CN106334023A - Method for preparing traditional Chinese medicine ointment for treating infant hemangioma - Google Patents
Method for preparing traditional Chinese medicine ointment for treating infant hemangioma Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention relates to a method for preparing a traditional Chinese medicine ointment for treating infant hemangioma. The method comprises the steps of weighing 10-50 parts of prunella vulgaris, 10-50 parts of houttuynia cordata, 50-20 parts of musk, 5-25 parts of alum, 10-40 parts of Sichuan lovage rhizome and 5-10 parts of mint, placing the raw materials in water at 65-95 DEG C to perform decoction for 30-50 min, taking filtrate, adding vitamin E and vitamin B12 into the filtrate according to a certain mass ratio, performing stirring dissolution and then adding a thickening agent and a wetting penetrating agent according to a certain mass ratio, performing stirring evenly, and performing cooling and then obtaining the traditional Chinese medicine ointment for treating infant hemangioma. The traditional Chinese medicine ointment is an external use medicine and is particularly suitable for infants having inconvenience in medicine taking and injection.
Description
Technical field
The present invention relates to a kind of preparation method of the Chinese medicinal ointment for treating infant hemangioma.
Background technology
Hemangioma is the modal congenital non-malignant vascular tumor of infant, is apt to occur in women, men and women's disease rates are about
1:3~1:4.Sickness rate in neonate for the hemangioma is 2%~3%, and the sickness rate of less than 1 years old child is about 10%, and early
Newborn baby or the neonatal sickness rate of under-weight may be up to 22%~30%.Hemangioma can betide whole body everywhere, such as: skin, flesh
The internal organs such as meat, bone and brain, liver, heart, wherein betide incidence (60%) at most, next to that trunk (25%) and extremity
(15%).Most of hemangioma can voluntarily disappear, and the course of disease can be divided into proliferation period, paracmasis and disappear the phase of completing.General 1 years old with
Interior for proliferation period, extend to sometimes in latter 18 months of birth, subsequently gradually transit to paracmasis.Although 85%~90% blood
Tuberculation when 7~10 years old can spontaneous regression, but some serious hemangioma can be permanently present, or even influences whether the breathing of baby
The vitals adjacent with vision and compressing.Therefore, part hemangioma needs the process to accelerate it to reduce for the treatment.
Infant, due to too little, select drug administration treatment or injection treatment, not only bothers but also may bring other
Hidden danger, market lacks a kind of external used medicine being applied to treatment infant hemangioma.
Drug research situation involved in the present invention is as follows:
Spica Prunellae (scientific name: prunella vulgaris l), another name: wheat head selfheal, iron wire selfheal (Yunnan clump
Book), Mai Xia is withered, the iron wire summer withered (the southern regions of the Yunnan Province book on Chinese herbal medicine), sunset sentence, Nedong (this warp) etc..Relieve inflammation or internal heat improving eyesight, conjunctival congestion can be controlled and swell
Bitterly, have a headache.
Herba Houttuyniae (English name herba houttuyniae) is the medical herbs that Chinese Pharmacopoeia is included.Have antibacterial, antiviral,
Improve the effect such as immunity of organisms, diuresis.
Moschus also known as Moschus, Moschus, Moschuss, smelly sub, fragrant umbilicuss.Removing blood stasis are had to become silted up effect, anemia of pregnant woman's inedibility.
Alumen also known as Alumen, arcanite, potassium aluminium alum, potassium alum.Alumen nature and flavor are sour and astringent, tremble with fear, poisonous.Therefore have antibacterial action, receipts
Hold back effect.
Rhizoma Chuanxiong also known as big Rhizoma Chuanxiong, comfort vault, separately have wine Rhizoma Chuanxiong.Have sensible QI and blood effect, therefore control the chest side of body of qi depression to blood stasis, abdominal part
All pains.
Herba Menthae popular name, " lunar caustic grass ", is labiate, that is, belongs to other together and herb is dried.It is pungent cool property sweating and heat resolving
Medicine, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.External can control neuralgia, skin pruritus, erythra
With eczema etc..
Vitamin e is used for preventing and treating male infertility, burn, cold injury, capillary hemorrhage, climacteric syndrome, beauty treatment etc.
Aspect.Recently also find that vitamin e can suppress the lipid peroxidation reaction in ocular lens body, make peripheral vasodilation, improve blood
Liquid circulates, pre- Anti-myopic eye occurrence and development.
Vitamin b12 main Physiological Function is to participate in manufacturing erythrocyte, prevents pernicious anemia;Cerebral nerve is prevented to be subject to
To destruction.
