CN106309901A - Radix scrophulariae buccal tablets and preparation method thereof - Google Patents
Radix scrophulariae buccal tablets and preparation method thereof Download PDFInfo
- Publication number
- CN106309901A CN106309901A CN201610858555.9A CN201610858555A CN106309901A CN 106309901 A CN106309901 A CN 106309901A CN 201610858555 A CN201610858555 A CN 201610858555A CN 106309901 A CN106309901 A CN 106309901A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- radix scrophulariae
- door
- buccal tablets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses radix scrophulariae buccal tablets, which is prepared from the following raw material components in parts by weight: 20-40 parts of radix scrophulariae, 20-40 parts of radix asparagi, 20-40 parts of dwarf lilyturf tuber, 10-30 parts of sweet wormwood herb, 5-15 parts of fructus rosae laevigatae, 0.5-1.5 parts of menthol and 5-15 parts of liquorice root. The invention also discloses a preparation method of the radix scrophulariae buccal tablets. Clinical tests prove that the radix scrophulariae buccal tablets disclosed by the invention are high in healing power, do not have toxic action on the heart, the liver, the kidney and the hematopoietic system when being taken, and do not have irritation on the digestive tract, thus being a reliable and effective traditional Chinese medicine preparation. Furthermore, the buccal tablets provided by the invention are convenient to carry and take.
Description
Technical field
The invention belongs to a kind of buccal tablet Chinese medicine and health food, particularly to a kind of Radix Scrophulariae buccal tablet and preparation method thereof.
Background technology
Oral ulcer belongs to the categories such as the traditional Chinese medical science " aphtha ", " erosion of the oral mucosa ".Oral ulcer is that the oral mucosa of a kind of recurrent exerbation is burst
Infections is damaged, and is common oral disease clinically.The superficial ulcer being to occur on oral mucosa, big I from the grain of rice to
Semen Glycines size, circular or oval, ulcer surface is recessed, the most congested, can cause pain because of irritable food, be apt to occur in mouth
The edge of transmucosal and tongue, more preferably sends out with the position poor without keratinization or keratinization, such as Mucosa of lip, the tip of the tongue, lingual margin, tongue abdomen, soft
The position such as palate and tonsil, and infection, digestive functional disturbance, endocrine regulation, Nervous and Mental Factors, inherited genetic factors, trace element lack
The factors such as weary and wound are relevant.Although a lot of to the Therapeutic Method of oral ulcer, but be essentially all symptomatic treatment, alleviate slow and
Easily recurrence.The most popular method mainly has gentamycin therapy, vitamin E therapy, YUNNAN BAIYAO therapy, BINGPENG SAN to treat
Method etc., but all there is respective limitation.For primary disease, its recurrent is an insoluble problem.
Pharyngitis is the whole world one of most common " outpatient service disease ", and in recent years, Chinese's pharyngitis sickness rate presents and persistently rises
Trend, pharyngitis pharmaceutical market capacity is huge.Data shows, China suffers from the crowd of pharyngolaryngitis in various degree and accounts for healthy population
40%, and people the most nearly all can obtain pharyngitis.Pharyngitis is easiest to become " voice worker " such as teacher, ticket seller, push away
The occupation disease of pin person etc., part unvoiced sound worker is big because of operating pressure, and rhythm of life makes body be chronically at confirmed fatigue soon,
General immunity ability is caused to decline, easy repeated infection antibacterial and virus, cause pharyngolaryngitis recurrent exerbation and form chronic pharyngitis.
Coming, China's most area occurs wide range of haze weather in succession year after year so that respiratory disease patient quantity substantially increases.This
Outward, some region is especially higher at Guangdong hot area sickness rate.Therefore the treatment strengthening acute/chronic pharyngitis has important meaning
Justice.
Modern medicine uses antibiotics to treat acute/chronic pharyngitis mostly, and chronic pharyngitis is in conventional Drug therapy
Middle performance is more obstinate, and easily recurrent exerbation, common with middle age, and Reusability antibiotic can make microorganism to antibiotic
Produce drug resistance.
In sum, the effectively treatment about oral ulcer, acute/chronic pharyngitis is still the visitor that field of medicaments need to constantly be studied
Body.
Summary of the invention
In view of this, it is an object of the invention to provide a kind of Radix Scrophulariae buccal tablet and preparation method thereof.Described Radix Scrophulariae is sucked
Sheet is used for treating oral ulcer, acute/chronic pharyngitis, and its curative effect does not recurs.
