CN106334109A - Medicinal composition for treating dyspepsia, preparation method thereof and preparation - Google Patents
Medicinal composition for treating dyspepsia, preparation method thereof and preparation Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/235—Foeniculum (fennel)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a medicinal composition for treating dyspepsia, a preparation method thereof and a preparation. The medicinal composition comprises the following raw materials in parts by weight: 10 to 20 parts of liquorice, 15 to 25 parts of medicated leaven, 3 to 9 parts of iris japonica thumb, 8 to 18 parts of pinenut kernels, 4 to 10 parts of garlic, 7 to 14 parts of pericarpium citri reticulatae viride, 6 to 12 parts of the fruit of Chinese wolfberry, 5 to 15 parts of hawthorn roots, 3 to 10 parts of millet powder, 4 to 11 parts of fennel and 6 to 12 parts of olive oil. The raw materials supplement each other to have a significant curative effect of treating the dyspepsia; furthermore, side effects are avoided and the price is low.
Description
Technical field
The present invention relates to dyspeptic pharmaceutical composition, its system are treated in treatment indigestion field, more particularly, to one kind
Preparation Method and preparation.
Background technology
Indigestion refers to malaise symptoms such as epigastric pain, big belly, early satiety, belch, poor appetite, Nausea and vomiting,
Exclusion causes one group of clinical syndrome of the organic disease of above-mentioned symptom on inspection.
Indigestion can cause following symptom: stomachache, because peristole is less able, digestive function weakness, when patient just
When often taking food or eating stodgy food, increase stomach load and arise that stomachache situation, more serious after general feed；For a long time
Constipation, often eats and drinks immoderately, and excessively eats the irritable food such as pungent, raw and cold, due to gastric indigestion, leads to enteron aisle to be born
Weight, food bulk deposition and enteron aisle, thus cause constipation situation；Frequently, due to gastric indigestion, gut function is disturbed diarrhoea,
Diarrhoea will be produced.If blindness using antidiarrheal agent can lead to toxin accumulate in vivo, intestinal obstruction may be brought；Cause stomach
Ulcer, the long-term infringement of hydrochloric acid in gastric juice is the principal element leading to gastric ulcer to occur.Because long-term ingestion is bad, hydrochloric acid in gastric juice resides in stomach for a long time
In, the probability that the crowd's gastric ulcer with functional dyspepsia FD occurs is far longer than the normal person of stomach function.
At present mostly for dyspeptic treatment is to adopt western medicine, but it is big to pharmacological dependence to there is patient, and
The problems such as organ of drugs on patients has certain toxic and side effect.
Content of the invention
In view of this, it is an object of the invention to provide one kind treat dyspeptic pharmaceutical composition, its preparation method and
Preparation, therapeutic effect is good, Small side effects, and cure rate is high.
To achieve these goals, the following technical scheme of present invention offer:
One kind treats dyspeptic pharmaceutical composition, including the raw material of following parts by weight:
Preferably, including the raw material of following parts by weight:
Present invention also offers the preparation method of the dyspeptic pharmaceutical composition of above-mentioned treatment, comprise the following steps:
Radix Glycyrrhizae, Divine Comedy, fringed iris rhizome, SEMEN PINI KORAIENSIS, garlic, rascal, the fruit of Chinese wolfberry, Chinese hawthorn root, millet powder, fennel seeds are immersed in
In water, decoct, filter, concentrate, obtain a compounding substances；
Add olive oil in a mixture, after stirring, freeze-drying, that is, obtain pharmaceutical composition.
Preferably, described decoct as secondary decoction, first time decocting time is 5～8h, second decocting time be 2～
4h.
Present invention also offers a kind of preparation, by the dyspeptic pharmaceutical composition of above-mentioned treatment and pharmaceutically acceptable
Auxiliary material is made.
Preferably, described preparation is granule, capsule, tablet, pill, oral liquid or syrup.
Preferably, described auxiliary material includes antiplastering aid and controlled release agent.
Preferably, described antiplastering aid is plant amylum.
Preferably, described plant amylum is in starch from sweet potato, cornstarch, green starch, farina, Rhizoma Nelumbinis starch
One or more.
Preferably, described controlled release agent is acetate succinate or odium stearate.
