CN106334056A - Traditional Chinese medicine preparation for treating bronchial asthma in children - Google Patents
Traditional Chinese medicine preparation for treating bronchial asthma in children Download PDFInfo
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- CN106334056A CN106334056A CN201610791557.0A CN201610791557A CN106334056A CN 106334056 A CN106334056 A CN 106334056A CN 201610791557 A CN201610791557 A CN 201610791557A CN 106334056 A CN106334056 A CN 106334056A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating bronchial asthma in children and belongs to the technical field of traditional Chinese medicines. An applicant selects traditional Chinese medicines comprising asiatic cudweed, aster ageratoides, herba inulae, herb of ceylon leucas, mariscus umbellatus and sweet polygala tenuifolia to prepare traditional Chinese medicine decoction in clinical treatment practice for many years according to the cause of the bronchial asthma in children and according to diagnosis and treatment rules based on overall analysis of the traditional Chinese medicine; by clinical experiments, the total effective rate reaches 100.0% and is obviously more excellent than that of a control group, and toxic and side effects are avoided.
Description
Technical field
The present invention relates to technical field of Chinese medicines, more particularly to a kind of Chinese medicine preparation treating bronchial asthma of child.
Background technology
Bronchial asthma is a kind of children's period common respiratory tract chronic disease, and clinical manifestation mainly has asthma repeatedly to send out
Make with the passing of time not heal.Increasingly serious with air pollution, the sickness rate of bronchial asthma of child has the trend of rising.Bronchus are roared
Breathe heavily abbreviation asthma, be one of common respiratory tract disease of department of pediatrics.It is now recognized that bronchial asthma is a kind of chronic airway continuing
Diseases associated with inflammation, many cells play an important role wherein, such as lymphocyte, eosinophilic granulocyte, mastocyte etc., and companion
Non-specific airway significant reaction is had to increase, a kind of multi-cause disease with the high response (bhr) of air flue as main clinical characteristics
Disease.Clinically be mainly shown as repeatedly reversible pant and coughing fit, uncomfortable in chest, dyspnea, these symptoms are often can
Inverse, asthma can be fallen ill at any age.At present, the medicine for the treatment of bronchial asthma of child is more, but mostly there is curative effect
The deficiency such as inconspicuous, treatment time length, toxic and side effects are big.
Content of the invention
It is an object of the invention to provide a kind of Chinese medicine preparation treating bronchial asthma of child.
The purpose of the present invention is achieved through the following technical solutions, the Chinese medicine preparation of this treatment bronchial asthma of child by
The Chinese medicine of following weight portion is made: Herba Gnaphalii Hypoleuci 2-4 part, Herba Asteris Ageratoidis 1-2.5 part, Herba Inulae 0.5-1.5 part, Herba leucadis zeylanicae 1.5-
2.5 parts, Herba Marisci Umbellati 1-2.5 part, Radix Polygalae sibiricae 3-7 part.
Preferred: 3 parts of Herba Gnaphalii Hypoleuci, 1.8 parts of Herba Asteris Ageratoidis, 0.8 part of Herba Inulae, 2 parts of Herba leucadis zeylanicae, 1.8 parts of Herba Marisci Umbellati, sweet remote
5 parts of will.
Preparation method: traditionally make decoction.
Fang Zhong: Herba Gnaphalii Hypoleuci wind-dispelling, dispersing lung-QI and dissipating phlegm, relieving cough and asthma, blood pressure lowering, solution noxious dampness；The removing toxic substances of Herba Asteris Ageratoidis wind and heat dispersing,
Eliminating phlegm and relieving cough；Jinfeicao powder wind and cold, resolving sputum drink, detumescence poison；Herba leucadis zeylanicae induce sweat cough-relieving, stimulate the menstrual flow, improving eyesight；Herba Marisci Umbellati relieving cough and resolving phlegm,
Diffusing lung, relieving exterior syndrome；Radix Polygalae sibiricae nourishing YIN and clearing away heat, eliminating the phlegm removing toxic substances.
Specific embodiment
Embodiment one: weigh Herba Gnaphalii Hypoleuci 2g, Herba Asteris Ageratoidis 1g, Herba Inulae 0.5g, Herba leucadis zeylanicae 1.5g, Herba Marisci Umbellati 1g, sweet
Radix Polygalae 3g, traditionally makes decoction.
Embodiment two: weigh Herba Gnaphalii Hypoleuci 3g, Herba Asteris Ageratoidis 1.8g, Herba Inulae 0.8g, Herba leucadis zeylanicae 2g, Herba Marisci Umbellati 1.8g,
Radix Polygalae sibiricae 5g, traditionally makes decoction.
Embodiment three: weigh Herba Gnaphalii Hypoleuci 4g, Herba Asteris Ageratoidis 2.5g, Herba Inulae 1.5g, Herba leucadis zeylanicae 2.5g, Herba Marisci Umbellati
2.5g, Radix Polygalae sibiricae 7g, traditionally make decoction.