For achieving the above object, following technical scheme is specifically provided:
1, a kind of Radix Scrophulariae buccal tablet, raw material consists of the following composition by weight ratio: Radix Scrophulariae 20-40 part, Radix Asparagi door 20-
40 parts, door 20-40 part Radix Ophiopogonis, Herba Artemisiae Annuae 10-30 part, Fructus Rosae Laevigatae 5-15 part, Mentholum 0.5-1.5 part, Radix Glycyrrhizae 5-15 part.
Preferably, raw material consists of the following composition by weight ratio: Radix Scrophulariae 30 parts, 30 parts of Radix Asparagi door, 30 parts of door Radix Ophiopogonis,
Herba Artemisiae Annuae 20 parts, Fructus Rosae Laevigatae 10 parts, Mentholum 1 part, 10 parts of Radix Glycyrrhizae.
2, the preparation method of described a kind of Radix Scrophulariae buccal tablet, comprises the steps:
(1) Radix Scrophulariae 300g, Radix Asparagi door 300g, door 300g Radix Ophiopogonis, Herba Artemisiae Annuae 200g, Fructus Rosae Laevigatae 100g, Radix Glycyrrhizae 100g are weighed also
Mixing；
(2) adding the water of mixed 10 times of weight of component, decoct and extract 1 hour, second time adds medical material gross weight 8 times
Water, decoct and extract 0.5 hour, merge twice extracting solution, then to be evaporated to relative density be the clear of 1.25-1.3 (60 DEG C)
Cream；
(3) in the clear paste that step (2) obtains, 400g dextrin and mix homogeneously are added, in vacuum 0.07Mpa, temperature 80
At DEG C, microwave decompression is dried to dry, is ground into fine powder, then adds 240g microcrystalline Cellulose, 300g mannitol, 60g sulfur in fine powder
Acid calcium, 1.25g Aspartame, 1.1g citric acid, use 95v/v% alcohol granulation, and 60 DEG C are dried, obtain dry granule standby；
(4) take 10g Mentholum, dissolve with 95v/v% ethanol, join in dry granule, airtight 30 minutes, add 2g hard
Fatty acid magnesium, mixing, it is pressed into 1000, obtains the tablet of 1.0g/ sheet.
The beneficial effects of the present invention is:
(1) present invention is based on traditional tcm treatment according to syndrome differentiation, carries out scientific compatibility in conjunction with clinical practice, and repeatedly real
Testing the optimal using dosage determining various composition, oral ulcer, acute/chronic pharyngitis curative effect are especially pronounced, and curative effect is not the most multiple
Send out.Radix Scrophulariae used by the present invention is sweet, bitter, salty, be slightly cold, and has effect of clearing away heat and cooling blood, detoxicating and resolving stagnation of pathogens, nourishing YIN to lower pathogenic fire；Radix Asparagi
Door lung heat clearing pathogenic fire reducing is nourshing Yin and drynsessmoistening prescription；Radix Ophiopogonis door nourishing YIN and moistening the lung, clear away heart-fire relieving restlessness, reinforcing stomach reg fluid；Herba Artemisiae Annuae heat clearing away, expelling summer-heat, except steaming, control temperature
Disease, summer-heat, hectic fever due to YIN-deficiency consumptive fever, malaria, dysentery, jaundice, scabies, pruritus；Fructus Rosae Laevigatae relieving cough and asthma, spasmolytic.Through clinical trial, this
Its healing power of the Radix Scrophulariae buccal tablet of disclosure of the invention is high, takes medicine period, to the heart, liver, kidney, the most non-toxic action of hemopoietic system, the most not
Occur that digestive tract stimulates phenomenon, be a kind of reliable and effective Chinese medicine preparation.And the invention provides the tablet of a kind of oral type,
Its easy to carry, taking convenience.
Detailed description of the invention
Below the preferred embodiments of the present invention are described in detail.The experiment side of unreceipted actual conditions in embodiment
Method, generally according to normal condition or according to the condition proposed by manufacturer.
Embodiment 1
A kind of Radix Scrophulariae buccal tablet, its concrete preparation technology is: by Radix Scrophulariae 300g, Radix Asparagi 300g, Radix Ophiopogonis 300g, Herba Artemisiae Annuae
200g, Fructus Rosae Laevigatae 100g and the mixing of Radix Glycyrrhizae 100g Six-element medical material, add the water of medical material gross weight 10 times for the first time, decoct extraction 1
Hour, second time adds the water of medical material gross weight 8 times, decocts and extracts 0.5 hour, merges twice extracting solution, filters, and filtrate concentrates
To the clear paste that relative density is 1.25-1.3 (60 DEG C), add the mixing of 400g dextrin, at vacuum 0.07Mpa, temperature 80 DEG C
Microwave decompression is dried to dry, is ground into fine powder, adds 240g microcrystalline Cellulose, 300g mannitol, 60g calcium sulfate, 1.25g Ah bar
This is sweet, 1.1g citric acid, uses 95v/v% alcohol granulation, and 60 DEG C are dried, obtain dry granule standby；Take 10g Mentholum, use 95v/
V% ethanol dissolves, and joins in dry granule, airtight 30 minutes, adds 2g magnesium stearate, mixing, is pressed into 1000,
The tablet of 1.0g/ sheet.
