. The noni extract emulsion provided by the invention can be directly applied to skin care and whitening, and can also be applied to preparation of other whitening cosmetics or skin care products.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (3)

1. A noni extract emulsion is characterized by comprising, by weight, 10% of noni extract, 8% of surfactant, 0.1% of ethanol and the balance of water;
the preparation method of the noni extract emulsion comprises the following steps: dissolving 3.8g of sodium dodecyl benzene sulfonate and 4.4g C10-14 alkyl glycoside in 100mL of ethanol water solution, wherein the mass fraction of ethanol is 20%; chopping 180g of fresh noni, adding into the ethanol water solution, stirring at 80 deg.C and 250r/min for 10 hr, standing for 1 hr, and filtering to obtain noni extract emulsion.
2. The noni extract emulsion according to claim 1, wherein the filtering is performed using a 100-400 mesh sieve.
3. Use of the noni extract emulsion according to any one of claims 1 to 2 for the preparation of cosmetics.
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