CN106309917A - Compound preparation with efficacy of resisting aging and preventing cardiovascular and cerebrovascular diseases and preparation method of compound preparation - Google Patents
Compound preparation with efficacy of resisting aging and preventing cardiovascular and cerebrovascular diseases and preparation method of compound preparation Download PDFInfo
- Publication number
- CN106309917A CN106309917A CN201610854426.2A CN201610854426A CN106309917A CN 106309917 A CN106309917 A CN 106309917A CN 201610854426 A CN201610854426 A CN 201610854426A CN 106309917 A CN106309917 A CN 106309917A
- Authority
- CN
- China
- Prior art keywords
- compound preparation
- preparation
- parts
- adjuvant
- pulverize
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a compound preparation with the efficacy of resisting aging and preventing cardiovascular and cerebrovascular diseases and a preparation method of the compound preparation. Specifically, the compound preparation is prepared from the following auxiliary materials in parts by weight and the following traditional Chinese medicinal components: 8 to 12 parts of radix ginseng, 20 to 30 parts of Chinese angelica, 20 to 30 parts of rhizoma polygonati, 20 to 30 parts of radix ophiopogonis, 20 to 30 parts of Chinese gall and 4 to 6 parts of poria cocos. The method for preparing the compound preparation comprises the following steps: firstly, crushing the radix ginseng and the poria cocos; secondly, performing water extraction on the Chinese angelica, the rhizoma polygonati, the radix ophiopogonis and the Chinese gall, preparing paste, drying and crushing; thirdly, adding the auxiliary materials to obtain the compound preparation. The compound preparation with the efficacy of resisting aging and preventing cardiovascular and cerebrovascular diseases, provided by the invention, can be used for effectively clearing free radicals generated in a body, enhancing myocardial functions, and effectively strengthening heart and increasing pressure, and has better effects of resisting aging and preventing the cardiovascular and cerebrovascular diseases. Through inspection, the compound preparation is high in active ingredient and free of toxic or side effects.
Description
Technical field
The present invention relates to Chinese medicine compound field, be specifically related to a kind of defying age, the compound preparation of prevention cardiovascular and cerebrovascular disease
And preparation method thereof.
Background technology
The aging of cell is closely related with apoptosis.Think in the industry at present, cause apoptotic main extraneous factor
Including free radical, it is believed that free radical is attacked biomembrane, polyunsaturated fatty acid, DNA, protein and other biological macromole and drawn
The oxidative damage sent out is to cause organism aging process and the principal element of many senile disease.Main free radical in human body is hydroxyl free
Base and ultra-oxygen anion free radical.
Cardiovascular and cerebrovascular disease (CVD) is the general designation of cardiovascular and cerebrovascular disease, refers to owing to hyperlipemia, blood stick
Ischemic that heart that thick, atherosclerosis, hypertension etc. are caused, brain and body tissue occur or hemorrhage.
Cardiovascular and cerebrovascular disease is a kind of serious threat mankind, the commonly encountered diseases of particularly more than 50 years old middle-aged and elderly people health, has high ill
Rate, high disability rate and the feature of high mortality, even if the treatment means that application is most advanced, perfect, still can have more than 50%
Cerebrovas-cularaccident survivor life can not take care of oneself completely, the whole world is died from the number of cardiovascular and cerebrovascular disease every year and is up to 15,000,000
People, occupies the various cause of the death the first.
Cardiovascular and cerebrovascular disease mainly includes pathological changes and the pathological changes of blood vessel itself of blood.Problem in terms of blood includes blood fat
Rising, hyperlipidemia, blood pressure rise the problems such as high, and the pathological changes in terms of blood vessel includes the improper metabolism of vascular smooth muscle cell
Deng.
Atherosclerosis is the Etiological of cardiovascular and cerebrovascular disease, and what its risk factor formed was currently known has nearly
300 kinds, can be divided into and can intervene risk factor and risk factor can not be intervened two big classes, hypertension, smoking, hyperlipidemia, diabetes,
Imbalance diet, obesity, lack exercise, stress etc. is the risk factor that can intervene, sex, age, race, heredity etc. are
The risk factor that can not intervene.
