CN106362039A

CN106362039A - Traditional Chinese medicine oral liquid for treating scrotum damp caused by dampness-heat in lower energizer

Info

Publication number: CN106362039A
Application number: CN201610854946.3A
Authority: CN
Inventors: 杨巧霞
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-09-27
Filing date: 2016-09-27
Publication date: 2017-02-01

Abstract

The invention provides traditional Chinese medicine oral liquid for treating scrotum damp caused by dampness-heat in lower energizer. The traditional Chinese medicine oral liquid is prepared from the following crude drugs: cortex phellodendri, radix sophorae flavescentis, semen plantaginis, herba polygoni avicularis, talcum, radix trichosanthis, radix salviae miltiorrhizae, cortex moutan, red paeony root, largehead atractylodes rhizome, poria cocos, semen coicis, rhizoma coptidis, honeysuckle flower, herba schizonepetae and radix cyathulae. The traditional Chinese medicine oral liquid has the advantage of treating based on syndrome differentiation, and overcomes the defects that the traditional western medicines cannot distinguish syndrome types and no corresponding efficient drug is used for treatment based on syndromes; the traditional Chinese medicine can be taken orally so as to replace the western medicines, so that drug dependence, side effects and the like are reduced; the traditional Chinese medicine oral liquid has better curative effect and degree of satisfaction.

Description

The Chinese medicine oral liquid for the treatment of damp-heat in lower-JIAO dampness of scrotum

Technical field

The present invention relates to technical field of Chinese medicine, more particularly, to a kind of extract oral treating damp-heat in lower-JIAO dampness of scrotum Liquid.

Background technology

Dampness of scrotum refers to genitals and (includes at femoribus internus nearly stock the moon) partly often hyperhidrosis about, and the stink with perspiration smell of urine Smelly disease.Common to be grown up.Ancients are referred to as " polyhidrosis around the external genitals ", " leakage essence ", " eczema of scrotum " etc., are one of andrology's commonly encountered diseases.But often Get the brush-off.Because pudendum is chronically at the environment of humidity, a lot of antibacterials are caused easily to grow, thus being easily caused skin of scrotum Inflammation, balanitises etc.；Because scrotum is in damp and hot environment, local temperature raises, and so that testicular spermatogenic ability and spermioteleosis is subject to Impact, thus leading to sperm quantity to reduce and motility of sperm reduction, even results in sperm deformity excessive.

Dampness of scrotum refers to that skin of scrotum surface is not any change, and the abnormal sensory such as hyperhidrosis, humidity but or send out cool.Cloudy Capsule has certain systolic and diastolic function, has substantial amounts of sweat gland in its skin, such that it is able to adjust the temperature of local, if scrotum secretion The perspiration going out can not distribute in time, and local temperature raises, and sweat secretion increases, and will feel that scrotum is always wet, for a long time The moist scrotum of hyperhidrosis is easily subject to produce inflammation, pruritus vulvae unbearably.

Dampness of scrotum is probably one of classical symptom of chronic prostatitiss, also with long-term sitting, in hot environment Work and varicocele are relevant.It is also likely to be eczema scrotum, it is moister to show as scrotum position, slightly itches.By disease The evolution of disease can part be acute stage, subacute stage, 3 processes of chronic phase.During acute attack, symptom mostly is skin of scrotum tide Red, prurituss, there is pimple, prurituss are scratched much, can expose smooth red skin.During subacute outbreak, symptom is that scrotum is violent Prurituss, do not take charge of diet, dilute, yellow urine of defecating, and sometimes have blister and slightly erosion.

During chronic seizures, have when disconnected during prurituss, psychentonia, drink, eat prurituss during maror and aggravate, skin of scrotum is touched Get up harder, skin surface color is in dark red or puce.Chronic prostatitiss in this way, should positive anti-inflammatory treatment.The traditional Chinese medical science thinks, The eczema scrotum that deficiency of the kidney yin causes, perspire when being mainly shown as soreness of the waist and knees, the heating of brothers' heart, xerostomia, hectic fever in the afternoon, sleeping etc., The available traditional Chinese medical science prescription universe (sound is the same) unit soup, moist scrotum most cases belong to what deficiency of the kidney yin caused.As caused because of dampness-heat in the liver and gallbladder Eczema scrotum, be mainly shown as that liver pain, bitter taste, appetite are poor, or the jaundice of body mesh, oliguria with reddish urine, heavy sensation of the body be tired, yellow fur Greasy etc..

For traditional Chinese medical science angle, the first is exactly this insufficiency of the spleen weight in wet base that we say.The traditional Chinese medical science thinks the aqueous metabolism master of people If three internal organs, first lung, second spleen, the 3rd is kidney, is some insufficiency of the spleen people, because The spleen has the function to transport and transform nutrients, the traditional Chinese medical science is said The function of spleen is that pipe is digested and assimilated, and after people has eaten, food and water are all transported to corporal parts by spleen.Have inborn The heredity of aspect, such as father and mother, just weaker in this block of function of spleen.

Second be exactly damp-heat in lower-JIAO it is also possible to caused by the imbalance of people's viscera function it is also possible to be because natural climate Caused it is also possible to be because, unhygienic diet, or diet this respect oneself can not get well diet modification and cause.Than As liked the people drinking, love eats the people of peppery thing, and such people is frequently just damp and hot especially big, discharge tongue, and tongue is especially thick Greasy, glue sticky yellow urine, this frequent dampness of scrotum.There is relation with his diet, certainly relevant with weather is that often wet weather connects Silk floss, sticky weather, add that insufficiency of the spleen people's scrotum is moister.

The damp-heat in lower-JIAO pattern of syndrome that Chinese medicine preparation of the present invention is directed in both the above pattern of syndrome targetedly carries out prescription medicine, The generation of primary disease is more concealed, according to traditional Chinese medical science exopathogenic factor external treatment, should adopt lotion or Chinese medicine ointment etc., it is contemplated that patient Factor at heart, the such as daily corresponding site that soaks is more inconvenient, therefore uses Chinese medicine oral liquid instead, effect quite, is conveniently easy to get simultaneously, It is easier to meet the demand that patient cures the disease.

