CN106334064A - Externally used medicament for erythema multiforme - Google Patents

Abstract

The invention relates to an externally used medicament for erythema multiforme, belongs to the technical field of medicine, and aims to solve the problem that the erythema multiforme is difficult to treat. The externally used medicament for the erythema multiforme is mainly prepared from the following traditional Chinese medicaments in parts by mass: 20 parts of fresh mulberry leaves, 10 parts of radix saposhnikoviae, 10 parts of fructus trichosanthis, 12 parts of cotex dictamni, 15 parts of cortex moutan, 10 parts of peach seeds, 6 parts of flos cartham, 10 parts of radix paeoniae rubra, 10 parts of radix rehmanniae, 12 parts of lonicerae japonicae flos, 10 parts of fructus forsythia, 10 parts of bighead atractylodes rhizome, 10 parts of radix angelicae dahurioae, 12 parts of rhizoma dioscoreae, 10 parts of semen cassia, and 10 parts of radix lithospermi.

Description

A kind of external used medicine of erythema multiforme

Technical field

The present invention relates to a kind of medicine treating erythema multiforme, particularly to the externally applied drug of plurality of Chinese combined therapy Thing, belongs to pharmaceutical technology field.

Background technology

Erythema multiforme (erythemamultiforme, em) is acute self-limited inflammatory dermatoses, in view of lesion Tissue introversion have more diffusate to occur, therefore this disease also known as erythema multiforme exudativu or dermatostomatitis (erythemamultiformeexudativum, eme), severe claims Stevens Johnson syndrome.Erythema multiforme is in target shape to exceed skin Erythema be characterized recurring skin disease, often symmetrical.

Erythema multiforme is presently believed to be a kind of allergic disease.It is probably skin thin vessels to some sensitization The allergy that material causes.Its allergen may be bacterium, virus, fungi, protozoon, mycoplasma or some drugses such as sulfanilamide (SN) Class, salicylic acid, penicillin, arsenical etc..Also can be due to spoiled food fishes and shrimps etc., other are as the irradiation of x line, paramenia, gestation Can occur together Deng also.In addition also as relevant in cold and climate change with physical factor.The traditional Chinese medical science thinks this cause of disease because of blood-head or insufficiency of the spleen wet Contain, the heresy of sense wind-heat or chill again so that disharmony between ying and wei, qi and blood stagnation strongly fragrant in skin；Or because diet is not normal, eat taboo and induce. General anxious, about 1/3 patient 1 week premonitory symptom such as appearance heating, discomfort, pharyngalgia, runny nose, cough before skin damaged of falling ill.Light-duty skin Damage based on papular type, be kermesinus maculopapule during beginning, be gradually increased to 0.5～1cm diameter, more than two circles in edge part Concentric circles erythema, center be purple or hemorrhagic oedema patch, referred to as target shape or iris shape (iris) infringement, examine for this disease Disconnected foundation, typical person symmetrically promulgates that, in the back of the hand, palm, wrist, forearm, foot, elbow, knee, minority can be gone out with back in face Existing, typically with the back of the hand for predilection site.Skin damaged occurs in 5～10 days after morbidity in batch, and 2～3 Zhou Houke voluntarily disappear.Even See there is blister and epidermolysis infringement, but number is less.Invade once in a while and oral mucosa, bleb or rotten to the corn face occur, number is few.This Type erythema multiforme more after often easily recur.Heavy also known as stevens johnson syndrome.Onset is hurried, with hyperpyrexia, headache, General malaise, pharynx and the symptom such as tonsillotome congestion and swelling pain, arthralgia.Skin damaged inflammatory reaction weight, with edematous erythema, blister, big Based on blister infringement, the very easily rotten to the corn incrustation of infringement, whole body can be distributed widely in, and with around accent for work.The normal popularity of mucous membrane , including lip, oral cavity, nose, pharynx, eye, urethra, anus, respiratory tract etc. mucous membrane, bleb, rotten to the corn bleeding or bursts in serious involvement Ulcer.Constitutional symptom is serious, can enter depletion in a short time.The most common person of complication damages for eye, including seriousness Catarrhal Or purulence combines film inflammation, perforation of cornea, anterior uveitis or panophthalmitis, 10% can be blind.If internal organ involvement may result in when serious Death, case fatality rate 5%～15%, mainly die from lung inflammation and renal failure.The severe type course of disease about 3～6 weeks, rear recidivist Few.

