CN106361611A - Insect and acarus killing shampoo for animals and preparation method thereof - Google Patents
Insect and acarus killing shampoo for animals and preparation method thereof Download PDFInfo
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- CN106361611A CN106361611A CN201610976068.2A CN201610976068A CN106361611A CN 106361611 A CN106361611 A CN 106361611A CN 201610976068 A CN201610976068 A CN 201610976068A CN 106361611 A CN106361611 A CN 106361611A
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- shampoo
- deinsectization
- animal
- preparation
- acaricide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses insect and acarus killing shampoo for animals and a preparation method thereof. The shampoo is prepared from sodium lauryl ether sulfate, coconut oil momoethanolamide, cocoamido propyl hydroxy sulfobetaine, C12-13 alkyl lactate, natural essence, vegetable amino acids, deionized water and at least one of azadirachtin or neem oil, and is further prepared from at least one of pyrethrin, cnidium lactone and sophocarpidine. The preparation method comprises the steps of weighing and dispersing. According to the formula, the azadirachtin and the neem oil are adopted as main functional components and are reasonably compatible with other raw materials, so that symptoms such as animal skin itching, local erythema and unhairing can be effectively relieved. The insect and acarus killing shampoo is safe, environmentally friendly, good in insect and acarus control effect and lasting in control effect and is prepared from simple components. According to the preparation method, a nanometer shearing machine is adopted for shearing raw materials, the raw materials are sufficiently mixed to be uniform through the nanometer technology, the preparation method is simple, convenient to implement, low in cost and applicable to large-scale industrial production.
Description
Technical field
The present invention relates to a kind of shampoo is and in particular to a kind of deinsectization acaricide shampoo and preparation method thereof of animal.
Background technology
Azadirachta Indica A. (azadirachta indica) belongs to Meliaceae miliaceae, aiphyllium, neem seed, leaf and bark
Can be used for medicine, fuel, lubricant etc..But it has the positive effects such as refusing to eat, repellent to many Agriculture, forestry And Animal Husbandry insects, can be used as killing
Worm agent.So far, also find concentration 20 to 100ppm concentration nimbin nearly 20 various insects are all had significantly anti-
Control effect, particularly the pest species of serious resistance have been produced to those.
The experimental results both domestic and external show: nimbin have efficiently, wide spectrum and low toxicity feature, its median lethal dose(LD 50)
Ld50 is about 5000mg/kg, has suppression insect growth promoter, refusing to eat, the vermins-proof effect such as deterrent, or even to multiple nematicides and true
Bacterium also has good killing action.
Closely during the last ten years, various countries scientist, with modern biomedical technology and method, enters to multiple extracts of Azadirachta Indica A. tree
Go a series of research, found that it has antiviral (inclusion HIV (human immunodeficiency virus)), antibacterial (includes escherichia coli, kerekou pneumonia primary
Salmonella, staphylococcus aureus, Candida albicans, oral cavity streptococcus mutans, enterococcus, various Gram-positive and negative bacteria
Deng) and antifungal obvious effect；In addition also have certain at aspects such as contraception, antitumor, liver protection, blood sugar lowering, immunomodulating
Curative effect.
With the acceleration of Chinese society expanding economy and urbanization process, the upsurge of raising petss is fluffy in China city
Vigorous growth rises.But the thing followed is house pet is easy to parasitic various insect in vitro, such as louse, acarid and flea etc., sometimes also can take
Band species pathogenic bacteria, harm house pet healthy it is also possible to cause the cross infection of people, animal disease.At present, domestic and international house pet washes shield
Mainly adopt shampoo, but the animal removing lice such as existing house pet and poultry and more single except driving demodicid mite species, and mostly contain chemistry and close
Become material.
Content of the invention
It is an object of the invention to overcoming the shortcoming of prior art, provide a kind of deinsectization acaricide shampoo of animal, this shampoo
Main active is extracted form natural plant elite, safe and environment-friendly, deinsectization acaricide effect is good and preventive effect is lasting.
Another object of the present invention is to providing the preparation method of this kind of animal deinsectization acaricide shampoo, the method operation letter
Singly, prepare convenience, low cost, be applied to industrialization large-scale production.
The purpose of the present invention is achieved through the following technical solutions: a kind of deinsectization acaricide shampoo of animal, in parts by weight,
Its component is:
Wherein, nimbin and neem oil can not be 0 simultaneously.
