CN1063028A - A kind of preparation method of medicine cigarette - Google Patents
A kind of preparation method of medicine cigarette Download PDFInfo
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- CN1063028A CN1063028A CN 91100116 CN91100116A CN1063028A CN 1063028 A CN1063028 A CN 1063028A CN 91100116 CN91100116 CN 91100116 CN 91100116 A CN91100116 A CN 91100116A CN 1063028 A CN1063028 A CN 1063028A
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- gynostemma pentaphylla
- cigarette
- cauline leaf
- fermentation
- pentaphylla cauline
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Abstract
The present invention is a kind of preparation method that contains the cigarette of medicinal herb components.Main points of the present invention are in the technology of the production smoke product of routine, and the gynostemma pentaphylla cauline leaf is evenly joined in the pipe tobacco, and its addition is the 1%-10% of pipe tobacco weight.It is additive that the present invention selects gynostemma pentaphylla for use, science grafts on the pipe tobacco carrier, and the gynostemma pentaphylla cauline leaf is completed and fermentation process, gynosaponin active ingredient is fully volatilized when smoking, thereby make cigarette product reduce the content of TPM in the smog, weakened the toxic action of tar human body.
Description
The invention belongs to tobacco industry, specifically it relates to a kind of preparation method that contains the cigarette of Chinese herbal medicine composition.
Smoking is a human hobby greatly, but smoking is to the toxic effect of human body.According to reports: contain multiple noxious material in cigarette smoke, these materials can cause increasing of disease incidents such as human body cancer, arterial thrombotic disease, immunologic function reduction, breathing problem, hypogona dism.Therefore, weaken smoking hobby person suffered murder by poisoning in smoking as a kind of low toxicity how or few malicious cigarette, not having is a major issue that the worth relevant personnel pay attention to fixed attention.In recent years done a large amount of work both at home and abroad in this regard, the emphasis of research is the prescription that improves tobacco, reduces tar content to reduce the murder by poisoning of cigarette.
China's traditional Chinese medicine and pharmacy is the treasure-house of a greatness, for thousands of years the people is prevented and cured diseases, multiplies the Chinese nation and played great function, and the efficacy of a drug and effect that it is magical are more and more attracted attention by countries in the world.When China develops blended type cigarette at home and abroad in recent years, at first the theory with traditional Chinese medicine is applied in the tobacco industry, promptly under instruction of Chinese Medicine theory, in cigarette, add the Chinese herbal medicine of preventing and curing diseases, increase Abwehrkraft des Koepers, make and in smoking, to prevent and treat some disease.
It as application number the preparation method of having introduced in 86101200 the patent application prospectus by a kind of Chinese herbal medicine curative effect cigarette of Jiangxi branch company of China Tobacco Corporation Jiangxi south cigar mill exploitation, this method is 0.01%-0.6%(weight) oil of negundo chastetree be dissolved in 0.3%(weight) flavouring essence for tobacco, add 0.1-3.0%(weight after the blending in dry) Chloranthus glaber medicinal extract, spray into pipe tobacco behind the fixation.It is said that this smoking set eliminates the phlegm, antibechic, antiasthmatic effect, chronic bronchitis is had therapeutic action.
Application number is a kind of medicine cigarette that contains coral ginger composition of having introduced in China's patent application prospectus of 89100495 by Qing Song Cigarette Factory, Guizhou Prov.'s development for another example, it be add to after Chinese medicine coral ginger is made essential oil, water juice or makes dry plate, silk and powder stir in the pipe tobacco after routinely technology roll cigarette getting final product.This cigarette be utilize cigarette combustion exist temperature from high to low thermograde and the Chinese medicine of interpolation have volatile characteristics, thereby make the not burned purpose that reaches diseases prevention, cures the disease in the human body that just is inhaled into of Chinese medicine.It is said that this cigarette is very effective to disease anti-, treating respiratory system, have relieving asthma, eliminate the phlegm, effect such as antibechic.
The medicine cigarette that is representative with above-mentioned these two kinds of cigarettes mainly is the disease of anti-treating respiratory system, but to other disease effect of being of no curative effect that causes owing to smoking, and this smoking set has certain flavour of a drug, must suck by drug dose, can produce certain side effect above sucking number, as healthy people it is used as common cigarette and sucks for a long time, develop immunity to drugs possibly and other side effect, so it is sucked market and is very restricted.
