CN106309555A - Composite medicine containing liquorice roots, cinnamon and ceftiofur sodium for beasts and birds - Google Patents
Composite medicine containing liquorice roots, cinnamon and ceftiofur sodium for beasts and birds Download PDFInfo
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- CN106309555A CN106309555A CN201610839493.7A CN201610839493A CN106309555A CN 106309555 A CN106309555 A CN 106309555A CN 201610839493 A CN201610839493 A CN 201610839493A CN 106309555 A CN106309555 A CN 106309555A
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- Prior art keywords
- radix glycyrrhizae
- cortex cinnamomi
- drug resistance
- ceftiofur sodium
- cinnamon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to composite medicine containing liquorice roots, cinnamon and ceftiofur sodium for beasts and birds. The composite medicine is prepared from the ceftiofur sodium, the liquorice roots and the cinnamon according to the weight ratio of 1:(20 to 30): (4 to 5). The invention also provides a compound preparation prepared by using the composite medicine for beasts and birds. The composite medicine has the beneficial effects that experiment study proves that when the ceftiofur sodium, the liquorice roots and the cinnamon are used in a combined way at a specific weight proportion, the synergistic effect is obvious; the curative effect taking speed is high; the cost is low, and the like.
Description
Technical field
The invention belongs to poultry compound medicine technical field, particularly relate to a kind of containing Radix Glycyrrhizae, Cortex Cinnamomi and ceftiofur sodium
Poultry compound medicine, infected, by colon bacillus, the disease that causes for treating poultry.
Background technology
Radix Glycyrrhizae is pulse family Glycyrrhiza perennial herb, and the root and rhizome of Radix Glycyrrhizae has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, eliminates the phlegm
Many effects such as cough-relieving, relieving spasm to stop pain, the mediation property of medicine, raising animal body immunity.At present, the root and rhizome of Radix Glycyrrhizae frequently as in
Medical herbs feed additive, medicine source is enriched, is had no side effect in animal body, almost without residual, does not the most produce drug resistance, collects nutrition
Keep healthy, prevent disease, seasoning flavouring, promote Production of Livestock and Poultry and improve animal meat quality in one.Radix Glycyrrhizae root and rhizome is raised poultry
Feed additives not only has stimulating appetite, strengthening digestion, improve local flavor, function that growth promotion is fattened, and there is prevention and control
Treating the function of multiple livestock and poultry, research shows, adds Radix Glycyrrhizae and can promote growth of animals or poultry, eat for a long time in additive for farm animal feed
With making poultry fur light, domestic animal gets fat soon, and poultry egg laying is many.Radix Glycyrrhizae adds in the Chinese medicine fodder of prevention and treatment common diseases of chickens
When adding in agent application, have that prophylactic treatment is effective, without any side effects, raw material is easy to get, cheap advantage.Additionally,
Radix Glycyrrhizae root and rhizome can be additionally used in the poisoning of piglet furazolidone, domestic animal eats the poisoning of the animal such as toxic plant poisoning, pig mouldy cron poisoning by mistake
Rescue, rescued effect is preferable.Radix Glycyrrhizae root and rhizome can be used for the treatment and prevention of multiple livestock and poultry as veterinary medicine, and obtains
Extraordinary treatment and prevention effect.
After poultry are infected by colon bacillus, the multiple locations such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis can be caused
Severe infections, causes huge economic loss to livestock and poultry cultivation.Amoxicillin, norfloxacin, florfenicol etc. are to prevent and treat this type of
The conventional Western medicine of disease, along with medication is more and more spread unchecked, its Resistant strain is the most, and drug cost is the most increasing, but
Therapeutic effect and drug resistance situation are not taken a turn for the better, and go from bad to worse on the contrary.
Through retrieval, do not inquire to combine Radix Glycyrrhizae, Cortex Cinnamomi and Western medicine and infected by colon bacillus for treating poultry
The relevant report of the disease caused.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound medicines containing Radix Glycyrrhizae, Cortex Cinnamomi and ceftiofur sodium
Thing, its synergism is obvious, it is possible to eliminate the colon bacillus drug resistance to ceftiofur sodium, improves therapeutic effect.
