CN106310113A - Traditional Chinese medicinal composition for treating syndromes of liver depression and qi stagnation as well as preparation method and application of traditional Chinese medicinal composition - Google Patents
Traditional Chinese medicinal composition for treating syndromes of liver depression and qi stagnation as well as preparation method and application of traditional Chinese medicinal composition Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicinal composition for treating syndromes of liver depression and qi stagnation as well as a preparation method and an application of the traditional Chinese medicinal composition. An active ingredient of the traditional Chinese medicinal composition is extracted and prepared from the following raw materials in parts by weight: 1-10 parts of radix bupleuri, 4-11 parts of radix paeoniae alba, 2-13 parts of pericarpium citri reticulatae viride, 1-12 parts of cortex magnoliae officinalis, 1-10 parts of radix angelicae sinensis, 2-17 parts of radix salviae miltiorrhizae, 3-12 parts of roasted rhizoma atractylodis macrocephalae, 2-13 parts of radix curcumae, 1-14 parts of flos rosae rugosae, 2-15 parts of pericarpium citri reticulatae, 3-16 parts of cowherb seeds and 10-30 parts of rhizoma sparganii. The traditional Chinese medicinal composition for treating the syndromes of liver depression and qi stagnation has functions of nourishing and soothing liver, softening liver, promoting qi circulation and relieving depression, promoting blood circulation, removing stasis and alleviating pain; and based upon clinical verification, the traditional Chinese medicinal composition also has the advantages of being good in curative effect and being safe and stable. A massaging cream, which is prepared from the traditional Chinese medicinal composition for treating the syndromes of liver depression and qi stagnation provided by the invention and a matrix or a carrier, is convenient to use, good in curative effect, safe and stable, mild and non-irritant to skin and free from toxic and side effects.
Description
Technical field
The present invention relates to Chinese medicine external product field, particularly relate to a kind of Chinese medicine composition treating Liver depression and Qi stagnation
Thing and its preparation method and application.
Background technology
Liver depression and Qi stagnation is one of clinical common TCM syndrome, and stagnation of QI due to depression of the liver causes due to a variety of causes
Emotion is not relaxed, anxiety and rage, stagnation of spleen-QI, depression etc. cause the catharsis of liver not normal, causes the gas of liver
Machine stasis is not smooth, liver disorder, and qi-blood-body fluid is run not smooth, also known as hepatic depression combined symptoms, is called for short stagnation of liver-QI
Card.Clinical manifestation is: depressed emotion, and the breast side of body or few distention and fullness in the abdomen are altered bitterly, depressed emotion or irritability, sighing frequently,
Or see foreign body in pharynx sense, or cervical region goiter, or the lower lump of the side of body；Distending pain of the breast seen from women, menoxenia,
Dysmenorrhea, thin white fur of tongue, stringy pulse.Liver depression and Qi stagnation is directed not only to multiple disease, and usually derivation is other
Disease, card feelings are complicated and changeable, are detrimental to health.
At present the common drug for the treatment of stagnation of QI due to depression of the liver mostly is oral prescription, such as ease pill, bupleurum powder for relieving liver-qi etc.,
The efficacy of a drug can be slackened by effects such as the Digestive systems in gastrointestinal disturbances road after medicine oral administration, simultaneously can be to gastrointestinal disturbances
Road produces to stimulate, and affects digestive function.On the contrary, topical drug has the advantages such as easy to use, safe, but
The most also it is not related to treat the relevant report of the Chinese medicine external product of stagnation of QI due to depression of the liver.
Summary of the invention
Based on this, it is necessary to the oral drugs for conventional treatment Liver depression and Qi stagnation have intestines and stomach stimulation
And the shortcoming such as less effective, it is provided that a kind of easy to use, safety and stability, good effect, have no side effect
Chinese medicine composition for the treatment of Liver depression and Qi stagnation and its preparation method and application.
It is an object of the invention to provide a kind of Chinese medicine composition treating Liver depression and Qi stagnation.
Concrete technical scheme is as follows:
A kind of Chinese medicine composition treating Liver depression and Qi stagnation, the active component of described Chinese medicine composition is by following heavy
Amount part raw material extracts and is prepared from: Radix Bupleuri 1-10 part, Radix Paeoniae Alba 4-11 part, Pericarpium Citri Reticulatae Viride 2-13 part, Cortex Magnoliae Officinalis 1-12
Part, Radix Angelicae Sinensis 1-10 part, Radix Salviae Miltiorrhizae 2-17 part, Rhizoma Atractylodis Macrocephalae (parched) 3-12 part, Radix Curcumae 2-13 part, Flos Rosae Rugosae 1-14 part,
Pericarpium Citri Reticulatae 2-15 part, Semen Vaccariae 3-16 part, Rhizoma Sparganii 10-30 part.