Preferably: in parts by weight, its component is:
A kind of animal preparation method of deinsectization acaricide shampoo, it comprises the following steps:
S1. weigh: weigh each raw material by above-mentioned formula proportion, and heat the water to 40～60 DEG C, standby；
S2. disperse: load weighted each raw material is added and in nano-shearing machine, carries out shearing dispersion, prepared animal is removed with deinsectization
Demodicid mite shampoo.
Further: the linear velocity of described nano-shearing machine is 5～15m/s, shear time is 10～20min.
The invention has the advantages that adopting nimbin and neem oil to be main functional component in the formula of the present invention, with
Other raw material reasonable compatibilities, can effectively alleviate the symptoms such as animal skin prurituss, local erythema, depilation.Neem oil is a kind of from print
The plants essential oil extracting in chinaberry seed, has potent antimicrobial acivity containing active component nimbin, has drive simultaneously
Worm effect.The product safety of the present invention, environmental protection, composition are simple, and have a prevention effect to worm, demodicid mite good, and preventive effect is lasting；The present invention
Preparation method using nano-shearing machine, raw material is sheared, so that each raw material is fully mixed by nanotechnology, preparation method
It is simple and convenient to operate, low cost, be applied to industrialization large-scale production.
Specific embodiment
With reference to embodiment, the present invention will be further described, and protection scope of the present invention is not limited to following institute
State.
Embodiment 1: a kind of deinsectization acaricide shampoo of animal, in parts by weight, its component is:
The above-mentioned animal preparation method of deinsectization acaricide shampoo, it comprises the following steps:
S1. weigh: weigh each raw material by above-mentioned formula proportion, and heat the water to 40 DEG C, standby；
S2. disperse: load weighted each raw material is added and in nano-shearing machine, carries out shearing dispersion, prepared animal is removed with deinsectization
Demodicid mite shampoo, wherein, the linear velocity of described nano-shearing machine is 5m/s, and shear time is 20min.
Embodiment 2: a kind of deinsectization acaricide shampoo of animal, in parts by weight, its component is:
The above-mentioned animal preparation method of deinsectization acaricide shampoo, it comprises the following steps:
S1. weigh: weigh each raw material by above-mentioned formula proportion, and heat the water to 60 DEG C, standby；
S2. disperse: load weighted each raw material is added and in nano-shearing machine, carries out shearing dispersion, prepared animal is removed with deinsectization
Demodicid mite shampoo, wherein, the linear velocity of described nano-shearing machine is 15m/s, and shear time is 10min.
Embodiment 3: a kind of deinsectization acaricide shampoo of animal, in parts by weight, its component is:
The above-mentioned animal preparation method of deinsectization acaricide shampoo, it comprises the following steps:
S1. weigh: weigh each raw material by above-mentioned formula proportion, and heat the water to 45 DEG C, standby；
S2. disperse: load weighted each raw material is added and in nano-shearing machine, carries out shearing dispersion, prepared animal is removed with deinsectization
Demodicid mite shampoo, wherein, the linear velocity of described nano-shearing machine is 7m/s, and shear time is 12min.
Embodiment 4: a kind of deinsectization acaricide shampoo of animal, in parts by weight, its component is:
The above-mentioned animal preparation method of deinsectization acaricide shampoo, it comprises the following steps:
S1. weigh: weigh each raw material by above-mentioned formula proportion, and heat the water to 50 DEG C, standby；
S2. disperse: load weighted each raw material is added and in nano-shearing machine, carries out shearing dispersion, prepared animal is removed with deinsectization
Demodicid mite shampoo, wherein, the linear velocity of described nano-shearing machine is 10m/s, and shear time is 15min.
Embodiment 5: a kind of deinsectization acaricide shampoo of animal, in parts by weight, its component is:
The above-mentioned animal preparation method of deinsectization acaricide shampoo, it comprises the following steps:
S1. weigh: weigh each raw material by above-mentioned formula proportion, and heat the water to 53 DEG C, standby；
S2. disperse: load weighted each raw material is added and in nano-shearing machine, carries out shearing dispersion, prepared animal is removed with deinsectization
Demodicid mite shampoo, wherein, the linear velocity of described nano-shearing machine is 12m/s, and shear time is 17min.
