CN106281978B - A kind of combined type defoaming paddle and the miniature organism reactor using combined type defoaming paddle - Google Patents
A kind of combined type defoaming paddle and the miniature organism reactor using combined type defoaming paddle Download PDFInfo
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- CN106281978B CN106281978B CN201610643053.4A CN201610643053A CN106281978B CN 106281978 B CN106281978 B CN 106281978B CN 201610643053 A CN201610643053 A CN 201610643053A CN 106281978 B CN106281978 B CN 106281978B
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- paddle
- combined type
- ring
- mechanical sealing
- agitating shaft
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/02—Means for regulation, monitoring, measurement or control, e.g. flow regulation of foam
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
- C12M27/08—Stirrer or mobile mixing elements with different stirrer shapes in one shaft or axis
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- Bioinformatics & Cheminformatics (AREA)
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- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
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- Analytical Chemistry (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses a kind of combined type defoaming paddle and using the miniature organism reactor of combined type defoaming paddle, combined type defoaming paddle includes blade, retaining ring, and a pair of of blade is horizontally set on the outer ring of retaining ring, passes straight through the geometric center of retaining ring where blade；The miniature organism reactor includes tank body, agitating shaft, cover, mechanical seal and agitating paddle；Agitating shaft passes through the centre bore of cover, is arranged in the inner cavity of tank body；Mechanical sealing linkage ring, agitating paddle are arranged on agitating shaft；Combined type defoaming paddle is additionally provided on agitating shaft.Combined type defoaming paddle provided by the invention and the miniature organism reactor that paddle is defoamed using combined type, its is compact-sized, it is rationally distributed, the retaining ring for defoaming paddle and mechanical sealing linkage ring uses fabricated structure, on the basis of guaranteeing defoaming function, the coefficient of miniature organism reactor is effectively increased, while simplifying structure in tank, convenient for operation, cleaning, dead angle risk is reduced, more preferably meets the requirement of microreactor.
Description
Technical field
The present invention relates to microreactor technical field, espespecially a kind of combined type defoams paddle and using combined type defoaming paddle
Miniature organism reactor.
Background technique
In recent years, designative species have played increasing effect in national economy, have received more multimedia and
The concern of common people.The technology source of microbial fermentation pharmacy is the strain of microorganism, and a good microorganism fungus kind is certain
The quality and quantity for the drug that microbial fermentation generates is determined in degree.And the High Throughput Screening Assay of strain is its performance improvement
One of important link.
Currently, High Throughput Screening Assay increasingly obtains paying attention to and developing because of its screening efficiency height, and high flux screening needs
It to be completed by miniature organism reactor.
Defoaming paddle is the important component of bioreactor, and effect is the bubble smashing the ventilation of reactor internal cause and stirring and being formed
Foam prevents foam from taking out of in reactor with exhaust, and reactor is caused to escape liquid.
Conventional bioreactor construction schematic diagram, as shown in Figure 1.Conventional bioreactor includes tank body, cover, stirs
Mix axis, mechanical sealing linkage ring, mechanical sealing static ring, agitating paddle, conventional retaining ring, the conventional defoaming paddle being made of blade and wheel hub.
It is separate structure positioned at the mechanical sealing linkage ring of tank interior, retaining ring, defoaming paddle, retaining ring is being stirred for compressing setting
The mechanical sealing linkage ring on axis is mixed, mechanical sealing linkage ring is caused to mutually compress with the stationary ring being located in cover locating slot, is guaranteed anti-
The sealing of gas in device is answered to form tank pressure；Defoaming paddle is usually mounted on the agitating shaft between liquid level and cover, according to liquid level
Height can carry out high low adjustment with foam situation, with control foam position height.
Since the requirement of microreactor axial dimension is smaller, traditional structure is such as used, the position for defoaming paddle will reduce, shadow
The coefficient of microreactor is rung, while increasing the difficulty of operation and maintenance in a limited space.
Summary of the invention
The miniature organism reactor of paddle is defoamed the object of the present invention is to provide a kind of combined type defoaming paddle and using combined type,
On the basis of not influencing defoaming function, the axial space of miniature organism reactor is effectively reduced, convenient for cleaning and maintenance, letter
The internal structure and operation for having changed the microreactor for high flux screening require.
Technical solution provided by the invention is as follows:
A kind of combined type defoaming paddle comprising: a pair of of blade and retaining ring, the pair of blade are horizontally set on the outer of retaining ring
Circle, and the geometric center of retaining ring is passed straight through where the pair of blade.