Wherein in an embodiment, the active component of described Chinese medicine composition is to be carried by following raw material
Take and be prepared from: Radix Bupleuri 5-8 part, Radix Paeoniae Alba 6-9 part, Pericarpium Citri Reticulatae Viride 5-9 part, Cortex Magnoliae Officinalis 4-9 part, Radix Angelicae Sinensis 5-8 part,
Radix Salviae Miltiorrhizae 5-13 part, Rhizoma Atractylodis Macrocephalae (parched) 4-10 part, Radix Curcumae 5-9 part, Flos Rosae Rugosae 3-12 part, Pericarpium Citri Reticulatae 4-11 part, king
Do not stay row 5-10 part, Rhizoma Sparganii 20-28 part.
Wherein in an embodiment, the active component of described Chinese medicine composition is to be carried by following raw material
Take and be prepared from: Radix Bupleuri 7 parts, the Radix Paeoniae Alba 7 parts, 7 parts of Pericarpium Citri Reticulatae Viride, Cortex Magnoliae Officinalis 7 parts, Radix Angelicae Sinensis 7 parts, Radix Salviae Miltiorrhizae 9
Part, Rhizoma Atractylodis Macrocephalae (parched) 7 parts, Radix Curcumae 7 parts, Flos Rosae Rugosae 7 parts, Pericarpium Citri Reticulatae 7 parts, Semen Vaccariae 7 parts, Rhizoma Sparganii 26
Part.
The Chinese medicine composition for the treatment of Liver depression and Qi stagnation of the present invention, according to the reason of Chinese medicine " monarch "
Opinion compatibility forms, and adds Radix Bupleuri, Pericarpium Citri Reticulatae Viride, the Radix Paeoniae Alba, Cortex Magnoliae Officinalis are monarch, have Shugan Qingre, dispelling the stagnated QI resolving depression,
Effect of easing the affected liver to relieve pain；Add Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae is minister, has blood circulation promoting and blood stasis dispelling, the effect of pain relieving of enriching blood；Add
Add Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae is assistant, has invigorating the spleen and benefiting QI, effect of dampness；Add Radix Curcumae, Flos Rosae Rugosae, king not
Stay row, Rhizoma Sparganii for making, there is effect of promoting flow of QI and blood.
Above-mentioned each composition is made a concerted effort, and gathers effects of dispersing liver and promoting blood circulation, promoting QI circulation for relieving depression altogether.
The pharmacological action of each composition is as follows:
Radix Bupleuri: pungent, bitter, is slightly cold.Evacuation is brought down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, rises and lifts yang-energy.For distending pain in the chest and hypochondrium,
Menoxenia etc..
The Radix Paeoniae Alba: bitter, sour, is slightly cold.Nourishing blood for regulating menstruation, easing the affected liver to relieve pain, suppressing liver-YANG.For menoxenia,
Hypochondriac pain etc..
Pericarpium Citri Reticulatae Viride: bitter, pungent, temperature.Soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.For distending pain in the chest and hypochondrium, hernia pain etc..
Cortex Magnoliae Officinalis: bitter, pungent, temperature.Dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass vomiting and diarrhoea etc..
Radix Angelicae Sinensis: sweet, acrid, warm.Replenishing and activating blood, menstruction regulating and pain relieving.For menoxenia, amenorrhea dysmenorrhea etc..
Radix Salviae Miltiorrhizae: bitter, is slightly cold.Blood circulation promoting and blood stasis dispelling, relieving pain of dysmenorrhea, clear away heart-fire relieving restlessness, removing heat from blood eliminating carbuncle.For the thoracic obstruction
Pained, gastral cavity abdomen hypochondriac pain etc..
Rhizoma Atractylodis Macrocephalae (parched): bitter, sweet, temperature.Invigorating the spleen and benefiting QI, dampness diuretic.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels.
Radix Curcumae: pungent, bitter, cold.Promoting blood circulation and stopping pain, promoting the circulation of QI to relieve pain, clear away heart-fire removing heat from blood, promoting the function of the gallbladder to alleviate jaundice.For breast
Side of body twinge, obstruction of qi in the chest and cardialgia, amenorrhea dysmenorrhea, distending pain of the breast etc..
Flos Rosae Rugosae: hardship sweet, micro-, temperature.Promoting QI circulation for relieving depression, invigorate blood circulation, pain relieving.For stagnation of liver-QI and stomach-QI, menstruation is not
Adjust.
Pericarpium Citri Reticulatae: bitter, pungent, temperature.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For abdominal distention etc..
Semen Vaccariae: bitter is flat.Promoting blood circulation to restore menstrual flow, stimulating milk secretion detumescence, inducing diuresis for treating stranguria syndrome.For amenorrhea dysmenorrhea etc..
Rhizoma Sparganii: pungent, bitter is flat.Removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.For dysmenorrhea, congestion amenorrhea, the thoracic obstruction heart
Pain etc..
It is a further object of the present invention to provide the preparation side of the Chinese medicine composition of a kind of above-mentioned treatment Liver depression and Qi stagnation
Method.