The active ingredient of Chinese herbs that can reduce blood fat includes flavonoid, saponins and active polysaccharide etc., Flavonoid substances fall blood
The mechanism of action of fat is mainly realized by antioxidation.The blood fat reducing mechanism of saponins is to be combined with cholesterol, blocks liver sausage
Circulation, minimizing body, to cholesterol absorption, reaches lipid-lowering effect.The mechanism of active polysaccharide blood fat reducing with protein-based seemingly, increase
Add the wriggling of intestinal and promote that cholesterol converts to cholic acid, thus increasing excretion.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention aims to provide a kind of defying age, prevention cardiovascular and cerebrovascular vessel
The compound preparation of disease.
The purpose of the present invention realizes by the following technical solutions:
A kind of defying age, the compound preparation of prevention cardiovascular and cerebrovascular disease, by adjuvant by weight and following Chinese drug-treated group
Divide and make:
As preferably, this defying age, prevention cardiovascular and cerebrovascular disease compound preparation by following components system by weight
Become:
As preferably, this defying age, prevention cardiovascular and cerebrovascular disease compound preparation by following components system by weight
Become:
As preferably, described adjuvant is maltodextrin and magnesium stearate.
As preferably, the number of described maltodextrin is 25-35 part, and the number of described magnesium stearate is 2-4 part.
Another object of the present invention is to provide the method preparing above-mentioned compound preparation, comprise the following steps:
1) pulverize: the Radix Ginseng and the Poria that take formula ratio are pulverized；
2) water carries: takes the Radix Angelicae Sinensis of formula ratio, Rhizoma Polygonati, Radix Ophiopogonis, the decoction extraction of Fructus Schisandrae Chinensis mixing and water adding, takes extracting solution, decompression
It is concentrated to give extractum, vacuum drying, pulverize；
3) preparation: by step 1) pulverize after material and step 2) pulverize after material, add adjuvant mix homogeneously, packaging.
As preferably, step 2) in, adding water volume is after mixing 8-12 times of material cumulative volume, decocts at twice, every time
Decocting time is 2-3 hour.
As preferably, step 2) in, being concentrated into relative density is 1.25-1.30.
As preferably, step 2) in, the pressure of concentrating under reduced pressure is 0.06-0.08Mpa, and temperature is 70-80 DEG C.
As preferably, step 3) in, described adjuvant is maltodextrin and magnesium stearate, fills capsulation.
The compound preparation that the present inventor provides, its principle active component includes total saponins, crude polysaccharides and flavonoid, concertedness
The free radical in human body is removed on ground, reduces hyperlipidemia.Wherein, the combination of Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis, have supplementing QI and nourishing YIN,
Promoting the production of body fluid to quench thirst, yin fluid astringing take off effect admittedly, and it has strengthening heart and boosting pressure, increases coronary artery blood flow, minimizing myocardial oxygen consumption, the increase heart
Flesh blood supply, the effect of the oxygen-derived free radicals that resists myocardial ischemia, removes, thus defying age, prevention cardiovascular and cerebrovascular disease.
Compared to existing technology, the beneficial effects of the present invention is:
The defying age of present invention offer, the compound preparation of prevention cardiovascular and cerebrovascular disease, it can the interior generation of purged body effectively
Free radical, strengthen myocardial function, effective strengthening heart and boosting pressure, have preferable defying age, prevention cardiovascular and cerebrovascular disease effect.Should
Compound preparation is through inspection, and active component is high, have no side effect.
Detailed description of the invention
Below, in conjunction with detailed description of the invention, the present invention is described further:
The present invention provides a kind of defying age, the compound preparation of prevention cardiovascular and cerebrovascular disease, by adjuvant by weight and
Following Chinese medicinal components is made:
In this compound preparation, total saponins is the significant composition of Radix Ginseng, also contains high level in Radix Ophiopogonis and Fructus Schisandrae Chinensis
Total saponins；Crude polysaccharides is the significant composition of Radix Angelicae Sinensis, Rhizoma Polygonati, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Poria.In addition, Radix Angelicae Sinensis, Rhizoma Polygonati, wheat
Containing substantial amounts of flavone and flavonoid in winter, Fructus Schisandrae Chinensis.The free radical produced in total saponins, flavone purged body effectively, can have
Effect slows down cellular oxidation process, makes holding youth vigor；Crude polysaccharides reduces blood fat, reduces blood viscosity, effectively reduces heart and brain
The morbidity source of angiopathy.This three major types material concertedness effect in vivo, the free radical in purged body, improves cellular metabolism and lives
Property, promote that hemolysin, hemolysis plaque are formed and lymhocyte transformation rate, thus defying age, prevention cardiovascular and cerebrovascular disease.