Content of the invention

The technical problem to be solved is to provide a kind of Chinese medicine for treating damp-heat in lower-JIAO pattern of syndrome dampness of scrotum Oral liquid, has the advantage of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, overcome traditional Western medicine cannot be distinguished by pattern of syndrome and no corresponding specific medicament carry out right Card treatment, for oral administration by Chinese medicine, the use of Western medicine can be substituted, reduce drug dependence and side effect etc., or using in The Therapeutic Method that doctor trained in Western medicine combines, has more preferable curative effect and satisfaction.

For solving above-mentioned technical problem, the present invention provides a kind of extract oral treating damp-heat in lower-JIAO pattern of syndrome dampness of scrotum Liquid, its crude drug include Cortex Phellodendri, Radix Sophorae Flavescentiss, Semen Plantaginiss, storage, Talcum, Radix Trichosanthis, Radix Salviae Miltiorrhizae, Cortex Moutan, Radix Paeoniae Rubra, the Rhizoma Atractylodis Macrocephalae, Poria, Semen Coiciss, Rhizoma Coptidis, Flos Lonicerae, Herba Schizonepetae and Radix Cyathulae.

Wherein, in described Chinese medicine oral liquid, the weight of each crude drug is respectively Cortex Phellodendri 30g～40g, Radix Sophorae Flavescentiss 30g～60g, car Front sub- 20g～30g, storage 20g～30g, Talcum 20g～30g, Radix Trichosanthis 10g～15g, Radix Salviae Miltiorrhizae 15g～25g, Cortex Moutan 10g ～20g, Radix Paeoniae Rubra 10g～20g, Rhizoma Atractylodis Macrocephalae 15g～25g, Poria 10g～20g, Semen Coiciss 15g～20g, Rhizoma Coptidis 20g～30g, gold silver Flower 15g～20g, Herba Schizonepetae 10g～15g and Radix Cyathulae 10g～20g.

Wherein, in described Chinese medicine oral liquid each crude drug weight be respectively Cortex Phellodendri 35g, Radix Sophorae Flavescentiss 35g, Semen Plantaginiss 25g, Store 25g, Talcum 25g, Radix Trichosanthis 10g, Radix Salviae Miltiorrhizae 20g, Cortex Moutan 15g, Radix Paeoniae Rubra 15g, Rhizoma Atractylodis Macrocephalae 20g, Poria 15g, Semen Coiciss 20g, Rhizoma Coptidis 25g, Flos Lonicerae 20g, Herba Schizonepetae 10g and Radix Cyathulae 15g.

Present invention also offers the preparation method of above-mentioned Chinese medicine oral liquid, particularly as follows:

The first step, Cortex Phellodendri, Radix Sophorae Flavescentiss, Rhizoma Coptidis, the extraction of effective ingredient of honeysuckle；

Second step, the extraction of remaining material effective component；

3rd step, the preparation of oral liquid.

Wherein, the first step specially weighs Cortex Phellodendri, Radix Sophorae Flavescentiss, Rhizoma Coptidis and Flos Lonicerae by weight, mixes, plus with respect to The determining alcohol that 3～5 times of mixture is 80% ethanol, ebuillition of heated, flow back 2～4 hours, filter, medicinal residues add again with respect to Mixture adds 2～4 times amount determining alcohols be 80% ethanol, ebuillition of heated, flow back 1～2 hour, filtration, merge filtrate twice, When being evaporated to 50～60 DEG C under vacuum about 0.06～0.09mpa, relative density is 1.05～1.10 clear paste, spray dried Dry, 70～80 DEG C of 160～180 DEG C of the inlet temperature of spray dryer, leaving air temp, make dried cream powder.

Wherein, second step specially weighs remaining material medicine component by weight, mixes, plus with respect to mixture 6 ～8 times of water, after soaking 30～60 minutes, intense fire seethes with excitement 15 minutes, is subsequently seethed with excitement 1～2 hour with slow fire, filters, and separates, takes Supernatant, is cooled to 30～40 DEG C, obtains extracting solution, adds the dried cream powder of first step preparation, stirs and be completely dissolved to dried cream powder, It is condensed into crude drug concentration 1g/ml.

Wherein, the 3rd step specially takes the concentrated solution 300ml of second step preparation, adds 500ml distilled water, merges and mixes, It is subsequently added polyoxyethylene sorbitan monoleate, 8g～15g sucrose and the sodium benzoate 1g～2g mixing of 1g～3g, add deionized water further To 1000ml, subpackage, sterilizing, obtain final product.

Beneficial technique effect

The present invention provides a kind of Chinese medicine oral liquid for treating damp-heat in lower-JIAO pattern of syndrome dampness of scrotum, has determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs Advantage, overcomes that traditional Western medicine cannot be distinguished by pattern of syndrome and no corresponding specific medicament carries out verification treatment, for oral administration by Chinese medicine, The use of Western medicine can be substituted, reduce drug dependence and side effect etc., or the Therapeutic Method using the combination of Chinese and Western medicine, have Preferably curative effect and satisfaction.

