CN106344824B - 一种雪莲培养物口服液及其制备方法 - Google Patents
一种雪莲培养物口服液及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种雪莲培养物口服液及其制备方法，由下列按重量份计算的原料制备而成：雪莲培养物粉20‑30份、芒草18‑22份、荷叶10‑12份、磷酸氢二钾2‑4份、低聚玉米肽5‑12份、L阿拉伯糖1‑3份、决明子速溶粉5‑10份、树莓浓缩汁2‑5份、聚葡萄糖1‑2份、木糖醇1‑5份和黄原胶2‑5份。本发明能起到降脂、间接阻糖，进而达到降压的实际功效，在调节三高的同时，还可以改善肠道功能，提高机体免疫力从而到达标本兼治的最终效果。
Description
技术领域
本发明属于保健口服液领域，具体涉及一种雪莲培养物口服液及其制备方法。
背景技术
由于雪莲具有很好的药效价值，在市场上使用越来越广泛，但由于其自然生长周期长，以及人们的过度开发，导致野生雪莲资源的匮乏，而人工种植虽然可短暂缓解这种情况，但是人工种植的环境要求苛刻，成活率低，而且药效成分的含量不理想。随着雪莲培养物生物技术的提高，雪莲培养物具有与野生天山雪莲相似的成分和药效，而且雪莲培养物中各成分含量均高于野生天山雪莲，更适用于保健品市场。
芒草是快生植物，生长环境要求不高而且成本低，目前的利用领域比较窄，多是作为能源作物，用于生产生物燃料或合成一些化学产品，利用率不高，由于芒草中也含有多种氨基酸和黄酮，而黄酮可阻止氧化，改善血液循环，具有一定的药效成分，但是由于芒草的青味以及其中黄酮在水中溶解度较差，没有很好的提取方法，因此目前芒草还未广泛地应用在食品或保健品领域。荷叶中含有荷叶碱和荷叶黄酮，可以在食品及保健品领域加以利用，现有技术中运用在食品行业提取黄酮的方法都不是太理想。
发明内容
为了克服上述技术问题，本发明提供了一种雪莲培养物口服液及其制备方法，通过芒草、荷叶提取液，并混合雪莲培养物，阿拉伯糖，低聚玉米肽，决明子，起到降脂、间接阻糖，进而达到降压的实际功效。在调节三高的同时，还可以改善肠道功能，提高机体免疫力，从而到达标本兼治的最终效果。
目前芒草基本还没有应用于食品领域，因此对其的制备方法的技术基本没有，而针对荷叶的提取液已有一些方法，但是基本是采用在热水中多次提取的方法，由于黄酮在水中的溶解度较差，因此提取液中黄酮的提取效果不理想。针对这个问题，本发明在热水中加入磷酸氢二钾，形成弱碱性溶液环境并辅以超声提取可得到较好的提取效果。
本发明所采用的技术方案是：一种雪莲培养物口服液，由下列按重量份计算的原料制备而成：雪莲培养物粉20-30份、芒草18-22份、荷叶10-12份、磷酸氢二钾2-4份、低聚玉米肽5-12份、L阿拉伯糖1-3份、决明子速溶粉5-10份、树莓浓缩汁2-5份、聚葡萄糖1-2份、木糖醇1-5份和黄原胶2-5份。
雪莲培养物口服液的制备方法包括以下步骤：
（1）将芒草超声清洗后切小块，隔水蒸2小时，然后进行榨汁，过滤得到芒草汁和芒草滤渣；将荷叶超声清洗后切小块，榨汁，过滤得到荷叶汁和荷叶滤渣；
（2）将芒草滤渣烘箱中干燥1-2h，用气流粉碎机粉碎投入浸提罐中，加入10-15倍的饮用纯化水，45℃下浸泡1h，加入磷酸氢二钾总质量的70%，在85-90℃下超声辅助提取40min，滤膜过滤；滤渣第二次加入5-10倍的饮用纯化水，加入磷酸氢二钾总质量的20%，在85-90℃下超声辅助提取40min，滤膜过滤；将两次滤液合并，减压浓缩至原来体积的1/2，即得芒草提取液；