One kind that the present invention provides treats dyspeptic pharmaceutical composition, its preparation method and preparation, this drug regimen
Thing includes the Radix Glycyrrhizae of 10～20 weight portions, the Divine Comedy of 15～25 weight portions, the fringed iris rhizome of 3～9 weight portions, 8～18 weight portions
SEMEN PINI KORAIENSIS, the garlic of 4～10 weight portions, the rascal of 7～14 weight portions, the fruit of Chinese wolfberry of 6～12 weight portions, 5～15 weight portions
Chinese hawthorn root, the millet powder of 3～10 weight portions, the fennel seeds of 4～11 weight portions, the olive oil of 6～12 weight portions, above-mentioned raw materials
Complement each other, to treatment indigestion, there is significant curative effect, and have no side effect, cheap.
Specific embodiment
In order to further appreciate that the present invention, with reference to embodiment, the preferred embodiments of the invention are described, but
It is it should be appreciated that these descriptions are simply to further illustrate the features and advantages of the present invention rather than to patent requirements of the present invention
Limit.
The invention provides one kind treats dyspeptic pharmaceutical composition, including the raw material of following parts by weight:
Radix Glycyrrhizae has the effect of regulating qi-flowing for eliminating phlegm, preventing or arresting vomiting dissipate-swelling, liver soothing and speen fortifying and stomach.In the present invention, the weight portion of Radix Glycyrrhizae
Number is 10～20 parts；In an embodiment of the present invention, the parts by weight of Radix Glycyrrhizae are 14～16 parts.
Divine Comedy has strengthening the spleen and stomach, the effect of promoting digestion and removing indigestion.In the present invention, the parts by weight of Divine Comedy are 15～25 parts；
In an embodiment of the present invention, the parts by weight of Divine Comedy are 18～22 parts.
Fringed iris rhizome has clearing heat and detoxicating, effect of swelling and pain relieving.In the present invention, the parts by weight of fringed iris rhizome are 3～9
Part；In an embodiment of the present invention, the parts by weight of fringed iris rhizome are 5～7 parts.
SEMEN PINI KORAIENSIS has nourishing Yin and moistening lung, beautifying and antisenility, the effect promoted longevity.In the present invention, the weight portion of SEMEN PINI KORAIENSIS
Number is 8～18 parts；In an embodiment of the present invention, the parts by weight of SEMEN PINI KORAIENSIS are 11～15 parts.
Garlic has middle benefit gas stomach invigorating, the effect of the qi-regulating that helps digestion.In the present invention, the parts by weight of garlic are 4～10 parts；?
In embodiments of the invention, the parts by weight of garlic are 6～8 parts.
Rascal has soothing the liver relieving stagnant Qi, the stagnant effect of long-pendingization that disappear.In the present invention, the parts by weight of rascal are 7～14 parts；?
In the other embodiment of the present invention, the parts by weight of rascal are 9～12 parts.
The fruit of Chinese wolfberry has nourishing liver and kidney, effect of benefiting shrewd head.In the present invention, the parts by weight of the fruit of Chinese wolfberry are 6～12
Part；In an embodiment of the present invention, the parts by weight of the fruit of Chinese wolfberry are 8～10 parts.
Chinese hawthorn root has treatment and disappears long-pending, wind-dispelling, the effect of hematuria treating.In the present invention, the parts by weight of Chinese hawthorn root be 5～
15 parts；In an embodiment of the present invention, the parts by weight of Chinese hawthorn root are 8～12 parts.
Millet powder has functions that the deficient and middle kidney-nourishing of strengthening the spleen and stomach, help, removes thermal detoxification.In the present invention, millet powder
Parts by weight be 3～10 parts；In other embodiments of the invention, the parts by weight of millet powder are 5～8 parts.
Fennel seeds have eliminating cold to stop pain, the effect of regulating qi-flowing for harmonizing stomach.In the present invention, the parts by weight of fennel seeds are 4～11
Part；In an embodiment of the present invention, the parts by weight of fennel seeds are 6～9 parts.
Olive oil has functions that to relax bowel.In the present invention, the parts by weight of olive oil are 6～12 parts；At this
In bright embodiment, the parts by weight of olive oil are 8～10 parts.
The dyspeptic pharmaceutical composition for the treatment of that the present invention provides, by Radix Glycyrrhizae, Divine Comedy, fringed iris rhizome, SEMEN PINI KORAIENSIS, big
The pharmaceutical composition that garlic, rascal, the fruit of Chinese wolfberry, Chinese hawthorn root, millet powder, fennel seeds and olive oil prepare has non-to indigestion
Often good curative effect, and curative effect is stable, Small side effects, and cure rate is high.
The present invention is not particularly limited to the source of all raw materials, is commercially available.