Content of the invention
The technical problem to be solved is to provide a kind of preparation of the Chinese medicinal ointment for treating infant hemangioma
Method, prepared Chinese medicinal ointment more remarkable treatment effect, easy to use and safety has no side effect.
In order to solve above-mentioned technical problem, the present invention employs the following technical solutions:
A kind of preparation method of the Chinese medicinal ointment for treating infant hemangioma is it is characterised in that enter according to following steps
OK:
1), prepare Chinese medicine composition: weigh 10~50 parts of Spica Prunellae, 10~50 parts of Herba Houttuyniae, 5~20 parts of Moschus, Alumen 5
~25 parts, 10~40 parts of Rhizoma Chuanxiong, 5~10 parts of Herba Menthae, mix homogeneously obtains Chinese medicine composition;Described part refers to mass parts;
2), prepare filtrate: in water Chinese medicine composition being put into 65~95 DEG C, decoct 30~50min, Chinese medicine composition
Mass ratio with water is 10~50:100, after filtration, obtains filtrate;
3), prepare Chinese medicinal ointment: vitamin e and vitamin b12 are proportionally added in filtrate, stirring and dissolving, after cooling,
Add thickening agent and wetting and penetrating agent according to certain mass ratio, vitamin e, vitamin b12, thickening agent, wetting and penetrating agent and
The mass ratio of filtrate is 1~5:1~5:0.1~0.5:0.5~5:100, stirs, prepared Chinese medicinal ointment;
Described thickening agent is one of sodium alginate, gelatin, sodium polyacrylate and polyacrylamide or arbitrary proportion
Two or more;Described wetting and penetrating agent is one of sorbitan fatty acid ester -20, Tween-60, glycerol and ethanol
Or arbitrary proportion is two or more.
Step 1) in 40 parts of Spica Prunellae, 40 parts of Herba Houttuyniae, 15 parts of Moschus, 20 parts of Alumen, 25 parts of Rhizoma Chuanxiong, 5 parts of Herba Menthae.
Step 2) described temperature is 85 DEG C, decocts 45min, the mass ratio of Chinese medicine composition and water is 20:100.
Step 3) described in thickening agent be the gelatin and sodium alginate compositionss according to mass ratio 1:2;Wetting and penetrating agent is
Sorbitan fatty acid ester -20, Tween-60 and glycerol are according to the compositionss of mass ratio 2:1:2;Vitamin e, vitamin
The mass ratio of b12, thickening agent, wetting and penetrating agent and filtrate is 3:2:0.3:1.5:100.
Invent and there are following Advantageous Effects:
1st, medicine of the present invention and vitamin collocation, during Drug therapy, prevent angiorrbagia, promote blood
Circulation, therapeutic effect is better than and is used alone Drug therapy.
2nd, the present invention adds wetting and penetrating agent to promote the absorption to medicine for the skin, improves drug effect.
3rd, the present invention determines the optimal proportion of wetting and penetrating agent and filtrate by many experiments.
Specific embodiment
Further illustrate the present invention with reference to instantiation.
Embodiment 1
Prepare Chinese medicine composition: weigh 40 parts of Spica Prunellae, 40 parts of Herba Houttuyniae, 15 parts of Moschus, 20 parts of Alumen, 25 parts of Rhizoma Chuanxiong,
5 parts of Herba Menthae, obtains Chinese medicine composition;Described part is mass parts, similarly hereinafter.
Preparation filtrate: decoct 45min, the mass ratio of Chinese medicine composition and water in water Chinese medicine composition being put into 85 DEG C
For 20:100, after filtration, obtain filtrate;
Prepare for treating infant hemangioma Chinese medicinal ointment: vitamin e and vitamin b12 are added according to certain mass ratio
Enter in filtrate, stirring and dissolving, after cooling, add thickening agent and wetting and penetrating agent, vitamin e, dimension according to certain mass ratio
Raw element b12, the mass ratio of thickening agent, wetting and penetrating agent and filtrate are 3:2:0.3:1.5:100, stir, are obtained and are used for controlling
Treat infant hemangioma Chinese medicinal ointment.
