CN106310362A - Traditional Chinese medicine liquid dressing and preparation method - Google Patents
Traditional Chinese medicine liquid dressing and preparation method Download PDFInfo
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/426—Immunomodulating agents, i.e. cytokines, interleukins, interferons
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Abstract
The invention belongs to the field of surgical dressing and specifically relates to a traditional Chinese medicine liquid dressing and a preparation method. The traditional Chinese medicine liquid dressing comprises the following components by weight percent: 1.0%-6.0% of film-forming material, 2.0%-4.0% of glycerinum, 0.5%-3.0% of menthol, 0.3%-1.0% of coptis chinensis extract, 1.0%-2.0% of honeysuckle extract and the balance of solvent. The traditional Chinese medicine liquid dressing provided by the invention is acquired according to the steps of mixing the above components in turn, uniformly stirring and filling. The traditional Chinese medicine liquid dressing provided by the invention has the advantages of simple component, short film-forming time, waterproof effect, good antibacterial effect, no drug-fast property and capability of boosting wound healing and shortening the wound healing time.
Description
Technical field
The invention belongs to medical dressing field, be specifically related to a kind of Chinese medicinal liquor dressing and preparation method.
Background technology
Medical dressing plays protection wound in wound healing process, reduces infection, absorption secretions and promote that wound is more
The effect closed.The advantages such as normal gauze class dressing has that absorbability is good, wide material sources, preparation are simple, but there is also and cannot keep
Wound surface is moistening, poor biocompatibility, easily occur tissue adhesions, pathogen easily through and the problem such as wound infection.Clinical employing resists
Raw element medicine is combined prevention wound infection with gauze dressing, but life-time service antibiotic can produce drug resistance.
Along with the development of therapeutic treatment technology, the requirement of medical dressing is improved by people, and liquid dressing arises at the historic moment.
Liquid dressing stores the most in liquid form, is not limited by wound site and size, it is possible to quick in wound location
Form macromolecule membrane.Liquid dressing has good breathable and waterproof, with after without removing, it is to avoid because more change dressings causes two
Secondary injury.Liquid dressing is made up of macromolecule filming material, solvent and functional materials.Macromolecule filming material includes natural
Macromolecular material and synthesis macromolecular material.Natural macromolecular material includes chitin, chitosan, sodium alginate
Deng, this kind of macromolecular material safety is high, good biocompatibility.Synthesis macromolecular material includes that polyvinyl alcohol, polyvinyl alcohol contract
Butyraldehyde, carbomer etc..This kind of macromolecular material has special chemical constitution, can degrade under the effect of acid or alkali, simultaneously
It can be that wound surface provides micro-acid wet, micro-and low-oxygen environment, beneficially wound healing.Functional materials includes cosolvent, swelling binder
With anti-inflammation composition etc..Anti-inflammation composition includes nanometer silver, povidone iodine and triclosan etc., but life-time service
Learn class antibacterial can health be damaged.
Chinese medicine due to its anti-inflammation, safety non-toxic and be not likely to produce the advantages such as drug resistance skin wounds treat in unique
Characteristic.But, it is relatively big that Chinese medicine plays the dosage required for curative effect, Chinese medicinal powder spreads on wound, then wraps up with gauze, exist
Preserve and use the problems such as inconvenient, medicated powder is easy to fall off, causing it to be restricted in terms of clinical practice.
Chinese medicine is combined a kind of Chinese medicinal liquor dressing of preparation by the present invention with liquid film forming matrix so that liquid dressing possesses anti-
Bacterium antiinflammatory performance, it can provide micro-wet environment for wound surface simultaneously, has excellent air permeable waterproof performance, will not produce drug resistance
Property, it is possible to effectively facilitate wound healing.
Summary of the invention
It is an object of the invention to the advantage combining liquid dressing with Chinese medicine, it is provided that a kind of containing Rhizoma Coptidis, Flos Lonicerae extraction
The Chinese medicinal liquor dressing of thing and preparation method, the liquid dressing of the present invention can have good life at wound fast filming
The thing compatibility, antibiotic property, moisture-penetrable ventilated property, its safety non-toxic, is not likely to produce drug resistance simultaneously, beneficially wound healing.
The purpose of the present invention is achieved through the following technical solutions: a kind of Chinese medicinal liquor dressing, it is characterised in that include following
The raw material of percentage by weight:
Described filmogen is polyvinyl alcohol or polyvinyl butyral resin.