Concrete technical scheme is as follows:
The preparation method of the Chinese medicine composition of a kind of above-mentioned treatment Liver depression and Qi stagnation, comprises the following steps: weigh
Described raw material, adds water after being sufficiently mixed or pulverizing or ethanol that mass fraction is 25-65% carries out extracting 1-3
Secondary, filter, after concentrating filter liquor, obtain described Chinese medicine composition；Extracting method extracts for decocting or ultrasonic carries
Take or reflux, extract, or seepage pressure effects.
The Chinese medicine composition that it is a further object of the present invention to provide a kind of above-mentioned treatment Liver depression and Qi stagnation is controlled in preparation
Treat the application in the topical drug of Liver depression and Qi stagnation.
Concrete scheme is as follows:
The Chinese medicine composition of a kind of above-mentioned treatment Liver depression and Qi stagnation is at the topical drug of preparation treatment Liver depression and Qi stagnation
In application.
It is a further object of the present invention to provide a kind of massage cream treating Liver depression and Qi stagnation.
Concrete technical scheme is as follows:
A kind of massage cream treating Liver depression and Qi stagnation, described massage cream is by above-mentioned treatment Liver depression and Qi stagnation
Substrate or carrier that drug composition and massage cream are commonly used are prepared from.
Wherein in an embodiment, described Chinese medicine extract percetage by weight in described massage cream is
10.0-30.0%.
Wherein in an embodiment, described Chinese medicine extract percetage by weight in described massage cream is
13.0-22.0%.
Wherein in an embodiment, described substrate or carrier include water, chelating agen, conditioner, wetting agent,
Suspending agent, opacifier, emulsifying agent, preservative, essence.
Wherein in an embodiment, described massage cream is to be prepared from by the raw material of following percetage by weight:
Described Chinese medicine composition 14.0-20.0%, water 44.0-47.0%, chelating agen 0.05-0.15%, conditioner
0.15-0.35%, wetting agent 24.0-28.0%, suspending agent 0.35-0.55%, opacifier 0.4-0.8%, emulsifying agent
6.0-9.0%, preservative 0-1.5%, essence 0-0.3%.
Wherein in an embodiment, described massage cream is to be prepared from by the raw material of following percetage by weight:
Described Chinese medicine composition 17.0%, water 45.80%, chelating agen 0.10%, conditioner 0.25%, wetting agent 26.50%,
Suspending agent 0.45%, opacifier 0.60%, emulsifying agent 8.0%, preservative 1.20%, essence 0.10%.
Wherein in an embodiment, described massage cream is to be prepared from by the raw material of following percetage by weight:
17.0% Chinese medicine composition, 0.1%EDTA disodium, 0.1% allantoin, 3.0% glycerol, 0.2% xanthan gum, 0.5%
Glycine betaine, 5.0%1, ammediol, 0.25% sodium alginate, 45.8% water, 0.6% titanium dioxide, 3.0% fourth two
Alcohol, 1.5% stereth-2,2.0% stereth-21,4.5% glyceryl stearate, 3.5% spermaceti is hard
Lipidol, 4.0% isopropyl myristate, 4.0% octanoic acid or tricaprin, 2.0% polydimethylsiloxane,
0.03% bisabolol, 0.1% pantothenylol, 1.5% butanediol, 0.02% tetrahydrochysene piperine, 0.6% phenoxyethanol or
Sensiva SC50,0.6% Methylisothiazolinone or chlorphenesin, 0.1% essence.
The Chinese medicine composition for the treatment of Liver depression and Qi stagnation provided by the present invention, using pure Chinese medicine is raw material, according to
The tcm theory compatibility of monarch forms, and reaches soothing the liver by Shugan Qingre, blood circulation promoting and blood stasis dispelling, regulating qi-flowing for strengthening spleen
Effect of nourishing the liver, according to clinical verification, the advantage also with good effect, safety and stability.
The preparation method of the Chinese medicine composition of above-mentioned treatment Liver depression and Qi stagnation provided by the present invention, has technique
Simply, the advantage of safety and sanitation.
Chinese medicine composition by above-mentioned treatment Liver depression and Qi stagnation provided by the present invention and massage cream commonly use substrate or
The external massage cream that carrier is prepared from, easy to use, good effect, safety and stability, stingless to skin gentleness
Swash, have no side effect.
Detailed description of the invention
Further describe the present invention below in conjunction with embodiment, but these embodiments be merely to illustrate the present invention and not
For limiting the scope of the present invention.In embodiment in addition to having special instruction, described ratio is weight
Percentage ratio.