Embodiment 6: a kind of deinsectization acaricide shampoo of animal, in parts by weight, its component is:
The above-mentioned animal preparation method of deinsectization acaricide shampoo, it comprises the following steps:
S1. weigh: weigh each raw material by above-mentioned formula proportion, and heat the water to 58 DEG C, standby；
S2. disperse: load weighted each raw material is added and in nano-shearing machine, carries out shearing dispersion, prepared animal is removed with deinsectization
Demodicid mite shampoo, wherein, the linear velocity of described nano-shearing machine is 14m/s, and shear time is 19min.
Embodiment 7: a kind of deinsectization acaricide shampoo of animal, in parts by weight, its component is:
The above-mentioned animal preparation method of deinsectization acaricide shampoo, it comprises the following steps:
S1. weigh: weigh each raw material by above-mentioned formula proportion, and heat the water to 43 DEG C, standby；
S2. disperse: load weighted each raw material is added and in nano-shearing machine, carries out shearing dispersion, prepared animal is removed with deinsectization
Demodicid mite shampoo, wherein, the linear velocity of described nano-shearing machine is 7m/s, and shear time is 16min.
Below by way of test description beneficial effects of the present invention:
1. supply reagent thing and animal
The animal deinsectization acaricide shampoo of embodiment 1-7 preparation；The epizoites such as clinical definite infection louse, acarid, flea
The domestic pets dog of parasitosis, cat totally 350.
2 methods
2.1 pairs of common epizoa killing effects are observed
To the pet dog infected with louse, flea, after for examination shampoo, observe its clinical symptoms in 24-72h, outer to judge
Parasitic infection situation.Take galley proof, the ectozoic species of microscopy and its quantity, choose polypide, microscopy survival condition is stiff
It is dead that no active person sentences work.Respectively pathological material of disease microscopy is scraped in latter seven days using specified property Ah Bai to the house pet made a definite diagnosis with acaricide,
Observe the active situation of acarid and its clinical symptoms of house pet.
Shampoo for pets deinsectization test effect criterion:
Cure: after a course for the treatment of, all clinical symptom disappearance, pet activity recovers normal, checks and has no pathogen and disease
Substance Excreta.
Effective: after a course for the treatment of, all clinical symptom reliefs, but do not recover to premorbid state, check pathogen and disease
The quantity of substance Excreta significantly reduces.
Invalid: after a course for the treatment of, clinical symptoms no significant change even increases, and checks pathogen and pathogen Excreta not
See minimizing.
2.2 killing in vitro epizoa tests
The epizoa capturing from house pet body surface is placed in plate, sample will be divided into for examination shampoo simultaneously, and be positioned over
In plate, rubber belt sealing plate.At 22 DEG C of room temperature, observe per hour under anatomical lens 1 time, after Continuous Observation 6h, see every 6h
Examine 1 time to 48h, observe the effect to polypide for the shampoo for pets.Matched group does not use shampoo.Motionless simultaneously with parasite limbs and claw
Stiff it is judged to death.
3 testing results
3.1 pairs of common epizoa killing effects
Choose and clinically infect louse, the pet dog of flea ectoparasite disease, cat totally 350, wherein, be divided into 7 groups, every group 50
Only, numbering respectively is 1,2,3,4,5,6,7；Substantially, animal shows as dysphoria, scratches case ectoparasite disease Clinical symptoms
Itch, scratch everywhere and rub, check that Rhizoma Imperatae portion can find louse, flea Excreta.
Using for examination shampoo, it is 1 that the shampoo of embodiment 1-7 corresponds respectively to numbering, and 2,3,4,5,6,7 house pet, in 24h
After observe its clinical response, wherein 338 pet dog clinical symptom disappearance, phenomenon of no scratching where it itches, diet rest all recovers normal, gives
After pet bathing, 24h checks that Rhizoma Imperatae portion does not find louse, flea Excreta again；9 pet dog clinical symptoms substantially mitigate, and diet is stopped
Breath returns to normal, and after having a bath, 24h checks and finds only have a small amount of louse, flea Excreta；3 pet dog are faced using for after examination shampoo
Bed symptom no significant change, and the shampoo effect of embodiment 7 is preferably, concrete outcome is as shown in table 1.