Specifically, a pair of of blade is arranged on the outer ring of retaining ring, position level is opposite, passes straight through gear where blade
The geometric center of circle.
It is further preferred that the lower part of the blade is provided with zigzag structure or flat impeller structure or orthogonal circle
The composite structure of bar and thin bar, to guarantee good defoaming effect.
Specifically, blade lower part according to requirements used by zigzag, put down on leaf, lateral circular bar shape or round bar plus
Fill the bubble contact in the form structures, with tank body such as vertical bar on liquid level, it is easier to bubble is poked, to destroy in tank body on liquid level
Bubble, guarantee good defoaming effect.
It is further preferred that the bottom of the blade is flushed with the bottom of retaining ring.
Specifically, the design that the bottom of blade is flushed with the bottom of retaining ring, is effectively ensured combined type defoaming paddle manufacture craft
Uniformity, thus guarantee defoam paddle structure consistency, to avoid the multi-channel miniature reactor based on parallel test principle
Mutual internal components structure size is inconsistent, and influences the test data of high flux screening.
The present invention also provides a kind of miniature organism reactors comprising tank body, agitating shaft, cover, mechanical sealing linkage ring,
Mechanical sealing static ring and agitating paddle；The mechanical sealing static ring is fixed below cover；Agitating shaft passes through the centre bore of cover,
It is arranged in the inner cavity of tank body；The mechanical sealing linkage ring, agitating paddle are arranged on agitating shaft；Be additionally provided on agitating shaft as
Combined type above-mentioned defoams paddle.
It is further preferred that the lower part of the mechanical sealing linkage ring is arranged in the combined type defoaming paddle, wherein described group
Press the mechanical sealing linkage ring at the top of retaining ring on box-like defoaming paddle to realize axial limiting.
It is further preferred that position of the combined type defoaming paddle on the agitating shaft is adjustable, to adjust to the machine
The compression degree of tool moving sealing ring.
It is further preferred that passing through clamp screw after position of the combined type defoaming paddle on the agitating shaft determines
Combined type defoaming paddle is fixed on the agitating shaft by nail.
It is further preferred that after position of the combined type defoaming paddle on the agitating shaft determines, by wearing pin
The retaining ring is fixed on the agitating shaft by column, combined type defoaming paddle is fixed on the agitating shaft, to fix
To the crush of the mechanical sealing linkage ring.
A kind of combined type defoaming paddle provided through the invention and the miniature organism reactor using combined type defoaming paddle, energy
Enough bring it is following at least one the utility model has the advantages that
(1) defoaming paddle uses fabricated structure, compact-sized, rationally distributed, ensure that the defoaming of miniature organism reactor
Function.
(2) paddle is defoamed using combined type, can effectively reduces the axial space of miniature organism reactor, meets microreactor
Use and operation require.The stirring system of standard biologic reactor, be by the retaining ring of mechanical sealing linkage ring with defoaming paddle respectively
It is independently arranged, and the tank body geometric dimension of miniature organism reactor is smaller, especially tank inner height is inadequate, and setting two is independent
Structure (retaining ring and defoaming paddle) just makes defoaming paddle position too low, reduces the coefficient of microreactor, while in the confined space
Inside increase the difficulty of operation and maintenance.In the present invention, it is integrated into for compressing the retaining ring of mechanical sealing linkage ring with defoaming paddle
One, combined type defoam the retaining ring in paddle and both compress to mechanical sealing linkage ring, while retaining ring is made to defoam the wheel hub use of paddle again；And
And blade also acts as defoaming effect.Such structure can not only play the position-limiting action to mechanical sealing linkage ring, but also keep away
The position for exempting to defoam paddle is too low, can effectively crush foam.Further, both this structure being integrated also effectively reduces
The axial space requirement of miniature organism reactor.
Detailed description of the invention
Below by clearly understandable mode, preferred embodiment is described with reference to the drawings, to a kind of combined type defoam paddle and
Above-mentioned characteristic, technical characteristic, advantage and its implementation using the miniature organism reactor of combined type defoaming paddle give into one
Walk explanation.
Fig. 1 is traditional bioreactor construction schematic diagram；
Fig. 2 is combined type defoaming a kind of structural schematic diagram of embodiment of paddle of the present invention；
Fig. 3 is a kind of miniature organism reactor structural schematic diagram of embodiment of the present invention using combined type defoaming paddle.