（3）向荷叶滤渣中加入5倍质量的体积分数为75%的乙醇，80℃下搅拌30min后，微波辅助回流提取15min，继续超声辅助80℃回流1h，减压抽滤得第一次滤渣和第一次滤液，向第一次滤渣中加入3倍质量的体积分数为75%的乙醇，80℃下微波辅助回流提取15min，继续超声辅助80℃回流1h，减压抽滤得第二次滤渣和第二次滤液；将第一次滤液和第二次滤液合并减压浓缩回收乙醇，得到浓缩液，加入2倍质量的水，搅拌10min后静置10min,滤布过滤，即得荷叶提取液；
（4）将雪莲培养物粉先经超微粉碎机粉碎，加入相同重量的引用纯化水，在50℃下搅拌20min,保温的状态下加入磷酸氢二钾总质量的10%，超声辅助提取1h，滤膜过滤，得到第一次雪莲滤液和滤渣，在滤渣中加入相同重量的饮用纯化水保持在50℃，然后加入0.5-1%的质量比2:1的纤维素酶和果胶酶，酶解2h，升至90℃灭酶，滤膜过滤，得到第二次雪莲滤液，将两次雪莲滤液合并得到雪莲液；
（5）将芒草汁、荷叶汁、芒草提取液、荷叶提取液、雪莲液、低聚玉米肽、L阿拉伯糖、决明子速溶粉加入到混合提取液中，在40℃下搅拌混合2h，然后再加入树莓浓缩汁、聚葡萄糖、木糖醇和黄原胶搅拌混合30min；然后将混合料液抽入管式微滤膜中，调节压力至0.2MPa，收集通过管式微滤膜的滤液；
（6）90℃杀菌，冷却至55℃，进入高压均质机均质，均质压力为25MPa，均质后的料液即雪莲培养物口服液。
芒草先蒸2h，去除其青味，产生香气，然后榨汁，得到的芒草汁味道更好。芒草和荷叶榨汁后，虽然很多营养成分都在汁里了，但是芒草渣和荷叶渣中残存有黄酮，为了更充分的利用，把芒草渣和荷叶渣一起进行提取。
在对芒草渣、荷叶渣进行提取时，45℃下先浸泡1h，然后加入磷酸氢二钾，在85-90℃下超声辅助提取40min，由于加入磷酸氢二钾使得溶液呈弱碱性以及超声辅助提取，提取效率较之单纯热水的提取效率高，因此首次提取只需加10-15倍的水，相对于现有技术，加水量大大减少，降低了能耗。
将雪莲培养物粉先进行提取，然后对雪莲滤渣进行酶解，能尽量多的得到雪莲中的有效成分，而且果胶酶的加入使得雪莲液较为澄清，成色较好；最后将芒草汁、荷叶汁、雪莲液、低聚玉米肽、L阿拉伯糖、决明子速溶粉加入到混合提取液中，在40℃下搅拌混合2h，各组分能更好的相互融合，药效更好，同时得到的口服液的口感更加细腻，而且低聚玉米肽、L阿拉伯糖、决明子速溶粉都可以很好的溶解于水中，因此本发明得到的雪莲培养物口服液毫无颗粒感。
雪莲培养物具有显著的调血脂功能，阿拉伯糖可抑制蔗糖的吸收，低聚玉米肽降压效果明显、决明子对于原发性的高血压有很好的疗效
本发明的有益效果：高效提取芒草、荷叶中黄酮，结合雪莲培养物、低聚玉米肽、L阿拉伯糖、决明子速溶粉等成分，能起到降脂、间接阻糖，进而达到降压的实际功效。本发明对原料的有效成分进行最大的利用，而且在调节三高的同时，还可以改善肠道功能，提高机体免疫力，口感好而细腻，毫无颗粒感，营养和保健效果双保证，更适用于工业化生产。
具体实施方式
实施例1
一种雪莲培养物口服液，由下列按重量份计算的原料制备而成：雪莲培养物粉20份、芒草22份、荷叶12份、磷酸氢二钾4份、低聚玉米肽12份、L阿拉伯糖3份、决明子速溶粉10份、树莓浓缩汁5份、聚葡萄糖2份、木糖醇5份和黄原胶5份。
制备工艺为：（1）将22份芒草超声清洗后切小块，隔水蒸2小时，然后进行榨汁，过滤得到芒草汁和芒草滤渣；将12份荷叶超声清洗后切小块，榨汁，过滤得到荷叶汁和荷叶滤渣；
（2）将芒草滤渣烘箱中干燥1h，用气流粉碎机粉碎投入浸提罐中，加入12倍的饮用纯化水，浸泡1h，加入2.8份磷酸氢二钾，在88℃下超声辅助提取40min，滤膜过滤；滤渣第二次加入7倍的饮用纯化水，加入0.8份磷酸氢二钾，在88℃下超声辅助提取40min，滤膜过滤；将两次滤液合并，减压浓缩至原来体积的1/2，即得芒草提取液；