Specific embodiment

Dampness of scrotum can induce multiple andropathy's symptoms and be mainly shown as genitals and (include femoribus internus near about The cloudy place of stock) partly often hyperhidrosis stink with perspiration is shy smelly and the later stage occurs the disease of pudendal pruritus, common to be grown up.Ancients are referred to as " cloudy Antiperspirant ", " leakage essence ", " eczema of scrotum " etc., insufficiency of the spleen leading to overabundance of dampness or two kinds of pattern of syndrome of damp-heat in lower-JIAO nothing more than.Trouble for damp-heat in lower-JIAO pattern of syndrome Person, the traditional Chinese medical science thinks hyperhidrosis humidity for there being the damp abnormal smells from the patient smell of urine smelly for there being pathogenic heat, and the damp-heat gluing each other later stage will show as at evil poison accumulation Skin pruritus.For the patient of insufficiency of the spleen weight in wet base pattern of syndrome, its hyperhidrosis is dilute cold, shows spiritlessness and weakness more, anorexia and loose stool etc..The present invention Chinese medicine preparation carries out prescription medicine for damp-heat in lower-JIAO pattern of syndrome dampness of scrotum, and the generation of primary disease is more concealed, according to traditional Chinese medical science exopathogenic factor External treatment, should adopt lotion or Chinese medicine ointment etc., it is contemplated that the factor at heart of patient, such as daily immersion corresponding site is more Inconvenience, therefore uses Chinese medicine oral liquid instead, and effect quite, is conveniently easy to get simultaneously, is easier to meet the demand that patient cures the disease.It is based on This, the present invention provides a kind of Chinese medicine oral liquid treating damp-heat in lower-JIAO pattern of syndrome damp-heat in lower-JIAO dampness of scrotum, and its crude drug is specially Cortex Phellodendri, Radix Sophorae Flavescentiss, Semen Plantaginiss, storage, Talcum, Radix Trichosanthis, Radix Salviae Miltiorrhizae, Cortex Moutan, Radix Paeoniae Rubra, the Rhizoma Atractylodis Macrocephalae, Poria, Semen Coiciss, Rhizoma Coptidis, gold silver Flower, Herba Schizonepetae and Radix Cyathulae.

Its prescription thinking is described below:

Mutually tie the dampness of scrotum patient of pattern of syndrome for damp-heat in lower-JIAO, heat clearing away can not be attached undue importance to one thing to the neglect of the other with damp eliminating, and heat is easily clear, and wet difficulty Dispel, work as eliminating dampness by diuresis to separate it from pathogenic heat, mutually do not fight with heat, certainly will orphan.Chinese medicine preparation reuse Cortex Phellodendri therefore of the present invention, Radix Sophorae Flavescentiss and Semen Plantaginiss, Storing two groups of medicines is monarch drug group, Cortex Phellodendri, Radix Sophorae Flavescentiss bitter cold, and bitter with dampness, cold with heat clearing away, property sedimentation is longer than clear damp-heat in lower-JIAO, its In, Radix Sophorae Flavescentiss single dose Chinese medicine is no less than 30g, and not more than 60g, then cannot play good heat clearing and damp drying effect less than 30g, if using Amount more than 60g, upset one's stomach by its bitter cold, is easily caused the untoward reaction such as patient's stomachache, diarrhoea, its oral liquid taste is extremely bitter simultaneously, suffers from Person is difficult to swallow, and with Radix Sophorae Flavescentiss cooperation, Cortex Phellodendri consumption is advisable in 30g～45g, and uses Semen Plantaginiss, stores two medicines, and Semen Plantaginiss are sweet Light, store bitter cold, specially in clearing away heat-damp and promoting diuresis, Semen Plantaginiss consumption must not exceed 30g for GUIXIN small intestinal and bladder warp, stores and is less than 30g, Within this range can with dampness removing heat clearing away, if cross with just hindering, it is understood that there may be potential injury of kidney, two drug regimens use, divide disappear damp and hot, Interior heat clearing away is evil, under draw damp, play eliminating damp-heat effect altogether.Chinese medicine preparation of the present invention uses Talcum, cooperation monarch drug Semen Plantaginiss, storage Clearing away heat and promoting diuresis, heat conduction is descending, adds Rhizoma Atractylodis Macrocephalae, Poria, Semen Coiciss spleen invigorating to help fortune, diuresis damp eliminating, and all medicines share is ministerial drug group；This Invention Chinese medicine preparation adds a small amount of Rhizoma Coptidis, Flos Lonicerae, Herba Schizonepetae heat-clearing and toxic substances removing, modern medicine study, and three medicines are for antibacterial and funguses Cause infected with good therapeutical effect, Herba Schizonepetae has expelling wind and removing dampness effect simultaneously, damp and hot sweep along, easy impairment of YIN moves blood, therefore Add Radix Trichosanthis clearing away heat and promoting production of body fluid, add Radix Salviae Miltiorrhizae, Cortex Moutan, Radix Paeoniae Rubra clearing away heat and cooling blood, nourshing blood and promoting blood circulation, all medicines share, is adjuvant drug；This With Radix Cyathulae for making medicine, heat conduction is descending to coordinate all diuretics with the action of eliminating dampness, in addition with promoting blood circulation, tonifying liver in urine to bright Chinese medicine preparation The effects such as kidney, bone and muscle strengthening, there is benefit to have in making to let out logical, be unlikely to eliminating evil too to hinder healthy energy.

Comprehensive analysis Chinese medicine preparation of the present invention, it has good heat clearing away, dampness, spleen invigorating, turns round and look at effect of shield healthy energy, is suitable for In clinical application.

In described Chinese medicine oral liquid, the weight of each crude drug is respectively Cortex Phellodendri 30g～45g, Radix Sophorae Flavescentiss 30g～60g, Semen Plantaginiss 20g～30g, store 20g～30g, Talcum 20g～30g, Radix Trichosanthis 10g～15g, Radix Salviae Miltiorrhizae 15g～25g, Cortex Moutan 10g～ 20g, Radix Paeoniae Rubra 10g～20g, Rhizoma Atractylodis Macrocephalae 15g～25g, Poria 10g～20g, Semen Coiciss 15g～20g, Rhizoma Coptidis 20g～30g, Flos Lonicerae 15g～20g, Herba Schizonepetae 10g～15g and Radix Cyathulae 10g～20g.

Further preferably, in described Chinese medicine oral liquid, the weight of each crude drug is respectively Cortex Phellodendri 35g, Radix Sophorae Flavescentiss 35g, Semen Plantaginiss 25g, storage 25g, Talcum 25g, Radix Trichosanthis 10g, Radix Salviae Miltiorrhizae 20g, Cortex Moutan 15g, Radix Paeoniae Rubra 15g, Rhizoma Atractylodis Macrocephalae 20g, Poria 15g, Semen Coiciss Core 20g, Rhizoma Coptidis 25g, Flos Lonicerae 20g, Herba Schizonepetae 10g and Radix Cyathulae 15g.

Present invention also offers the preparation method of above-mentioned Chinese medicine oral liquid, comprising:

Second step, the extraction of remaining material effective component；

3rd step, the preparation of oral liquid.