Clinical case efficacy analysis
1, treatment oral ulcer volume
Oral ulcer belongs to the categories such as the traditional Chinese medical science " aphtha ", " erosion of the oral mucosa ".The existing exopathogenic factor of its cause of disease, also has endogenous cause of ill.Endogenous cause of ill duty in
Natural endowment is not enough or weakness due to chronic disease and be prone to suffer from primary disease.Nursing in usually of exopathogenic factor duty is improper, eating and drinking without temperance, and surfeit is pungent
The thing of stimulation, or emotional stress, or overstrain, all may result in visceral dysfunction, damp-heat accumulation, intimately smoke bright dispute and cause
Sick.Aphtha of the mouth and tongue more than one full year of life at age 18, pain is abnormal, and pain connects throat, in statistics 660 example patients, three times a day, each 2
Sheet, buccal, within 2-6 days, all there is symptom in various degree to take a turn for the better, have 260 example medication further consultation in 3 days, feel good, various irritant reaction
Normally, toposcopy ulcer surface heals, and is considered as healing and accounts for 39.39%.Having 400 example patients after controlling 3 days, subjective symptoms is the best
Turning, vinegar-pepper stimulation still has local pain, checks that local ulcer surface is obviously reduced, and these patients are considered as improvement and account for 60.6%.Take medicine
The heart, liver, kidney, hemopoietic system etc. are had no side effect by period, also without obvious respiratory tract, digestive tract stimulation.
2, treatment acute/chronic pharyngitis
B. for acute/chronic pharyngitis, its pathogenesis is many because of acute sore throat recurrent exerbation, so that visceral dysfunction, lung kidney yin
Void, hyperactivity of deficient fire, throat lose foster caused.Age the pharyngitis patient 200 of 18 to 50 one full year of life, be randomly divided into treatment group and
Matched group, treatment group 88 people, male 50 people, female 38 people；Matched group 112 example, male 60 examples, female 72 example.Patient's course of disease is different in size,
Short 6 days, the longest 5 years.Patient is embodied in not smooth, not out, the energy feeling there is expectorant in pharyngeal discomfort, pharynx, gulps down for a long time
Tired, repeated cold, thin lingual fur, pale tongue, diet are depressed, weak pulse.Therapeutic Method: treatment group is administered orally of the present invention sucking
Sheet, three times a day, each 2, warm water is taken after mixing it with water；Matched group oral vitamin C 2, three times a day, two groups equal 7 days is 1 course for the treatment of.
Criterion of therapeutical effect is effective, and acute patient i.e. cures for 5 to 7 days, and symptom gradually alleviates to disappearance.Chronic patients adheres to taking two weeks
Rear symptom also has and substantially alleviates, and within 3 to 4 months, gradually fully recovers.Therapeutic outcome treatment two courses for the treatment of after evaluate curative effect: treatment group 88
People, the most effective 67 examples (76.14%), 20 examples that take a turn for the better (22.72%), invalid 2 examples (2.27%), total effective rate 97.73%.Right
According to organizing 112 examples, the most effective 27 examples (24.11%), 49 examples that take a turn for the better (43.75%), invalid 36 examples (32.14%), total effective rate
67.86%.Being found by clinical trial, the curative effect for the treatment of group is not only better than matched group, and curative effect is fast, and relapse rate is low.Treatment
Later six months, follow-up investigation found, none recurrence for the treatment of group, matched group recurs 18 examples.Take medicine period, to the heart, liver, kidney, hemopoietic system
All nonhazardous effects, do not occur that digestive tract stimulates phenomenon yet.
3, about the situation of prevention
In the experiment of healthy population, taking through 790 people, every 10 days once, buccal, Throat diseases morbidity in 3 years
Rate is less than 3/1000ths, without any untoward reaction；And the crowd under same environment, similarity condition carries out adding up sickness rate and exists
More than 40%, it is clear that the prevention effect of the present invention highlights.