The present inventor is when carrying out the developmental research of gynostemma pentaphylla, found that gynosaponin can treat and suppress the multiple disease that causes owing to smoking, its pharmacology, toxicology and clinical proof are reliable to body-care, and the effect mystery can have following effect by the effect conclusion:
1, reduces blood fat, study of anti-atherogenic effect.
Atherosis at the mid-aged population medium sized artery is a kind of common disease, frequently-occurring disease.Cause coronary heart disease and cranial vascular disease by atherosclerotic, become the first cause of disease that causes the elderly dead.Its incidence, the smoker wants high than the non-smoker.Pharmacological evaluation proves, arterial lumen is atherosis an antagonism to gynostemma pentaphyllum total saponin to forming.
2, antithrombotic forms.
Think at present, platelet aggregation and release, blood viscosity raises, and plays an important role in the generation of coronary heart disease, cerebral thrombus and evolution.Pharmacological evaluation proves that gynostemma pentaphyllum total saponin has remarkable platelet aggregation-against and release action, and therefore for preventing and treating coronary heart disease, cerebral thrombus has crucial meaning.
3, strengthen myocardial contractive power, the protection ischemic myocardium dwindles the effect of myocardial infarct size.
Experimental results show that: gynostemma pentaphyllum total saponin can obviously improve the shrinkage of cardiac muscle, strengthens myocardial contractive power.Experiment is proof also; gynostemma pentaphyllum total saponin has the protection myocardial ischemia-reperfusion injury; improve myocardium antioxidant enzyme-glutathione oxidase activity; reduce the myocardial lipid peroxide mda content; thereby protection cardiac muscle fibre ultra microstructure; dwindle myocardial infarct size, reduce incidence of arrhythmia.Therefore, can be used for prevention and treatment coronary heart disease myocardial infarction, myocarditis and cardiomyopathies, cardiac insufficiency etc.
4, strengthen the effect of immune function of human body.
The human immunologic function has infection resisted and immunosurveillance, when immune function of human body is low, unmanageable infection takes place easily.Immunosurveillance is low, can not the kill mutation cell, malignant tumour easily takes place.Pharmacology and clinical research prove that gynostemma pentaphyllum total saponin has highly significant and strengthens human body cell immunity and humoral immunity effect.The clinical preventing cold that is used for, viral disease and treatment immunocompromised diseases such as hepatitis demonstrate curative effect preferably.
5, pharmacological evaluation proves, gynostemma pentaphyllum total saponin has remarkable inhibition growth of tumour cell, is 87% to S-180 sarcoma inhibiting rate, and cultivating proof through cell has direct killing action to tumour cell, kill ratio is up to 91%, and known anticancer drugs endoxan effect at present is obvious.The clinical liver cancer, cancer of the stomach, thyroid cancer of being used for the treatment of has effect preferably.
6, delaying senility function.
Adopt cell culture method to experiment showed, that during cell proliferation gynostemma pentaphyllum total saponin can make Werner syndrome patient's epidermal cell proliferation, be increased to for 27 generations by 22 generations, promptly prolong 22.7% of cell survival.Cell is the basis of life, and gynostemma pentaphyllum total saponin can be used as the cell activity agent, strengthens ability of cell proliferation and prolongs cell survival.Prove that through pharmacological evaluation gynostemma pentaphyllum total saponin can prolong the tired time 40-61% till death of small white mouse swimming, and have significant anti-weary oxygen and reduce the lipid peroxide effect, thus obvious delaying senility function.
The purpose of this invention is to provide and a kind ofly add the effective-part of Gynostemma pentaphyllum in the cigarette process, the health-care effect of gynostemma pentaphylla is given full play in smoke product, thereby provide a kind of disease that is not subjected to plant the restriction and the health medical cigarette of the amount of being sucked restriction not, it has weakening, reduces the murder by poisoning of tar to body, quicken the accretion rate of tar in human body, strengthen the characteristics of the self-defense system of human body, play the effect of " setting upright reinforcing ".
Be used for the meaning that the following term of this specification has aftermentioned to show.
Gynostemma pentaphylla: be a kind of Curcurbitaceae herbaceous species plant, its formal name used at school is Gynostemma Pentaphyllum Makino, kind of ginseng saponin's material surplus it contains 80, and wherein six kinds is panaxoside-Rb
1, Rb
3, Rd, Rg
3, F
2, ginsengenin K, the isomers of all the other glucosides, these isomers are found in panax ginseng plant as yet.Its total saponin content is three times of genseng, and wherein Rd content is the octuple of genseng.