The first step specially weighs Cortex Phellodendri, Radix Sophorae Flavescentiss, Rhizoma Coptidis and Flos Lonicerae by weight, mixes, plus with respect to mixing The determining alcohol that 3～5 times of thing is 80% ethanol, ebuillition of heated, flows back 2～4 hours, filters, and medicinal residues add again with respect to mixing Thing adds 2～4 times amount determining alcohols be 80% ethanol, ebuillition of heated, flow back 1～2 hour, filtration, merge filtrate twice, in vacuum When being evaporated to 50～60 DEG C under degree about 0.06～0.09mpa, relative density is 1.05～1.10 clear paste, is spray-dried, spray 160～180 DEG C of the inlet temperature of mist drying machine, 70～80 DEG C of leaving air temp, make dried cream powder.

Second step, weighs remaining material medicine component by weight, mixes, plus the water with respect to 6～8 times of mixture, After soaking 30～60 minutes, intense fire seethes with excitement 15 minutes, is subsequently seethed with excitement 1～2 hour with slow fire, filters, and separates, takes supernatant, cooling To 30～40 DEG C, obtain extracting solution, add the dried cream powder of first step preparation, stir and be completely dissolved to dried cream powder, be condensed into crude drug Concentration 1g/ml.

3rd step, takes the concentrated solution 300ml of second step preparation, adds 500ml distilled water, merges and mixes, is subsequently added 1g The polyoxyethylene sorbitan monoleate of～3g, 8g～15g sucrose and sodium benzoate 1g～2g mixing, add deionized water further to 1000ml, Subpackage, sterilizing, obtain final product.

Each crude drug pharmacology is as follows:

Cortex Phellodendri: bitter in the mouth, cold in nature, return kidney, bladder, large intestine channel, there is heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat Effect, for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, tinea pedis, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema scabies The card such as itch.

Radix Sophorae Flavescentiss: latin name sophorae flavescentis radix, bitter in the mouth；Cold in nature, enter liver；Kidney；Large intestine；Small intestinal；Wing Guang；Heart channel, has heat clearing and damp drying, parasite killing, effect of diuresis, cures mainly hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, and swelling of the vulva is cloudy Itch, eczema, eczema, skin pruritus, scabies leprosy etc. is demonstrate,proved.

Semen Plantaginiss: sweet in the mouth, cold in nature, enter kidney, bladder warp, there is relieving stranguria by diuresis, liver heat removing and eyesight improving, effect of removing heat from the lung and dissipating phlegm, use In dysuria, drench and drip puckery pain, have loose bowels, wind heat Akamu swells and ache, many tear of photophobia etc. is demonstrate,proved.

Store: bitter in the mouth, cold nature, enter bladder warp, there is relieving stranguria by diuresis, effect of killing parasites for relieving itching, for stranguria, especially Sand Stranguria, stranguria caused by urinary stone, dysuria, jaundice due to damp-heat, dysentery, carry inferior card.

Talcum: sweet in the mouth, light, cold in nature, return bladder, lung, stomach, there is inducing diuresis for treating stranguria syndrome, clearing away summer-heat, the work(of damp eliminating sore Effect.For pyretic stranguria, stranguria caused by urinary stone, urinate hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea；External treatment eczema, eczema, miliaria etc. is demonstrate,proved.

Radix Trichosanthis: latin name trichosanthis radix, sweet in the mouth, slight bitter, cold nature, enter lung, stomach, there is heat clearing away Promote the production of body fluid, effect of detumescence and apocenosis, for pyreticosis polydipsia, lung-heat type cough, Heat Diabetes, sore swollen toxin etc. is demonstrate,proved.

Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature, GUIXIN, Liver Channel, there is promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, relieving restlessness that clears away heart-fire, support Effect of blood and tranquilizing mind, cures mainly menoxenia, closed dysmenorrhea, lump in the abdomen, chest and abdomen shouting pain, hot numbness pain, sore swell and ache curative, vexed not Sleep；Hepatosplenomegaly, angina pectoriss etc. are demonstrate,proved.

Cortex Moutan: bitter in the mouth, pungent, cold nature, enter the heart, liver and kidney channel, there is clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, cure mainly temperature The calentura pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, calentura later stage hot Fu Yin distribution heat, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle skin ulcer Poison, the pain of injury caused by falling and tumbling, beriberoid pyretic arthralgia etc. are demonstrate,proved.

Radix Paeoniae Rubra: bitter in the mouth, slight bitter, return liver warp, there is removing fire from the liver, clearing away heat and cooling blood, effect of stasis-dispelling and pain-killing, cure mainly high liver fire Conjunctival congestion and swelling pain, have a dizzy spell, pain in chest and hypochondrium, the fever of the body crimson tongue of the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, macule bleeding, and blood stasis is through closing； The intimately haematemesis hematuria of the absurd row of flourishing forcing blood；Women's heat in blood trip waits card through excessive.

The Rhizoma Atractylodis Macrocephalae: latin name atractylodis macrocephalae rhizoma, bitter in the mouth, sweet, warm in nature, enter spleen, stomach, There is invigorating the spleen and benefiting QI, eliminate dampness and have diuretic effect, hidroschesis, antiabortive effect, for weakness of the spleen and stomach, lack of appetite distension, fatigue and weakness, have loose bowels, water Wet stop, phlegm retention, edema, exterior deficiency spontaneous perspiration etc. is demonstrate,proved.

Poria: sweet in the mouth, light, mild-natured, enter the heart, lung, spleen, kidney channel, there are eliminating dampness and diuresises, spleen invigorating mind calming, be mainly used in The edema of retention of water-damp, dysuria；The pyretic stranguria of damp-heat accumulation, the anorexia and loose stool of stagnation of dampness due to deficiency of the spleen, phlegm retention stagnation, epilepsy etc. are demonstrate,proved.

Semen Coiciss: sweet in the mouth, property are light, returns spleen, stomach, lung meridian have functions that spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus, eliminating impediment, diuretic, Cure mainly dysuria, edema, tinea pedis, lung abscess, acute appendicitis, rheumatic arthralgia, Spasm of the tendons and damp-warm diseases etc. are demonstrate,proved.