For solving above technical problem, the present invention by the following technical solutions: a kind of containing Radix Glycyrrhizae, Cortex Cinnamomi and ceftiofur sodium
Poultry compound medicine, be made up of ceftiofur sodium and Radix Glycyrrhizae, Cortex Cinnamomi, the weight ratio of ceftiofur sodium and Radix Glycyrrhizae, Cortex Cinnamomi is
1:20-30:4-5。
The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.
The present invention possesses and provides the benefit that: prove through experimental study, and ceftiofur sodium and Radix Glycyrrhizae, Cortex Cinnamomi are with specific weight
Amount ratio is used in combination, and has synergism obvious, and curative effect is fast, low cost and other advantages.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme and beneficial effect are described further, except Special Statement
Outward, Radix Glycyrrhizae of the present invention, Cortex Cinnamomi weight are dry weight.
One, Radix Glycyrrhizae, the Cortex Cinnamomi mensuration to the drug resistance elimination effect of Western medicine
1. assay method
It is 1:10:1,1:20:2,1:20:5,1:30:5,1:25:4,1:40 according to the weight ratio of Western medicine and Radix Glycyrrhizae, Cortex Cinnamomi:
5 prepare Western medicine and Radix Glycyrrhizae, the admixing medical solutions of Cortex Cinnamomi respectively；Choose the bacterial strain to Western medicine drug resistance as subjects, utilize flat board
Dilution method carries out Secondary Culture, measures each process medicinal liquid MIC situation of change to Resistant strain；Set Radix Glycyrrhizae, Cortex Cinnamomi, each west simultaneously
Prescription agent is sun comparison, compares as the moon if being not added with any medicine.
Above-mentioned process was cultivated for 3 generations the most continuously.
2. result of the test
After cultivating for 3 generations continuously, the process flat board of cloudy comparison is long bacterium, and other each medicaments and admixing medical solutions are for large intestine angstrom
The result statistics of the MIC (μ g/mL) of uncommon Salmonella is as shown in table 1:
Can be concluded that by upper table
1. when the weight ratio of amoxicillin and Radix Glycyrrhizae, Cortex Cinnamomi is 1:20:2,1:20:5,1:30:5 and 1:25:4, A Mo
XiLin all reduces more than 32 times to the minimal inhibitory concentration of drug resistance colon bacillus, it is seen then that drug resistance colon bacillus to Ah
The drug resistance of Amdinocillin substantially reduces.And when the weight ratio of amoxicillin and Radix Glycyrrhizae, Cortex Cinnamomi is 1:10:1 and 1:40:5, A Mo
The minimal inhibitory concentration of drug resistance colon bacillus compared with sun comparison (pure Western medicine) being not added with Radix Glycyrrhizae, Cortex Cinnamomi, is not had by XiLin
Significant change.
2., when the weight ratio of florfenicol and Radix Glycyrrhizae, Cortex Cinnamomi is 1:20:5,1:30:5 and 1:25:4, florfenicol is to resistance to
The minimal inhibitory concentration of medicine colon bacillus all reduces more than 64 times, it is seen then that drug resistance colon bacillus is to florfenicol
Drug resistance substantially reduces.And when the weight ratio of florfenicol and Radix Glycyrrhizae, Cortex Cinnamomi is 1:10:1,1:20:2 and 1:40:5, fluorobenzene
Buddhist nun examine the minimal inhibitory concentration to drug resistance colon bacillus be not added with Radix Glycyrrhizae, Cortex Cinnamomi sun comparison (pure Western medicine) compared with, do not have
Significant change.