Gynosaponin: be meant the method for taking various extraction saponins and total saponin or part saponin or the saponin monomer that from gynostemma pentaphyllum herb, extracts.
The objective of the invention is to adopt following technical measures to realize, produce in the production process of cigarette in routine, after gynostemma pentaphylla cauline leaf process airing and the break process, it is joined in the pipe tobacco, addition is the 1%-10% of pipe tobacco weight, and mixes with pipe tobacco.Break process preferably is cut into the gynostemma pentaphylla cauline leaf thread.
In order to eliminate the clear grass flavor of gynostemma pentaphylla cauline leaf, the present invention can be to the gynostemma pentaphylla processing that completes before airing and break process, its fixing method and process are: the gynostemma pentaphylla cauline leaf is after removal of impurities is handled, and layering is packed in the container, is warming up to 100-260 ℃, kept 15-45 minute, and took out cool the solarization.
In order to help the release volatilization of active ingredient, the present invention is before airing and break process, also can carry out fermentation process to the gynostemma pentaphylla cauline leaf, its fermentation process and process are: the insulation of packing in the container of gynostemma pentaphylla cauline leaf is allowed its spontaneous fermentation 12-24 hour, fermentation temperature maintains 20-40 ℃, treats to take out cool the solarization 1-3 hour from container after the flavescence of gynostemma pentaphylla cauline leaf.As the one time fermentation poor effect, also can carry out the second time or fermentation for the third time.
In order to obtain best care treatment effect, the present invention also can add icariine and/or Bergenin, and its addition is the 0.001%-0.01% of pipe tobacco or tobacco leaf weight, also can add the other medicines composition simultaneously.
The front is mentioned, and smoking is people's a hobby greatly, but smoking also has certain harm to health.One, smoking has harm to cardiovascular system, can make T-CHOL rising in the blood, and low-density lipoprotein raises, and HDL reduces, and easily causes atherosclerosis.Also possibility elevating blood viscosity strengthens platelet aggregation and release action, easily produces coronary heart disease; Its two, smoking reduces immune function of human body, the easy infection various diseases; Its three, smoking might make cell undergo mutation, and causes cancer to take place.Particularly lung cancer patient and smoking have very big relation or the like.Prove that from above-mentioned gynostemma pentaphyllum total saponin pharmacological action and clinical research it all has prevention effect well to smoking to the multiple harm that human body brings.The present invention utilizes this effect of gynostemma pentaphyllum total saponin and gynostemma pentaphylla is joined in the cigarette, and takes effective processing procedure that the gynostemma pentaphyllum total saponin composition is evaporated from pipe tobacco, to play the effect that reduces noxious material in the cigarette, prevents and cures diseases.
Can for the release of volatilizing of the active ingredient in the gynostemma pentaphylla cauline leaf that confirms to add in the pipe tobacco, the present invention detects flue gas.Its result is: through to carry out thin-layer chromatography qualitative to containing the strand blue smoke, spectrophotometry and high pressure liquid phase are measured proof, and 75-80% can be dispersed in the flue gas when gynostemma pentaphyllum total saponin burnt at cigarette.
In order further to confirm to be added with the functions of prevention and health care of the cigarette of gynostemma pentaphylla to body, the present invention has also carried out pharmacology, toxicity and experimental study such as clinical to cigarette product, and its result is as follows.
To containing the pharmacological research of strand blue smoke.
As follows through 45 days experimental results of small white mouse contamination:
1, adds gynostemma pentaphylla cauline leaf cigarette general situation of animal and peripheral blood are learned obviously influence of nothing.
2, with the contrast cigarette relatively, add the strand blue smoke and can resist tar toxicity, prolong the incubation period of animal cough reaction, the cholesterol that do not raise, this is its characteristics.
3, add the strand blue smoke by the acute toxicity contrast and experiment, the LD of contrast cigarette
50Be 14.26ml/kg, and add the LD of strand blue smoke
50Be 22.44ml/kg, reduced by 1.92 times than the blank smoke toxicity thereby proof adds the strand blue smoke.
To containing the toxicological study result of gynostemma pentaphyllum total saponin cigarette:
1, the TPM in the flue gas after measured, adding the strand blue smoke is that 23.38mg/ props up (cigarette), the contrast cigarette is that 25.94mg/ props up (cigarette), as seen contain the harmful material " TPM " in the gynostemma pentaphyllum total saponin cigarette, compare with the contrast cigarette and to have reduced 2.56mg/ and prop up (cigarette), this endangers less cigarette to for the moment can not the ES providing undoubtedly.