4, model case
Case one, patient Lee xx, female, 38 years old, teacher, suffer from chronic pharyngitis 4 years, bottleneck throat has foreign body sensation, by cough and
Swallowing and all cannot eliminate, sound of speaking is the most tired and hoarse, has acid regurgitation, belch symptom, eats before liking sleeping.Recurrent exerbation,
Can not take food time serious, once take a lot of medicine the most invalid, take buccal tablet of the present invention 14 days, pharyngitis symptom gradually subtracts
Gently, fully recovering after 2 months, 1 year without recurrence.
Case two, Liu xx, female, 22 years old, company clerk, tells regular thirsty and dry pharynx, throat itching and cough, pronunciation fatiguability, inspection
Looking into and see that mucosa diffusivity is congested, thin vessels is expanded, and color is dark red, attached a small amount of thick secretions, is diagnosed as chronic simple pharyngitis.With
The Radix Scrophulariae buccal tablet buccal of embodiment 1, every day 4-6 time, each 1,10 days be a course for the treatment of, after adhering to taking three courses for the treatment of,
Patients symptomatic disappears.
The Radix Scrophulariae buccal tablet prepared by embodiment 1, every day 4-6 time, each 1, after medication 3 days, oral ulcer starts bright
Showing and alleviate, treat about 8 days, symptom disappears substantially.After three weeks, normal nothing pain of speaking, to have a meal smooth and easy, tongue fur, pulse condition are stable
Normally, body temperature is stablized normal.
Case three, an xx, man, 55 years old, suffer from oral ulcer 5 years, recurrent exerbation, conventional cydiodine, meaning can be pasted and in other
Western medicine, subtracts with rear disease, sends out the most again.Emaciated physique, pale complexion are shown in inspection, and oral mucosa there are about size more than 10 and locates ulceration, and burst place
Pale erosion, red tongue, no fur, xerostomia, thready and rapid pulse, insomnia and dreamful sleep, anorexia is dull, and two just adjust, for imbalance of YIN and YANG, deficient YIN affecting YANG
Time.By the Radix Scrophulariae buccal tablet buccal of embodiment 1, every day 4-6 time, each 1,10 days be a course for the treatment of, takes a course for the treatment of
After, xerostomia, insomnia and dreamful sleep take a turn for the better, and are obviously reduced at ulceration, continuous with taking 5 all diseases disappearances course for the treatment of again.Follow up a case by regular visits to 1 year not send out.
The Radix Scrophulariae buccal tablet prepared by embodiment 1, every day 4-6 time, each 1, after medication 3 days, pharyngalgia starts to alleviate, and controls
Treat about 10 days, substantially disappear, after three weeks, the transference cures such as pharyngeal color is normal, pharyngalgia cough, tongue fur, pulse condition are stably normal,
Body temperature is stablized normal.
Finally illustrate, preferred embodiment above only in order to technical scheme to be described and unrestricted, although logical
Cross above preferred embodiment the present invention to be described in detail, it is to be understood by those skilled in the art that can be
In form and it is made various change, without departing from claims of the present invention limited range in details.
Claims (3)
1. a Radix Scrophulariae buccal tablet, it is characterised in that raw material consists of the following composition by weight ratio: Radix Scrophulariae 20-40 part, sky
Winter door 20-40 part, door 20-40 part Radix Ophiopogonis, Herba Artemisiae Annuae 10-30 part, Fructus Rosae Laevigatae 5-15 part, Mentholum 0.5-1.5 part, Radix Glycyrrhizae 5-15
Part.
A kind of Radix Scrophulariae buccal tablet, it is characterised in that raw material is by weight ratio by following component group
Become: Radix Scrophulariae 30 parts, 30 parts of Radix Asparagi door, 30 parts of door Radix Ophiopogonis, Herba Artemisiae Annuae 20 parts, Fructus Rosae Laevigatae 10 parts, Mentholum 1 part, 10 parts of Radix Glycyrrhizae.