Toxicity test
1st, laboratory animal cleaning grade health sd female rats 40, weight (208 ± 3) g, as chronic toxicity；
Cleaning grade health Kunming female white mice 30, weight (22 ± 4) g, as acute toxicological experiment.Feed with normal diet, general
Logical drinking-water.Room temperature controls in (24 ± 3) DEG C, humidity (51 ± 3) %, natural lighting.
2nd, acute toxicological experiment is according to (Chinese medicine, researches on natural drugs registration service manual), from cleaning grade health Kunming
Female white mice 30, is randomly divided into 2 groups, Chinese medicine group and each 15 of blank control group.Chinese medicine group is pressed adult normal's oral dose and is rolled over
It is counted as the dosage of white mice, gavage Chinese medicine 1 time daily.Blank control group gives 1ml/20g weight 0.9% sodium chloride injection to fill
Clothes.
3rd, long term toxicity test cleaning grade health sd female rats 40, are randomly divided into 4 groups, Normal group and Chinese medicine
Group little, in, heavy dose of each 10.Matched group gives 1ml/20g weight 0.9% sodium chloride injection, Chinese medicine group little, in,
Heavy dose of group of be that adult normal consumption is converted to rat dosage 20,30,40 times, are gastric infusion, one time a day, experiment week
Phase is 3 months.
4th, acute toxicity testing result white mice is no dead in administration 10d, to observation post administration mice outward appearance, hair color, light
Pool is normal, and social behavior, reaction are all normal, ingests, drains normally.After 10d, artificial putting to death is dissected, and observes its heart, liver, spleen
Dirty, lungs, kidney, brain, ovary, uterus are showed no exception.Pathological examination: single-minded Yihong of Lignum Sappan (he) dyeing, Chinese medicine group is dirty
Device smooth surface, organizational structure aligned orderly, cell size, form are normal, and endochylema, karyon dyeing are clear, with blank control group
Comparing difference not statistically significant (p ＞ 0.05).
5th, chronic toxicity result Chinese medicine group little, in, the outward appearance of heavy dose of group and rats in normal control group, hair color,
Social behavior, zest etc. and all not statistically significant to comparing differences such as surrounding, food, the interest of water (p ＞ 0.05).
After 4 groups of rat experiments weight all relatively this group experiment before increase (p ＜ 0.05), but 4 groups experiment after weight comparing difference all no
Statistical significance (p ＞ 0.05), blood cytology index, blood biochemical analysis index, important organ coefficient ratio after 4 groups of rat experiments
All not statistically significant compared with difference (p ＞ 0.05).At 4 groups of rats, after death important organ row staining pathologic section checks, he dyes.
Chinese medicine group Rats Organs and Tissues organizational structure aligned orderly, cell size, form are normal, and endochylema, karyon dyeing are clear, with normal control
Group comparing difference not statistically significant (p ＞ 0.05).
Toxicity test shows, has no toxic reaction after the Chinese medicine preparation administration of the treatment bronchial asthma of child of the present invention.
Clinical data
1st, the bronchial asthma of child patient 80 that physical data is treated in the court's acceptance, wherein man 45, female 35,
Age be 3-10 year.On the basis of patient knows the inside story and be voluntary, patient is divided into 8 groups by us；Only take Herba Gnaphalii Hypoleuci single medicinal material
Organize for a group, only take Herba Asteris Ageratoidis single medicinal material group be b group, only take Herba Inulae single medicinal material group be c group, only take Herba leucadis zeylanicae single
Medicine group be d group, only take Herba Marisci Umbellati single medicinal material group be e group, only take Radix Polygalae sibiricae single medicinal material group be f group, take the present invention by reality
Apply mode two preparation group to be treatment group, be matched group using routine treatment.Each group is more no united in physical data such as age, sexes
Meaning (p ＞ 0.05) learned by meter, has comparability.
2nd, Therapeutic Method: the medicament that treatment group takes by embodiment of the present invention two is obtained is treated；Weigh respectively a,
The weight of b, c, d, e, f each single medicinal material group, traditionally makes medicament and is treated, and the above every dose point of morning and evening of each group takes twice
With matched group inhalation of budesonide is treated.Each group 5 days is a course for the treatment of.
3rd, the standard of curative effect evaluation is cured: Asthma control, and wheezing sound disappears；Take a turn for the better: Stable asthma, or attack times minimizing；
Do not heal: symptom is unchanged.