Present invention also offers a kind of preparation method treating dyspeptic pharmaceutical composition, comprise the following steps:
Radix Glycyrrhizae, Divine Comedy, fringed iris rhizome, SEMEN PINI KORAIENSIS, garlic, rascal, the fruit of Chinese wolfberry, Chinese hawthorn root, millet powder, fennel seeds are immersed in
In water, decoct, filter, concentrate, obtain a compounding substances；
Add olive oil in a mixture, after stirring, freeze-drying, that is, obtain pharmaceutical composition.
The source of all raw materials of the present invention is not particularly limited, and is commercially available.
Wherein, Radix Glycyrrhizae, Divine Comedy, fringed iris rhizome, SEMEN PINI KORAIENSIS, garlic, rascal, the fruit of Chinese wolfberry, Chinese hawthorn root, millet powder, fennel seeds and
Olive oil is all same as above, will not be described here.
In the present invention, Radix Glycyrrhizae, Divine Comedy, fringed iris rhizome, SEMEN PINI KORAIENSIS, garlic, rascal, the fruit of Chinese wolfberry, Chinese hawthorn root, millet powder, little
Fennel is immersed in water, decocts, filters, concentrates, obtains a compounding substances.In an embodiment of the present invention, decoct and decoct for secondary
Boil, first time decocting time is 5～8h, second decocting time is 2～4h.
After obtaining a compounding substances, add olive oil in a compounding substances, after stirring, naturally cool to room temperature, cold
Lyophilized dry, that is, obtain pharmaceutical composition.
It should be noted that olive oil does not decoct together with other drugs, and it is directly added in a compounding substances,
And by freeze-drying so that olive oil can give full play to its drug effect so that the drug effect of pharmaceutical composition is best.
The preparation method of the dyspeptic pharmaceutical composition for the treatment of that the present invention provides, by being added directly into olive oil
So that the drug effect of the pharmaceutical composition being obtained by freeze-drying is preferably such that it is able to effectively treat digestion in a compounding substances
Bad, Small side effects, cure rate is high.
Present invention also offers a kind of preparation, by the dyspeptic pharmaceutical composition for the treatment of and pharmaceutically acceptable auxiliary material
Make.
Wherein, pharmaceutical composition ibid, will not be described here.
In an embodiment of the present invention, preparation is granule, capsule, tablet, pill, oral liquid or syrup.
In an embodiment of the present invention, auxiliary material includes antiplastering aid and controlled release agent；In present invention others embodiment, resist
Stick is plant amylum；In a further embodiment, plant amylum is selected from starch from sweet potato, cornstarch, green starch, potato
One or more of starch, Rhizoma Nelumbinis starch.
In an embodiment of the present invention, the mass ratio of antiplastering aid and controlled release agent is (2～3): 1, antiplastering aid and slow controlled release
The gross mass of agent and the mass ratio of pharmaceutical composition are (0.06～0.1)): 1.
In order that the drug effect of preparation has stable persistence, in an embodiment of the present invention, controlled release agent is acetate succinate
Acid esters or odium stearate.
The preparation that the present invention provides, said preparation has extraordinary curative effect to indigestion, and efficacy stability is persistently, does not have poison
Side effect.
In order to further illustrate the present invention, the dyspeptic medicine group for the treatment of that the present invention provided with reference to embodiment
Compound, its preparation method and preparation are described in detail, but they can not be interpreted as limiting the scope of the present invention.
In following examples raw material used be commercially available.
Embodiment 1
By 160g Radix Glycyrrhizae, 180g Divine Comedy, 50g fringed iris rhizome, 150g SEMEN PINI KORAIENSIS, 70g garlic, 100g rascal, the 90g fruit of Chinese wolfberry,
150g Chinese hawthorn root, 50g millet powder, 40g fennel seeds are immersed in water, decoct, filter, concentrate, obtain a compounding substances；
Add 80g olive oil in a mixture, after stirring, freeze-drying, that is, obtain pharmaceutical composition；
Add 22.4g cornstarch and 11.2g acetate succinate in pharmaceutical composition, make granule.
Embodiment 2
By 140g Radix Glycyrrhizae, 220g Divine Comedy, 70g fringed iris rhizome, 110g SEMEN PINI KORAIENSIS, 60g garlic, 70g rascal, the 80g fruit of Chinese wolfberry,
120g Chinese hawthorn root, 100g millet powder, 70g fennel seeds are immersed in water, decoct, filter, concentrate, obtain a compounding substances；
Add 100g olive oil in a mixture, after stirring, freeze-drying, that is, obtain pharmaceutical composition；To medicine
Add 48.9g starch from sweet potato and 19.5g odium stearate in composition, make oral liquid.