Rhizoma Coptidis: bitter in the mouth, cold in nature, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel, there is the work(of heat-clearing and toxic substances removing, eliminating fire and detoxication, parasite killing Effect, for damp and hot feeling of fullness, vomits acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, blood-head tells nosebleed, conjunctival congestion, Toothache, quench one's thirst, carbuncle swells furunculosis, external treatment eczema, eczema, auditory meatus suppurate wait demonstrate,prove.

Flos Lonicerae: latin name lonicerae japonicae flos, also known as Flos Lonicerae, Flos Lonicerae, Flos Lonicerae, two precious flowers, taste Sweet, cold in nature, enter the heart, lung, stomach, large intestine channel, there iss heat-clearing and toxic substances removing, and energy eliminating pathogenic heat from blood to cure dysentery, it is mainly used in affection due to external wind and heat, warm Febrile disease poison is relatively contained, or epidemic febrile disease from the beginning of pathogenic heat still when the part of the body cavity above the diaphragm housing the heart and lungs is not descending；Pyretic toxicity dysentery, stool hematochezia；Fever disease in summer is demonstrate,proved；Pyretic toxicity gathers Carbuncle sore from the beginning of, the heat person of swelling and ache, and other skin infections, this thing has preferable antipyretic effect, has antiinflammatory action, can promote Multiple pyococcuss and pathogenic entero becteria are had stronger bacteriostasis by the phagocytic function of leukocyte.

Herba Schizonepetae: acrid in the mouth, slightly warm in nature, enter lung, Liver Channel, have relieving the exterior syndrome by diaphoresis, the malicious rash of a surname, and the effect of blood hemostasis, main use No matter fever and headache caused by affection of exogenous wind-cold wind heat, have antiperspirant lossless, all can apply；The dizziness of having a headache attacked in wind heat, rash goes out not Thoroughly；Puerperal blood faintss apoplexy, discharging fresh blood stool etc. is demonstrate,proved.

Radix Cyathulae: sweet in the mouth, slight bitter, mild-natured, return liver and kidney channel, there is eliminating blood stasis and inducing menstruation, easing joint movement, the effect of inducing diuresis for treating stranguria syndrome, Cure mainly rheumatism lumbocrural pain, foot flaccidity clonic spasm of the muscle, stranguria with blood, hematuria, women's amenorrhea, lump in the abdomen.For amenorrhea lump in the abdomen, retention of placenta, joint Arthralgia pain, sufficient impotence muscle contraction, cards such as hematuria blood drenches, injury from falling down etc. is demonstrate,proved.

Hereinafter embodiments of the present invention are described in detail using embodiment, whereby to the present invention how application technology means To solve technical problem, and reach realizing process and fully understanding and implement according to this of technique effect.

Embodiment 1 oral liquid 1

Weigh Cortex Phellodendri 35g, Radix Sophorae Flavescentiss 35g, Rhizoma Coptidis 25g, Flos Lonicerae 20g, mix, plus the determining alcohol of 500g is 80% Ethanol, ebuillition of heated, flow back 3 hours, filter, the determining alcohol that medicinal residues add 350g again is 80% ethanol, ebuillition of heated, return Stream 1 hour, filtration, merge filtrate twice, when being evaporated to 60 DEG C under vacuum 0.07mpa relative density be 1.10 clear Cream, be spray-dried, 80 DEG C of 180 DEG C of the inlet temperature of spray dryer, leaving air temp, make dried cream powder, weigh Semen Plantaginiss 25g, Store 25g, Talcum 25g, Radix Trichosanthis 10g, Radix Salviae Miltiorrhizae 20g, Cortex Moutan 15g, Radix Paeoniae Rubra 15g, Rhizoma Atractylodis Macrocephalae 20g, Poria 15g, Semen Coiciss 20g, Herba Schizonepetae 10g and Radix Cyathulae 15g, mix, plus the water of 1.5kg, and after soaking 60 minutes, intense fire seethes with excitement 15 minutes, subsequently Seethed with excitement 2 hours with slow fire, filter, separate, take supernatant, be cooled to 30 DEG C, obtain extracting solution, add dry cream prepared above Powder, stirs and is completely dissolved to dried cream powder, is condensed into crude drug concentration 1g/ml, takes the concentrated solution 300ml of preparation, adds 500ml distillation Water, merges and mixes, and is subsequently added polyoxyethylene sorbitan monoleate, 10g sucrose and the sodium benzoate 1g mixing of 2g, adds deionized water further To 1000ml, subpackage, sterilizing, obtain final product.

Comparative example 1 oral liquid 2

Oral liquid 2 is prepared using preparation method same as Example 1, difference is not using Radix Sophorae Flavescentiss and Semen Plantaginiss.

Toxicology is tested

For damp-heat in lower-JIAO pattern of syndrome dampness of scrotum patient, how its clinical practice is with 1 week for a course for the treatment of, therefore toxicological experiment is Verify its safety, therefore carry out anxious toxicity test research.

Cleaning grade km mice, 40, male and female half and half, test preposition animal in indoor adaptation environment one week, freely ingest, take the photograph Water, 18～22 DEG C of room temperature, relative humidity 65～70%, light and shade replaces round the clock for illumination.

Take the embodiment of the present invention 1 preparation oral liquid 1, pressurized be concentrated into concentration containing crude drug be 34.4g/ml, take concentration Liquid 50ml, filters, 4 DEG C of preservations, standby, is heated to 36～39 DEG C during use.

Specific experiment method: according to table of random number, mice is divided into matched group and experimental group.Experimental group gastric infusion is originally The concentrated solution 34.4g/ml of the oral liquid 1 of inventive embodiments 1 preparation, gastric infusion amount is 0.1ml/10g body weight, is equivalent to crude drug Amount 103.2g/kg/d, matched group gavage distilled water 0.1ml/10g body weight.Two groups equal 3 times/day, successive administration 14 days, is discontinued and sees Examine 5 days.Record Mouse Weight, feed, drinking-water situation, the every reaction of mice, phase mice between gastric infusion after record gastric infusion Every physiological reaction, and death condition.