The preparation method of a kind of Radix Scrophulariae buccal tablet, it is characterised in that comprise the steps:
(1) weigh Radix Scrophulariae 300g, Radix Asparagi door 300g, door 300g Radix Ophiopogonis, Herba Artemisiae Annuae 200g, Fructus Rosae Laevigatae 100g, Radix Glycyrrhizae 100g and mix；
(2) adding the water of mixed 10 times of weight of component, decoct and extract 1 hour, second time adds medical material gross weight 8 times
Water, decocts and extracts 0.5 hour, merge twice extracting solution, then be evaporated to the clear paste that relative density is 1.25-1.3 (60 DEG C)；
(3) in the clear paste that step (2) obtains, 400g dextrin and mix homogeneously are added, at vacuum 0.07Mpa, temperature 80 DEG C
Microwave decompression is dried to dry, is ground into fine powder, then adds 240g microcrystalline Cellulose, 300g mannitol, 60g sulphuric acid in fine powder
Calcium, 1.25g Aspartame, 1.1g citric acid, use 95v/v% alcohol granulation, and 60 DEG C are dried, obtain dry granule standby；
(4) take 10g Mentholum, dissolve with 95v/v% ethanol, join in dry granule, airtight 30 minutes, add 2g stearic acid
Magnesium, mixing, it is pressed into 1000, obtains the tablet of 1.0g/ sheet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610858555.9A CN106309901A (en) | 2016-09-28 | 2016-09-28 | Radix scrophulariae buccal tablets and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610858555.9A CN106309901A (en) | 2016-09-28 | 2016-09-28 | Radix scrophulariae buccal tablets and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106309901A true CN106309901A (en) | 2017-01-11 |
Family
ID=57820358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610858555.9A Pending CN106309901A (en) | 2016-09-28 | 2016-09-28 | Radix scrophulariae buccal tablets and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106309901A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110898158A (en) * | 2019-12-10 | 2020-03-24 | 柳州两面针股份有限公司 | Application of anti-oral ulcer compound traditional Chinese medicine extract in oral care product |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491372A (en) * | 2014-11-27 | 2015-04-08 | 恩施硒都科技园有限公司 | Radix scrophulariae buccal tablet |
-
2016
- 2016-09-28 CN CN201610858555.9A patent/CN106309901A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491372A (en) * | 2014-11-27 | 2015-04-08 | 恩施硒都科技园有限公司 | Radix scrophulariae buccal tablet |
Non-Patent Citations (1)
| Title |
|---|
| 王虹: ""口炎冲剂治疗原发性疱疹性口炎疗效观察"", 《中医药学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110898158A (en) * | 2019-12-10 | 2020-03-24 | 柳州两面针股份有限公司 | Application of anti-oral ulcer compound traditional Chinese medicine extract in oral care product |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100374149C (en) | Traditional Chinese medicine formulation for treating bronchitis and tonsillitis | |
| CN102205107B (en) | Chinese medicinal preparation for treating duodenal ulcer and preparation method thereof | |
| CN102205108A (en) | Traditional Chinese medicine preparation for treating gastric ulcer and preparation method thereof | |
| CN103156984A (en) | Traditional Chinese medicine composition for treating gingivitis and preparation method thereof | |
| CN100457170C (en) | A Medicine for treatment of gastrointestinal diseases | |
| CN103495048A (en) | Traditional Chinese medicine composition for treating children's aphthous stomatitis | |
| CN105012770A (en) | Health drink and preparation method thereof | |
| CN106309901A (en) | Radix scrophulariae buccal tablets and preparation method thereof | |
| CN108404031A (en) | A kind of medicine pill for treating recurrent aphthous ulcer | |
| CN103463400B (en) | Chinese medicine composition for treating infantile asthma | |
| CN102813849B (en) | Preparation method of traditional Chinese medicine for treating dyspnea and tachypnea-type acute glomerulonephritis | |
| CN104510937A (en) | Traditional Chinese medicinal formula for treating infantile asthma and preparation method for paste of traditional Chinese medicinal formula | |
| CN104001070A (en) | Traditional Chinese medicine composition for treating constipation | |
| CN109663012A (en) | Dispelling wind and heat, removing toxic substances relieving sore-throat Chinese medicine composition and the preparation method and application thereof | |
| CN105920517B (en) | A kind of Radix Glycyrrhizae complex composition of clear throat | |
| CN116763880B (en) | Traditional Chinese medicine composition and preparation for treating functional dyspepsia accompanied with emaciation and application of traditional Chinese medicine composition and preparation | |
| CN116549595B (en) | Pharmaceutical composition for treating functional dyspepsia of children, preparation and application thereof | |
| CN102000253B (en) | Traditional Chinese medicine preparation for treating lower respiratory tract infections of infants | |
| CN103463537B (en) | Medicament for treating infantile asthma | |
| CN102641442B (en) | Traditional Chinese medicine preparation for treating recurrent aphthae | |
| CN103263620B (en) | Traditional Chinese medicine preparation for treating sjoegren syndrome and preparation method thereof | |
| CN102861147B (en) | Traditional Chinese medicine composition for treating carbon monoxide delayed encephalopathy | |
| CN100546623C (en) | The psoriatic Chinese medicine preparation of a kind of treatment | |
| CN105031499A (en) | Traditional Chinese medicine composition for treating duodenal ulcer | |
| CN117942372A (en) | Traditional Chinese medicine preparation for treating rhinitis and pharyngitis of respiratory system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170111 |
|
| RJ01 | Rejection of invention patent application after publication |