2, prove through subacute, genetic toxicology, immunotoxicity result of the test, add the cigarette of gynostemma pentaphylla, every physical signs of animal is not had influence, also hereditary-less toxicity, immunotoxicity reaction.
3, the cigarette that adds gynostemma pentaphylla is significant minimizing to the mouse chromosome distortion incidence, for the contrast cigarette half, thereby proof is added with the cigarette of gynostemma pentaphylla chromosomal damage is had protective effect, and this point is consistent with gynostemma pentaphylla medicine antitumor action.
4, studies have shown that through immunotoxicology, the obvious atrophy of common cigarette group mouse spleen, and add strand blue smoke mouse spleen weight near normal, compare no significant difference with the blank group.Thereby prompting adds gynostemma pentaphylla the mouse immune murder by poisoning that cigarette causes there is protective effect.
Contain the clinical research of gynostemma pentaphyllum total saponin cigarette.
Carry out clinical research through 540 routine healthy people being sucked respectively add the strand blue smoke and contrast cigarette, its result is:
1, adds the gynostemma pentaphylla smoking set certain reduction low-density lipoprotein, triglyceride, T-CHOL are arranged, blood sugar and whole blood are sticking than degree effect, and the effect of increasing high density lipoprotein, thereby to delaying artery sclerosis, the development of coronary heart disease and cerebrovascular disease has certain prevention meaning.
2, suction adds strand blue smoke group comparison T-CHOL, triglyceride, low-density lipoprotein before and after smoking all remarkable reduction, and antiatherosclerosis material-HDL obviously raises, and blood fat is also had reduction effect preferably.
3, contain the effect that the gynostemma pentaphyllum total saponin cigarette has certain reduction platelet adhesion reaction, gathering and release.Thereby to prevent and treat artery sclerosis, coronary heart disease has meaning.
4, add the side effect that the strand blue smoke has prevented cigarette substantially, and have certain adjustment t lymphocyte subset group structure, improve the pharmacological action of body's immunity, have certain meaning preventing immunocompromised diseases such as respiratory tract infection, tumour.
The present invention selects the gynostemma pentaphylla cauline leaf for use or is additive based on the Chinese herbal compound preparation of gynostemma pentaphylla cauline leaf, scientifically graft on the pipe tobacco carrier, and the gynostemma pentaphylla cauline leaf is completed and fermentation process, gynosaponin active ingredient is fully volatilized when smoking, thereby make cigarette product not only reduce the content of TPM in the smog, antagonism is arranged, weaken, degraded tar is to the toxic action of human body, quicken tar in body intracellular metabolite speed, also has the t lymphocyte subset of adjustment group structure, improve natural killer cell activity, strengthen human body immune function, reduce blood-fat and blood sugar, lower blood viscosity, resisting thrombotic diseases is regulated blood pressure, tonifying kidney and strengthening yang, the sharp phlegm of cough-relieving, the defense function of activation body self.Thereby a kind of not amount of being sucked and sick medicine cigarette of planting restriction are provided, have reached purpose of the present invention.
Below be several embodiments of the present invention, it can further describe the present invention, but does not limit the present invention.
Embodiment 1 packs the gynostemma pentaphylla cauline leaf in the wooden cylinder, covers the cotton-wadded quilt insulation, and temperature maintenance is at 30 ℃, allows its spontaneous fermentation 20 hours, and it is standby to take out airing during its leaf flavescence.Get 1 kilogram of above-mentioned gynostemma pentaphylla cauline leaf, chopping mixes itself and 100 kilograms of pipe tobaccos in the process of producing cigarette, and technology rolls cigarette routinely again.Goods are good through sucking mouthfeel alcohol fragrance.TPM is 24.75 milligrams/after measured, and tar content is 21.98 milligrams/.
Embodiment 2 gets 5 kilograms of the gynostemma pentaphylla cauline leafs of above-mentioned fermentation, and chopping mixes itself and 100 kilograms of pipe tobaccos in the process of producing cigarette, and technology rolls cigarette routinely again.Goods are good through sucking mouthfeel alcohol fragrance.TPM is 22.02 milligrams/after measured, and tar content is 19.82 milligrams/.