4th, each group treats comparative result after two courses for the treatment of
| Group | Number of cases | Dose (g) | Cure | Take a turn for the better | Invalid | Side effect | Total effective rate (%) |
| a | 10 | 22 | 1 | 1 | 8 | 1 | 20.0 |
| b | 10 | 22 | 0 | 1 | 9 | 2 | 10.0 |
| c | 10 | 22 | 1 | 1 | 8 | 2 | 20.0 |
| d | 10 | 22 | 0 | 1 | 9 | 1 | 10.0 |
| e | 10 | 22 | 1 | 0 | 9 | 3 | 10.0 |
| f | 10 | 22 | 1 | 1 | 8 | 2 | 20.0 |
| Treatment group | 10 | 14.4 | 7 | 3 | 0 | 0 | 100.0 |
| Matched group | 10 | Convention amount | 5 | 3 | 2 | 1 | 80.0 |
By the dose of single medicinal material each in upper table, do toxicity test by the above-mentioned method doing toxicity test respectively, tied by experiment
Fruit understands that each single medicinal material group is nontoxic level.By above clinical data, although less dose is taken by treatment group,
Achieve preferable therapeutic effect, total effective rate is higher than each single medicinal material total effective rate sum, be also significantly better than matched group, more gratifying
Be toxicity reduce, have no toxic side effect appearance, it follows that each medicine under synergistic function to the side being conducive to human health
To development, clinic popularization and application.
When carrying out follow-up to above treatment group patient, wherein there are 2 readmes " after taking the preparation of the present invention, not only little
Youngster's bronchial asthma has obtained effectively treatment, and night sweat symptom ".After obtaining this message, we are immediately to 20
With different degrees of night sweat patient, the Chinese medicine preparation being obtained using embodiment of the present invention two, one dose per day, a point morning and evening takes twice
Method is treated.Curative effect judging standard is fully recovered: night sweat stops completely, and concomitant symptom disappears substantially, is discontinued latter 1 year no again
Send out；Effective: night sweat stops substantially, concomitant symptom has been alleviated, and is discontinued and no recurs for latter 6 months；Invalid: night sweat and concomitant symptom are equal
No improve.Result: in 20 patients, 12 (60%) of fully recovering, effective 6 (30%), and invalid 2 (10%), total effective rate is pressed
Recovery from illness and effective meter, are 90%.It follows that taking the Chinese medicine preparation of the present invention, not only treat bronchial asthma of child curative effect
Significantly, and to night sweat there are good therapeutic effect, clinic popularization and application.
Claims (2)
1. a kind of Chinese medicine preparation treating bronchial asthma of child it is characterised in that this Chinese medicine preparation by following weight portion Chinese medicine
Make: Herba Gnaphalii Hypoleuci 2-4 part, Herba Asteris Ageratoidis 1-2.5 part, Herba Inulae 0.5-1.5 part, Herba leucadis zeylanicae 1.5-2.5 part, Herba Marisci Umbellati 1-2.5
Part, Radix Polygalae sibiricae 3-7 part.
2. as claimed in claim 1 a kind of Chinese medicine preparation treating bronchial asthma of child it is characterised in that this Chinese medicine preparation
It is made up of the Chinese medicine of following weight portion: 3 parts of Herba Gnaphalii Hypoleuci, 1.8 parts of Herba Asteris Ageratoidis, 0.8 part of Herba Inulae, 2 parts of Herba leucadis zeylanicae, Herba Marisci Umbellati
1.8 parts, 5 parts of Radix Polygalae sibiricae.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610791557.0A CN106334056A (en) | 2016-08-24 | 2016-08-24 | Traditional Chinese medicine preparation for treating bronchial asthma in children |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610791557.0A CN106334056A (en) | 2016-08-24 | 2016-08-24 | Traditional Chinese medicine preparation for treating bronchial asthma in children |
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| Publication Number | Publication Date |
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| CN106334056A true CN106334056A (en) | 2017-01-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610791557.0A Withdrawn CN106334056A (en) | 2016-08-24 | 2016-08-24 | Traditional Chinese medicine preparation for treating bronchial asthma in children |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147424A (en) * | 2014-08-26 | 2014-11-19 | 淄博夸克医药技术有限公司 | Traditional Chinese medicine for treating bronchial asthma |
| CN105288200A (en) * | 2015-11-30 | 2016-02-03 | 高琳本 | Traditional Chinese medicine preparation for treating children bronchial asthma and preparation method thereof |
| CN105616762A (en) * | 2016-03-28 | 2016-06-01 | 段风焕 | Traditional Chinese medicine for treating children bronchial asthma and preparation method of traditional Chinese medicine |
-
2016
- 2016-08-24 CN CN201610791557.0A patent/CN106334056A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147424A (en) * | 2014-08-26 | 2014-11-19 | 淄博夸克医药技术有限公司 | Traditional Chinese medicine for treating bronchial asthma |
| CN105288200A (en) * | 2015-11-30 | 2016-02-03 | 高琳本 | Traditional Chinese medicine preparation for treating children bronchial asthma and preparation method thereof |
| CN105616762A (en) * | 2016-03-28 | 2016-06-01 | 段风焕 | Traditional Chinese medicine for treating children bronchial asthma and preparation method of traditional Chinese medicine |
Non-Patent Citations (3)
| Title |
|---|
| 于文涛等: "《杨牧祥医术精要》", 30 June 2013, 中国中医药出版社 * |
| 孔增科: "《实用中药手册》", 30 June 1990, 天津科学技术出版社 * |
| 谢宗万等: "《全国中草药汇编 上 第2版》", 31 October 1996, 人民卫生出版社 * |
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Application publication date: 20170118 |