CN1063076C - Traditional Chinese medicinal leukogenic prepn. - Google Patents
Traditional Chinese medicinal leukogenic prepn. Download PDFInfo
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- CN1063076C CN1063076C CN97120998A CN97120998A CN1063076C CN 1063076 C CN1063076 C CN 1063076C CN 97120998 A CN97120998 A CN 97120998A CN 97120998 A CN97120998 A CN 97120998A CN 1063076 C CN1063076 C CN 1063076C
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Abstract
The present invention belongs to a traditional Chinese medicine preparation, particularly to a traditional Chinese medicine preparation for the adjuvant therapy of cancer by increasing leukocytes. The prescription of the present invention comprises: 30 to 55 wt% of spreading hedyotis herb, 30 to 55 wt% of astragalus root, and 15 to 40 wt% of solomonseal rhizome. All the materials are mixed and boiled with water, deslagged, concentrated, mixed with excipient flavoring agents, and made into various traditional Chinese medicine preparations. Proved by clinical practice, the present invention can improve leukocyte decrease in chemotherapy, increases leukocytes, improves marrow circulation, improves immunological functions, and has no toxic and side effect.
Description
The invention belongs to Chinese herbal and crude drugs preparations, relate in particular to a kind of Chinese medicine preparation of leukocyte increasing auxiliary for treating cancer.
The cancer method of treatment at present has four classes, i.e. operation, radiotherapy, chemotherapy and immunization therapy, the therapeutic alliance of these four kinds of methods has obtained great success, but chemotherapy can cause patient's bone marrow injury and leukopenia occur, and it is quite common clinically, nearly all patient all can occur, and most patients are also very serious to force chemotherapy to stop.How to make the very fast rising of leukocyte of decline, finish chemotherapy treatment, strengthen therapeutic effect, this also is a problem that is worth research in the chemotherapy at present, also is to desire the difficulty of being captured in the chemotherapy field.China's cancer morbidity is very high at present, and according to statistics in 1991, cancer took place annual about 1,250,000 people of China, about 900,000 people's death, these people all leukopenia can occur in chemotherapy, so research rises white method, seeking and rise the real necessity that belongs to of BAIYAO product, also is the task of top priority.The invention disclosed patent has at present: " Shengbaisan powder medicine for umbilicus and preparation using method " CN1131026A, " a kind of medicine for benefitting Qi, removing cancer and raising leucocyte and preparation method " CN1138476A " is used to improve human leukocytes.Hematoblastic Chinese patent medicine and preparation technology " CN1090191A, " restorative extract for raising leucocyte count " CN1081901A etc., but above-mentioned prior art effect is not satisfactory.
The objective of the invention is deficiency at above-mentioned prior art, from causing the Mechanism Study leukopenia of the bone marrow injury that cancer chemotherapy causes, the microcirculation that is mainly bone marrow suffers damage, cause that with chemotherapy in the past the infringement of bone marrow is that impaired this viewpoint of hematopoietic stem cell of bone marrow has different opinions, it is a kind of new viewpoint, to the treatment bone marrow injury, improve quantity of leucocyte, developed a kind of new white Chinese medicine preparation of the liter that has no side effect.
The object of the present invention is achieved like this: to improve the microcirculatory method of bone marrow, based on traditional Chinese medical science blood circulation promoting and blood stasis dispelling, nourishing kidney water, developed the white Chinese medicine preparation of a kind of liter, the prescription of said preparation is (percentage by weight): Herba Hedyotidis Diffusae 30-55%, Radix Astragali 30-55%, Rhizoma Polygonati 15-40%, through mixing decocting in water, remove slag, concentrate, add the figuration flavoring agent, as white sugar, starch etc., make injection, tablet, oral liquid, Chinese medicine preparation such as capsule.
The white Chinese medicine preparation clinical trial result of liter of the present invention: to 19 routine comparing property of leukopenia caused by cancer chemotherapy disease GP TH researchs, the result all obtains promising result with the kidney invigorating Chinese herbal medicine and Western medicine 654-II treatment group.19 examples are selected in treatment research, male 13 examples, and women 6 examples are divided into three treatment groups.General to rise white treatment group 6 examples be matched group, uses batyl alcohol 50mg, and January three times is oral, leucogen 20mg, and three times on the one are oral, treat for two weeks, and Chinese herbal treatment group 7 examples are used Chinese medicine formula, and decocting in water is obeyed potion every day, treats for two weeks.3 examples of 654-II treatment group 1 example and 654-II treatment group are being done the bone marrow analysis, and the bone marrow smear preceding with treatment compares, and observes the bone marrow recovery situation.
Curative effect determinate standard (4): total white blood cells rises to 4 * 10 in the week
9/ L is above to be produce effects, rises to 4 * 10 in two weeks
9/ L is above to be effectively, is lower than 4 * 10 in two weeks
9/ L is invalid.The results are shown in Table 1, table 2.