Studied by acute toxicological experiment, observe situation after the administration of 14d mouse stomach, before gastric infusion, each group animal body Weight, feed, drinking-water situation no difference of science of statistics, after gastric infusion, the change of each group Mouse Weight, feed drinking-water situation, no count Learn difference., death and other toxic reactions in behavioristicss' Non Apparent Abnormality.

This experimental group dosage crude drug concentration 103.2g/kg/d, mice is 10.01 with the dosage conversion coefficient of adult, Therefore mice dosage is 187.84 times of clinical adult's medication (5.5g/kg/d), and modern pharmacology is thought, anxious for medicine Property toxicity test, maximum tolerated dose is equivalent to more than 100 times of the clinical daily dosage of people and animal is no dead, and no overt toxicity reacts When situation occurs, this medicine is safe.Verified by this acute toxicity test, non-toxic reaction, it can be assumed that, this clinical drug Medication is safe.

Clinical experiment is observed

Case is all from the court's surgical wards surgical patient, according to " diagnosis of common disease and efficacy evaluation (mark Accurate) ", observe 248 damp-heat in lower-JIAO pattern of syndrome scrotal varices Post operation made a definite diagnosis altogether and merge eczema scrotum patient, patient was both Toward no eczema medical history, after surgery scrotum position acute eczema occurred in 3～12 days, skin lesion is intensive red papules, has scattered In vesicle, there is rotten to the corn face, have a large amount of sepages, it is seen that being dispersed in pus pimple when some patientss occur local infection due to scratching.

Exclude and suffer from connective tissue disease, tuberculosis, chronic active hepatitiss person, merging cardiovascular, liver, renal damage person, There is the severe primary disease patient such as brain and hemopoietic system；Psychotic；The full person to medicine allergy；Do not press predetermined treatment Person；Cannot judge that curative effect or data do not affect the treatment or peace property judgement person entirely.

248 patients are randomly divided into treatment group 129, matched group 119, treatment group's case course of disease 4～13 days, age 22～49 years old, the matched group course of disease 4～12 days, 23～53 years old age, the age of two groups of patients, the course of disease, skin lesion situation and conscious disease Shape etc. is respectively provided with comparability.

General treatment: two groups of patients take vitamin b2 piece 10mg, 2 times/d, acute stage have in a large number rotten to the corn face and sepage when With 3% borate soak, 4 times/d.

Matched group: on the basis of general treatment, oral Loratadine Tablets 10mg, 1 time/d, 10 days be 1 course for the treatment of, 1 course for the treatment of Observe curative effect afterwards.

Treatment group: on the basis of general treatment, the Chinese medicine oral liquid 1 of the oral embodiment of the present invention 1 preparation, 50ml/ time, 2 Secondary/d, 10 days is 1 course for the treatment of, observes curative effect after 1 course for the treatment of.

While carrying out above treatment patient carried out with necessary mental nursing, eczema scrotum patient from the beginning of when because This position belongs to privacy disease and is ashamed to mention, and produces shy psychology, may delay treatment and nursing.When making the rounds of the wards, be in time Patient inquiry, publicity medical knowledge and health care knowledge, induce his positive partner treatment and nursing, patient during late period is because disease Journey is long, recurrent exerbation.Acutely prurituss, impact rest is it is easy to irritated, anxiety, nervous, lacks patient, or even flies into a rage Mismatch treatment and nursing, now for the best opportunity of mental nursing.On the one hand to be held a consultation in time according to the state of an illness, consult, improvement is controlled Treat care regimen；On the other hand to patiently treat patient and will strengthen heart-to-heart talk comfort, that had both come then pacifies it.Face disease rule, Actively coordinate, firm confidence, prevent the long-time Mental health problem of patient, cause cardiogenic illness.

Curative effect determinate standard

Recovery from illness: skin lesion all disappears, prurituss stop；Effective: skin lesion disappears area ＞ more than 80%, and prurituss stop substantially； Effective: skin lesion disappears area ＞ more than 50%, prurituss mitigate；It is invalid: skin lesion disappears area ＜ 50%, or skin lesion recurrent exerbation, Prurituss no substantially mitigate.Effective percentage is in terms of fully recovering plus be effective.

Statistical method

Using spss16.0 statistics software, data is processed.Enumeration data is represented with rate (%), compares and adopt between group Use χ²Inspection；Measurement data is with mean ± standard deviationRepresent, compare between group using t inspection.

Result

Therapeutic outcome

Two groups of effective percentage comparing differences are statistically significant (p ＜ 0.05), the results are shown in Table 1.

1 liang of group therapeutic outcome of table compares (example)

Group	Number of cases	Recovery from illness	Effective	Effectively	Invalid	Effective percentage (%)
							Treatment group	129	43	57	25	4	96.90^*
Matched group	119	26	46	29	18	84.87

Compare with matched group,^*P ＜ 0.05

Two groups of patients are showed no obvious untoward reaction, are ground with the contrast of Western medicine Loratadine by Chinese medicine preparation of the present invention Study carefully, its effective percentage is significantly better than matched group, illustrate that Chinese medicine preparation of the present invention has good curative effect for the treatment of this disease, be suitable for In clinical application.

Typical clinical case is collected

Clinical experiment patient Sun Jiacheng of the present invention, man, 43 years old, patient's identification number: 0005484126877, scrotal varices handss Dampness of scrotum occurred in postoperative 6 days, skin lesion is intensive red papules, is dispersed in vesicle, has rotten to the corn face, have a large amount of sepages, right The identification of its TCM Syndrome Type, judges that it is damp-heat in lower-JIAO pattern of syndrome combined postoperative eczema scrotum patient, Primary Care, and patient takes dimension Raw element b2 piece 10mg, 2 times/d, acute stage have in a large number rotten to the corn face and sepage when with 3% borate soak, 4 times/d.In Primary Care On the basis of, the Chinese medicine oral liquid 1 of the oral embodiment of the present invention 1 preparation, 50ml/ time, 2 times/d, 10 days is 1 course for the treatment of, after 1 course for the treatment of Observe curative effect.After patient's medication, the 8th day skin lesion disappears area more than 80, and after taking medicine 10 days, skin lesion all disappears, and closes up, scabies Itch stopping, being judged as clinical cure.