Embodiment 3
By 100g Radix Glycyrrhizae, 200g Divine Comedy, 30g fringed iris rhizome, 180g SEMEN PINI KORAIENSIS, 80g garlic, 90g rascal, the 120g fruit of Chinese wolfberry,
80g Chinese hawthorn root, 30g millet powder, 60g fennel seeds are immersed in water, decoct, filter, concentrate, obtain a compounding substances；
Add 60g olive oil in a mixture, after stirring, freeze-drying, that is, obtain pharmaceutical composition；
Add 30.9g green starch and 0.3 acetate succinate in pharmaceutical composition, make pill.
Embodiment 4
By 200g Radix Glycyrrhizae, 150g Divine Comedy, 60g fringed iris rhizome, 80g SEMEN PINI KORAIENSIS, 100g garlic, 140g rascal, the 60g fruit of Chinese wolfberry,
50g Chinese hawthorn root, 50g millet powder, 110g fennel seeds are immersed in water, decoct, filter, concentrate, obtain a compounding substances；
Add 120g olive oil in a mixture, after stirring, freeze-drying, that is, obtain pharmaceutical composition；
Add 37.3g farina and 18.7g odium stearate in pharmaceutical composition, make tablet.
Embodiment 5
By 150g Radix Glycyrrhizae, 250g Divine Comedy, 90g fringed iris rhizome, 120g SEMEN PINI KORAIENSIS, 40g garlic, 120g rascal, the 100g fruit of Chinese wolfberry,
120g Chinese hawthorn root, 80g millet powder, 90g fennel seeds are immersed in water, decoct, filter, concentrate, obtain a compounding substances；
Add 90g olive oil in a mixture, after stirring, freeze-drying, that is, obtain pharmaceutical composition；
Add 42.2g Rhizoma Nelumbinis starch and 14.1g acetate succinate in pharmaceutical composition, make capsule.
First, safety testing:
The product mix grind into powder of Example 1～5.
Using the medicinal powder of above-mentioned gained as trial drug, with the small white mouse of body weight 18-20g male and female half and half as experimental animal,
Totally 150, be divided into 5 groups, respectively the medicine of gavage variable concentrations, concentration be respectively 10mg/ml, 40mg/ml, 60mg/ml,
80mg/ml, 100mg/ml, administered volume is 40ml/kg, to gastric infusion in mouse one day 3 times, accumulation gastric infusion volume
For 100ml/kg.Observe 7, have no overt toxicity reaction and the reaction of pawpaw enteron aisle.Through visually observing after dissection, main organs
Non Apparent Abnormality.
The small white mouse of body weight 18-20g male and female half and half is experimental animal, totally 80, is divided into two groups, carries out long term toxicity examination
Test, one group of administration concentration is 60mg/ml, and administered volume is 40ml/kg；Another group is isopyknic distilled water, continuously gavages 3
Individual month, carry out long term toxicity test.Long term toxicity test result shows, the general behavior activity of experimental animal is with body weight increase just
Often, to hematological indices, the organ coefficient of hepatic and renal function and main organs all has no significant effect, and the no obvious pathology of main organs damages
Wound, shows that medicine is non-toxic.
2nd, the preparation that embodiment 1～5 obtains is carried out clinical testing, result is as follows:
1st, experimenter selects: select the indigestion patient totally 600 that in May, 2011～2016 year January hospital accepts for medical treatment,
Wherein male patient 341, female patient 259.
2nd, packet design: all patients are randomly divided into six groups, respectively experimental group 1, experimental group 2, experimental group 3, experimental group
4th, experimental group 5 and control group, each 100, six groups of patients, in the aspects such as age, the state of an illness no significant difference, have comparativity.Wherein
Experimental group 1～5 is respectively using the preparation of embodiment 1～5 preparation.
3rd, instructions of taking: experimental group 1～5 takes the medicament of various formulations respectively, three times a day, 2 tablets once, and warm is taken
10 days.Control group uses other drugs (as medicines such as oryz aspergillus enzyme and pancreatin piece, dry ferment, pancreatin, alctasins).
4th, curative effect judging standard
Cure: people digest's ill symptomses disappear, body surface recovers normal；
Effective: people digest's ill symptomses gradually mitigate or symptom disappears；
Invalid: indigestion symptom no takes a turn for the better；
Total effective rate=(curing number of cases+effective number of cases)/case load.
