CN106344928A - Application of modified starch in medicine - Google Patents
Application of modified starch in medicine Download PDFInfo
- Publication number
- CN106344928A CN106344928A CN201610757165.2A CN201610757165A CN106344928A CN 106344928 A CN106344928 A CN 106344928A CN 201610757165 A CN201610757165 A CN 201610757165A CN 106344928 A CN106344928 A CN 106344928A
- Authority
- CN
- China
- Prior art keywords
- modified starch
- starch
- medicine
- application
- mixed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000881 Modified starch Polymers 0.000 title claims abstract description 20
- 239000004368 Modified starch Substances 0.000 title claims abstract description 20
- 239000003814 drug Substances 0.000 title claims abstract description 20
- 235000019426 modified starch Nutrition 0.000 title claims abstract description 20
- 229920002472 Starch Polymers 0.000 claims abstract description 10
- 239000004375 Dextrin Substances 0.000 claims abstract description 7
- 229920001353 Dextrin Polymers 0.000 claims abstract description 7
- 235000019425 dextrin Nutrition 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims abstract description 7
- 239000000843 powder Substances 0.000 claims abstract description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 6
- 229930195725 Mannitol Natural products 0.000 claims abstract description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 6
- 229930006000 Sucrose Natural products 0.000 claims abstract description 6
- 239000000594 mannitol Substances 0.000 claims abstract description 6
- 235000010355 mannitol Nutrition 0.000 claims abstract description 6
- 239000000080 wetting agent Substances 0.000 claims abstract description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims abstract description 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 8
- 239000005720 sucrose Substances 0.000 claims description 5
- 235000019890 Amylum Nutrition 0.000 claims description 3
- 108010010803 Gelatin Proteins 0.000 claims description 3
- 244000017020 Ipomoea batatas Species 0.000 claims description 3
- 235000002678 Ipomoea batatas Nutrition 0.000 claims description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 3
- 230000001476 alcoholic effect Effects 0.000 claims description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 3
- 238000000748 compression moulding Methods 0.000 claims description 3
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 3
- 239000008273 gelatin Substances 0.000 claims description 3
- 229920000159 gelatin Polymers 0.000 claims description 3
- 235000019322 gelatine Nutrition 0.000 claims description 3
- 235000011852 gelatine desserts Nutrition 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 229920001592 potato starch Polymers 0.000 claims description 3
- 229940069328 povidone Drugs 0.000 claims description 3
- 238000009702 powder compression Methods 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 240000000111 Saccharum officinarum Species 0.000 claims 1
- 235000007201 Saccharum officinarum Nutrition 0.000 claims 1
- 239000008107 starch Substances 0.000 abstract description 7
- 235000019698 starch Nutrition 0.000 abstract description 7
- 238000001816 cooling Methods 0.000 abstract description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 230000006835 compression Effects 0.000 abstract 1
- 238000007906 compression Methods 0.000 abstract 1
- 235000009508 confectionery Nutrition 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 229960004793 sucrose Drugs 0.000 abstract 1
- 239000003826 tablet Substances 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000007910 chewable tablet Substances 0.000 description 2
- 229940068682 chewable tablet Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 235000019605 sweet taste sensations Nutrition 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 244000182067 Fraxinus ornus Species 0.000 description 1
- 235000002917 Fraxinus ornus Nutrition 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 229940096978 oral tablet Drugs 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
Abstract
The invention provides an application of a modified starch in medicine; the modified starch is mixed with one more pharmaceutic adjuvant materials of cane sugar, milk sugar, microcrystalline cellulose, dextrin,mannitol, superfine silica powder and hard calcium hydrophosphate; meanwhile the modified starch comprises less wetting agent; during the preparation process of western medicine slice, the above mixture is added in the modified starch; and then the obtained powder is uniformly mixed; the starch is directly pressed by the powder; and then the modified starch is obtained by pre-pressingor one-off compression formation. The mixed starch provided in the invention is mixed with the powdered sugar with better compressibility and the dextrin; with better compressibility, the starch has no loosening, the mannitol is added to absorb heat when being dissolved in the mouth, so the starch has cooling feeling and a certain sweet, and the starch is suitable for preparing chewable table.