Experimentation

Experiment material

Kunming mouse 60, body weight 22 ± 3g, male.Experiment mice is put in animal observation ward, room temperature is maintained at Between 22 ± 3 DEG C, relative humidity 40%～60%.By experiment mice sub-cage rearing, 15, every cage.Animal observation ward should keep pacifying Quiet, it is to avoid the interference to mice of noise and other factors.Mice drinking public water supply, edible mice Mus material is fed, and drinking water does not limit.

Experimental drug

Chinese medicine preparation oral liquid 1 of the present invention, being adjusted to concentration containing crude drug is 0.75g/ml.

Chinese medicine preparation oral liquid 2 of the present invention, being adjusted to concentration containing crude drug is 0.75g/ml.

Prednisone acetate tablets specification: 5mg/ piece * 100, Zhejiang Province XianJu Pharmacy stock Co., Ltd produces.

Sodium chloride injection specification: 250ml, Jilin Cologne Cornell pharmaceutical Co. Ltd produces.

Experimental technique

According to random packet principle, 60 mices are randomly divided into 4 groups, i.e. physiological saline group, positive control (prednisone) Group, invention group, comparable group, every group 15.With 3% picric acid solution in order by mice right fore be No. 1, right hind 2, left Forelimb 3, left hind 4, tail No. 5, No. 6, neck 7, the back of the body No. 8, abdomen 9, unmarked No. 10 carry out labelling, every group of residue 5 Mice is standby.

After experiment mice adaptability is fed one week, body weight control, in 25 ± 5g, gives gavage while mice modeling and controls Treat.

Prepare before administration

Depilation: 4 groups of experiment mices are taken the rectangular region of long 3cm × wide 1cm size in abdominal part, with shears by this The hair scissors of area removes.

Chemicals dilating: the dilution of 0.5%dnfb acetone solution: take 4ml dnfb (2,4 dinitrofluorobenzene) 25 μ l with liquid-transfering gun Add 1ml acetone olive oil solution, that is, join 0.5% dnfb solution 5ml；1.6mldnfb4 μ l is taken to add with liquid-transfering gun 0.4ml acetone olive oil solution, that is, join 0.2% dnfb solution 2ml.

Modeling is administered

4 groups of mices are applied 0.5% in unhairing portion liquid-transfering gun in belly shaving area in the 1st day and the 2nd day in experiment Dnfb25 μ l sensitization.Induce dermatitis in the hard of hearing dnfb20 μ l applying 0.2% in a left side within 8th, auris dextra applies equivalent 4: 1 acetone Fructus Canarii albi oil base Matter compares.

Therapeutic administratp

4 groups of mices press the daily gastric infusion of following dosage 1 time, continuous use 9 days while modeling.Invention group 0.1ml/ The oral liquid 1 of 10g body weight gavage embodiment 1 preparation；The oral liquid 2 of comparable group 0.1ml/10g body weight gavage comparative example 1 preparation； Positive controls give prednisone suspension 0.45g/ml, 0.1ml/10g body weight gavage, and physiological saline group gavages isometric life Reason saline.

Observation index and method

General state is observed

Including the mental status of observation experiment mice, body weight, dietary amount, two just etc..

Laboratory animal is drawn materials and indices measure

The ropy measurement of ear about mice

After last dose, experiment mice is all put to death, first cut the left and right auricle of mice with shears, then justified with skin Punch in the middle part of shape card punch ear about mice, take the ear tissue of formed objects, using scales/electronic balance weighing, calculate left and right ear matter Amount is poor.

The measurement of mononuclear cell and neutrophilic granulocyte in mouse ear corium

Left ear tissue after weighing is placed in 10% formalin solution, paraffin embedding, section, conventional he dyeing, Net form eyepiece is used to count every mm under optical microscope²Neutrophilic granulocyte and mononuclear cell number.

Statistical procedures

Experimental result

After continuous use 9 days, exclude the mice being not in good state, only carried out into group with every group 10.

Detection indices result

Chinese medicine preparation of the present invention ropy impact on ear about mice, the results are shown in Table 2.

After modeling, the left auricle of 4 groups of mices all has different degrees of redness, with apply substrate auris dextra exterior feature have in appearance bright Aobvious difference, and about mice auricle of poor quality substantially, illustrate mice modeling successfully.Chinese medicine preparation group of the present invention, the positive are right According to group compared with physiological saline group, there are obvious inhibitory action, statistically significant (p ＜ 0.05) to mice auricle swelling degree； Comparable group, compared with physiological saline group, has inhibitory action to mice auricle swelling degree, but not statistically significant (p ＞ 0.05)；With Invention group compares, positive controls no difference of science of statistics, but compares average, and its effect relatively invention group is poor.

The ropy impact on ear about experiment mice of table 2 Chinese medicine preparation of the present invention

Group	Number of cases	Left and right ear is of poor quality to (g)
			Physiological saline group	10	0.0469±0.0013
Positive controls	10	0.0289±0.0014^#
			Comparable group	10	0.0311±0.0019^#△
Invention group	10	0.0226±0.0012^#

Note: compare with physiological saline group,^#P ＜ 0.05；Compare with invention group,^△P ＞ 0.05.

Chinese medicine preparation of the present invention, on mice left ear neutrophilic granulocyte and monocytic impact, the results are shown in Table 3.

Chinese medicine preparation group of the present invention, positive controls compared with physiological saline group, neutrophilic granulocyte in Mice Auricle corium, Mononuclear cell number significantly reduces, and can suppress cell infiltration, statistically significant (p ＜ 0.05)；Comparable group and physiological saline group Compare, no significant difference (p ＞ 0.05)；Positive controls are compared with invention group, no difference of science of statistics, but compare average, its Effect relatively invention group is poor, has significant difference, p ＜ 0.05.