Raw material employed in the present invention all can obtain by the way of commercially available.In detailed description below, all in
Medicine component all meets the Pharmacopoeia of the People's Republic of China one middle respective standard requirement of version in 2010, is purchased from Hebei Qi Xin Chinese medicine
Granule pieces company limited.Adjuvant maltodextrin meets the requirement of GB/T20884-2007 maltodextrin, has purchased from good lucky biochemistry
Limit company.Magnesium stearate meets the Pharmacopoeia of the People's Republic of China two middle respective standard requirements of version in 2010, purchased from Huzhou exhibition
Hope pharmaceutcal corporation, Ltd.
Embodiment 1:
A kind of defying age, the compound preparation of prevention cardiovascular and cerebrovascular disease, be made up of following components by weight:
The method preparing this compound preparation, comprises the following steps:
1) pulverize: take 5kg Radix Ginseng and 2.5kg Poria is pulverized；
2) water carries: takes 12.5kg Radix Angelicae Sinensis, 12.5kg Rhizoma Polygonati, 12.5kg Radix Ophiopogonis, the mixing of 12.5kg Fructus Schisandrae Chinensis, adds mixture
The water of 5 times of volumes of material, decocts after 2h, adds the soak by water 2h of 5 times of volumes of mixed material, united extraction liquid, 70-80 DEG C with
It is 1.25-1.30 that the pressure of 0.06-0.08Mpa is concentrated into mastic relative density, obtains extractum, vacuum drying, pulverizes,
10.84kg dry powder；
3) preparation: by step 1) pulverize after material and step 2) dry powder that obtains, add 1.5kg maltodextrin and 0.15kg
Magnesium stearate, mix homogeneously, fill capsulation.
Embodiment 2:
A kind of defying age, the compound preparation of prevention cardiovascular and cerebrovascular disease, be made up of following components by weight:
The method preparing this compound preparation, comprises the following steps:
1) pulverize: take 4kg Radix Ginseng and 2kg Poria is pulverized；
2) water carries: takes 10kg Radix Angelicae Sinensis, 10kg Rhizoma Polygonati, 10kg Radix Ophiopogonis, the mixing of 10kg Fructus Schisandrae Chinensis, adds 5 times of bodies of mixed material
Long-pending water, after decocting 2h, adds the soak by water 2h of 5 times of volumes of mixed material, and united extraction liquid, 70-80 DEG C with 0.06-
It is 1.25-1.30 that the pressure of 0.08Mpa is concentrated into mastic relative density, obtains extractum, vacuum drying, pulverizes, obtains 8.63kg
Dry powder；
3) preparation: by step 1) pulverize after material and step 2) dry powder that obtains, add 1.2kg maltodextrin and 0.12kg
Magnesium stearate, mix homogeneously, fill capsulation.
Embodiment 3:
A kind of defying age, the compound preparation of prevention cardiovascular and cerebrovascular disease, be made up of following components by weight:
The method preparing this compound preparation, comprises the following steps:
1) pulverize: take 6kg Radix Ginseng and 3kg Poria is pulverized；
2) water carries: takes 15kg Radix Angelicae Sinensis, 10kg Rhizoma Polygonati, 15kg Radix Ophiopogonis, the mixing of 10kg Fructus Schisandrae Chinensis, adds 5 times of bodies of mixed material
Long-pending water, after decocting 2h, adds the soak by water 2h of 5 times of volumes of mixed material, and united extraction liquid, 70-80 DEG C with 0.06-
It is 1.25-1.30 that the pressure of 0.08Mpa is concentrated into mastic relative density, obtains extractum, vacuum drying, pulverizes, obtains 11.98kg
Dry powder；
3) preparation: by step 1) pulverize after material and step 2) dry powder that obtains, add 1.4kg maltodextrin and 0.15kg
Magnesium stearate, mix homogeneously, fill capsulation.