Description
Technical field
The present invention relates to western medicine tablet production technical field is and in particular to application in medicine for the modified starch.
Background technology
A kind of filler adding in the oral tablet of existing western medicine tablet, is also diluent, Main Function is to increase medicine
Weight or volume, in order to medicine is pressed into tablet.
Generally, the requirement to tablet is: diameter can not be less than 6 millimeters, and weight is more than 100 milligrams.As chankings
Principal agent in agent only has several milligrams or tens milligrams, will be unable to make tablet.Now, can be increased by adding suitable filler
Plus volume, allow tablet reach component, help its molding；Existing additive design composition is unreasonable, and compressibility is poor, can make extrusion
Tablet is excessively loose.
Content of the invention
(1) technical problem solving
For the deficiencies in the prior art, the invention provides application in medicine for the modified starch, it is poor to solve pressure property,
The excessively loose problem of the tablet of extrusion can be made.
(2) technical scheme
For realizing object above, the present invention is achieved by the following technical programs:
A kind of application in medicine for modified starch, described modified starch be selected from sucrose, Lactose, micro- for one or more
Crystalline cellulose, dextrin, Mannitol, micropowder silica gel, the material mixing of the pharmaceutic adjuvant of hard calcium hydrogen phosphate, contain a small amount of moistening simultaneously
Agent；In Western medicine decoction pieces preparation process, said mixture material is added to wherein, then by the powder obtaining mix homogeneously, then
Using direct powder compression, precompressed or first compression molding, that is, obtain.
Described modified starch is sweet potato starch and amylum pregelatinisatum mixing, processes through superheat and obtains.
Described wetting agent is gelatin solution, sucrose solution, 4% aqueous povidone solution or alcoholic solution.
(3) beneficial effect
Embodiments provide application in medicine for the modified starch.Possesses following beneficial effect: form sediment using mixing
Preferable Icing Sugar, dextrin are used in mixed way powder with compressibility；Compressibility is good；It is not in loose situation；It has been also added with manna simultaneously
Alcohol, absorbs heat when orally-dissolvable, thus has cooling feeling, have certain sweet taste simultaneously, compare and be adapted to prepare chewable tablet.
Specific embodiment
Purpose, technical scheme and advantage for making the embodiment of the present invention are clearer, to the technology in the embodiment of the present invention
Scheme is clearly and completely described it is clear that described embodiment a part of embodiment that is the present invention, rather than whole
Embodiment.Based on the embodiment in the present invention, those of ordinary skill in the art are obtained under the premise of not making creative work
The every other embodiment obtaining, broadly falls into the scope of protection of the invention.
Embodiments provide specific embodiment, a kind of application in medicine for modified starch, described degeneration
Starch and one or more are selected from sucrose, Lactose, Microcrystalline Cellulose, dextrin, Mannitol, micropowder silica gel, the medicine of hard calcium hydrogen phosphate
With the material mixing of adjuvant, contain a small amount of wetting agent simultaneously；In Western medicine decoction pieces preparation process, said mixture material is added to
Wherein, then by the powder obtaining mix homogeneously, then adopt direct powder compression, precompressed or first compression molding, that is, obtain；Institute
The modified starch stated is sweet potato starch and amylum pregelatinisatum mixing, processes through superheat and obtains；Described wetting agent is that gelatin is molten
Liquid, sucrose solution, 4% aqueous povidone solution or alcoholic solution.
The present invention is used in mixed way using the preferable Icing Sugar of mixing starch and compressibility, dextrin；Compressibility is good；It is not in pine
Scattered situation；It has been also added with Mannitol simultaneously, absorbed heat when orally-dissolvable, thus have cooling feeling, there is certain sweet taste simultaneously, than
Relatively it is adapted to prepare chewable tablet.
It should be noted that herein, such as first and second or the like relational terms are used merely to a reality
Body or operation are made a distinction with another entity or operation, and not necessarily require or imply these entities or deposit between operating
In any this actual relation or order.And, term " inclusion ", "comprising" or its any other variant are intended to
Comprising of nonexcludability, wants so that including a series of process of key elements, method, article or equipment and not only including those
Element, but also include other key elements being not expressly set out, or also include for this process, method, article or equipment
Intrinsic key element.In the absence of more restrictions, the key element that limited by sentence "including a ..." it is not excluded that
Also there is other identical element including in the process of described key element, method, article or equipment.