Drawing reference numeral explanation:
1. retaining ring；2. blade；
3. agitating shaft；4. tank body；5. agitating paddle；6. cover；7. mechanical sealing linkage ring；
8. tank body；9. cover；10. agitating shaft；11. mechanical sealing linkage ring；12. agitating paddle；13. traditional retaining ring；14. tradition
Defoam paddle.
Specific embodiment
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, Detailed description of the invention will be compareed below
A specific embodiment of the invention.It should be evident that drawings in the following description are only some embodiments of the invention, for
For those of ordinary skill in the art, without creative efforts, it can also be obtained according to these attached drawings other
Attached drawing, and obtain other embodiments.
To make simplified form, part related to the present invention is only schematically shown in each figure, they are not represented
Its practical structures as product.In addition, there is identical structure or function in some figures so that simplified form is easy to understand
Component only symbolically depicts one of those, or has only marked one of those.Herein, "one" is not only indicated
" only this ", can also indicate the situation of " more than one ".
Fig. 1 is traditional bioreactor construction schematic diagram, and traditional bioreactor includes tank body 8, cover 9, stirring
Axis 10, mechanical sealing linkage ring 11, agitating paddle 12, traditional retaining ring 13, tradition defoaming paddle 14.
Traditional retaining ring 13, tradition defoaming paddle 14 inside tank body 8 are separate structure, and traditional retaining ring 13 is set for compressing
Set the mechanical sealing linkage ring 11 on agitating shaft 10, cause mechanical sealing linkage ring 11 be located at 9 stationary ring locating slot of cover in it is quiet
Ring mutually compresses, and guarantees that the sealing of gas in reactor forms tank pressure；Defoaming paddle is formed for smashing the ventilation of tank internal cause with stirring
Foam, prevent foam from taking out of in tank with exhaust and cause to escape liquid, tradition defoaming paddle 14 be usually mounted between liquid level and cover 9
On agitating shaft 10, high low adjustment can be carried out according to the height of liquid level and foam situation, to control foam position height.Retaining ring with disappear
Bubble paddle relies on holding screw and laterallys secure from the hub positions of the two on agitating shaft.And in microreactor, due to tank
Body geometric dimension is small, and especially tank inner height is inadequate, and two wheel hubs are arranged and make defoaming paddle position too low, and due to minisize reaction
The requirement of device axial dimension is smaller, using above-mentioned traditional structure, and can reduce the stocking volume of reactor, increase cleaning and operation
Difficulty.
In the embodiment one of combined type of the present invention defoaming paddle comprising a pair of of blade, retaining ring, wherein a pair of of blade water
The flat outer ring that retaining ring is set, and the geometric center of retaining ring is passed straight through where blade, to realize symmetrical structure, to guarantee
The even results of defoaming.Structure through this embodiment, can be by the mechanical sealing linkage ring retaining ring and defoaming paddle in traditional structure
It is combined into one, when effectively reducing combined type defoaming paddle applied in miniature organism reactor, to axially mounted bulk
Requirement, while simplifying structure in the tank of reactor, convenient for operation, cleaning, reduce dead angle risk.
Preferably, on the basis of example 1, the embodiment of the present invention two is provided with zigzag knot in the lower part of blade
The composite structure of structure or flat impeller structure or orthogonal round bar and thin bar, to guarantee good defoaming effect.
Preferably, on the basis of example 1, the bottom of the bottom of the blade in the embodiment of the present invention three and retaining ring
It flushes, so that the uniformity of combined type defoaming paddle manufacture craft is effectively ensured, to guarantee the consistency of defoaming paddle structure, to keep away
It is inconsistent to exempt from the mutual internal components structure size of multi-channel miniature reactor based on parallel test principle, and influences high pass
Measure the test data of screening.
In a specific preferred embodiment of combined type of the present invention defoaming paddle, referring to Fig. 2, combined type defoams paddle packet
Include: blade 2, retaining ring 1, a pair of of blade 2 are horizontally set on the outer ring of retaining ring 1, in the geometry that retaining ring 1 is passed straight through where blade 2
The heart.The lower part of blade 2 is provided with zigzag structure, and the bottom of blade 2 is flushed with the bottom of retaining ring 1.Combined type of the invention
Paddle is defoamed under the premise of guaranteeing mixing effect, by the fabricated structure of retaining ring and blade, it is empty to effectively reduce axial installation
Between size, so that microreactor can be increased when combined type defoaming paddle of the invention to be applied in miniature organism reactor
Stocking volume, simplify the intracorporal structure of reactor tank, convenient for operation, cleaning, reduce dead angle risk.