Described solvent is distilled water or ethanol.
Preferably liquid dressing, including the raw material of following percentage by weight:
Liquid dressing further preferably, including the raw material of following percentage by weight:
The alcoholysis degree of described polyvinyl alcohol is 87.0-89.0mol%, and viscosity is 20.5-24.5mpa.s.
The viscosity of described polyvinyl butyral resin is 15.0-35.0mpa.s, and fourth aldehyde group content is 45.0%-49.0%.
Described a kind of Chinese medicinal liquor dressing, it is characterised in that the preparation of described Chinese medicine extract can comprise the following steps that
1) Rhizoma Coptidis is pulverized, take its powder and join the ethanol solution that volume fraction is 60% infiltrates overnight, add afterwards
Circumfluence distillation 3 times, filtered while hot, merge 3 filtrates, filtrate is concentrated postlyophilization, obtains Rhizoma Coptidis extract；
2) Flos Lonicerae is pulverized, take its powder and join the ethanol solution that volume fraction is 60% infiltrates overnight, afterwards
Heating and refluxing extraction 2 times, filtered while hot, merging filtrate, filtrate is concentrated postlyophilization, obtains Flos Lonicerae extract.
The preparation method of described a kind of Chinese medicinal liquor dressing, it is characterised in that comprise the following steps:
1) by filmogen heating for dissolving, stirring cooling；
2) weigh menthol, join in ethanol solution and dissolve；
3) weigh Rhizoma Coptidis extract, join in the ethanol solution that volume fraction is 60%-70% and dissolve；
4) weigh Flos Lonicerae extract, join in the ethanol solution that volume fraction is 60%-70% and dissolve；
5) by glycerol, menthol solutions, Rhizoma Coptidis extract solution, Flos Lonicerae extract solution, it is added sequentially in proportion
Process 1) in filmogen solution in, be stirred well to mix homogeneously；
6) fill, to obtain final product.
Use above scheme, the invention provides a kind of Chinese medicinal liquor dressing.Wherein, Rhizoma Coptidis and Flos Lonicerae are as antibacterial
Matter.Rhizoma Coptidis extract has broad-spectrum antibacterial action, to colon bacillus, staphylococcus aureus, Pseudomonas aeruginosa, dysentery
Shigella etc. have significant inhibitory action.Rhizoma Coptidis extract also has immunoregulation effect and antitumor action.Flos Lonicerae
Medicinal history is long, has the title of " antibiotic in Chinese medicine ".Flos Lonicerae extract is to acute, granulomatous and chronic inflammatory disease is equal
There is certain inhibitory action, there is stronger broad-spectrum antibacterial action, the most also there is antioxidation and anti-tumor activity.Rhizoma Coptidis and gold
Flos Lonicerae with the use of, there is antimicrobial and anti-inflammation efficacy, and antimicrobial spectrum can be widened, be not likely to produce drug resistance.
Filmogen used in the present invention is the macromolecule medical material that biocompatibility is good.Wherein, polyethylene
Alcohol (PVA) is a kind of water-soluble high-molecular material, and film property, flexibility and hygroscopicity are all good, are most widely used film forming
Material.Polyvinyl butyral resin (PVB) is dissolvable in water the multiple organic solvents such as alcohols, esters, ketone, and film forming required time is few,
Film property and excellent in stability.
Chinese medicine extract is joined and prepares liquid dressing in filmogen by the present invention；Glycerol, as wetting agent, strengthens anti-
The moisture-keeping function of Mycoderma, makes antibacterial film soft, is close to affected part.Menthol is as transdermal enhancer, and it acts on skin simultaneously, tool
There is refrigerant itching-relieving action, produce comfort.
The Chinese medicinal liquor dressing of the present invention smear or spray after film forming, there is good biocompatibility, it is possible to effectively
Resist antibacterial to infect, keep wound surface to moisten, because of more change dressings, wound will not be caused secondary injury, thus promote wound healing,
It is applicable to little areas of skin hurt, damage, abrade and burn and scald etc..
In sum, the Chinese medicinal liquor dressing of the present invention has the advantage that 1) anti-inflammation is effective, shortens wound more
The conjunction time, 2) be easy to observe wound healing situation, 3) be not likely to produce drug resistance, 4) good waterproof performance, 5) can fast filming, 6) peace
Atoxic, good biocompatibility, 7) technique is simple, is suitable to large-scale production.