Above example only in order to technical scheme to be described, is not intended to limit；Although with reference to the foregoing embodiments
The present invention has been described in detail, it will be understood by those within the art that: it still can be to aforementioned each enforcement
Technical scheme described in example is modified, or carries out equivalent to wherein some technical characteristics；And these modification or
Replace, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention skill scheme.
Claims (3)
1. a kind of application in medicine for modified starch it is characterised in that: described modified starch and be selected from sugarcane one or more
Sugar, Lactose, Microcrystalline Cellulose, dextrin, Mannitol, micropowder silica gel, the material mixing of the pharmaceutic adjuvant of hard calcium hydrogen phosphate, contain simultaneously
There is a small amount of wetting agent；In Western medicine decoction pieces preparation process, said mixture material is added to wherein, then the powder obtaining is mixed
Close uniformly, then adopt direct powder compression, precompressed or first compression molding, that is, obtain.
2. a kind of application in medicine for the modified starch according to claim 1 it is characterised in that: described modified starch
For sweet potato starch and amylum pregelatinisatum mixing, process through superheat and obtain.
3. a kind of application in medicine for the modified starch according to claim 1 it is characterised in that: described wetting agent is
Gelatin solution, sucrose solution, 4% aqueous povidone solution or alcoholic solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610757165.2A CN106344928A (en) | 2016-08-31 | 2016-08-31 | Application of modified starch in medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610757165.2A CN106344928A (en) | 2016-08-31 | 2016-08-31 | Application of modified starch in medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106344928A true CN106344928A (en) | 2017-01-25 |
Family
ID=57856995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610757165.2A Pending CN106344928A (en) | 2016-08-31 | 2016-08-31 | Application of modified starch in medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106344928A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334285A (en) * | 2000-05-01 | 2002-02-06 | 国家淀粉及化学投资控股公司 | Polysaccharide material for direct tabletting |
| CN1456163A (en) * | 2003-04-01 | 2003-11-19 | 杭州华卫制药技术开发有限公司 | Oral medicine of leucovocin calcium and its preparing method |
| CN1723905A (en) * | 2005-07-13 | 2006-01-25 | 张志生 | Cefdinir oral disintegration tablet, and its prepn. method |
| CN1839827A (en) * | 2006-01-16 | 2006-10-04 | 重庆医药工业研究院有限责任公司 | Strontium ranelate chewing tablet and its preparation process |
| WO2011024028A1 (en) * | 2009-08-24 | 2011-03-03 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Direct compression tablets of otilonium |
| WO2016050768A1 (en) * | 2014-09-30 | 2016-04-07 | Molkerei Meggle Wasserburg Gmbh & Co.Kg | Direct compression excipient based on lactose, cellulose and starch |
-
2016
- 2016-08-31 CN CN201610757165.2A patent/CN106344928A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334285A (en) * | 2000-05-01 | 2002-02-06 | 国家淀粉及化学投资控股公司 | Polysaccharide material for direct tabletting |
| CN1456163A (en) * | 2003-04-01 | 2003-11-19 | 杭州华卫制药技术开发有限公司 | Oral medicine of leucovocin calcium and its preparing method |
| CN1723905A (en) * | 2005-07-13 | 2006-01-25 | 张志生 | Cefdinir oral disintegration tablet, and its prepn. method |
| CN1839827A (en) * | 2006-01-16 | 2006-10-04 | 重庆医药工业研究院有限责任公司 | Strontium ranelate chewing tablet and its preparation process |
| WO2011024028A1 (en) * | 2009-08-24 | 2011-03-03 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Direct compression tablets of otilonium |
| WO2016050768A1 (en) * | 2014-09-30 | 2016-04-07 | Molkerei Meggle Wasserburg Gmbh & Co.Kg | Direct compression excipient based on lactose, cellulose and starch |
Non-Patent Citations (2)
| Title |
|---|
| 过冠介,龚建明: "可压性淀粉在全粉末直接压片工艺中的应用", 《上海医药》 * |
| 黄方言: "《现代实用中药新剂型新技术》", 30 April 2001, 人民卫生出版社 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170125 |