CN106334010A - Traditional Chinese medicine potion mainly for treating acute and chronic ulcerative colitis and preparation method thereof - Google Patents
Traditional Chinese medicine potion mainly for treating acute and chronic ulcerative colitis and preparation method thereof Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 20
- 206010009900 Colitis ulcerative Diseases 0.000 title claims abstract description 16
- 201000006704 Ulcerative Colitis Diseases 0.000 title claims abstract description 16
- 230000001684 chronic effect Effects 0.000 title claims abstract description 15
- 230000001154 acute effect Effects 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title 1
- 240000000588 Hericium erinaceus Species 0.000 claims abstract description 13
- 235000007328 Hericium erinaceus Nutrition 0.000 claims abstract description 13
- 239000009636 Huang Qi Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000008367 deionised water Substances 0.000 claims abstract description 10
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 10
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 11
- 241000195474 Sargassum Species 0.000 claims description 10
- 244000309464 bull Species 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 238000000703 high-speed centrifugation Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 239000000047 product Substances 0.000 claims description 3
- 238000010025 steaming Methods 0.000 claims description 3
- 235000011158 Prunus mume Nutrition 0.000 claims 1
- 244000018795 Prunus mume Species 0.000 claims 1
- 238000002242 deionisation method Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 6
- 230000003750 conditioning effect Effects 0.000 abstract description 2
- 230000036039 immunity Effects 0.000 abstract description 2
- 241000213006 Angelica dahurica Species 0.000 abstract 3
- 241001647745 Banksia Species 0.000 abstract 3
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 3
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 3
- 244000223760 Cinnamomum zeylanicum Species 0.000 abstract 3
- 235000009917 Crataegus X brevipes Nutrition 0.000 abstract 3
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 abstract 3
- 235000009685 Crataegus X maligna Nutrition 0.000 abstract 3
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 abstract 3
- 235000009486 Crataegus bullatus Nutrition 0.000 abstract 3
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 abstract 3
- 235000009682 Crataegus limnophila Nutrition 0.000 abstract 3
- 235000004423 Crataegus monogyna Nutrition 0.000 abstract 3
- 240000000171 Crataegus monogyna Species 0.000 abstract 3
- 235000002313 Crataegus paludosa Nutrition 0.000 abstract 3
- 235000009840 Crataegus x incaedua Nutrition 0.000 abstract 3
- 241000202807 Glycyrrhiza Species 0.000 abstract 3
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 3
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 3
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 3
- 244000236658 Paeonia lactiflora Species 0.000 abstract 3
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 3
- 241000220317 Rosa Species 0.000 abstract 3
- 235000017803 cinnamon Nutrition 0.000 abstract 3
- 229940010454 licorice Drugs 0.000 abstract 3
- 244000179560 Prunella vulgaris Species 0.000 abstract 2
- 235000010674 Prunella vulgaris Nutrition 0.000 abstract 2
- 230000007774 longterm Effects 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
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- 210000001072 colon Anatomy 0.000 description 3
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- 208000008454 Hyperhidrosis Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 206010009887 colitis Diseases 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 2
- 235000021286 stilbenes Nutrition 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241000244186 Ascaris Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 description 1
- 206010036049 Polycystic ovaries Diseases 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
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- 230000003419 expectorant effect Effects 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
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- 210000003734 kidney Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
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- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 description 1
- 229960004963 mesalazine Drugs 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
- 229960001940 sulfasalazine Drugs 0.000 description 1
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
A traditional Chinese medicine potion mainly for treating acute and chronic ulcerative colitis is composed of radix astragali, Chinese angelica, cassia twig, white peony root, dark plum, scorched hawthorn, cinnamon, banksia rose, hericium erinaceus, alga, prunella vulgaris, licorice and deionized water. The traditional Chinese medicine potion comprises, by mass parts, 20-25 parts of radix astragali, 15-20 parts of Chinese angelica, 15-20 parts of cassia twig, 20-25 parts of white peony root, 10-15 parts of dark plum, 5-10 parts of scorched hawthorn, 3-5 parts of cinnamon, 3-5 parts of banksia rose, 3-5 parts of hericium erinaceus, 5-8 parts of alga, 3-5 parts of prunella vulgaris, 15-20 parts of licorice and 800-1200 parts of deionized water. Radix astragali, Chinese angelica, cassia twig, white peony root, dark plum, scorched hawthorn, cinnamon, banksia rose, hericium erinaceus and licorice are in compatibility to be used for conditioning and treatment of acute and chronic ulcerative colitis, the immunity of the organism can be enhanced if the traditional Chinese medicine potion is used for a long term, yin and yang balance is adjusted, and thus a whole regulation effect is brought into play to achieve the goal of treating ulcerative colitis.