Table 1: to common epizoa killing effect experimental result
| Numbering | Symptom disappears (only) | Symptom substantially mitigates (only) | Non-evident sympton (only) |
| 1 | 47 | 0 | 3 |
| 2 | 45 | 5 | 0 |
| 3 | 50 | 0 | 0 |
| 4 | 50 | 0 | 0 |
| 5 | 46 | 4 | 0 |
| 6 | 50 | 0 | 0 |
| 7 | 50 | 0 | 0 |
Choose and clinically infect the ectozoic pet dog of mite class, cat totally 100.Around the house pet eye socket of infection acaricide,
Substantially, pigementation in part house pet depilation area skin for nose depilation.Take galley proof, visible acarid live body after microscopy.Make
With for examination shampoo, taking galley proof microscopy to observe acarid activity situation after 3d again, find mite population, activity and use shampoo
Before significantly reduce and reduce, show respond well to the Clinical practice of house pet acaricide for examination shampoo.
3.2 killing in vitro epizoa effects
From clinical onset case body surface capture louse, flea amount to 350, will wherein 175 be placed in plate, simultaneously by house pet
Shampoo embodiment 1-7 respectively takes some as sample, is also placed in interior in plate, is set to experimental group: in addition 175 are placed in plate,
As a control group, use rubber belt sealing plate respectively, at 22 DEG C of room temperature, in dissection Microscopic observation.Criterion: polypide limbs and foot
Pawl is motionless and is directly judged to death.
Test group Continuous Observation 5h, in plate, louse, flea mobility decline, all dead after 8h, and rigid limbs are no alive
Dynamic, subsequent limbs shrink agglomerating；In comparison plate, 175 parasite 12h are showed no exception, and activity is normal, as shown in table 2.Body
Outer result of the test shows that tested shampoo for pets is respond well to expeling louse, flea epizoa.
Table 2: killing in vitro epizoa effect experimental result
| Sequence number | 5h | 8h | 12h |
| Experimental group (175) | Louse, flea mobility decline | All dead | All dead |
| Matched group (175) | No abnormality seen | No abnormality seen | No abnormality seen |
Claims (4)
1. a kind of animal with deinsectization acaricide shampoo it is characterised in that: in parts by weight, its component is:
Dodecyl ether sulfate: 1～8；Coconut monoethanol amide: 1～3；
Cocoamido propyl hydroxy sulfobetaine: 8～10；C12-13 alkyl lactate ester: 2～15；
Nimbin: 0～5；Neem oil: 0～20；
Pyrethrin: 0～10；Osthole: 0～15；
Natural essence: 0.3～1；Matrine: 0～10；
Plant amino acid: 10～50；Deionized water: 50～60；
Wherein, nimbin and neem oil can not be 0 simultaneously.
2. as claimed in claim 1 a kind of animal with deinsectization acaricide shampoo it is characterised in that: in parts by weight, its component is:
Dodecyl ether sulfate: 4；Coconut monoethanol amide: 1.5；
Cocoamido propyl hydroxy sulfobetaine: 9；C12-13 alkyl lactate ester: 10；
Nimbin: 1；Neem oil: 5；
Pyrethrin: 3；Osthole: 6；
Natural essence: 0.7；Matrine: 3；
Plant amino acid: 25；Deionized water: 55.
3. as claimed in claim 1 or 2 a kind of animal with the preparation method of deinsectization acaricide shampoo it is characterised in that: it includes
Following steps:
S1. weigh: weigh each raw material by above-mentioned formula proportion, and heat the water to 40～60 DEG C, standby；
S2. disperse: load weighted each raw material is added and in nano-shearing machine, carries out shearing dispersion, prepared animal deinsectization acaricide
Shampoo.
4. as claimed in claim 3 a kind of animal with the preparation method of deinsectization acaricide shampoo it is characterised in that: described nanometer is cut
The linear velocity cutting machine is 5～15m/s, and shear time is 10～20min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610976068.2A CN106361611A (en) | 2016-11-07 | 2016-11-07 | Insect and acarus killing shampoo for animals and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610976068.2A CN106361611A (en) | 2016-11-07 | 2016-11-07 | Insect and acarus killing shampoo for animals and preparation method thereof |
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| CN106361611A true CN106361611A (en) | 2017-02-01 |
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| CN201610976068.2A Pending CN106361611A (en) | 2016-11-07 | 2016-11-07 | Insect and acarus killing shampoo for animals and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114984086A (en) * | 2022-05-16 | 2022-09-02 | 媞颂日化用品(广州)有限公司 | Plant extract insecticidal composition and application thereof in pet washing and caring products |
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2016
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114984086A (en) * | 2022-05-16 | 2022-09-02 | 媞颂日化用品(广州)有限公司 | Plant extract insecticidal composition and application thereof in pet washing and caring products |
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