Comparative example 1:
A kind of defying age, the compound preparation of prevention cardiovascular and cerebrovascular disease, be made up of following components by weight:
The method preparing this compound preparation, comprises the following steps:
1) water carries: take 6kg Radix Ginseng, 3kg Poria, 15kg Radix Angelicae Sinensis, 10kg Rhizoma Polygonati, 15kg Radix Ophiopogonis, the mixing of 10kg Fructus Schisandrae Chinensis, first
Add water boiling and extraction 2h of 6 times of volumes of mixed material, collect extracting solution, add the soak by water of 26 times of volumes of mixed material
Extracting 2h, united extraction liquid, 70-80 DEG C is concentrated into mastic relative density as 1.25-with the pressure of 0.06-0.08Mpa
1.30, obtain extractum, vacuum drying, pulverize, obtain 13.22kg dry powder；
2) preparation: by step 1) dry powder that obtains, add 1.4kg maltodextrin and 0.15kg magnesium stearate, mix homogeneously, fill out
Fill capsulation.
Comparative example 2
A kind of defying age, the compound preparation of prevention cardiovascular and cerebrovascular disease, be made up of following components by weight:
The method preparing this compound preparation, comprises the following steps:
1) pulverize: take 6kg Radix Ginseng and pulverize；
1) water carries: takes 3kg Poria, 15kg Radix Angelicae Sinensis, 10kg Rhizoma Polygonati, 15kg Radix Ophiopogonis, the mixing of 10kg Fructus Schisandrae Chinensis, adds mixture
The water boiling and extraction of 12 times of volumes of material, takes extracting solution, and 70-80 DEG C to be concentrated into mastic with the pressure of 0.06-0.08Mpa relative
Density is 1.25-1.30, obtains extractum, vacuum drying, pulverizes, obtains 12.59kg dry powder；
2) preparation: by step 1) dry powder that obtains, add 1.4kg maltodextrin and 0.15kg magnesium stearate, mix homogeneously, fill out
Fill capsulation.
The compound preparation that embodiment 1-3 and comparative example 1-2 obtain is capsule, and its content is powder, content face
Color is brown, and free from extraneous odour is visible by naked eyes impurity.Preparation packing specification is 0.4g/ grain, it is recommended that day dose 6, i.e. every day 2
Secondary, each 3, folding post dose is 0.04g/kg.bw.
Detection embodiment:
1. functional component inspection
By Ministry of Public Health " health food detection and assessment technique specification " 2003 editions, embodiment 1-3 and comparative example 1-2 are obtained
To compound preparation carry out total saponins, crude polysaccharides detection, its result is as shown in the table:
Table 1 functional component is checked
As shown in Table 1, embodiment 1-3 obtains its total saponins of compound preparation and crude polysaccharides content the most relatively comparative example 1 and 2
Height, and comparative example 2 the most relatively comparative example 1 is high, say, that Radix Ginseng and Poria are directly pulverized, and other Chinese medicinal components uses extraction
Mode, contribute to the abundant release of effective ingredient.
2. physicochemical property detection
By the requirement of GB16740-1997, the compound preparation obtaining embodiment 1-3 and comparative example 1-2 carries out a huge sum of money
The physicochemical property detection of genus, moisture, ash, disintegration time and pesticide residues, its result is as shown in the table.
Table 2 compound preparation physical and chemical index detects
As shown in Table 2, the physicochemical property of the compound preparation that embodiment 1-3 and comparative example 1-2 obtain is satisfied by GB16740-
The requirement of 1997.
3. sanitary microorganism detection
By the requirement of GB16740-1997, it is total that the compound preparation obtaining embodiment 1-3 and comparative example 1-2 carries out bacterium colony
Number, coliform group count, mycete, yeast, gold-coloured staphylococci, Salmonella, shigella, Hemolytic streptococcus health micro-
Biological detection, its result is as shown in the table.
Table 3 sanitary microorganism detects
As shown in Table 3, the compound preparation that embodiment 1-3 and comparative example 1-2 obtain, total plate count, coliform group count, mould
Bacterium, yeast are in critical field, and respectively do not go out pathogenic bacterium, and sanitary microorganism index is satisfied by the requirement of GB16740-1997.
4. Toxicological evaluation
The compound preparation obtaining embodiment 1-3 and comparative example 1-2 carries out acute oral toxicity test, genetoxic examination
Test, the sanitary microorganism of 30 days feeding trials of mice detects, and its result is as shown in the table:
Table 4 safety Toxicological Assessment
As seen from the above table, the compound preparation that embodiment 1-3 and comparative example 1-2 obtain all belongs to non-toxic type, to mice without causing
Mutation effect, its maximum without agent is human body recommended amounts more than 100 times.