Embodiment 3 packs the layering of gynostemma pentaphylla cauline leaf in the container, feeds Steam Heating 30 minutes, take out cool shine standby.Get 10 kilograms of this treated gynostemma pentaphylla cauline leafs, chopping mixes itself and 100 kilograms of pipe tobaccos in the process of producing cigarette, and technology rolls cigarette routinely again.Goods are good through sucking mouthfeel alcohol fragrance.TPM is 23.04 milligrams/after measured, and tar content is 19.98 milligrams/.
Claims (5)
1, a kind of preparation method of medicine cigarette, adopt the production technology of conventional production cigarette product, feature of the present invention is to produce in the production process of cigarette in routine, after gynostemma pentaphylla cauline leaf process airing and break process, join in the pipe tobacco, addition is the 1%-10% of pipe tobacco weight, and mixes with pipe tobacco.
2, in accordance with the method for claim 1, it is characterized in that break process is to be cut into the gynostemma pentaphylla cauline leaf thread.
3, according to claim 1 or 2 described methods, it is characterized in that before airing and break process, can be to the gynostemma pentaphylla processing that completes, its fixing method and process are: the gynostemma pentaphylla cauline leaf is after removal of impurities is handled, and layering is packed in the container, is warming up to 100-260 ℃, kept 15-45 minute, and took out cool the solarization.
4, according to claim 1 or 2 described methods, it is characterized in that before airing and break process, also can carry out fermentation process to the gynostemma pentaphylla cauline leaf, its fermentation process and process are: the insulation of packing in the container of gynostemma pentaphylla cauline leaf is allowed its spontaneous fermentation 12-24 hour, fermentation temperature maintains 20-40 ℃, treats to take out cool the solarization 1-3 hour from container after the flavescence of gynostemma pentaphylla cauline leaf.
5, in accordance with the method for claim 3, it is characterized in that before airing and break process, also can carry out fermentation process to the gynostemma pentaphylla cauline leaf, its fermentation process and process are: the insulation of packing in the container of gynostemma pentaphylla cauline leaf is allowed its spontaneous fermentation 12-24 hour, fermentation temperature maintains 20-40 ℃, treats to take out cool the solarization 1-3 hour from container after the flavescence of gynostemma pentaphylla cauline leaf.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91100116 CN1021722C (en) | 1991-01-05 | 1991-01-05 | Method for preparing medicine tabacco |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91100116 CN1021722C (en) | 1991-01-05 | 1991-01-05 | Method for preparing medicine tabacco |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1063028A true CN1063028A (en) | 1992-07-29 |
| CN1021722C CN1021722C (en) | 1993-08-04 |
Family
ID=4904452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 91100116 Expired - Fee Related CN1021722C (en) | 1991-01-05 | 1991-01-05 | Method for preparing medicine tabacco |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1021722C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104783326A (en) * | 2015-04-17 | 2015-07-22 | 张嘉河 | Producing method for cigarette with lung clearing function and cigarette with lung clearing function |
| CN105533792A (en) * | 2016-03-07 | 2016-05-04 | 玉溪开元金蓝生物科技有限责任公司 | Cigarette substitute prepared from plumeria rubra and preparation method thereof |
| CN105768200A (en) * | 2016-04-06 | 2016-07-20 | 玉溪开元金蓝生物科技有限责任公司 | Application of plumeria rubra and leaves in cigarette |
-
1991
- 1991-01-05 CN CN 91100116 patent/CN1021722C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104783326A (en) * | 2015-04-17 | 2015-07-22 | 张嘉河 | Producing method for cigarette with lung clearing function and cigarette with lung clearing function |
| CN105533792A (en) * | 2016-03-07 | 2016-05-04 | 玉溪开元金蓝生物科技有限责任公司 | Cigarette substitute prepared from plumeria rubra and preparation method thereof |
| CN105533792B (en) * | 2016-03-07 | 2017-01-18 | 玉溪开元金蓝生物科技有限责任公司 | Cigarette substitute prepared from plumeria rubra and preparation method thereof |
| CN105768200A (en) * | 2016-04-06 | 2016-07-20 | 玉溪开元金蓝生物科技有限责任公司 | Application of plumeria rubra and leaves in cigarette |
| CN105768200B (en) * | 2016-04-06 | 2017-04-19 | 玉溪开元金蓝生物科技有限责任公司 | Application of plumeria rubra and leaves in cigarette |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1021722C (en) | 1993-08-04 |
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Granted publication date: 19930804 Termination date: 20100105 |