Description
Technical field
The present invention relates to a kind of the intestines and stomach maintenance medicine is and in particular to a kind of Chinese medicine for the treatment of acute and chronic ulcerative colitiss is drunk
Agent and its compound method.
Background technology
Ulcerative colitiss include acute ulcer colitis and chronic ulcerative colitis, and its cause of disease is not yet explained completely
Bright, mainly invade and colonic mucosa chronic nonspecific inflammatory diseasess, often start from left hemicolon, can be to colon near-end or even complete
Colon, is gradually in progress in a continuous manner.Clinical features differ, and alleviation can be had to alternate with outbreak, patient can only have colon
Symptom, also can occur together General Symptomies.Healing potion mostly is Western medicine, such as mesalazine and sulfasalazine at present, but for a long time
Take, to healthy, there is larger side effect.
Content of the invention
The present invention is in view of the shortcomings of the prior art, there is provided a kind of Chinese medicine drink for the treatment of acute and chronic ulcerative colitiss
Agent and its compound method.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of Traditional Chinese medicine potion for the treatment of acute and chronic ulcerative colitiss, by the Radix Astragali；Radix Angelicae Sinensis；Ramulus Cinnamomi；The Radix Paeoniae Alba；Fructus Mume；Burnt short, bristly hair or beard；
Cortex Cinnamomi；The Radix Aucklandiae；Hericium erinaceus (Bull. Ex Fr.) Pers.；Sargassum；Spica Prunellae；Radix Glycyrrhizae and deionized water composition, the mass parts ratio that wherein each component uses is: yellow
Stilbene 20-25 part；Radix Angelicae Sinensis 15-20 part；Ramulus Cinnamomi 15-20 part；Radix Paeoniae Alba 20-25 part；Fructus Mume 10-15 part；Burnt short, bristly hair or beard 5-10 part；Cortex Cinnamomi 3-5
Part；Radix Aucklandiae 3-5 part；Hericium erinaceus (Bull. Ex Fr.) Pers. 3-5 part；Sargassum 5-8 part；Spica Prunellae 3-5 part；Radix Glycyrrhizae 15-20 part and deionized water 800～1200
Part.
The compound method of the Traditional Chinese medicine potion of above-mentioned treating acute and chronic ulcerative colitiss, concrete grammar step is as follows:
(1) by the Radix Astragali；Radix Angelicae Sinensis；Ramulus Cinnamomi；The Radix Paeoniae Alba；Fructus Mume；Burnt short, bristly hair or beard；Cortex Cinnamomi；The Radix Aucklandiae；Hericium erinaceus (Bull. Ex Fr.) Pers.；Sargassum；Spica Prunellae and Radix Glycyrrhizae
Weigh respectively according to proportioning, after being then passed through nine steaming nine solarization, then these medicines are soaked through decocting extraction, have decocted every time all
Filtered, take filtrate standby；
(2) filtrate is adopted cryogenic vacuum to concentrate, then carry out high speed centrifugation precipitation, take supernatant standby；
(3) deionized water is added in blending tank, start stirring, the supernatant then step (2) being obtained add to
In blending tank, stir；
(4) by the liquid sub-bottle fill in blending tank, after high temperature sterilize, just can get finished product.