The most both effectiveness test
The compound preparation obtaining embodiment 1 carries out efficacy test, arranges 0.4g/kg.bw, 0.8g/kg.bw and 1.2g/
The low, medium and high dosage of kg.bw, Balb/c mice male to SPF carries out lymphocyte transformation experiment (mtt assay) and serum hemolysis
Element test.Its result is as shown in the table,
Table 5 lymph conversion test
As shown in Table 5, the compound preparation that embodiment 1 obtains, 0.4g/kg.bw and 0.8g/kg.bw dosage group and matched group
Compare, its optical density value without significant difference (P > 0.05), 1.2g/kg.bw dosage group compared with control group mice, its optical density value
Without significant difference (P < 0.01).
Table 6 serolysin test
In serolysin test, the compound preparation that embodiment 1 obtains is in the 0.8g/kg.bw dosage group of recommended dose
Relative to matched group, there were significant differences compared with matched group for the antibody product in Mice Body (P < 0.05), 1.2g/kg.bw dosage
Group group is relative to matched group, and difference is more notable (P < 0.01).
In sum, the defying age of present invention offer, the compound preparation of prevention cardiovascular and cerebrovascular disease, through safety toxicology
Evaluating, all do not make significant difference body weight, body weight gains and the internal organs/weight ratio of mice, this compound preparation makes under recommended dose
Comparatively safe with may be considered.Defying age that the present invention provides, the compound preparation of resisting fatigue are 10-30 times of recommended dose
The interior immunocompetence that can improve body, improves serum sanguinin state, the cell viability of enhancing body, the cellular metabolism of lifting body
Ability, it is thus possible to effectively play defying age, the effect of prevention cardiovascular and cerebrovascular disease.
It addition, it will be apparent to those skilled in the art that can technical scheme as described above and design, make other
Various corresponding changes and deformation, and all these change and deformation all should belong to the protection of the claims in the present invention
Within the scope of.
Claims (10)
1. a defying age, the compound preparation of prevention cardiovascular and cerebrovascular disease, it is characterised in that by adjuvant by weight and with
Lower Chinese medicinal components is made:
Compound preparation the most according to claim 1, it is characterised in that by adjuvant by weight and following Chinese medicinal components
Make:
Compound preparation the most according to claim 1, it is characterised in that by adjuvant by weight and following Chinese medicinal components
Make:
4. according to the compound preparation described in any one of claim 1-3, it is characterised in that described adjuvant is maltodextrin and tristearin
Acid magnesium.
Compound preparation the most according to claim 4, it is characterised in that the number of described maltodextrin is 25-35 part, described
The number of magnesium stearate is 2-4 part.
6. the method for preparation compound preparation described in any one of claim 1-5, comprises the following steps:
1) pulverize: the Radix Ginseng and the Poria that take formula ratio are pulverized；
2) water carries: taking the Radix Angelicae Sinensis of formula ratio, Rhizoma Polygonati, Radix Ophiopogonis, Fructus Schisandrae Chinensis mixing, boiling is extracted, taken extracting solution, concentrating under reduced pressure
Obtain extractum, vacuum drying, pulverize；
3) preparation: by step 1) pulverize after material and step 2) pulverize after material add adjuvant and mix homogeneously, pack.
Method the most according to claim 6, it is characterised in that step 2) in, add water volume for material cumulative volume after mixing
8-12 times, decoct at twice, each decocting time is 2-3 hour.
Method the most according to claim 6, it is characterised in that step 2) in, being concentrated into relative density is 1.25-1.30.
Method the most according to claim 6, it is characterised in that step 2) in, the pressure of concentrating under reduced pressure is 0.06-
0.08Mpa, temperature is 70-80 DEG C.