The treatment of erythema multiforme: (one) disease is to treat, and finds out the cause of disease as far as possible to be treated, to severe type multiform Property erythema, be important to inquire medication history in detail, find will to be discontinued immediately during suspicious sensitizing drugs, advise patient from now on not again with such Medicine, and remember among medical record.(2) the suitable hospitalization of anti symptom treatment heavy type person.No bed when must remain in a hospital under observation until whole body disease Till when shape mitigates, skin bulla disappears, scabies secondary infection controls completely.1. intensive care, keeps Water-Electrolyte to sanction balance；② General glucocorticosteroid should early, widely apply, taking prednisone as a example, dosage be 60～80mg/d.Oral difficulty person, quiet Arteries and veins instillation butanedioic acid hydrocortisone 200～300mg or dexamethasone 5～10mg is in 5%～10% glucose 500～1000ml.Extremely Above-mentioned dose of reason is maintained after 5～7 days, to take the circumstances into consideration gradually decrement less.

Content of the invention

Erythema multiforme has viral infectivity, but the immunity of the physique reason of people and people, power of resisting are also lowly to hold Susceptible reason, with traditional Chinese medicine viewpoint analysis erythema multiforme, belongs to liver splenic hygropyrexia, wind toxin enter blood, skin void blood dry, pent up in Skin, taking orally should be with the drug therapy of clearing heat and detoxicating, soothing the liver cool blood, and external curing should be drawn out pus by applying a plaster to the affected part with heat-clearing, wind-dispelling dampness elimination, promoting blood circulation and removing blood stasis Chinese Medicine and Clavicular smelting treat.

A kind of external used medicine of erythema multiforme is to combine by following each traditional Chinese medicine quality part ratio: 20 parts of fresh mulberry leaves, Windproof 10 parts, 10 parts of Snakegourd Fruit, 12 parts of favus skin, 15 parts of the root bark of tree peony, 10 parts of peach kernel, 6 parts of safflower, 10 parts of the radix paeoniae rubrathe, 10 parts of the dried rhizome of rehmannia, gold and silver Spend 12 parts, 10 parts of the capsule of weeping forsythia, 10 parts of the bighead atractylodes rhizome, 10 parts of the root of Dahurain angelica, 12 parts of Chinese yam, 10 parts of cassia seed, 10 parts of Asian puccoon.