Accompanying drawing illustrates:
Fig. 1 (A) is the transmission electron microscope picture of the Chinese medicinal liquor dressing in the embodiment of the present invention 1；(B) it is the embodiment of the present invention 4
In the transmission electron microscope picture of Chinese medicinal liquor dressing.
Fig. 2 (A) is the inhibition zone test result to staphylococcus aureus of the Chinese medicinal liquor dressing in the embodiment of the present invention 1
Figure；(B) it is the inhibition zone test result figure to colon bacillus of the Chinese medicinal liquor dressing in the embodiment of the present invention 1.
Fig. 3 is burned rats wound healing outside drawing (the 3rd, 7,15,21 days), and wherein, A is the herb liquid in embodiment 4
Body dressing group；B is positive controls (erythromycin group)；C is negative control group (normal saline group).
Fig. 4 is After Scalding In Rat pathology detection result figure, and wherein, A is After Scalding In Rat；B is the Chinese medicine in the embodiment of the present invention 4
Liquid dressing group；C is positive controls (erythromycin group)；D is negative control group (normal saline group).
Detailed description of the invention:
Below in conjunction with embodiment, the present invention is further described.
The preparation of Rhizoma Coptidis extract: being pulverized by Rhizoma Coptidis, taking its powder and joining 12 times amount volume fractions is the ethanol of 60%
Infiltrating overnight in solution, be heated to reflux 1h, filtered while hot afterwards, it is the ethanol solution of 60% that filtering residue adds 10 times amount volume fractions
Being heated to reflux 1h, filtered while hot, filtering residue adds ethanol solution heating and refluxing extraction 1h that 8 times amount volume fractions are 60%, again
Filtered while hot, merges 3 filtrates, filtrate is concentrated postlyophilization, obtains Rhizoma Coptidis extract, and wherein content of berberine hydrochloride is
27.5%, palmatine content is 7.3%, and the content of coptisine is 6.2%, and epiberberine content is 4.2%；
The preparation of Flos Lonicerae extract: being pulverized by Flos Lonicerae, taking its powder and joining 10 times amount volume fractions is 60%
Infiltrating overnight in ethanol solution, be heated to reflux 2h, filtered while hot afterwards, it is the ethanol of 60% that filtering residue adds 8 times amount volume fractions
It is heated to reflux 2h, again filtered while hot, merging filtrate, filtrate is concentrated postlyophilization, obtains Flos Lonicerae extract, its medium green
Determination of Chlorogenic Acid is 6.5%.
Embodiment 1
A kind of Chinese medicinal liquor dressing, including the raw material of following percentage by weight, as a example by 100g:
Preparation method is as follows:
1) weigh 2.0g polyvinyl alcohol, join in 30mL distilled water, carry out mechanical agitation to being completely dissolved in 60 DEG C, shape
Become solution A；
2) weighing 0.7g menthol, join in 6mL ethanol solution, stirring, to being completely dissolved, forms solution B；
3) weighing 0.3g Rhizoma Coptidis extract, join in the ethanol solution that 23mL volume fraction is 60%, stirring is to completely
Dissolve, form solution C；
4) weighing 1.0g Flos Lonicerae extract, join in the ethanol solution that 45mL volume fraction is 60%, stirring is to complete
CL, forms solution D；
5) 1.6mL glycerol, solution B, C, D are added sequentially in solution A, stir；
6) fill.
Embodiment 2
A kind of Chinese medicinal liquor dressing, including the raw material of following percentage by weight, as a example by 100g:
Preparation method is as follows:
1) weigh 4.0g polyvinyl alcohol, join in 27mL distilled water, carry out mechanical agitation to being completely dissolved in 60 DEG C, shape
Become solution A；
2) weighing 1.1g menthol, join in 6mL ethanol solution, stirring, to being completely dissolved, forms solution B；
3) weighing 0.5g Rhizoma Coptidis extract, join in the ethanol solution that 23mL volume fraction is 60%, stirring is to completely
Dissolve, form solution C；
4) weighing 1.0g Flos Lonicerae extract, join in the ethanol solution that 45mL volume fraction is 60%, stirring is to complete
CL, forms solution D；
5) 1.8mL glycerol, solution B, C, D are added sequentially in solution A, stir；
6) fill.