3., when the weight ratio of colistin and Radix Glycyrrhizae, Cortex Cinnamomi is 1:20:2,1:20:5,1:30:5, colistin is to resistance to
The minimal inhibitory concentration of medicine colon bacillus all reduces more than 256 times, it is seen then that drug resistance colon bacillus is to colistin
Drug resistance substantially reduces.And when the weight ratio of colistin and Radix Glycyrrhizae, Cortex Cinnamomi is 1:10:1,1:25:4 and 1:40:5, viscous bar
The minimal inhibitory concentration of drug resistance colon bacillus compared with sun comparison (pure Western medicine) being not added with Radix Glycyrrhizae, Cortex Cinnamomi, is not had by rhzomorph
Significant change.
4. when the weight ratio of amikacin and Radix Glycyrrhizae, Cortex Cinnamomi is 1:10:1,1:20:2,1:20:5,1:30:5, A meter Ka
Star all reduces more than 128 times to the minimal inhibitory concentration of drug resistance colon bacillus, it is seen then that drug resistance colon bacillus is to Ah rice
The drug resistance of card star substantially reduces.And when the weight ratio of amikacin and Radix Glycyrrhizae, Cortex Cinnamomi is 1:25:4 and 1:40:5, A meter Ka
Star to the minimal inhibitory concentration of drug resistance colon bacillus compared with sun comparison (pure Western medicine) being not added with Radix Glycyrrhizae, Cortex Cinnamomi, the brightest
Aobvious change.
5. when the weight ratio of sulfamonomethoxine sodium and Radix Glycyrrhizae, Cortex Cinnamomi is 1:20:2,1:20:5,1:30:5, sulfanilamide
Between Sulfamonomethoxine sodium the minimal inhibitory concentration of drug resistance colon bacillus is all reduced more than 128 times, it is seen then that drug resistance large intestine angstrom wish
The drug resistance of sulfamonomethoxine sodium is substantially reduced by Salmonella.And when sulfamonomethoxine sodium and Radix Glycyrrhizae, the weight of Cortex Cinnamomi
When ratio is for 1:10:1,1:25:4 and 1:40:5, the sulfamonomethoxine sodium minimal inhibitory concentration to drug resistance colon bacillus
Compared with sun comparison (pure Western medicine) being not added with Radix Glycyrrhizae, Cortex Cinnamomi, there is no significant change.
6. when the weight ratio of LIJUNJING and Radix Glycyrrhizae, Cortex Cinnamomi is 1:10:1,1:20:2,1:20:5,1:30:5, LIJUNJING pair
The minimal inhibitory concentration of drug resistance colon bacillus all reduces more than 320 times, it is seen then that drug resistance colon bacillus is to LIJUNJING
Drug resistance substantially reduces.And when the weight ratio of LIJUNJING and Radix Glycyrrhizae, Cortex Cinnamomi is and when 1:25:4,1:40:5, and LIJUNJING is to drug resistance
The minimal inhibitory concentration of colon bacillus, compared with sun comparison (pure Western medicine) being not added with Radix Glycyrrhizae, Cortex Cinnamomi, does not has significant change.
7., when the weight ratio of norfloxacin and Radix Glycyrrhizae, Cortex Cinnamomi is 1:20:5, norfloxacin is to drug resistance colon bacillus
Minimal inhibitory concentration all reduce more than 320 times, it is seen then that the drug resistance of norfloxacin is substantially dropped by drug resistance colon bacillus
Low.And when the weight ratio of norfloxacin and Radix Glycyrrhizae, Cortex Cinnamomi is 1:20:2,1:10:1,1:30:5,1:25:4 and 1:40:5, promise
The minimal inhibitory concentration of drug resistance colon bacillus compared with sun comparison (pure Western medicine) being not added with Radix Glycyrrhizae, Cortex Cinnamomi, is not had by Flucloxacillin
There is significant change.
8. when the weight ratio of ceftiofur sodium and Radix Glycyrrhizae, Cortex Cinnamomi is 1:20:5,1:30:5 and 1:25:4, ceftiofur sodium
The minimal inhibitory concentration of drug resistance colon bacillus is all reduced more than 32 times, it is seen then that drug resistance colon bacillus is to cephalo thiophene
The drug resistance of furan sodium substantially reduces.And when the weight ratio of ceftiofur sodium and Radix Glycyrrhizae, Cortex Cinnamomi is 1:10:1,1:20:2 and 1:40:5
Time, ceftiofur sodium to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Radix Glycyrrhizae, the sun of Cortex Cinnamomi compares (pure Western medicine)
Compare, there is no significant change.