Embodiment 1 treats the Chinese medicine composition of Liver depression and Qi stagnation
A kind of Chinese medicine composition treating Liver depression and Qi stagnation, the active component of described Chinese medicine composition is by following heavy
Amount part raw material extracts and is prepared from: Radix Bupleuri 10 parts, the Radix Paeoniae Alba 4 parts, 2 parts of Pericarpium Citri Reticulatae Viride, Cortex Magnoliae Officinalis 12 parts, Radix Angelicae Sinensis
10 parts, Radix Salviae Miltiorrhizae 2 parts, Rhizoma Atractylodis Macrocephalae (parched) 3 parts, Radix Curcumae 2 parts, Flos Rosae Rugosae 14 parts, Pericarpium Citri Reticulatae 15 parts, Wang Buliu
Row 3 parts, Rhizoma Sparganii 30 parts.
The preparation method of the Chinese medicine composition of this treatment Liver depression and Qi stagnation is:
Weigh the raw material of above-mentioned weight portion, be sufficiently mixed, be placed in extraction pot, add above-mentioned raw materials weight 4
The water boiling and extraction of times amount 2 times, extracting solution filters, and filtrate is concentrated into the 40% of about medical material weight, i.e. obtains
The Chinese medicine composition for the treatment of Liver depression and Qi stagnation.
Embodiment 2 treats the Chinese medicine composition of Liver depression and Qi stagnation
A kind of Chinese medicine composition treating Liver depression and Qi stagnation, the active component of described Chinese medicine composition is by following heavy
Amount part raw material extracts and is prepared from: Radix Bupleuri 1 part, the Radix Paeoniae Alba 11 parts, 13 parts of Pericarpium Citri Reticulatae Viride, Cortex Magnoliae Officinalis 1 part, Radix Angelicae Sinensis 1
Part, Radix Salviae Miltiorrhizae 17 parts, Rhizoma Atractylodis Macrocephalae (parched) 12 parts, Radix Curcumae 13 parts, Flos Rosae Rugosae 1 part, Pericarpium Citri Reticulatae 2 parts, Semen Vaccariae
16 parts, Rhizoma Sparganii 10 parts.
The preparation method of the Chinese medicine composition of this treatment Liver depression and Qi stagnation is:
Weigh the Chinese crude drug of above-mentioned weight portion, pulverize, obtain medicated powder, medicated powder is placed in extraction pot, in addition
State the second alcohol soluble substance supersound extraction that mass fraction is 45% 2 times of raw material weight 6 times amount, extracting solution low speed from
The heart, it is thus achieved that centrifugal liquid 1 and medicinal residues 1, centrifugal liquid 1 high speed centrifugation again, it is thus achieved that centrifugal liquid 2；Medicinal residues 1 add again
The mass fraction entering 4 times amount medical material weight is 40% second alcohol soluble substance supersound extraction 1 time, extracting solution low-speed centrifugal,
Obtaining centrifugal liquid 3 and medicinal residues 2, it is abandoned by medicinal residues 2, centrifugal liquid 3 high speed centrifugation again, it is thus achieved that centrifugal liquid 4.Close
And centrifugal liquid 2 and centrifugal liquid 4, concentrating under reduced pressure (70 DEG C-75 DEG C ,-0.08Mpa～-0.1Mpa), reclaim ethanol,
It is concentrated into the 40% of medical material weight.
Embodiment 3 treats the Chinese medicine composition of Liver depression and Qi stagnation
A kind of Chinese medicine composition treating Liver depression and Qi stagnation, the active component of described Chinese medicine composition is by following heavy
Amount part raw material extracts and is prepared from: Radix Bupleuri 7 parts, the Radix Paeoniae Alba 7 parts, 7 parts of Pericarpium Citri Reticulatae Viride, Cortex Magnoliae Officinalis 7 parts, Radix Angelicae Sinensis 7
Part, Radix Salviae Miltiorrhizae 9 parts, Rhizoma Atractylodis Macrocephalae (parched) 7 parts, Radix Curcumae 7 parts, Flos Rosae Rugosae 7 parts, Pericarpium Citri Reticulatae 7 parts, Semen Vaccariae 7
Part, Rhizoma Sparganii 26 parts.
The preparation method of the Chinese medicine composition of this treatment Liver depression and Qi stagnation is:
Weigh the Chinese crude drug of above-mentioned weight portion, be sufficiently mixed, smash, obtain coarse powder, be placed in supersonic extractors,
The alcohol reflux that mass fraction is 55% of addition above-mentioned raw materials weight 8 times amount 1 time, extracting solution filters,
Filtering residue adds the alcohol reflux 1 time that mass fraction is 25%, and extracting solution filters, and merges twice filtrate,
Reclaim ethanol and be concentrated into the 40% of medical material weight, the Chinese medicine composition of Liver depression and Qi stagnation must be treated.
Embodiment 4 treats the Chinese medicine composition of Liver depression and Qi stagnation
A kind of Chinese medicine composition treating Liver depression and Qi stagnation, the active component of described Chinese medicine composition is by following heavy
Amount part raw material extracts and is prepared from: Radix Bupleuri 5 parts, the Radix Paeoniae Alba 6 parts, 5 parts of Pericarpium Citri Reticulatae Viride, Cortex Magnoliae Officinalis 4 parts, Radix Angelicae Sinensis 8
Part, Radix Salviae Miltiorrhizae 5 parts, Rhizoma Atractylodis Macrocephalae (parched) 10 parts, Radix Curcumae 9 parts, Flos Rosae Rugosae 3 parts, Pericarpium Citri Reticulatae 4 parts, Semen Vaccariae 5
Part, Rhizoma Sparganii 28 parts.