Embodiment 2
Prepare Chinese medicine composition: weigh 40 parts of Spica Prunellae, 40 parts of Herba Houttuyniae, 15 parts of Moschus, 20 parts of Alumen, 25 parts of Rhizoma Chuanxiong,
5 parts of Herba Menthae, obtains Chinese medicine composition;
Preparation filtrate: decoct 45min, the mass ratio of Chinese medicine composition and water in water Chinese medicine composition being put into 85 DEG C
For 20:100, after filtration, obtain filtrate;
Prepare for treating infant hemangioma Chinese medicinal ointment: vitamin e and vitamin b12 are added according to certain mass ratio
Enter in filtrate, stirring and dissolving, after cooling, add thickening agent and wetting and penetrating agent, vitamin e, dimension according to certain mass ratio
Raw element b12, the mass ratio of thickening agent, wetting and penetrating agent and filtrate are 3:2:0.3:0.5:100, stir, are obtained and are used for controlling
Treat infant hemangioma Chinese medicinal ointment.
Embodiment 3
Prepare Chinese medicine composition: weigh 40 parts of Spica Prunellae, 40 parts of Herba Houttuyniae, 15 parts of Moschus, 20 parts of Alumen, 25 parts of Rhizoma Chuanxiong,
5 parts of Herba Menthae, obtains Chinese medicine composition;
Preparation filtrate: decoct 45min, the mass ratio of Chinese medicine composition and water in water Chinese medicine composition being put into 85 DEG C
For 20:100, after filtration, obtain filtrate;
Prepare for treating infant hemangioma Chinese medicinal ointment: vitamin e and vitamin b12 are added according to certain mass ratio
Enter in filtrate, stirring and dissolving, after cooling, add thickening agent and wetting and penetrating agent, vitamin e, dimension according to certain mass ratio
Raw element b12, the mass ratio of thickening agent, wetting and penetrating agent and filtrate are 3:2:0.3:1:100, stir, are obtained for treating
Infant hemangioma Chinese medicinal ointment.
Embodiment 4
Prepare Chinese medicine composition: weigh 40 parts of Spica Prunellae, 40 parts of Herba Houttuyniae, 15 parts of Moschus, 20 parts of Alumen, 25 parts of Rhizoma Chuanxiong,
5 parts of Herba Menthae, obtains Chinese medicine composition;
Preparation filtrate: decoct 45min, the mass ratio of Chinese medicine composition and water in water Chinese medicine composition being put into 85 DEG C
For 20:100, after filtration, obtain filtrate;
Prepare for treating infant hemangioma Chinese medicinal ointment: vitamin e and vitamin b12 are added according to certain mass ratio
Enter in filtrate, stirring and dissolving, after cooling, add thickening agent and wetting and penetrating agent, vitamin e, dimension according to certain mass ratio
Raw element b12, the mass ratio of thickening agent, wetting and penetrating agent and filtrate are 3:2:0.3:2:100, stir, are obtained for treating
Infant hemangioma Chinese medicinal ointment.
In embodiment 1 to 4, described thickening agent is the gelatin and sodium alginate compositionss according to mass ratio 1:2;Moistening is permeated
Agent is sorbitan fatty acid ester -20, the Tween-60 and glycerol compositionss according to mass ratio 2:1:2.
Further illustrate beneficial effects of the present invention with reference to experimental data:
1st, physical data
Inventor, between in May, 2013~2016 year July, uses the present invention to blood in Hospital Affiliated to Bingzhou Medical Collage
Tuberculation infant smears treatment, collects 330 altogether, one full year of life at age 0~1, is randomly divided into 5 groups, and every group of 66 people smear 3 daily
Secondary, 1 week of the course for the treatment of.
2nd, test method
Be commonly used for treating infant hemangioma Chinese medicinal ointment (except not plus in addition to wetting and penetrating agent, other manufacture methods and reality
Apply example 1 consistent), embodiment 1, embodiment 2, embodiment 3 and embodiment 4 test respectively for 5 groups.
3rd, treatment standard and therapeutic outcome
3.1 treatment standards
Recovery from illness: clinical symptoms all disappear.Take a turn for the better: clinical symptoms substantially mitigate.It is invalid: clinical symptoms are no clearly better,
Have and increase trend.
3.2 therapeutic outcome statistics such as table 1.
1: five group of Comparison of therapeutic of table
Group | Recovery from illness (example) | Take a turn for the better (example) | Invalid (example) | Total effective rate (%) | Untoward reaction |
Common drug | 26 | 37 | 3 | 95.2 | No |
Embodiment 1 | 37 | 29 | 0 | 100 | No |
Embodiment 2 | 29 | 35 | 2 | 96.8 | No |
Embodiment 3 | 32 | 33 | 1 | 98.4 | No |
Embodiment 4 | 35 | 31 | 0 | 100 | No |
Can be seen that the present invention has positive effect, wherein embodiment 1 effect to treatment infant hemangioma by table 1 data
Good.