Table 1:
The paired observation of three treatment group therapeutic effect
Table 2: the recovery of Chinese herbal treatment and 654-II group treatment back bone marrow granulocyte series changes
| Rank | Total white blood cells * 10 9/l | Produce effects | Effectively | Invalid | ||
| Before the treatment | Treat a week | Treated for two weeks | ||||
| Chinese herbal medicine group (7 example) | 2.582 | 4.014 | 5.485 | 4 | 2 | 1 |
| 654-2 organizes (6 example) | 2.775 | 4.166 | 5.800 | 3 | 1 | 2 |
| Matched group (6 example) | 2.966 | 2.983 | 2.783 | 0 | 1 | 5 |
| The cell title | (12 example) meansigma methods before the treatment | Chinese drug-treated group treatment back (7 example) meansigma methods | 654-II treatment back (5 example) meansigma methods |
| Myeloblast | 0.73 | 0.78 | 0.33 |
| Promyelocyte | 6.18 | 5.64 | 6.83 |
| Children's grain in the neutrality | 10.86 | 10.14 | 11.33 |
| Young of neutral evening | 10.72 | 13.21↑ | 11.00↑ |
| Neutral band form nucleus | 9.27 | 10.92↑ | 10.16↑ |
| Neutral leaflet nuclear | 10.36 | 12.50↑ | 11.83↑ |
| Eosinophilic granulocyte | 1.59 | 2.35↑ | 2.83 |
| Have a liking for the alkali granulocyte | 0.61 | 0.42 | 0.33 |
Proved with the kidney invigorating Chinese herbal treatment from table 1, table 2 destructive microcirculation can significantly be recovered and take a turn for the better, treat aplastic anemia with anisodamine, can improve the bone marrow microcirculation, aplastic anemia is taken a turn for the better, above basic research and clinical practice prove, form prescription to leukopenia caused by cancer chemotherapy disease with the kidney invigorating Chinese herbal medicine pointedly, curative effect is all felt quite pleased as a result, the curative effect that obtains by this tentative treatment proves, has confirmed the microcirculatory infringement of bone marrow just of leukopenia caused by cancer chemotherapy disease more.All have no side effect with rising white Chinese medicine preparation by the clinical practice proof.
Embodiment one: Herba Hedyotidis Diffusae 55%, the Radix Astragali 30%, Rhizoma Polygonati 15%.
Embodiment two: Herba Hedyotidis Diffusae 30%, the Radix Astragali 55%, Rhizoma Polygonati 15%.
Embodiment three: Herba Hedyotidis Diffusae 30%, the Radix Astragali 30%, Rhizoma Polygonati 40%.
By above-mentioned prescription, claim complete putting in the enamel extraction pot with Herba Hedyotidis Diffusae, the Radix Astragali, Rhizoma Polygonati, use the distilled water lixiviate, filtrate is collected in steaming and decocting, filtration, and then decocts with distilled water, merging filtrate, concentrate and to add the figuration flavoring agent,, can be made into various injections, tablet, oral liquid, capsule etc. as white sugar, starch etc.
Claims (2)
1, a kind of leukocyte increasing Chinese medicine preparation is characterized in that being made by the following raw material medicines in percentage by weight thing: Herba Hedyotidis Diffusae 30-55%, Radix Astragali 30-55%, Rhizoma Polygonati 15-40% and an amount of figuration flavoring agent.
2, Chinese medicine preparation as claimed in claim 1 is characterized in that described figuration flavoring agent is white sugar, starch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97120998A CN1063076C (en) | 1997-12-09 | 1997-12-09 | Traditional Chinese medicinal leukogenic prepn. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97120998A CN1063076C (en) | 1997-12-09 | 1997-12-09 | Traditional Chinese medicinal leukogenic prepn. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1184667A CN1184667A (en) | 1998-06-17 |
| CN1063076C true CN1063076C (en) | 2001-03-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97120998A Expired - Fee Related CN1063076C (en) | 1997-12-09 | 1997-12-09 | Traditional Chinese medicinal leukogenic prepn. |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884730A (en) * | 2010-05-21 | 2010-11-17 | 吉林大学 | Chinese medicinal preparation for treating hypoproteinemia caused by liver damage |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1085409A (en) * | 1992-09-19 | 1994-04-20 | 黄琼林 | Schizandrol |
| CN1099993A (en) * | 1994-04-08 | 1995-03-15 | 蓝烈风 | Biological immunopotentiator "Kangaiping" |
-
1997
- 1997-12-09 CN CN97120998A patent/CN1063076C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1085409A (en) * | 1992-09-19 | 1994-04-20 | 黄琼林 | Schizandrol |
| CN1099993A (en) * | 1994-04-08 | 1995-03-15 | 蓝烈风 | Biological immunopotentiator "Kangaiping" |
Non-Patent Citations (3)
| Title |
|---|
| 《中华血液杂志》9(3) 1988.3.31 李琰等，HPOAP方案中医药治疗急性非淋巴细胞白血病55例 * |
| 《贵州医药》12(1) 1988.1.31 张礼宾等，微量元素结合中药治疗慢性粒细胞性血病 * |
| 《贵州医药》12(1) 1988.1.31 张礼宾等，微量元素结合中药治疗慢性粒细胞性血病;《中华血液杂志》9(3) 1988.3.31 李琰等，HPOAP方案中医药治疗急性非淋巴细胞白血病55例 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884730A (en) * | 2010-05-21 | 2010-11-17 | 吉林大学 | Chinese medicinal preparation for treating hypoproteinemia caused by liver damage |
| CN101884730B (en) * | 2010-05-21 | 2012-07-25 | 吉林大学 | Chinese medicinal preparation for treating hypoproteinemia caused by liver damage |
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| Publication number | Publication date |
|---|---|
| CN1184667A (en) | 1998-06-17 |
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