The present invention cures mainly in the Traditional Chinese medicine potion formula of follicular dysplasia caused by polycystic ovary: the 1, Radix Astragali: has QI invigorating solid
Table, diuretic and maintain drug, evacuation of pus, effect of expelling pus and promoting granulation.2nd, Radix Angelicae Sinensis: benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation.3rd, Ramulus Cinnamomi: diaphoresis
Expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, helps yang transforming qi, dispersing cold for relieving pain.4th, the Radix Paeoniae Alba: blood-supplementing blood-nourishing, suppressing liver-YANG, astringing YIN to stop sweating.5th, Fructus Mume: hold back
Lung, astringing intestine to stop diarrhea, promote the production of body fluid, relieving colic caused by ascaris, there is the function of sterilization, be also prevented from food and degenerate in the intestines and stomach..6th, burnt short, bristly hair or beard: promoting digestion and removing stagnation intestinal stasis relieving.7、
Cortex Cinnamomi: complement sun, warming the spleen and stomach, removing accumulated cold, effect of coronary circulation-promoting pain-relieving and antidiarrheal.8th, the Radix Aucklandiae: promoting the circulation of QI to relieve pain；Intestinal stasis relieving in tune.9th, monkey
Head mushroom: mild-natured, sweet in the mouth, sharp the five internal organs are aid digestion；There is the effect of stomach invigorating, qi-restoratives, anticancer, kidney tonifying essence.10th, Sargassum: expectorant is soft
Hard, mass dissipating and swelling eliminating.11st, Spica Prunellae: eliminating phlegm and softening indurated mass, mass dissipating and swelling eliminating.12nd, Radix Glycyrrhizae: heat-clearing and toxic substances removing, expelling phlegm for arresting cough.
The present invention is by the Radix Astragali；Radix Angelicae Sinensis；Ramulus Cinnamomi；The Radix Paeoniae Alba；Fructus Mume；Burnt short, bristly hair or beard；Cortex Cinnamomi；The Radix Aucklandiae；Hericium erinaceus (Bull. Ex Fr.) Pers. and Radix Glycyrrhizae compatibility are used for
The conditioning and treating of acute and chronic ulcer colitis, life-time service can enhancing human body immunity power, adjust equilibrium between yin and yang, thus playing whole
Body adjustment effect is to reach the purpose for the treatment of ulcerative colitiss.
Specific embodiment
A kind of Traditional Chinese medicine potion for the treatment of acute and chronic ulcerative colitiss, by the Radix Astragali；Radix Angelicae Sinensis；Ramulus Cinnamomi；The Radix Paeoniae Alba；Fructus Mume；Burnt short, bristly hair or beard；
Cortex Cinnamomi；The Radix Aucklandiae；Hericium erinaceus (Bull. Ex Fr.) Pers.；Sargassum；Spica Prunellae；Radix Glycyrrhizae and deionized water composition, the mass parts ratio that wherein each component uses is: yellow
Stilbene 20-25 part；Radix Angelicae Sinensis 15-20 part；Ramulus Cinnamomi 15-20 part；Radix Paeoniae Alba 20-25 part；Fructus Mume 10-15 part；Burnt short, bristly hair or beard 5-10 part；Cortex Cinnamomi 3-5
Part；Radix Aucklandiae 3-5 part；Hericium erinaceus (Bull. Ex Fr.) Pers. 3-5 part；Sargassum 5-8 part；Spica Prunellae 3-5 part；Radix Glycyrrhizae 15-20 part and deionized water 800～1200
Part.
The compound method of the Traditional Chinese medicine potion of above-mentioned treating acute and chronic ulcerative colitiss, concrete grammar step is as follows:
(1) by the Radix Astragali；Radix Angelicae Sinensis；Ramulus Cinnamomi；The Radix Paeoniae Alba；Fructus Mume；Burnt short, bristly hair or beard；Cortex Cinnamomi；The Radix Aucklandiae；Hericium erinaceus (Bull. Ex Fr.) Pers.；Sargassum；Spica Prunellae and Radix Glycyrrhizae
Weigh respectively according to proportioning, after being then passed through nine steaming nine solarization, then these medicines are soaked through decocting extraction, have decocted every time all
Filtered, take filtrate standby；
(2) filtrate is adopted cryogenic vacuum to concentrate, then carry out high speed centrifugation precipitation, take supernatant standby；
(3) deionized water is added in blending tank, start stirring, the supernatant then step (2) being obtained add to
In blending tank, stir；
(4) by the liquid sub-bottle fill in blending tank, after high temperature sterilize, just can get finished product.