Embodiment 3
A kind of Chinese medicinal liquor dressing, including the raw material of following percentage by weight, as a example by 100g:
Preparation method is as follows:
1) weigh 5.0g polyvinyl alcohol, join in 26mL distilled water, carry out mechanical agitation to being completely dissolved in 60 DEG C, shape
Become solution A；
2) weighing 1.5g menthol, join in 4mL ethanol solution, stirring, to being completely dissolved, forms solution B；
3) weighing 0.8g Rhizoma Coptidis extract, join in the ethanol solution that 23mL volume fraction is 60%, stirring is to completely
Dissolve, form solution C；
4) weighing 1.6g Flos Lonicerae extract, join in the ethanol solution that 45mL volume fraction is 60%, stirring is to complete
CL, forms solution D；
5) 2.0mL glycerol, solution B, C, D are added sequentially in solution A, stir；
6) fill.
Embodiment 4
A kind of Chinese medicinal liquor dressing, including the raw material of following percentage by weight, as a example by 100g:
Preparation method is as follows:
1) weigh 2.2g polyvinyl butyral resin, join in 45mL ethanol solution, carry out mechanical agitation in 50 DEG C
To being completely dissolved, form solution A；
2) weighing 1.4g menthol, join in 5mL ethanol solution, stirring, to being completely dissolved, forms solution B；
3) weighing 0.3g Rhizoma Coptidis extract, join in the ethanol solution that 27mL volume fraction is 70%, stirring is to completely
Dissolve, form solution C；
4) weighing 1.0g Flos Lonicerae extract, join in the ethanol solution that 36mL volume fraction is 70%, stirring is to complete
CL, forms solution D；
5) 1.6mL glycerol, solution B, C, D are added sequentially in solution A, stir；
6) fill.
Embodiment 5
A kind of Chinese medicinal liquor dressing, including the raw material of following percentage by weight, as a example by 100g:
Preparation method is as follows:
1) weigh 3.8g polyvinyl butyral resin, join in 37mL ethanol solution, carry out mechanical agitation in 50 DEG C
To being completely dissolved, form solution A；
2) weighing 2.7g menthol, join in 6mL ethanol solution, stirring, to being completely dissolved, forms solution B；
3) weighing 0.6g Rhizoma Coptidis extract, join in the ethanol solution that 27mL volume fraction is 70%, stirring is to completely
Dissolve, form solution C；
4) weighing 1.0g Flos Lonicerae extract, join in the ethanol solution that 38mL volume fraction is 70%, stirring is to complete
CL, forms solution D；
5) 2.0mL glycerol, solution B, C, D are added sequentially in solution A, stir；
6) fill.
Embodiment 6
A kind of Chinese medicinal liquor dressing, including the raw material of following percentage by weight, as a example by 100g:
Preparation method is as follows:
1) weigh 6.0g polyvinyl butyral resin, join in 33mL ethanol solution, carry out mechanical agitation in 50 DEG C
To being completely dissolved, form solution A；
2) weighing 3.0g menthol, join in 3mL ethanol solution, stirring, to being completely dissolved, forms solution B；
3) weighing 1.0g Rhizoma Coptidis extract, join in the ethanol solution that 34mL volume fraction is 70%, stirring is to completely
Dissolve, form solution C；
4) weighing 1.5g Flos Lonicerae extract, join in the ethanol solution that 32mL volume fraction is 70%, stirring is to complete
CL, forms solution D；
5) 3.0mL glycerol, solution B, C, D are added sequentially in solution A, stir；
6) fill.
The transmissioning electric mirror test of the Chinese medicinal liquor dressing of embodiment 7 present invention
The Chinese medicinal liquor dressing of Example 1,4 preparation, takes the carbon coating copper mesh dropping in a diameter of 3mm on a small quantity with liquid-transfering gun
On, after sucking excessive moisture with filter paper, it is placed under infrared lamp and is dried 1h.Copper mesh is sent into transmission electron microscope, at 200kv electricity
The lower imaging of pressure bombardment, characterizes the internal structure of this dressing with this.Result is shown in Fig. 1.