The preparation method of the Chinese medicine extract of this treatment Liver depression and Qi stagnation is:
Weigh the Chinese crude drug of above-mentioned weight portion, be sufficiently mixed, smash, obtain coarse powder, add above-mentioned raw materials weight
The mass fraction of 10 times amount is the ethanol of 65%, stirs, and after placing 1 hour, transfers to percolation and carries
Taking in tank, the ethanol that mass fraction is 45% adding raw material weight 6 times amount carries out seepage pressure effects, percolation speed
Degree collects 1 liter of percolation thing per hour by every kilogram of medical material, and after having extracted, percolate reclaims ethanol and concentrates
To medical material: the weight ratio of concentrate is 1:0.5, must treat the Chinese medicine composition of Liver depression and Qi stagnation.
Embodiment 5 treats the Chinese medicine composition of Liver depression and Qi stagnation
A kind of Chinese medicine composition treating Liver depression and Qi stagnation, the active component of described Chinese medicine composition is by following heavy
Amount part raw material extracts and is prepared from: Radix Bupleuri 8 parts, the Radix Paeoniae Alba 9 parts, 9 parts of Pericarpium Citri Reticulatae Viride, Cortex Magnoliae Officinalis 9 parts, Radix Angelicae Sinensis 8
Part, Radix Salviae Miltiorrhizae 13 parts, Rhizoma Atractylodis Macrocephalae (parched) 4 parts, Radix Curcumae 5 parts, Flos Rosae Rugosae 12 parts, Pericarpium Citri Reticulatae 11 parts, Semen Vaccariae
10 parts, Rhizoma Sparganii 20 parts.
The preparation method of above-mentioned Chinese medicine composition is same as in Example 1.
Embodiment 6 treat Liver depression and Qi stagnation massage cream and preparation method thereof
A kind of massage cream treating Liver depression and Qi stagnation, is prepared from by the raw material of following percetage by weight: 17.0%
Chinese medicine composition that embodiment 3 prepares, 45.80% water, 0.10% chelating agen, 0.25% conditioner, 26.50%
Wetting agent, 0.45% suspending agent, 0.60% opacifier, 8.0% emulsifying agent, 1.20% preservative, 0.10% essence；
Specifically include A phase (A1, A2, A3), B phase, C phase, D phase, E phase, F phase；Concrete raw material components
As shown in table 1 with content.
Massage cream raw material components and the percentage by weight thereof of Liver depression and Qi stagnation treated by table 1
The preparation method of the massage cream of this treatment Liver depression and Qi stagnation is as follows:
(1) A3 phase component manual mixing is uniform, cross colloid mill circulation and be milled to the full and uniform exquisiteness of powder body,
85 DEG C it are heated under stirring, standby；
(2) by C phase component stirring and dissolving to clear, standby；
(3) E phase component heated and stirred being dissolved to without granule clear shape, temperature is less than 50 DEG C,
Standby；
(4) A2 phase component is sequentially added into emulsifying pot, is heated to 85 DEG C under stirring (40r/min), fills
Divide stirring to complete swelling；
(5) A1 phase component is added aqueous phase agitated kettle, be heated with stirring to 90 DEG C, be incubated sterilizing in 20 minutes；
(6) B phase component is sequentially added into oil phase agitated kettle, under stirring (30r/min) state, is heated to 85 DEG C,
Stirring is to dissolving, insulated sterilizing 10 minutes；
(7) first aqueous phase pot component is filtered in (200 mesh) suction emulsifying pot, confirms that dispersed with stirring is uniform,
Continue under stirring (40r/min) slowly B phase component to be filtered (200 mesh) suction emulsifying pot, pre-breast
Change 5 minutes, keep vacuum (-0.02～-0.04Mpa), high speed homogenization 10 minutes, open emulsifying pot cover, add
Enter step (1) gained A3 phase component, continue high speed homogenization 15 minutes, maintain stirring (40r/min), and open
Open cooling water and start cooling；
(8) it is cooled to 60 DEG C, C, D phase component is slowly added to emulsifying pot, stir (40r/min), keep
Vacuum (-0.04～-0.06Mpa), continues stirring cooling；
(9) it is cooled to 50 DEG C, component E good with pretreatment for F phase component is sequentially added into emulsifying pot, stirring
(35r/min), high speed homogenization 2 minutes, keep vacuum (-0.04～-0.06Mpa), be cooled to 38 DEG C of stoppings and stirring
Mix, sampling detection pH value, qualified rear discharging, pack, obtain the massage of described treatment Liver depression and Qi stagnation
Cream.