Each herbal nature in a kind of external used medicine of erythema multiforme of lower surface analysis.Effect of the root bark of shaggy-fruited dittany and effect: heat-clearing Eliminating dampness, wind-dispelling removing toxic substances；For damp and hot sore, yellow water be dripping, eczema, mange sore leprosy, beriberoid pyretic arthralgia, jaundice urine is red；The root bark of shaggy-fruited dittany can Wind-dispelling, eliminating dampness, heat-clearing, removing toxic substances.Effect of mulberry leaf: mulberry leaf have dispelling wind and heat from the body, clearing away the lungheat and moisturizing, suppressing liver-YANG, clear liver and improve vision, cool blood Effect of hemostasis.For anemopyretic cold, lung-heat type cough, dizziness headache, hot eyes is dim-sighted.Windproof effect: expel pathogenic wind from the body surface, victory is wet Pain relieving, only convulsion；Cure mainly: diseases caused by external factors table card, rubella itch, arthralgia due to wind-dampness, lockjaw.Snakegourd Fruit effect and effect: clearing heat and eliminating phlegm, profit Gas defaecation, its effect is seemingly for anti-inflammatory, eliminating the phlegm, defaecation, external application promoting blood circulation network, the slow pain of promoting circulation of blood.The root bark of tree peony, taste is pungent is bitter, cool in nature；The thoughts of returning home, liver, Kidney, lung channel；Can heat-clearing；Promoting blood circulation to remove blood stasis；Main warm heat disease heat invading xuefen；Send out spot；Tell nosebleed；The distribution of germ later stage brimful of tears hot Fu Yin Heat；Deficiency of Yin osteopyrexia and fever；Amenorrhea due to stagnation of blood；Dysmenorrhoea；Carbuncle sore tumefacting virus；The pain of injury caused by falling and tumbling；Beriberoid pyretic arthralgia.The peach kernel promoting blood stasis of blood, moisturizes cunning Intestines, controlling through closing, lump in the abdomen, pyreticosis stores blood, wandering arthritis, malaria, traumatic injury, blood stasis and swelling pain, the dry constipation of blood.Safflower is warm in nature, taste is pungent, work Blood latus rectum, blood stasis removing analgesic, for Amenorrhea, dysmenorrhoea, lochia, abdominal mass lump in the abdomen, traumatic injury, are suitable for various varication, end Tip neuritis, blood circulation is bad, lower limb numbness or the mass formed by blood stasis such as livid purple.The radix paeoniae rubrathe have the functions such as the row stasis of blood, pain relieving, cool blood, detumescence, Control the stagnant Amenorrhea of the stasis of blood, the accumulation of hernia lump in the abdomen, stomachache, hypochondriac pain, bleeding from five sense organs or subcutaneous tissue, bloody flux, discharging fresh blood stool, hot eyes, carbuncle swells, injury from falling down.Fresh rehmannia root is supported The moon, clearing heat and promoting fluid, cool blood, hemostasis, for consumption of YIN caused by febrile disease, the deep red polydipsia of tongue, spot dermexanthesis, haematemesis, bleeding from five sense organs or subcutaneous tissue, abscess of throat.Gold and silver Flower is described as clearing heat and detoxicating good medicine from ancient times, its property sweet cold air fragrance, clear heat with drugs of sweet flavour and cold nature and do not injure one's stomach, fragrance thoroughly reach can eliminating evil, Honeysuckle can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile diseases, such as body heat, dermexanthesis, a spot.Capsule of weeping forsythia heat-clearing, solution Poison, dissipating bind, detumescence, control warm, erysipelas, macula, large carbuncle pyogenic infections, scrofula, urine leaching closes.Bighead atractylodes rhizome tonifying spleen, beneficial stomach, eliminating dampness, and in, Antiabortive, control deficient QI of the spleen and stomach, do not feel like eating, the few gas of burnout, void is swollen, has loose bowels, phlegm and retained fluid, oedema, jaundice, arthritis with fixed pain caused by dampness, difficult urination, head Dizzy, spontaneous perspiration, nausea is uneasy.The root of Dahurain angelica, taste is pungent, warm in nature, return lung, spleen, stomach, large intestine channel, function expels pathogenic wind from the body surface, eliminating cold to stop pain, dehumidifying Sensible, detumescence and apocenosis, modern pharmacological research proves, the root of Dahurain angelica is except having the effect such as antipyretic, analgesia, anti-inflammatory.Chinese yam has tonifying spleen to support Stomach, engender liquid and benefic lung, the action and efficacy of the puckery essence of kidney tonifying, because Chinese yam starch content is very big, external application has each middle medicine of adhesion and promoting blood circulation The effect of stagnation resolvation.Cassia seed bitter, sweet and cool in nature, there is clearing away the liver-fire, wines used as antirheumatic, clear liver and improve vision, sharp water defaecation, there is laxative to make The effects such as with, reducing blood pressure and blood fat.Asian puccoon cool blood, promoting blood circulation, heat-clearing, removing toxic substances, control warm macula, jaundice with damp-heat pathogen, purpura, tell, be defeated in battle, Hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, large carbuncle.