（3）向荷叶滤渣中加入5倍质量的体积分数为75%的乙醇，80℃下搅拌30min后，微波辅助回流提取15min，继续超声辅助80℃回流1h，减压抽滤得第一次滤渣和第一次滤液，向第一次滤渣中加入3倍质量的体积分数为75%的乙醇，80℃下微波辅助回流提取15min，继续超声辅助80℃回流1h，减压抽滤得第二次滤渣和第二次滤液；将第一次滤液和第二次滤液合并减压浓缩回收乙醇，得到浓缩液，加入2倍质量的水，搅拌10min后静置10min,滤布过滤，即得荷叶提取液；
（4）将20份雪莲培养物粉先经超微粉碎机粉碎，加入20份的饮用纯化水，在50℃下搅拌20min,保温的状态下加入0.4份磷酸氢二钾质量，超声辅助提取1h，滤膜过滤，得到第一次雪莲滤液和滤渣，在滤渣中加入相同重量的饮用纯化水保持在50℃，然后加入滤渣重量0.8%的质量比2:1的纤维素酶和果胶酶，酶解2h，升至90℃灭酶，滤膜过滤，得到第二次雪莲滤液，将两次雪莲滤液合并得到雪莲液；
（5）将芒草汁、荷叶汁、雪莲液、低聚玉米肽、L阿拉伯糖、决明子速溶粉加入到混合提取液中，在40℃下搅拌混合2h，然后再加入树莓浓缩汁、聚葡萄糖、木糖醇和黄原胶搅拌混合30min；然后将混合料液抽入管式微滤膜中，调节压力至0.2MPa，收集通过管式微滤膜的滤液；
（6）90℃杀菌，冷却至55℃，进入高压均质机均质，均质压力为25MPa，均质后的料液及时灌装于无菌的干净干燥瓶中（10ml/支），加盖密闭，100℃流通蒸汽灭菌30min，制得雪莲培养物口服液。
实施例2
一种雪莲培养物口服液，由下列按重量份计算的原料制备而成：雪莲培养物粉26份、芒草20份、荷叶11份、磷酸氢二钾3份、低聚玉米肽8份、L阿拉伯糖2份、决明子速溶粉8份、树莓浓缩汁4份、聚葡萄糖1份、木糖醇3份和黄原胶3份。
制备工艺为：（1）将20份芒草超声清洗后切小块，隔水蒸2小时，然后进行榨汁，过滤得到芒草汁和芒草滤渣；将11份荷叶超声清洗后切小块，榨汁，过滤得到荷叶汁和荷叶滤渣；
（2）将芒草滤渣烘箱中干燥2h，用气流粉碎机粉碎投入浸提罐中，加入15倍的饮用纯化水，浸泡1h，加入2.1份磷酸氢二钾，在90℃下超声辅助提取40min，滤膜过滤；滤渣第二次加入10倍的饮用纯化水，加入0.6份磷酸氢二钾，在90℃下超声辅助提取40min，滤膜过滤；将两次滤液合并，减压浓缩至原来体积的1/2，即得芒草提取液；
（3）向荷叶滤渣中加入5倍质量的体积分数为75%的乙醇，80℃下搅拌30min后，微波辅助回流提取15min，继续超声辅助80℃回流1h，减压抽滤得第一次滤渣和第一次滤液，向第一次滤渣中加入3倍质量的体积分数为75%的乙醇，80℃下微波辅助回流提取15min，继续超声辅助80℃回流1h，减压抽滤得第二次滤渣和第二次滤液；将第一次滤液和第二次滤液合并减压浓缩回收乙醇，得到浓缩液，加入2倍质量的水，搅拌10min后静置10min,滤布过滤，即得荷叶提取液；
（3）将26份雪莲培养物粉先经超微粉碎机粉碎，加入26份的饮用纯化水，在50℃下搅拌20min,保温的状态下加入0.3份磷酸氢二钾质量，超声辅助提取1h，滤膜过滤，得到第一次雪莲滤液和滤渣，在滤渣中加入相同重量的饮用纯化水保持在50℃，然后加入滤渣重量1%的质量比2:1的纤维素酶和果胶酶，酶解2h，升至90℃灭酶，滤膜过滤，得到第二次雪莲滤液，将两次雪莲滤液合并得到雪莲液；