Embodiment 7 irritation test
One, test objective
By contrast experiment, the massage cream of the treatment Liver depression and Qi stagnation of research embodiment 6 preparation is to rabbit skin
Zest.
Two, testing program
Test group: smear the massage cream of the treatment Liver depression and Qi stagnation of embodiment 6 preparation.
Matched group: smear substrate and (i.e. wipe out and treat insect pests and plant diseases in embodiment 6 outside the Chinese medicine composition treating Liver depression and Qi stagnation
Remaining material, i.e. carrier).
Test method:
Skin Irritation Test method and step are all according to the skin irritation in " cosmetics health specification 2007 editions "
Property test method is carried out with step.Using and contrast about consubstantiality self, left side is gone to hair-fields to smear embodiment 6 to make
The massage cream of standby treatment Liver depression and Qi stagnation, right side goes to hair-fields to smear substrate as comparison.
Three, result of the test
Result of the test is as shown in table 2.
Table 2 treats the massage cream of Liver depression and Qi stagnation to rabbit skin acute skin irritation test result
By table 2 test data it can be seen that the embodiment of the present invention 6 treatment Liver depression and Qi stagnation for preparing
Massage cream does not has any ill effect to skin, and irritation test has no zest, and safety is high.
Embodiment 8 microorganism and sanitary index detection test
One, testing goal
Study whether every microorganism and chemical index in the massage cream for the treatment of Liver depression and Qi stagnation of the present invention accord with
Close relevant criterion.
Two, detection scheme
The massage cream for the treatment of Liver depression and Qi stagnation embodiment 6 prepared is entrusted in GuangZhou, China analysis test
The heart, is measured according to " cosmetics health specification 2007 ".
Three, testing result
Testing result is as shown in table 3.
Table 3 massage cream microorganism and sanitary index
Data are detected it can be seen that the embodiment of the present invention 6 treatment Liver depression and Qi stagnation for preparing by table 3
The every microorganism of massage cream and sanitary index are the most qualified, illustrate that its safety and sanitation are good.
Embodiment 9 treats the clinical trial of the massage cream of Liver depression and Qi stagnation
One, diagnostic criteria and subject
Hypochondriac pain diagnostic criteria: depressed emotion, kind sigh, heating installation aftersensation is easypro, both sides side of body rib or distention and pain in the lower abdomen,
It is indefinite to walk to alter, the most then connect and breast shoulder, or distending pain of the breast, and feelings will excitation then pain is acute, can with indigestion and loss of appetite,
Abdominal distention.Thin white fur of tongue, stringy pulse.
Stomachache diagnostic criteria: epigastric distending pain, alters two sides of body bitterly, and heating installation frequency is made, and the most very, breast gastral cavity painful abdominal mass is vexed for dysphagia related to QI disorder pain,
Addicted to miscellaneous acid regurgitation, happiness is sighed.Red tongue margin, white and thin fur, deep and stringy pulse.
Dysmenorrhea diagnostic criteria: hypomenorrhea or blockage of menstruation, purple coloured menses dead color has clot, alleviation of pain under block, through clean
Pain disappear, lower abdominal pain, breast distending pain in the chest and hypochondrium, clot, the soreness of waist, irritable, suffer from diarrhoea and feel sick and vomit
Tell.
All meet above-mentioned being and be diagnosed as hypochondriac pain, stomachache and dysmenorrhea.
Subject: this organizes 150 examples all by above-mentioned diagnostic criteria.Wherein hypochondriac pain patient 50, male 15
Name, women 35；Wherein stomachache patient 50, male 23, women 27；Wherein dysmenorrhea patient
50.Age 15-48 year.
Two, given the test agent, sample using method and the time
(1) hypochondriac pain patient 50, are randomly divided into test group and comparative example group.
Test group: the massage cream of embodiment 6 preparation is smeared in massage.
Using method: the most each one, specification is that 5ml/ props up.Massage is applied in two side of body flanks.After 2-3 hour
Clean with warm water and smear position or disregard.
Comparative example group: oral Radix Bupleuri SHUGAN WAN.
Using method: 1 ball, 2 times on the one.Warm water delivery service.
(2) stomachache patient 50, is randomly divided into test group and comparative example group.
Test group: the massage cream of embodiment 6 preparation is smeared in massage.
Using method: the most each one, specification is that 5ml/ props up.Massage is applied in abdominal part.By temperature after 2-3 hour
Water cleans and smears position or disregard.
Comparative example group: oral soothing the liver JIANWEI WAN.
Using method: a 3-6g ball, 3 times on the one.Warm water delivery service.
(3) dysmenorrhea patient 50, are randomly divided into test group and comparative example group.
Test group: the massage cream of embodiment 6 preparation is smeared in massage.
Using method: the most each one, specification is that 5ml/ props up.Massage is applied in umbilical part.By temperature after 2-3 hour
Water cleans and smears position or disregard.