Claims (5)
1. a kind of preparation method of the Chinese medicinal ointment for treating infant hemangioma is it is characterised in that follow the steps below:
1), prepare Chinese medicine composition: weigh 10~50 parts of Spica Prunellae, 10~50 parts of Herba Houttuyniae, 5~20 parts of Moschus, Alumen 5~25
Part, 10~40 parts of Rhizoma Chuanxiong, 5~10 parts of Herba Menthae, mix homogeneously obtains Chinese medicine composition;Described part refers to mass parts;
2), prepare filtrate: in water Chinese medicine composition being put into 65~95 DEG C, decoct 30~50min, Chinese medicine composition and water
Mass ratio be 10~50:100, after filtration, obtain filtrate;
3), prepare Chinese medicinal ointment: vitamin e and vitamin b12 are proportionally added in filtrate, stirring and dissolving, after cooling, according to
Certain mass ratio adds thickening agent and wetting and penetrating agent, vitamin e, vitamin b12, thickening agent, wetting and penetrating agent and filtrate
Mass ratio be 1~5:1~5:0.1~0.5:0.5~5:100, stir, prepared Chinese medicinal ointment;
Described thickening agent is two kinds of one of sodium alginate, gelatin, sodium polyacrylate and polyacrylamide or arbitrary proportion
More than;Described wetting and penetrating agent is one of sorbitan fatty acid ester -20, Tween-60, glycerol and ethanol or appoints
Meaning ratio two or more.
2. the as claimed in claim 1 preparation method being used for treating the Chinese medicinal ointment of infant hemangioma it is characterised in that: step
1) 40 parts of Spica Prunellae, 40 parts of Herba Houttuyniae, 15 parts of Moschus, 20 parts of Alumen, 25 parts of Rhizoma Chuanxiong, 5 parts of Herba Menthae in.
3. the as claimed in claim 1 or 2 preparation method being used for treating the Chinese medicinal ointment of infant hemangioma it is characterised in that:
Step 2) described temperature is 85 DEG C, decocts 45min, the mass ratio of Chinese medicine composition and water is 20:100.
4. the as claimed in claim 1 or 2 preparation method being used for treating the Chinese medicinal ointment of infant hemangioma it is characterised in that:
Thickening agent described in step 3) is the gelatin and sodium alginate compositionss according to mass ratio 1:2;Wetting and penetrating agent is Sorbitan
Alcohol fatty acid ester -20, Tween-60 and glycerol are according to the compositionss of mass ratio 2:1:2;Vitamin e, vitamin b12, thickening
The mass ratio of agent, wetting and penetrating agent and filtrate is 3:2:0.3:1.5:100.
5. the as claimed in claim 3 preparation method being used for treating the Chinese medicinal ointment of infant hemangioma it is characterised in that: step
3) thickening agent described in is the gelatin and sodium alginate compositionss according to mass ratio 1:2;Wetting and penetrating agent is Sorbitan alcohol ester
Fat acid esters -20, Tween-60 and glycerol are according to the compositionss of mass ratio 2:1:2;Vitamin e, vitamin b12, thickening agent,
The mass ratio of wetting and penetrating agent and filtrate is 3:2:0.3:1.5:100.
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1120955A (en) * | 1995-08-26 | 1996-04-24 | 郑庸 | Medicine for curing haemangioma cutis and its compounding process |
CN102228529A (en) * | 2011-06-20 | 2011-11-02 | 张佑强 | Traditional Chinese medicine formula for treating infant epidermal hemangioma |
CN102579412A (en) * | 2012-02-16 | 2012-07-18 | 山东省立医院 | External medicament for treating infant hemangioma and preparation method thereof |
CN102631464A (en) * | 2012-05-18 | 2012-08-15 | 许从玉 | Chinese medicinal ointment for treating infantile hemangioma and preparation method thereof |
-
2016
- 2016-10-27 CN CN201610954358.7A patent/CN106334023A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1120955A (en) * | 1995-08-26 | 1996-04-24 | 郑庸 | Medicine for curing haemangioma cutis and its compounding process |
CN102228529A (en) * | 2011-06-20 | 2011-11-02 | 张佑强 | Traditional Chinese medicine formula for treating infant epidermal hemangioma |
CN102579412A (en) * | 2012-02-16 | 2012-07-18 | 山东省立医院 | External medicament for treating infant hemangioma and preparation method thereof |
CN102631464A (en) * | 2012-05-18 | 2012-08-15 | 许从玉 | Chinese medicinal ointment for treating infantile hemangioma and preparation method thereof |
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Application publication date: 20170118 |