The water vapour permeability of the Chinese medicinal liquor dressing of embodiment 8 present invention
Measure the Chinese medicinal liquor dressing that 15mL embodiment 1-6 prepares, respectively its cast flat is laid on 7cm × 11.5cm transparent
On glass plate, it is dried 30min in being placed in 50 DEG C of baking ovens, takes out, from glass plate, take medicine film off；Weigh 0.5g medicine film, covered
(area is 1.77cm to cover the bottle mouth position at open vials2), wherein containing the anhydrous CaCl of 10g in bottle2, use teflin tape
Bottleneck surrounding is sealed；Positive controls uses the bottle sealed, containing the anhydrous CaCl of 10g in bottle2；Negative control group uses
The bottle of opening, containing the anhydrous CaCl of 10g in bottle2；Being placed in exsiccator by all bottles, wherein exsiccator is contained within saturated
NaCl solution (its relative humidity is 70%RH), is placed in exsiccator in 37 DEG C of baking ovens, measures bottle in certain time interval
Quality, calculate water vapour permeability, the results are shown in Table 1.
Table 1 Chinese medicinal liquor dressing water vapour permeability experimental result
As known from Table 1, experimental group, compared with negative control group, can efficiently reduce water vapour permeability, therefore this
The medicine film that bright Chinese medicinal liquor dressing is formed is possible to prevent moisture loss, maintains wound surface to moisten.
The film formation time of the Chinese medicinal liquor dressing of embodiment 9 present invention
Measure the Chinese medicinal liquor dressing that 1.5mL embodiment 1,4 prepares, respectively its cast flat is laid on 2.5cm × 7.5cm saturating
On bright glass plate, stopwatch starts timing, and when film body is uncovered from glass plate, timing stops, and the results are shown in Table 2.
Table 2 Chinese medicinal liquor dressing film formation time test result
As known from Table 2, the film formation time of the Chinese medicinal liquor dressing of the present invention increases along with temperature and shortens, at the one-tenth of 37 DEG C
The film time can foreshorten to 2min.
The fungistatic effect of the Chinese medicinal liquor dressing of embodiment 10 present invention
Chinese medicine extract antibacterial activity in vitro measures: use agar dilution, measures the minimum antibacterial dense of Chinese medicine extract
Degree (MIC).Experimental strain uses staphylococcus aureus (Staphylococcus aureus ATCC29213), enterococcus faecalis
(Enterococcus faecalis ATCC 29212), colon bacillus (Escherichia coli ATCC25922),
Klebsiella Pneumoniae (Klebsiella pneumonia ATCC700603) and Pseudomonas aeruginosa (Pseudomonas
Aeruginosa CMCC (B) 10104) etc..Result shows, Rhizoma Coptidis extract MIC value is 2.5mg/mL, Flos Lonicerae extract MIC
Value is 10mg/mL.
The mensuration of the fungistatic effect of Chinese medicinal liquor dressing:
Prepared by sample: weigh 50mg Rhizoma Coptidis extract, joins in the ethanol solution that 10mL volume fraction is 60%, obtains
Rhizoma Coptidis extract medicinal liquid；Weigh 100mg Flos Lonicerae extract, join in the ethanol solution that 10mL volume fraction is 60%,
To Flos Lonicerae extract medicinal liquid.Chinese medicinal liquor dressing prepared by Example 1-6.
Strain selects: represent gram with staphylococcus aureus (Staphylococcus aureus ATCC29213)
Positive bacteria, colon bacillus (Escherichia coli ATCC25922) represents gram negative bacteria, buys in Jiangsu Province
Kang Hua medical sci-tech industry center.
Culture medium: bacteria culture media be pH value be the nutrient agar of 7.2 ± 0.2.Culture medium is bought in Beijing three
Medicine scientific and technological development company.
Assay method: measure the inhibition zone size of Chinese medicinal liquor dressing prepared by embodiment 1-6 with Beating holes method, passes judgment on
The bacteriostatic activity of the Chinese medicinal liquor dressing of the present invention.The bacteria suspension (10 that 2mL is diluted8Cfu/mL) 50 DEG C of water bath condition are joined
Lower volume is in the liquid culture medium of 200mL, and mix homogeneously.By above-mentioned for the 20mL media transfer of bacteria suspension that is mixed with to cultivating
(clump count is 10 to make it solidify in ware6-107cfu/mL).On flat board, get 3 holes with card punch, be evenly distributed, away from limit be
1.5cm, chooses agar block with sterilizing toothpick, flame back cover.70 μ L liquid dressings are injected in each hole, cultivate in 37 DEG C
24h.Inhibition zone measurement result is shown in Fig. 2.Antibacterial circle diameter is shown in Table 3.