9. the combination weight ratio working as fosfomycin and Radix Glycyrrhizae, Cortex Cinnamomi is 1:10:1,1:20:2,1:20:5,1:30:5,1:25:
4, during 1:40:5, to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Radix Glycyrrhizae, the sun of Cortex Cinnamomi compares (pure Western medicine) phase
Ratio, does not has significant change.
Two, the experiment in vitro that Western medicine and Radix Glycyrrhizae, Cortex Cinnamomi are used in combination
By amoxicillin, florfenicol, colistin, amikacin, sulfamonomethoxine sodium, LIJUNJING, promise fluorine sand
Star, 8 kinds of Western medicine of ceftiofur sodium are that 1:20:5 mixes with Radix Glycyrrhizae (powder) and Cortex Cinnamomi (powder) according to weight ratio respectively, make powder,
Respectively as test group 1#-8#；Separately set amoxicillin, florfenicol, colistin, amikacin, sulfamonomethoxine sodium,
LIJUNJING, norfloxacin, ceftiofur sodium, Radix Glycyrrhizae single dose, Cortex Cinnamomi single dose, Radix Glycyrrhizae+Cortex Cinnamomi (20:5) are respectively as matched group 1#-
11#。
Subjects is the chicken group making a definite diagnosis and having infected E.coli from chickens disease.
Morbidity chicken group is divided into 19 groups of administrations.The equal SM of each group 5 days.
Dosage and result of the test are as shown in the table:
Claims (2)
1. one kind containing Radix Glycyrrhizae, Cortex Cinnamomi and the poultry compound medicine of ceftiofur sodium, it is characterised in that by ceftiofur sodium and sweet
Grass, Cortex Cinnamomi composition, the weight ratio of ceftiofur sodium and Radix Glycyrrhizae, Cortex Cinnamomi is 1:20-30:4-5.
2. by the compound preparation become prepared by the poultry compound medicine described in claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610839493.7A CN106309555A (en) | 2016-09-21 | 2016-09-21 | Composite medicine containing liquorice roots, cinnamon and ceftiofur sodium for beasts and birds |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610839493.7A CN106309555A (en) | 2016-09-21 | 2016-09-21 | Composite medicine containing liquorice roots, cinnamon and ceftiofur sodium for beasts and birds |
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| CN106309555A true CN106309555A (en) | 2017-01-11 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948930A (en) * | 2014-05-14 | 2014-07-30 | 广西大学 | Red paeonia/beta-lactam-antibacterial-agent-containing compound medicine for livestock and fowl |
| CN104306422A (en) * | 2014-11-07 | 2015-01-28 | 广西大学 | Balsamiferou Blumea herb and beta-lactam antibacterial drug containing compound medicine for livestock and poultry |
| CN104435011A (en) * | 2014-11-12 | 2015-03-25 | 广西大学 | Compound medicine containing herba pteridis multifidae and beta-lactam antibiotics drugs for livestock and poultry |
-
2016
- 2016-09-21 CN CN201610839493.7A patent/CN106309555A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948930A (en) * | 2014-05-14 | 2014-07-30 | 广西大学 | Red paeonia/beta-lactam-antibacterial-agent-containing compound medicine for livestock and fowl |
| CN104306422A (en) * | 2014-11-07 | 2015-01-28 | 广西大学 | Balsamiferou Blumea herb and beta-lactam antibacterial drug containing compound medicine for livestock and poultry |
| CN104435011A (en) * | 2014-11-12 | 2015-03-25 | 广西大学 | Compound medicine containing herba pteridis multifidae and beta-lactam antibiotics drugs for livestock and poultry |
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Application publication date: 20170111 |