Comparative example group: ointment for the treatment of dysmenorrhea.
Using method: 3 times on the one.Massage is applied in umbilical part.
Three, the test course for the treatment of and relevant evaluation criteria
(1) hypochondriac pain
Effective: the one or both sides pain over the hypochondriac region disappears, substantially alleviates or alleviate, and remaining symptom takes a turn for the better.
Invalid: the pain over the hypochondriac region is unchanged with other symptoms.
(2) stomachache
Effective: at the nearly pit of the stomach of gastral cavilty, pain disappears, substantially alleviates or alleviate, and remaining symptom takes a turn for the better.
Invalid: at the nearly pit of the stomach of gastral cavilty, pain and other symptoms are unchanged.
(3) dysmenorrhea
Effective: after treatment, stomachache disappears, substantially alleviates or alleviate, and remaining symptom takes a turn for the better.
Invalid: stomachache and symptom thereof are without changing.
Four, test result
Table 4 massage cream treatment hypochondriac pain clinical test results
| Subject | Effectively | Invalid | Effective percentage | |
| Test group | 25 | 23 | 2 | 92.00% |
| Comparative example group | 25 | 20 | 5 | 80.00% |
Table 5 massage cream treatment stomachache clinical test results
| Subject | Effectively | Invalid | Effective percentage | |
| Test group | 25 | 21 | 4 | 84.00% |
| Comparative example group | 25 | 18 | 7 | 72.00% |
Table 6 massage cream treatment dysmenorrhea clinical test results
| Subject | Effectively | Invalid | Effective percentage | |
| Test group | 25 | 23 | 2 | 92.00% |
| Comparative example group | 25 | 15 | 10 | 60.00% |
By table 4, table 5, table 6 clinical data it can be seen that compared with the medicine of oral medication Liver depression and Qi stagnation,
The present invention by the Chinese medicine composition of described treatment Liver depression and Qi stagnation and substrate or carrier be prepared from external by
The cream that rubs has more prominent curative effect, by Shugan Qingre, blood circulation promoting and blood stasis dispelling, regulating qi-flowing for strengthening spleen, reaches soothing the liver nourishing the liver
Effect, according to clinical verification, the advantage also with good effect, safety and stability.
Each technical characteristic of embodiment described above can combine arbitrarily, for making description succinct, the most right
The all possible combination of each technical characteristic in above-described embodiment is all described, but, if these skills
There is not contradiction in the combination of art feature, is all considered to be the scope that this specification is recorded.
Embodiment described above only have expressed the several embodiments of the present invention, and it describes more concrete and detailed,
But can not therefore be construed as limiting the scope of the patent.It should be pointed out that, for this area
For those of ordinary skill, without departing from the inventive concept of the premise, it is also possible to make some deformation and change
Entering, these broadly fall into protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be with appended power
Profit requires to be as the criterion.
Claims (10)
1. the Chinese medicine composition treating Liver depression and Qi stagnation, it is characterised in that the work of described Chinese medicine composition
Property composition be by following raw material extract be prepared from: Radix Bupleuri 1-10 part, Radix Paeoniae Alba 4-11 part, Pericarpium Citri Reticulatae Viride 2-13
Part, Cortex Magnoliae Officinalis 1-12 part, Radix Angelicae Sinensis 1-10 part, Radix Salviae Miltiorrhizae 2-17 part, Rhizoma Atractylodis Macrocephalae (parched) 3-12 part, Radix Curcumae 2-13 part,
Flos Rosae Rugosae 1-14 part, Pericarpium Citri Reticulatae 2-15 part, Semen Vaccariae 3-16 part, Rhizoma Sparganii 10-30 part.
The Chinese medicine composition for the treatment of Liver depression and Qi stagnation the most according to claim 1, it is characterised in that institute
The active component stating Chinese medicine composition is to be extracted by following raw material to be prepared from: Radix Bupleuri 5-8 part, the Radix Paeoniae Alba
6-9 part, Pericarpium Citri Reticulatae Viride 5-9 part, Cortex Magnoliae Officinalis 4-9 part, Radix Angelicae Sinensis 5-8 part, Radix Salviae Miltiorrhizae 5-13 part, Rhizoma Atractylodis Macrocephalae (parched) 4-10 part,
Radix Curcumae 5-9 part, Flos Rosae Rugosae 3-12 part, Pericarpium Citri Reticulatae 4-11 part, Semen Vaccariae 5-10 part, Rhizoma Sparganii 20-28 part.
The Chinese medicine composition for the treatment of Liver depression and Qi stagnation the most according to claim 1, it is characterised in that institute
The active component stating Chinese medicine composition is to be extracted by following raw material to be prepared from: Radix Bupleuri 7 parts, the Radix Paeoniae Alba 7
Part, 7 parts of Pericarpium Citri Reticulatae Viride, Cortex Magnoliae Officinalis 7 parts, Radix Angelicae Sinensis 7 parts, Radix Salviae Miltiorrhizae 9 parts, Rhizoma Atractylodis Macrocephalae (parched) 7 parts, Radix Curcumae 7 parts, rose
Rare spend 7 parts, Pericarpium Citri Reticulatae 7 parts, Semen Vaccariae 7 parts, Rhizoma Sparganii 26 parts.