Claims (2)
1. a kind of Traditional Chinese medicine potion for the treatment of acute and chronic ulcerative colitiss, is characterized in that by the Radix Astragali；Radix Angelicae Sinensis；Ramulus Cinnamomi；The Radix Paeoniae Alba；Crow
Prunus mume (sieb.) sieb.et zucc.；Burnt short, bristly hair or beard；Cortex Cinnamomi；The Radix Aucklandiae；Hericium erinaceus (Bull. Ex Fr.) Pers.；Sargassum；Spica Prunellae；Radix Glycyrrhizae and deionized water composition, the quality that wherein each component uses
Part ratio is: Radix Astragali 20-25 part；Radix Angelicae Sinensis 15-20 part；Ramulus Cinnamomi 15-20 part；Radix Paeoniae Alba 20-25 part；Fructus Mume 10-15 part；Burnt short, bristly hair or beard 5-10
Part；Cortex Cinnamomi 3-5 part；Radix Aucklandiae 3-5 part；Hericium erinaceus (Bull. Ex Fr.) Pers. 3-5 part；Sargassum 5-8 part；Spica Prunellae 3-5 part；Radix Glycyrrhizae 15-20 part and deionization
800～1200 parts of water.
2. the compound method of the Traditional Chinese medicine potion for the treatment of acute and chronic ulcerative colitiss described in claim 1, is characterized in that concrete
Method and step is as follows:
(1) by the Radix Astragali；Radix Angelicae Sinensis；Ramulus Cinnamomi；The Radix Paeoniae Alba；Fructus Mume；Burnt short, bristly hair or beard；Cortex Cinnamomi；The Radix Aucklandiae；Hericium erinaceus (Bull. Ex Fr.) Pers.；Sargassum；Spica Prunellae and Radix Glycyrrhizae according to
Proportioning weighs respectively, and after being then passed through nine steaming nine solarization, then these medicines are soaked through decocting extraction, have decocted every time and have all carried out
Filter, take filtrate standby；
(2) filtrate is adopted cryogenic vacuum to concentrate, then carry out high speed centrifugation precipitation, take supernatant standby；
(3) deionized water is added in blending tank, starts stirring, the supernatant then obtaining step (2) adds to mixing
In tank, stir；
(4) by the liquid sub-bottle fill in blending tank, after high temperature sterilize, just can get finished product.
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| Application Number | Priority Date | Filing Date | Title |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110507813A (en) * | 2019-10-12 | 2019-11-29 | 德州学院 | Cure mainly the traditional Chinese medicine reagent and its preparation method of canker sore |
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| CN1985982A (en) * | 2005-12-20 | 2007-06-27 | 广州王老吉药业股份有限公司 | Medicine for treating colitis and its preparing method |
| CN101700358A (en) * | 2009-11-12 | 2010-05-05 | 林喜彬 | Medicine for treating acute and chronic nonspecific ulcerative colitis and preparation method thereof |
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| CN1985982A (en) * | 2005-12-20 | 2007-06-27 | 广州王老吉药业股份有限公司 | Medicine for treating colitis and its preparing method |
| CN1985982B (en) * | 2005-12-20 | 2010-05-05 | 广州王老吉药业股份有限公司 | Medicine for treating colitis and its preparing method |
| CN101700358A (en) * | 2009-11-12 | 2010-05-05 | 林喜彬 | Medicine for treating acute and chronic nonspecific ulcerative colitis and preparation method thereof |
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| CN110507813A (en) * | 2019-10-12 | 2019-11-29 | 德州学院 | Cure mainly the traditional Chinese medicine reagent and its preparation method of canker sore |
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