（4）将芒草汁、荷叶汁、雪莲液、低聚玉米肽、L阿拉伯糖、决明子速溶粉加入到混合提取液中，在40℃下搅拌混合2h，然后再加入树莓浓缩汁、聚葡萄糖、木糖醇和黄原胶搅拌混合30min；然后将混合料液抽入管式微滤膜中，调节压力至0.2MPa，收集通过管式微滤膜的滤液；
（5）90℃杀菌，冷却至55℃，进入高压均质机均质，均质压力为25MPa，均质后的料液及时灌装于无菌的干净干燥瓶中（10ml/支），加盖密闭，100℃流通蒸汽灭菌30min，制得雪莲培养物口服液。
实施例3
一种雪莲培养物口服液，由下列按重量份计算的原料制备而成：雪莲培养物粉30份、芒草18份、荷叶10份、磷酸氢二钾2份、低聚玉米肽6份、L阿拉伯糖1份、决明子速溶粉6份、树莓浓缩汁3份、聚葡萄糖1份、木糖醇2份和黄原胶2份。
制备工艺为：（1）18份芒草超声清洗后切小块，隔水蒸2小时，然后进行榨汁，过滤得到芒草汁和芒草滤渣；将10份荷叶超声清洗后切小块，榨汁，过滤得到荷叶汁和荷叶滤渣；
（2）将芒草滤渣烘箱中干燥2h，用气流粉碎机粉碎投入浸提罐中，加入10倍的饮用纯化水，45℃浸泡1h，加入1.4份磷酸氢二钾，在85℃下超声辅助提取40min，滤膜过滤；滤渣第二次加入5倍的饮用纯化水，加入0.4份磷酸氢二钾，在85℃下超声辅助提取40min，滤膜过滤；将两次滤液合并，减压浓缩至原来体积的1/2，即得芒草提取液；
（3）向荷叶滤渣中加入5倍质量的体积分数为75%的乙醇，80℃下搅拌30min后，微波辅助回流提取15min，继续超声辅助80℃回流1h，减压抽滤得第一次滤渣和第一次滤液，向第一次滤渣中加入3倍质量的体积分数为75%的乙醇，80℃下微波辅助回流提取15min，继续超声辅助80℃回流1h，减压抽滤得第二次滤渣和第二次滤液；将第一次滤液和第二次滤液合并减压浓缩回收乙醇，得到浓缩液，加入2倍质量的水，搅拌10min后静置10min,滤布过滤，即得荷叶提取液；
（4）将30份雪莲培养物粉先经超微粉碎机粉碎，加入30份的饮用纯化水，在50℃下搅拌20min,保温的状态下加入0.2份磷酸氢二钾质量，超声提取1h，滤膜过滤，得到第一次雪莲滤液和滤渣，在滤渣中加入相同重量的饮用纯化水保持在50℃，然后加入0.5%的质量比2:1的纤维素酶和果胶酶，酶解2h，升至90℃灭酶，滤膜过滤，得到第二次雪莲滤液，将两次雪莲滤液合并得到雪莲液；
（5）将芒草汁、荷叶汁、雪莲液、低聚玉米肽、L阿拉伯糖、决明子速溶粉加入到混合提取液中，在40℃下搅拌混合2h，然后再加入树莓浓缩汁、聚葡萄糖、木糖醇和黄原胶搅拌混合30min；然后将混合料液抽入管式微滤膜中，调节压力至0.2MPa，收集通过管式微滤膜的滤液；
（6）90℃杀菌，冷却至55℃，进入高压均质机均质，均质压力为25MPa，均质后的料液及时灌装于无菌的干净干燥瓶中（10ml/支），加盖密闭，100℃流通蒸汽灭菌30min，制得雪莲培养物口服液。
为表明本发明的保健效果，本发明对50例高血压、50例高血脂患者作了系统的临床观察：
受试人群：选择病史、病情、年龄、性别及原治疗方法相当的高血压及高血脂患者，年龄在45-55岁之间，无心血管、肝、肾等严重原发性疾病及精神病。高血压：在未使用抗高血压药物情况下，收缩压≥139mmHg和/或舒张压≥90mmHg，按照血压水平将高血压分为1、2、3级。高血脂：以成年人空腹血清总胆固醇超过5.72毫摩尔/升，甘油三酯超过1.70毫摩尔/升，诊断为高血脂症，将总胆固醇在5.2-5.7毫摩尔/升称为边缘性升高。受试者在原有治疗基础上，停用降压降脂药，服用本发明口服液。定期检查血压和空腹血脂，观察期两个月，30天为一疗程。
服用方法：本发明口服液10ml/次，日服3次，饭前服用。观察期间，受试者需保持合理饮食结构及作息时间，禁止非观察的其他药物。