4. the preparation method of the Chinese medicine composition of the treatment Liver depression and Qi stagnation described in claim 1-3, its feature
It is, comprises the following steps: weigh described raw material, add water after being sufficiently mixed or pulverizing or mass fraction is
The ethanol of 25-65% carries out extracting 1-3 time, filters, obtains described Chinese medicine composition after concentrating filter liquor；Carry
Access method is for decocting extraction or supersound extraction or reflux, extract, or seepage pressure effects.
5. the Chinese medicine composition of the treatment Liver depression and Qi stagnation described in claim 1-3 is at preparation treatment stagnation of QI due to depression of the liver
Application in the topical drug of card.
6. the massage cream treating Liver depression and Qi stagnation, it is characterised in that described massage cream is by claim
The Chinese medicine composition of the treatment Liver depression and Qi stagnation described in any one of 1-3 and substrate or carrier are prepared from.
The massage cream for the treatment of Liver depression and Qi stagnation the most according to claim 6, it is characterised in that in described
Drug composition percetage by weight in described massage cream is 10.0-30.0%.
The massage cream for the treatment of Liver depression and Qi stagnation the most according to claim 6, it is characterised in that described press
The cream that rubs is to be prepared from by the raw material of following percetage by weight: described Chinese medicine composition 14.0-20.0%, water
44.0-47.0%, chelating agen 0.05-0.15%, conditioner 0.15-0.35%, wetting agent 24.0-28.0%, suspend
Agent 0.35-0.55%, opacifier 0.4-0.8%, emulsifying agent 6.0-9.0%, preservative 0-1.5%, essence 0-0.3%.
The massage cream for the treatment of Liver depression and Qi stagnation the most according to claim 8, it is characterised in that described press
The cream that rubs is to be prepared from by the raw material of following percetage by weight: described Chinese medicine composition 17.0%, water 45.80%,
Chelating agen 0.10%, conditioner 0.25%, wetting agent 26.50%, suspending agent 0.45%, opacifier 0.60%,
Emulsifying agent 8.0%, preservative 1.20%, essence 0.10%.
The massage cream for the treatment of Liver depression and Qi stagnation the most according to claim 9, it is characterised in that described
Massage cream is to be prepared from by the raw material of following percetage by weight: 17.0% Chinese medicine composition, 0.1%EDTA bis-
Sodium, 0.1% allantoin, 3.0% glycerol, 0.2% xanthan gum, 0.5% glycine betaine, 5.0%1, ammediol, 0.25%
Sodium alginate, 45.8% water, 0.6% titanium dioxide, 3.0% butanediol, 1.5% stereth-2,2.0% is stearic
Alcohol polyethers-21,4.5% glyceryl stearate, 3.5% cetearyl alcohol, 4.0% isopropyl myristate, 4.0%
Octanoic acid or tricaprin, 2.0% polydimethylsiloxane, 0.03% bisabolol, 0.1% pantothenylol, 1.5%
Butanediol, 0.02% tetrahydrochysene piperine, 0.6% phenoxyethanol or Sensiva SC50,0.6% methylisothiozoline
Ketone or chlorphenesin, 0.1% essence.
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Citations (4)
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|---|---|---|---|---|
| CN101444613A (en) * | 2008-12-19 | 2009-06-03 | 宗翠红 | Traditional Chinese medicine formula for treating chronic hepatitis |
| CN102380083A (en) * | 2011-11-15 | 2012-03-21 | 梁淑花 | External plaster for treating mammary gland hyperplasia and lactation mastitis |
| CN103301408A (en) * | 2013-06-28 | 2013-09-18 | 珠海圣原生物科技有限公司 | Traditional Chinese medicine extract and massage cream prepared from extract |
| CN103623339A (en) * | 2013-08-09 | 2014-03-12 | 马建 | Externally-applied medicine for treating hyperplasia of mammary glands and preparation method thereof |
-
2015
- 2015-06-30 CN CN201510377182.9A patent/CN106310113B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101444613A (en) * | 2008-12-19 | 2009-06-03 | 宗翠红 | Traditional Chinese medicine formula for treating chronic hepatitis |
| CN102380083A (en) * | 2011-11-15 | 2012-03-21 | 梁淑花 | External plaster for treating mammary gland hyperplasia and lactation mastitis |
| CN103301408A (en) * | 2013-06-28 | 2013-09-18 | 珠海圣原生物科技有限公司 | Traditional Chinese medicine extract and massage cream prepared from extract |
| CN103623339A (en) * | 2013-08-09 | 2014-03-12 | 马建 | Externally-applied medicine for treating hyperplasia of mammary glands and preparation method thereof |
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