The antibacterial circle diameter of table 3 Chinese medicinal liquor dressing
As known from Table 3, Rhizoma Coptidis extract all has good inhibiting effect to staphylococcus aureus and colon bacillus,
Flos Lonicerae extract is better than the inhibition to colon bacillus to the inhibition of staphylococcus aureus；In the present invention
Medicine liquid dressing, compared with Chinese medicine extract, enhances fungistatic effect, and increasing along with Chinese medicine extract content, its antibacterial effect
Fruit also strengthens.
The safety evaluatio of the Chinese medicinal liquor dressing of embodiment 11 present invention
Taking body weight is 200-220g male SD rat (purchased from Zhejiang Province's Experimental Animal Center), uses 8% sodium sulfide solution
As depilatory, rat back is carried out depilation process, and washes away the hair taken off and depilatory with warm water.By embodiment 1-6 system
Standby Chinese medicinal liquor dressing is applied in depilation position, every rat 500 μ L, smears every day 1 time, smears one week continuously and observe,
Evaluate its safety.Result shows, compares with not smearing rat skin, and skin be there is no any by the Chinese medicinal liquor dressing of the present invention
Untoward reaction.
The Chinese medicinal liquor dressing of embodiment 12 present invention Healing to burned rats wound
After Scalding In Rat model: experiment uses body weight to be that 200-220g male SD rat is (purchased from Zhejiang Province's laboratory animal
The heart), after adaptability raises one week, it is randomly divided into by its body weight: positive controls (erythromycin group), negative control group (physiology salt
Water group) and experimental group (Chinese medicinal liquor dressing prepared by embodiment 1-6), often group 6.By rat anesthesia, use 8% sodium sulfide solution
Rat back is carried out depilation process, and washes away the hair taken off and depilatory with warm water.After 24h, with ether by rat anesthesia, will
Sterilize with 75% alcoholic solution in its position to be scalded.Scald and use 50g counterweight (a diameter of 2cm), counterweight is placed in 100 DEG C of boiling water
Middle balance 1min, after quickly drying moisture, is placed in depilation position 15s, removes counterweight at once, embodiment 1-6 prepared respectively
Chinese medicinal liquor dressing 500 μ L, normal saline 500 μ L, erythromycin 0.5g are coated on wound, and every rat list cage is raised.Every day
Rat wound is changed a dressing, within the 3rd, 5,7,11,15,21 days after wound, measures wound area and record the change of wound area
Change and calculate wound healing rate.Wound healing rate calculates: depicts wound with translucent template, cuts the paper of wound part
Sheet, is placed on balance and weighs and be converted into area.Wound healing rate=(original wound area-non-healing of wound area)/original
Wound area × 100%.Burned rats wound healing outward appearance is shown in Fig. 3.Pathology detection result is shown in Fig. 4.Wound healing rate result is shown in
Table 4.
Each experimental group rat wound healing rate of table 4 (N=6)
As known from Table 4, the healing effect of burned rats wound is connect by the Chinese medicinal liquor dressing of the present invention with positive controls
Closely, its no significant difference (P ＞ 0.05)；When the 21st day, rat wound surface healed substantially；Within the identical time, real
Test the healing rate of group apparently higher than negative control group (P ＜ 0.01).Wound healing rate result is consistent with pathology detection result.From figure
4 understand, and in the wound healing later stage, experimental group has been formed with the skin keratin of positive controls, hypodermic hair follicle, hair follicle
Gland is normal；And negative control group severe epithelial comes off, there is large-area necrosis, fiber group in hypodermic hair follicle body of gland
Knit severe hypertrophy.The Chinese medicinal liquor dressing of the present invention and erythromycin all can improve the pathology damage of rat, to burned rats wound
Have and significantly promote Healing.
Claims (8)
1. a Chinese medicinal liquor dressing, it is characterised in that include the raw material of following percentage by weight:
Described filmogen is polyvinyl alcohol or polyvinyl butyral resin；
Described solvent is distilled water or ethanol.
Chinese medicinal liquor dressing the most according to claim 1, it is characterised in that include the raw material of following percentage by weight:
Chinese medicinal liquor dressing the most according to claim 1, it is characterised in that include the raw material of following percentage by weight:
Chinese medicinal liquor dressing the most according to claim 1, it is characterised in that the alcoholysis degree of described polyvinyl alcohol is 87.0-
89.0mol%, viscosity is 20.5-24.5mpa.s.
Chinese medicinal liquor dressing the most according to claim 1, it is characterised in that the viscosity of described polyvinyl butyral resin is
15.0-35.0mpa.s, fourth aldehyde group content is 45.0-49.0%.
Chinese medicinal liquor dressing the most according to claim 1, it is characterised in that described Rhizoma Coptidis extract is adopted and made with the following method
Standby: Rhizoma Coptidis is pulverized, take its powder and join the ethanol solution that volume fraction is 60% infiltrates overnight, be heated to reflux afterwards carrying
Take 3 times, filtered while hot, merge 3 filtrates, filtrate is concentrated postlyophilization, obtains Rhizoma Coptidis extract.
Chinese medicinal liquor dressing the most according to claim 1, it is characterised in that described Flos Lonicerae extract is adopted with the following method
Preparation: pulverized by Flos Lonicerae, takes its powder and joins and infiltrate overnight in the ethanol solution that volume fraction is 60%, post-heating return
Stream extracts 2 times, filtered while hot, and filtrate is concentrated postlyophilization, obtains Flos Lonicerae extract by merging filtrate.
8. the preparation method of the Chinese medicinal liquor dressing described in any one of claim 1-7, it is characterised in that comprise the following steps:
1) by filmogen heating for dissolving, stirring cooling；
2) weigh menthol, join in ethanol solution and dissolve；
3) weigh Rhizoma Coptidis extract, join in the ethanol solution that volume fraction is 60%-70% and dissolve；
4) weigh Flos Lonicerae extract, join in the ethanol solution that volume fraction is 60%-70% and dissolve；
5) by glycerol, menthol solutions, Rhizoma Coptidis extract solution and Flos Lonicerae extract solution, process it is added sequentially in proportion
1), in the filmogen solution in, it is stirred well to mix homogeneously；
6) fill, to obtain final product.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308490A (en) * | 2017-06-07 | 2017-11-03 | 常州市天宁区鑫发织造有限公司 | A kind of preparation method of liquid antibiotic wound-protecting film |
| CN110201218A (en) * | 2018-12-23 | 2019-09-06 | 山东泰开制药有限公司 | Liquid adhesive bandage and preparation method thereof |
| CN110882413A (en) * | 2019-12-11 | 2020-03-17 | 河南承东生物科技有限公司 | Water-soluble long-acting physical antibacterial liquid dressing and preparation method thereof |
| CN111991604A (en) * | 2020-08-30 | 2020-11-27 | 云南古润生物科技有限责任公司 | Adhesive bandage based on cannabidiol and manufacturing method thereof |
| CN113952498A (en) * | 2021-09-28 | 2022-01-21 | 江西中医药大学 | Chinese medicine multi-component liquid wound healing dressing and preparation method thereof |
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| CN103083713A (en) * | 2012-12-10 | 2013-05-08 | 江苏华亿细胞组织工程有限公司 | Sterile polymerized covering dressing for wound surface |
| CN105457080A (en) * | 2015-12-09 | 2016-04-06 | 安徽宇宁生物科技有限公司 | Pectin adhesive bandage |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103083713A (en) * | 2012-12-10 | 2013-05-08 | 江苏华亿细胞组织工程有限公司 | Sterile polymerized covering dressing for wound surface |
| CN105457080A (en) * | 2015-12-09 | 2016-04-06 | 安徽宇宁生物科技有限公司 | Pectin adhesive bandage |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308490A (en) * | 2017-06-07 | 2017-11-03 | 常州市天宁区鑫发织造有限公司 | A kind of preparation method of liquid antibiotic wound-protecting film |
| CN110201218A (en) * | 2018-12-23 | 2019-09-06 | 山东泰开制药有限公司 | Liquid adhesive bandage and preparation method thereof |
| CN110882413A (en) * | 2019-12-11 | 2020-03-17 | 河南承东生物科技有限公司 | Water-soluble long-acting physical antibacterial liquid dressing and preparation method thereof |
| CN111991604A (en) * | 2020-08-30 | 2020-11-27 | 云南古润生物科技有限责任公司 | Adhesive bandage based on cannabidiol and manufacturing method thereof |
| CN113952498A (en) * | 2021-09-28 | 2022-01-21 | 江西中医药大学 | Chinese medicine multi-component liquid wound healing dressing and preparation method thereof |
| CN113952498B (en) * | 2021-09-28 | 2022-11-29 | 江西中医药大学 | Chinese medicine multi-component liquid wound healing dressing and preparation method thereof |
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Application publication date: 20170111 |