附表1 服用本发明口服液前后收缩压平均值与舒张压平均值
附表2 服用本发明口服液前后血脂平均浓度变化
从附表1和2可以看出，受试患者服用本发明后，未使用其他降压降脂药物就可达到降压降脂的目的。试验统计：用本发明口服液对50例高血脂患者、50例高血压患者作治疗试验，对降血脂、降血压的总显效率为88%，有效率为85%。在临床试验过程中未发现该药有明显不良反应，服用安全。
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明披露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。
Claims (2)
1.一种雪莲培养物口服液，其特征在于：由下列按重量份计算的原料制备而成：雪莲培养物粉20-30份、芒草18-22份、荷叶10-12份、磷酸氢二钾2-4份、低聚玉米肽5-12份、L阿拉伯糖1-3份、决明子速溶粉5-10份、树莓浓缩汁2-5份、聚葡萄糖1-2份、木糖醇1-5份和黄原胶2-5份；其制法包括以下步骤：
（1）将芒草超声清洗后切小块，隔水蒸2小时，然后进行榨汁，过滤得到芒草汁和芒草滤渣；将荷叶超声清洗后切小块，榨汁，过滤得到荷叶汁和荷叶滤渣；
（2）将芒草滤渣烘箱中干燥1-2h，用气流粉碎机粉碎投入浸提罐中，加入10-15倍的饮用纯化水，45℃下浸泡1h，加入磷酸氢二钾总质量的70%，在85-90℃下超声辅助提取40min，滤膜过滤；滤渣第二次加入5-10倍的饮用纯化水，加入磷酸氢二钾总质量的20%，在85-90℃下超声辅助提取40min，滤膜过滤；将两次滤液合并，减压浓缩至原来体积的1/2，即得芒草提取液；
（3）向荷叶滤渣中加入5倍质量的体积分数为75%的乙醇，80℃下搅拌30min后，微波辅助回流提取15min，继续超声辅助80℃回流1h，减压抽滤得第一次滤渣和第一次滤液，向第一次滤渣中加入3倍质量的体积分数为75%的乙醇，80℃下微波辅助回流提取15min，继续超声辅助80℃回流1h，减压抽滤得第二次滤渣和第二次滤液；将第一次滤液和第二次滤液合并减压浓缩回收乙醇，得到浓缩液，加入2倍质量的水，搅拌10min后静置10min,滤布过滤，即得荷叶提取液；
（4）将雪莲培养物粉先经超微粉碎机粉碎，加入相同重量的饮用 纯化水，在50℃下搅拌20min,保温的状态下加入磷酸氢二钾总质量的10%，超声辅助提取1h，滤膜过滤，得到第一次雪莲滤液和滤渣，在滤渣中加入相同重量的饮用纯化水保持在50℃，然后加入0.5-1%的质量比2:1的纤维素酶和果胶酶，酶解2h，升至90℃灭酶，滤膜过滤，得到第二次雪莲滤液，将两次雪莲滤液合并得到雪莲液；
（5）将芒草汁、荷叶汁、雪莲液、低聚玉米肽、L阿拉伯糖混合，决明子速溶粉加入到芒草提取液和荷叶提取液的混合提取液中，在40℃下搅拌混合2h，然后再加入树莓浓缩汁、聚葡萄糖、木糖醇和黄原胶搅拌混合30min；然后将混合料液抽入管式微滤膜中，调节压力至0.2MPa，收集通过管式微滤膜的滤液；
（6）90℃杀菌，冷却至55℃，进入高压均质机均质，均质压力为25MPa，均质后的料液即雪莲培养物口服液。
2.根据权利要求1所述的一种雪莲培养物口服液，其特征在于：由下列按重量份计算的原料制备而成：雪莲培养物粉26份、芒草20份、荷叶11份、磷酸氢二钾3份、低聚玉米肽8份、L阿拉伯糖2份、决明子速溶粉8份、树莓浓缩汁4份、聚葡萄糖1份、木糖醇3份和黄原胶3份。
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