Method the most according to claim 6, it is characterised in that step 3) in, described adjuvant is maltodextrin and stearic acid
Magnesium, fills capsulation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610854426.2A CN106309917B (en) | 2016-09-27 | 2016-09-27 | A kind of anti-aging, the compound preparation for preventing cardiovascular and cerebrovascular disease and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610854426.2A CN106309917B (en) | 2016-09-27 | 2016-09-27 | A kind of anti-aging, the compound preparation for preventing cardiovascular and cerebrovascular disease and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106309917A true CN106309917A (en) | 2017-01-11 |
| CN106309917B CN106309917B (en) | 2019-08-09 |
Family
ID=57820663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610854426.2A Active CN106309917B (en) | 2016-09-27 | 2016-09-27 | A kind of anti-aging, the compound preparation for preventing cardiovascular and cerebrovascular disease and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106309917B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108096145A (en) * | 2018-01-09 | 2018-06-01 | 广州环亚化妆品科技有限公司 | A kind of delay aging drug composition and its preparation method and application |
| DE102018116749A1 (en) * | 2018-07-11 | 2020-01-16 | Shanghai Juku Cosmetic CO., LTD | A PHARMACEUTICAL COMPOSITION FOR A MEDICAL THERAPY AND HEALTH HEAD COVER |
-
2016
- 2016-09-27 CN CN201610854426.2A patent/CN106309917B/en active Active
Non-Patent Citations (1)
| Title |
|---|
| 吴莹等: "生脉散对VD 大鼠行为学及海马组织NOS 和神经元细胞凋亡的影响", 《南方医科大学学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108096145A (en) * | 2018-01-09 | 2018-06-01 | 广州环亚化妆品科技有限公司 | A kind of delay aging drug composition and its preparation method and application |
| DE102018116749A1 (en) * | 2018-07-11 | 2020-01-16 | Shanghai Juku Cosmetic CO., LTD | A PHARMACEUTICAL COMPOSITION FOR A MEDICAL THERAPY AND HEALTH HEAD COVER |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106309917B (en) | 2019-08-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Li et al. | A review of polysaccharides from Schisandra chinensis and Schisandra sphenanthera: Properties, functions and applications | |
| Yang et al. | Resource, chemical structure and activity of natural polysaccharides against alcoholic liver damages | |
| Fuentes-Alventosa et al. | Preparation of bioactive extracts from asparagus by-product | |
| CN105727205B (en) | Composition with weight-losing and blood fat-reducing effects and preparation method and application thereof | |
| CN106266898A (en) | A kind of vital energy benefiting and the kidney invigorating, the compound preparation and preparation method thereof of defying age | |
| CN105395919A (en) | Composition containing black fungus extract and having effect of reducing blood fat and preparation method of composition | |
| CN102114102B (en) | Traditional Chinese medicine extract mixed preparation and application thereof | |
| KR100706111B1 (en) | A ginseng preparation using vitamin c and process for thereof | |
| CN103040057A (en) | Schisandra chinensis mixed beverage capable of relieving alcoholic liver injury and production technology thereof | |
| Bi et al. | A review on the application, phytochemistry and pharmacology of Polygonatum odoratum, an edible medicinal plant | |
| JP6140789B2 (en) | PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF NON-ALCOHOLIC FATTY LIVER PATIENT CONTAINING REINFORCED CONCENTRATE ENHANCED COMPOUND K COMPOUND AND HEALTH FUNCTIONAL FOOD | |
| CN106309917A (en) | Compound preparation with efficacy of resisting aging and preventing cardiovascular and cerebrovascular diseases and preparation method of compound preparation | |
| CN106581166A (en) | Anti-fatigue food, health product or pharmaceutical composition | |
| CN105219602B (en) | A kind of hypoglycemic root of kudzu vine yellow rice wine and preparation method thereof | |
| Choi | Processed gingers: current and prospective use in food, cosmetic, and pharmaceutical industry | |
| JP2008007473A (en) | Cassia obtusifolia l. or cassia tora l. seed extract | |
| CN106995772A (en) | A kind of health liquor of strengthen immunity | |
| CN106928376A (en) | The separation method of skunk bush polysaccharide and its application | |
| Hu | Nutraceutical innovation and health claims in China | |
| KR101154031B1 (en) | Composition for Antifati gue containin g herbal mixture extract as in gredient compounds | |
| KR100721931B1 (en) | The method and faculty food make from mushroom | |
| CN110898180A (en) | Composition for promoting blood circulation, reducing blood fat and losing weight and preparation method thereof | |
| Das et al. | 1 Phytochemicals and Medicinal Importance of Nelumbo nucifera | |
| CN106387876A (en) | Immunity enhancing and physical fatigue relieving health-care product recipe and preparation method thereof | |
| CN100528177C (en) | Red yeast preparation containing active components of glossy ganoderma and its preparation process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |