CN106344863A - 靶向修复胃的砂仁猴头菇压片糖果 - Google Patents
靶向修复胃的砂仁猴头菇压片糖果 Download PDFInfo
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Abstract
本发明涉及一种靶向修复胃的砂仁猴头菇压片糖果,其包含砂仁、猴头菇、肉豆蔻、肉桂、山楂、山药、麦芽、莱菔子、菊粉、蜂蜜和异麦芽酮糖。本发明的砂仁猴头菇压片糖果适口性好,靶向修复胃(胃黏膜、胃壁),对胃出血、胃溃疡、慢性胃炎、糜烂性胃炎、幽门螺旋杆菌阳性患者具有非常好的效果。
Description
技术领域
本发明涉及医疗保健领域,具体涉及一种靶向修复胃的砂仁猴头菇压片糖果,其包含异麦芽酮糖、蜂蜜、菊粉和以下的水提物:砂仁、猴头菇、肉豆蔻、肉桂、山楂、山药、麦芽和莱菔子。本发明的砂仁猴头菇压片糖果适口性好,靶向修复胃(胃黏膜、胃壁),对胃出血、胃溃疡、慢性胃炎、糜烂性胃炎、幽门螺旋杆菌阳性患者具有非常好的效果。
背景技术
近年来我国经济飞速发展,人民生活条件得到很大改善,高蛋白、高脂肪和低纤维的饮食方式以及酒消费量的增长,使人们胃壁和胃黏膜受损,胃功能紊乱、异常,胃微生物群失调,导致胃炎、胃癌等疾病的发病率提高。
胃每天在不停地工作,食物在消化的过程中会对黏膜造成机械性的损伤,保持有节制的饮食及合理的搭配是治胃养胃的关键,正所谓“三分治七分养”。
现在市场上辅助治疗胃损伤的保健品/药品要么疗效不明显,要么适口性不佳消费者难以接受。因此一种效果明显、适口性好的靶向修复胃的保健品/药品是消费者迫切需要的。
发明内容
本发明人研发了一种靶向修复胃的砂仁猴头菇压片糖果,其包含异麦芽酮糖、诺丽果浆、玛咖粉、番茄红素和以下的水提物:砂仁、猴头菇、枸杞子、海参、葛根、牡蛎、黑芝麻、淡豆豉、龙眼肉、红枣和松花粉。本发明的砂仁猴头菇压片糖果适口性好,靶向修复胃(胃黏膜、胃壁),对胃出血、胃溃疡、慢性胃炎、糜烂性胃炎、幽门螺旋杆菌阳性患者具有非常好的效果。
本发明的第一方面提供一种靶向修复肾的砂仁猴头菇压片糖果,其包含异麦芽酮糖、诺丽果浆、玛咖粉、番茄红素和以下的水提物:砂仁、猴头菇、枸杞子、海参、葛根、牡蛎、黑芝麻、淡豆豉、龙眼肉、红枣和松花粉。
在一个实施方案中,本发明的砂仁猴头菇压片糖果包含55-75重量份的异麦芽酮糖、5-15重量份的蜂蜜、1-10重量份的菊粉和以下的水提物:5-15重量份的砂仁、5-15重量份的猴头菇、1-10重量份的肉豆蔻、1-10重量份的肉桂、1-10重量份的山楂、1-10重量份的山药、1-10重量份的麦芽、和1-10重量份的莱菔子。
在一个实施方案中,本发明的砂仁猴头菇压片糖果包含60-70重量份的异麦芽酮糖、8-12重量份的蜂蜜、3-7重量份的菊粉和以下的水提物:8-12重量份的砂仁、8-12重量份的猴头菇、3-7重量份的肉豆蔻、3-7重量份的肉桂、3-7重量份的山楂、3-7重量份的山药、3-7重量份的麦芽和3-7重量份的莱菔子。。
在一个实施方案中,本发明的砂仁猴头菇压片糖果包含65重量份的异麦芽酮糖、10重量份的蜂蜜、5重量份的菊粉和以下的水提物:10重量份的砂仁、10重量份的猴头菇、5重量份的肉豆蔻、5重量份的肉桂、5重量份的山楂、5重量份的山药、5重量份的麦芽和5重量份的莱菔子。
在一个实施方案中,本发明的砂仁猴头菇压片糖果还包含粘合剂和崩解剂。
本发明的第二方面提供制备本发明第一方面所述的砂仁猴头菇压片糖果的方法,包括以下步骤:称量、前处理、配料、混合、制粒、干燥、压片、包装而制得。
在一个实施方案中,所述前处理包括以下的煮提、浓缩和干燥:砂仁、猴头菇、肉豆蔻、肉桂、山楂、山药、麦芽和莱菔子。
本发明的第三方面提供一种组合物在制备用于靶向修复胃,治疗胃出血、胃溃疡、慢性胃炎、糜烂性胃炎、幽门螺旋杆菌阳性患者的药物和保健品中的用途,所述组合物包含异麦芽酮糖、蜂蜜、菊粉和以下的水提物:砂仁、猴头菇、肉豆蔻、肉桂、山楂、山药、麦芽和莱菔子。
在一个实施方案中,所述组合物包含55-75重量份的异麦芽酮糖、5-15重量份的蜂蜜、1-10重量份的菊粉和以下的水提物:5-15重量份的砂仁、5-15重量份的猴头菇、1-10重量份的肉豆蔻、1-10重量份的肉桂、1-10重量份的山楂、1-10重量份的山药、1-10重量份的麦芽、和1-10重量份的莱菔子。
在一个实施方案中,所述组合物包含60-70重量份的异麦芽酮糖、8-12重量份的蜂蜜、3-7重量份的菊粉和以下的水提物:8-12重量份的砂仁、8-12重量份的猴头菇、3-7重量份的肉豆蔻、3-7重量份的肉桂、3-7重量份的山楂、3-7重量份的山药、3-7重量份的麦芽和3-7重量份的莱菔子。
在一个实施方案中,所述组合物包含65重量份的异麦芽酮糖、10重量份的蜂蜜、5重量份的菊粉和以下的水提物:10重量份的砂仁、10重量份的猴头菇、5重量份的肉豆蔻、5重量份的肉桂、5重量份的山楂、5重量份的山药、5重量份的麦芽和5重量份的莱菔子。
在一个实施方案中,所述组合物还包含粘合剂和崩解剂。
具体实施方式
本发明使用的原辅料均可由市场购得,其中:
异麦芽酮糖应符合QB 1581的要求。
砂仁、肉豆蔻、肉桂、山楂、山药、麦芽、莱菔子应符合《中华人民共和国药典》2015年版一部的要求。
菊粉应符合《关于批准菊粉、多聚果糖为新资源食品的公告(卫计委2009年第5号)》的要求。
蜂蜜应符合GB 14963的要求。
猴头菇应符合GB 7096的要求。
以上原辅料还应符合GB 2761、GB2762、GB2763的要求。
本发明所述的称量、煮提、浓缩、干燥、配料、混合、制粒、干燥、压片、包装均为本领域公知的含义,本发明对上述过程并无特别要求。
实施例
为更好地说明本发明,便于理解本发明的技术方案,本发明的典型但非限制性的实施例如下。
一、本发明压片糖果的制备
将10重量份的砂仁、10重量份的猴头菇、5重量份的肉豆蔻、5重量份的肉桂、5重量份的山楂、5重量份的山药、5重量份的麦芽和5重量份的莱菔子按1:10的料水比混合,在80℃下浸泡15分钟,收集浸提液,筛去浸提液中的残渣;将浸提液在50℃、真空度80KPa下真空浓缩至固形物含量为40%;将所得浓缩液与65重量份的异麦芽酮糖、10重量份的蜂蜜、5重量份的菊粉混合造粒得到湿粒;将湿粒在50℃下干燥数小时;将干燥后的粒子混合后进行压片,制备得到1g/片的压片糖果。
制备得到的压片糖果满足以下标准
二.动物实验
取20只SPF级SD大鼠,180-220g,雌雄各半,6周龄,按如下方法建立大鼠慢性浅表性胃炎模型:以0.02%氨水自由饮用,配合饥饱失常法(2d足食,1d禁食)喂食,连续90d。造模结束后,随机取5只大鼠,处死后取其胃黏膜,经病理组织学检查确定大鼠慢性浅表性胃炎模型复制成功。
将造模成功的模型大鼠随机分为试验组和对照组,每组10只,雌雄各半;试验组按100mg/kg体重/天喂以本发明压片糖果;对照组喂以安慰剂,连续40天。末次给药后,禁食不禁水24h,然后脊椎脱臼法处死各组大鼠。剖腹,幽门环下0.3cm处结扎肠管,由食道向胃腔注入1Oml pH7.2-7.6的PBS缓冲盐溶液,随即食道结扎,取出胃并浸泡于冰PBS中。固定15min后沿胃大弯剪开暴露胃腔,计算胃黏膜损伤率;胃黏膜损伤率=胃黏膜损伤面积/胃黏膜总面积×100%。同时,取胃组织,用10%甲醛溶液固定,常规石蜡包埋,4μm切片,经HE染色切片,观察胃粘膜层组织病理学变化。
试验结果发现,试验组大鼠胃粘膜表面呈现光滑、柔软而又光泽,胃体部呈橘红色,幽门部为橘黄色;对照组胃粘膜充血水肿,色淡呈淡红色,红白相间,有散在点状、斑点或条状出血和糜烂,可见陈旧性出血和新鲜出血,黏膜损伤率高,个别动物胃窦部局部粘膜皱襞增厚,偶见粘液性黄色渗出物。动物实验显示用本发明压片糖果产品对胃损伤有显著的修复效果。
三、临床效果
观察慢性胃炎病例60例,年龄25-43岁,分为试验组30例,对照组30例。两组年龄、病情等资料无显著性差异,具有可比性。对试验组病例给予本发明压片糖果,使用量为每次3片,每日2次,温水送服。对照组病例给予治疗慢性胃炎的某验方治疗。10天1疗程,4疗程结束后统计。
疗效判定:
1、显效:体质增强,身上有劲;水肿明显缓解、消失;蛋白尿、血尿减少;检查肾功能指标改善。
2、有效:体质增强,身上有劲;水肿、蛋白尿、血尿等有所缓解。
3、无效:病症无变化。
通过统计,试验组20例患者疗程结束后显效率63.3%(19/30),有效率为33.3%(9/30),总有效率96.6%(28/30)。对照组30例患者疗程结束后显效率30%(9/30),有效率46.6%(14/30),总有效率76.6%。试验组的显效率和总有效率均更佳。
安全性:患者在实验过程中未发现明显不良反应。实验期间患者尿常规、粪常规、肝功能、肾功能、凝血功能均未见明显异常。
申请人声明,本发明通过上述实施例来说明本发明的详细方法,但本发明并不局限于上述详细方法,即不意味着本发明必须依赖上述详细方法才能实施。所属技术领域的技术人员应该明了,对本发明的任何改进,对本发明产品各原料的等效替换及辅助成分的添加、具体方式的选择等,均落在本发明的保护范围和公开范围之内。
Claims (10)
1.一种靶向修复胃的砂仁猴头菇压片糖果,其包含异麦芽酮糖、蜂蜜、菊粉和以下的水提物:砂仁、猴头菇、肉豆蔻、肉桂、山楂、山药、麦芽和莱菔子。
2.如权利要求1所述的砂仁猴头菇压片糖果,其包含55-75重量份的异麦芽酮糖、5-15重量份的蜂蜜、1-10重量份的菊粉和以下的水提物:5-15重量份的砂仁、5-15重量份的猴头菇、1-10重量份的肉豆蔻、1-10重量份的肉桂、1-10重量份的山楂、1-10重量份的山药、1-10重量份的麦芽、和1-10重量份的莱菔子。
3.如权利要求1所述的砂仁猴头菇压片糖果,其包含60-70重量份的异麦芽酮糖、8-12重量份的蜂蜜、3-7重量份的菊粉和以下的水提物:8-12重量份的砂仁、8-12重量份的猴头菇、3-7重量份的肉豆蔻、3-7重量份的肉桂、3-7重量份的山楂、3-7重量份的山药、3-7重量份的麦芽和3-7重量份的莱菔子。
4.如权利要求1所述的砂仁猴头菇压片糖果,其包含65重量份的异麦芽酮糖、10重量份的蜂蜜、5重量份的菊粉和以下的水提物:10重量份的砂仁、10重量份的猴头菇、5重量份的肉豆蔻、5重量份的肉桂、5重量份的山楂、5重量份的山药、5重量份的麦芽和5重量份的莱菔子。
5.制备如权利要求1-4任一项所述的砂仁猴头菇压片糖果的方法,包括以下步骤:称量、前处理、配料、混合、制粒、干燥、压片、包装而制得。
6.如权利要求5所述的方法,其中所述前处理包括以下成分的煮提、浓缩和干燥:砂仁、猴头菇、肉豆蔻、肉桂、山楂、山药、麦芽和莱菔子。
7.一种组合物在制备用于靶向修复胃,治疗胃出血、胃溃疡、慢性胃炎、糜烂性胃炎、幽门螺旋杆菌阳性患者的药物和保健品中的用途,所述组合物包含异麦芽酮糖、蜂蜜、菊粉和以下的水提物:砂仁、猴头菇、肉豆蔻、肉桂、山楂、山药、麦芽和莱菔子。
8.如权利要求7所述的用途,其中所述组合物包含55-75重量份的异麦芽酮糖、5-15重量份的蜂蜜、1-10重量份的菊粉和以下的水提物:5-15重量份的砂仁、5-15重量份的猴头菇、1-10重量份的肉豆蔻、1-10重量份的肉桂、1-10重量份的山楂、1-10重量份的山药、1-10重量份的麦芽、和1-10重量份的莱菔子。
9.如权利要求7所述的用途,其中所述组合物包含60-70重量份的异麦芽酮糖、8-12重量份的蜂蜜、3-7重量份的菊粉和以下的水提物:8-12重量份的砂仁、8-12重量份的猴头菇、3-7重量份的肉豆蔻、3-7重量份的肉桂、3-7重量份的山楂、3-7重量份的山药、3-7重量份的麦芽和3-7重量份的莱菔子。
10.如权利要求7所述的用途,其中所述组合物包含65重量份的异麦芽酮糖、10重量份的蜂蜜、5重量份的菊粉和以下的水提物:10重量份的砂仁、10重量份的猴头菇、5重量份的肉豆蔻、5重量份的肉桂、5重量份的山楂、5重量份的山药、5重量份的麦芽和5重量份的莱菔子。
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