5th, result is as shown in table 1
Table 1 experimental group 1～5 and the treatment results of control group
| Case load | Cure number of cases | Effectively number of cases | Invalid number of cases | Total effective rate | |
| Experimental group 1 | 100 | 94 | 6 | 0 | 100% |
| Experimental group 2 | 100 | 95 | 5 | 0 | 100% |
| Experimental group 3 | 100 | 93 | 7 | 0 | 100% |
| Experimental group 4 | 100 | 95 | 5 | 0 | 100% |
| Experimental group 5 | 100 | 94 | 5 | 1 | 99% |
| Control group 1 | 100 | 54 | 24 | 22 | 78% |
The one kind above present invention being provided is treated dyspeptic pharmaceutical composition, its preparation method and preparation and is carried out
Detailed introduction, specific case used herein is set forth to the principle of the present invention and embodiment, above example
Explanation be only intended to help understand the method for the present invention and its core concept it is noted that common for the art
For technical staff, under the premise without departing from the principles of the invention, the present invention can also be carried out with some improvement and modify, these
Improve and modify and also fall in the protection domain of the claims in the present invention.
Claims (10)
1. a kind of treat dyspeptic pharmaceutical composition it is characterised in that include following parts by weight raw material:
2. pharmaceutical composition as claimed in claim 1 is it is characterised in that include the raw material of following parts by weight:
3. a kind of as claimed in claim 1 or 2 treat dyspeptic pharmaceutical composition preparation method it is characterised in that
Comprise the following steps:
Radix Glycyrrhizae, Divine Comedy, fringed iris rhizome, SEMEN PINI KORAIENSIS, garlic, rascal, the fruit of Chinese wolfberry, Chinese hawthorn root, millet powder, fennel seeds are immersed in water
In, decoct, filter, concentrate, obtain a compounding substances；
Add olive oil in a mixture, after stirring, freeze-drying, that is, obtain pharmaceutical composition.
4. preparation method as claimed in claim 3 it is characterised in that described decoction be secondary decoction, first time decocting time
For 5～8h, second decocting time is 2～4h.
5. a kind of preparation is it is characterised in that the dyspeptic pharmaceutical composition of the treatment described in claim 1 or 2 and pharmacy
Upper acceptable auxiliary material is made.
6. preparation as claimed in claim 5 it is characterised in that described preparation be granule, capsule, tablet, pill, oral
Liquid or syrup.
7. preparation as claimed in claim 5 is it is characterised in that described auxiliary material includes antiplastering aid and controlled release agent.
8. preparation as claimed in claim 7 is it is characterised in that described antiplastering aid is plant amylum.
9. preparation as claimed in claim 8 is it is characterised in that described plant amylum is selected from starch from sweet potato, cornstarch, mung bean
One or more of starch, farina, Rhizoma Nelumbinis starch.
10. preparation as claimed in claim 7 is it is characterised in that described controlled release agent is acetate succinate or odium stearate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610795675.9A CN106334109A (en) | 2016-08-31 | 2016-08-31 | Medicinal composition for treating dyspepsia, preparation method thereof and preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610795675.9A CN106334109A (en) | 2016-08-31 | 2016-08-31 | Medicinal composition for treating dyspepsia, preparation method thereof and preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106334109A true CN106334109A (en) | 2017-01-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610795675.9A Pending CN106334109A (en) | 2016-08-31 | 2016-08-31 | Medicinal composition for treating dyspepsia, preparation method thereof and preparation |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274448A (en) * | 2011-09-02 | 2011-12-14 | 首都医科大学附属北京中医医院 | Pharmaceutical composition for treating spleen deficiency and qi stagnation type functional dyspepsia and preparation method |
| CN103877208A (en) * | 2012-12-19 | 2014-06-25 | 四川省中医药科学院 | Pharmaceutical composition for treating functional dyspepsia |
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2016
- 2016-08-31 CN CN201610795675.9A patent/CN106334109A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274448A (en) * | 2011-09-02 | 2011-12-14 | 首都医科大学附属北京中医医院 | Pharmaceutical composition for treating spleen deficiency and qi stagnation type functional dyspepsia and preparation method |
| CN103877208A (en) * | 2012-12-19 | 2014-06-25 | 四川省中医药科学院 | Pharmaceutical composition for treating functional dyspepsia |
Non-Patent Citations (1)
| Title |
|---|
| 贾小玉: "《饮疗治病小窍门》", 31 July 2015, 中国医药科技出版社 * |
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