Table 3 Chinese medicine preparation of the present invention is on mice left ear neutrophilic granulocyte and monocytic impact

Group	Number of cases	Neutrophilic granulocyte number (individual)	Mononuclear cell number (individual)
				Physiological saline group	10	69±8	53±6
Positive controls	10	34±5^#	29±3^#
				Comparable group	10	29±4^#△	24±4^#△
Invention group	10	17±9^#	19±7^#

The left ear tissue of each group mice changes

Pathological section he dyeing display: Mice Auricle epidermis thickens, and subcutaneous tissue is loose, and telangiectasis are congested, have Substantial amounts of lymphocyte and neutrophil infiltration.Chinese medicine preparation group of the present invention, the swelling of positive controls Mice Auricle, fill Blood, cell infiltration number and degree have notable mitigation, p ＜ 0.05 compared with physiological saline group, the present invention go Radix Sophorae Flavescentiss, Herba Plantaginis subgroup with Physiological saline group has and to a certain degree mitigates, but no difference of science of statistics, p ＞ 0.05.

By the experimentation of Chinese medicine preparation of the present invention it was confirmed Chinese medicine preparation of the present invention is to damp-heat in lower-JIAO pattern of syndrome scrotum tide Wet have good curative effect, and its effect is better than Western medicine control drug it is adaptable to clinical application.

All above-mentioned this intellectual properties of primary enforcement, do not set this new product of enforcement limiting other forms And/or new method.Those skilled in the art will be using this important information, and the above is changed, to realize similar execution feelings Condition.But, all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention is made with other forms, appoints What those skilled in the art possibly also with the disclosure above technology contents changed or be modified as equivalent variations etc. Effect embodiment.But every without departing from technical solution of the present invention content, according to the present invention technical spirit to above example institute Any simple modification, equivalent variations and the remodeling made, still falls within the protection domain of technical solution of the present invention.

Claims

1. a kind of Chinese medicine oral liquid treating damp-heat in lower-JIAO pattern of syndrome dampness of scrotum it is characterised in that: crude drug includes Cortex Phellodendri, hardship Ginseng, Semen Plantaginiss, storage, Talcum, Radix Trichosanthis, Radix Salviae Miltiorrhizae, Cortex Moutan, Radix Paeoniae Rubra, the Rhizoma Atractylodis Macrocephalae, Poria, Semen Coiciss, Rhizoma Coptidis, Flos Lonicerae, Herba Schizonepetae And Radix Cyathulae.

2. as claimed in claim 1 treatment damp-heat in lower-JIAO pattern of syndrome dampness of scrotum Chinese medicine oral liquid it is characterised in that: each raw material The weight of medicine be respectively Cortex Phellodendri 30g～40g, Radix Sophorae Flavescentiss 30g～60g, Semen Plantaginiss 20g～30g, store 20g～30g, Talcum 20g～ 30g, Radix Trichosanthis 10g～15g, Radix Salviae Miltiorrhizae 15g～25g, Cortex Moutan 10g～20g, Radix Paeoniae Rubra 10g～20g, Rhizoma Atractylodis Macrocephalae 15g～25g, Poria 10g～20g, Semen Coiciss 15g～20g, Rhizoma Coptidis 20g～30g, Flos Lonicerae 15g～20g, Herba Schizonepetae 10g～15g and Radix Cyathulae 10g～ 20g.

3. treatment damp-heat in lower-JIAO pattern of syndrome dampness of scrotum as claimed in claim 1 or 2 Chinese medicine oral liquid it is characterised in that: each The weight of crude drug is respectively Cortex Phellodendri 35g, Radix Sophorae Flavescentiss 35g, Semen Plantaginiss 25g, stores 25g, Talcum 25g, Radix Trichosanthis 10g, Radix Salviae Miltiorrhizae 20g, Cortex Moutan 15g, Radix Paeoniae Rubra 15g, Rhizoma Atractylodis Macrocephalae 20g, Poria 15g, Semen Coiciss 20g, Rhizoma Coptidis 25g, Flos Lonicerae 20g, Herba Schizonepetae 10g and river Radix Achyranthis Bidentatae 15g.

4. the preparation method of the Chinese medicine oral liquid for the treatment of damp-heat in lower-JIAO pattern of syndrome dampness of scrotum described in claims 1 to 3, its feature It is, comprising:

Second step, the extraction of remaining material effective component；

3rd step, the preparation of oral liquid.

5. Chinese medicine oral liquid as claimed in claim 4 preparation method it is characterised in that: the first step specially weighs Huang by weight Cypress, Radix Sophorae Flavescentiss, Rhizoma Coptidis and Flos Lonicerae, mix, plus the ethanol being 80% with respect to the determining alcohol of 3～5 times of mixture, heating Boiling, flows back 2～4 hours, filters, medicinal residues add again plus 2 with respect to mixture～4 times amount determining alcohols be 80% ethanol, plus Heat boiling, flows back 1～2 hour, and filtration merges filtrate twice, it is evaporated to 50 under vacuum about 0.06～0.09mpa～ When 60 DEG C, relative density is 1.05～1.10 clear paste, is spray-dried, 160～180 DEG C of the inlet temperature of spray dryer, air-out 70～80 DEG C of temperature, makes dried cream powder.

6. Chinese medicine oral liquid as claimed in claim 4 preparation method it is characterised in that: second step specially weighs remaining by weight Lower crude drug component, mixes, plus the water with respect to 6～8 times of mixture, and after soaking 30～60 minutes, intense fire seethes with excitement 15 points Clock, is subsequently seethed with excitement 1～2 hour with slow fire, filters, and separates, takes supernatant, be cooled to 30～40 DEG C, obtains extracting solution, adds the The dried cream powder of one step preparation, stirs and is completely dissolved to dried cream powder, be condensed into crude drug concentration 1g/ml.

7. Chinese medicine oral liquid as claimed in claim 4 preparation method it is characterised in that: the 3rd step specially take second step prepare Concentrated solution 300ml, add 500ml distilled water, merge mix, be subsequently added polyoxyethylene sorbitan monoleate, 8g～15g sucrose of 1g～3g With sodium benzoate 1g～2g mixing, add deionized water to 1000ml, subpackage, sterilizing further, obtain final product.