A kind of external used medicine beneficial effect of the invention of erythema multiforme is: a kind of external used medicine of erythema multiforme pass through with Medical science viewpoint analysis erythema multiforme has viral infectivity, but the immunity of the physique reason of people and people, power of resisting are also lowly Liable to infection reason, points out that the erythema multiforme cause of disease belongs to liver splenic hygropyrexia simultaneously, wind toxin enter blood, skin void blood dry, pent up in skin, adopt Take external curing, drawn out pus by applying a plaster to the affected part using heat-clearing, wind-dispelling dampness elimination, Chinese Medicine and Clavicular promoting blood circulation and removing blood stasis as external used medicine, receive obvious curative effect.

Specific embodiment

Below a kind of external used medicine of erythema multiforme is made with further enforcement explanation.

The dose drug that a kind of external used medicine of erythema multiforme is applied to that erythema multiforme patient uses be by Each traditional Chinese medicine quality combines below: 20 grams of fresh mulberry leaves, windproof 10 grams, 10 grams of Snakegourd Fruit, 12 grams of favus skin, 15 grams of the root bark of tree peony, peach 10 grams of benevolence, 6 grams of safflower, 10 grams of the radix paeoniae rubrathe, 10 grams of the dried rhizome of rehmannia, 12 grams of honeysuckle, 10 grams of the capsule of weeping forsythia, 10 grams of the bighead atractylodes rhizome, 10 grams of the root of Dahurain angelica, Chinese yam 12 Gram, 10 grams of cassia seed, 10 grams of Asian puccoon.

A kind of using method of the external used medicine of erythema multiforme has two kinds: one, bathing method: it is applied to generalized erythema, Said one dose drug proper amount of clear water is soaked heating after drenching and decoct into liquid, then liquid is added the clear of 3 times of quality Water is diluted, and is suitably heated into 38 DEG C ~ 45 DEG C of warm water and carries out bathing；2nd, hot application is it is adaptable to locality erythema, Each Chinese medicine is pulverized into mixed powder end, mixed powder end is added proper amount of clear water to be tuned into powder mud, heating powder mud is directly right Affected part carries out hot compress, but temperature can not be too high, is advisable with 40 DEG C ~ 50 DEG C, premised on not scalded skin.A kind of erythema multiforme External used medicine using treating more than secondary, disappears in the week daily substantially, if can coordinate for oral administration some clearing heat and detoxicating it Chinese medicine, disappears faster.

Claims (2)

1. a kind of external used medicine of erythema multiforme, is characterized in that combining by following each traditional Chinese medicine quality part ratio: fresh mulberry leaves 20 parts, windproof 10 parts, 10 parts of Snakegourd Fruit, 12 parts of favus skin, 15 parts of the root bark of tree peony, 10 parts of peach kernel, 6 parts of safflower, 10 parts of the radix paeoniae rubrathe, the dried rhizome of rehmannia 10 Part, 12 parts of honeysuckle, 10 parts of the capsule of weeping forsythia, 10 parts of the bighead atractylodes rhizome, 10 parts of the root of Dahurain angelica, 12 parts of Chinese yam, 10 parts of cassia seed, 10 parts of Asian puccoon.

2. a kind of external used medicine of the erythema multiforme described in a claim 1 is it is adaptable to what erythema multiforme patient used One dose drug is to combine by following each traditional Chinese medicine quality: 20 grams of fresh mulberry leaves, windproof 10 grams, 10 grams of Snakegourd Fruit, favus skin 12 grams, 15 grams of the root bark of tree peony, 10 grams of peach kernel, 6 grams of safflower, 10 grams of the radix paeoniae rubrathe, 10 grams of the dried rhizome of rehmannia, 12 grams of honeysuckle, 10 grams of the capsule of weeping forsythia, the bighead atractylodes rhizome 10 Gram, 10 grams of the root of Dahurain angelica, 12 grams of Chinese yam, 10 grams of cassia seed, 10 grams of Asian puccoon.