The invention also discloses a kind of miniature organism reactors.The miniature organism reactor occurred in the world at present is in structure
On generally include three classes: orifice-plate type microreactor (microtiter plate, MTP), based on existing shaking flask or fermentor prototype
The split type microreactor (miniature bioreactor, MBR) and Microfluid based Lab on a chip of micromation
(microfluid-based lab-on-a-chip).Although miniature organism reactor form is different, all with the following functions
And feature: 1. multi-parameter on-line checking function, can simultaneously pH value determination, DO (dissolved oxygen, dissolved oxygen), Pco2,
The important parameters such as OD (optical density, optical density)；2. high throughput analysis function integrates on a microreactor
Micro- fermentor number is differed up to 6,12,24,48,96；3. small in size, volume is generally less than 100mL, and some is even as low as
5mL, micro-fluidic chip are then nL grades of scales.In addition, there are also low cost, the consumption of reduction expensive raw materials, reduction labor intensity etc.
Advantage.
In the embodiment one of miniature organism reactor of the present invention, miniature organism reactor includes tank body, agitating shaft, tank
Lid, mechanical sealing linkage ring, mechanical sealing static ring and agitating paddle；The mechanical sealing static ring is fixed below cover；Agitating shaft
Across the centre bore of cover, it is arranged in the inner cavity of tank body；The mechanical sealing linkage ring, agitating paddle are arranged on agitating shaft；?
Combined type as the aforementioned defoaming paddle is additionally provided on agitating shaft, wherein the structure of combined type defoaming paddle are as follows: it include a pair of blade,
Retaining ring, wherein a pair of of blade is horizontally set on the outer ring of retaining ring, and passes straight through the geometric center of retaining ring where blade.This hair
The miniature organism reactor of bright offer can effectively be mentioned on the basis of meeting defoaming function by simplifying the structure of defoaming paddle
The high coefficient of miniature organism reactor, while structure in tank is simplified, convenient for operation, cleaning, reduce dead angle risk.
In the embodiment two of miniature organism reactor of the present invention, it is preferable that on the basis of the above embodiment 1, combination
The lower part of mechanical sealing linkage ring is arranged in formula defoaming paddle, and it is solid to press mechanical sealing linkage ring at the top of the retaining ring on combined type defoaming paddle
It is fixed, to realize the axial limiting to mechanical sealing linkage ring.Retaining ring on combined type defoaming paddle is fixed on agitating shaft by fastening screw
On, spring compression degree needed for can accumulating mismachining tolerance and mechanical sealing linkage ring according to the axial direction of stirring system is adjusted flexibly
Position on agitating shaft.
Preferably, position of the combined type defoaming paddle on agitating shaft is adjustable, to adjust the pressure to the mechanical sealing linkage ring
Tight degree.After position of the combined type defoaming paddle on agitating shaft determines, combined type defoaming paddle can be consolidated by holding screw
Due on agitating shaft.Combined type defoaming paddle can also be fixed on and stirred by retaining ring being fixed on agitating shaft to wearing pin
It mixes on axis, to fix the crush to mechanical sealing linkage ring.
In a specific preferred embodiment of miniature organism reactor of the present invention, referring to Fig. 2, Fig. 3, miniature organism is anti-
Answering device includes tank body 4, agitating shaft 3, cover 6, mechanical sealing linkage ring 7 and agitating paddle 5；Agitating shaft 3 passes through the center of cover 6
Hole is arranged in the inner cavity of tank body 4；Mechanical sealing linkage ring 7, agitating paddle 5 are arranged on agitating shaft 3；It is also set up on agitating shaft 3
There is combined type to defoam paddle, wherein the structure of combined type defoaming paddle are as follows: including blade 2, retaining ring 1, a pair of of blade 2 is horizontally set on
The outer ring of retaining ring 1 passes straight through the geometric center of retaining ring 1 where blade 2.The lower part of blade 2 is provided with zigzag structure, and paddle
The bottom of leaf 2 is flushed with the bottom of retaining ring 1.Meanwhile the lower part of mechanical sealing linkage ring 7, group is arranged in the combined type defoaming paddle
It is fixed that mechanical sealing linkage ring 7 is pressed at the top of retaining ring 1 on box-like defoaming paddle.Wherein, combined type defoams paddle on agitating shaft 3
Position is adjustable, to adjust the compression degree to mechanical sealing linkage ring 7.
In the present embodiment, the structure of agitating paddle can also be using such as flowering structure: it includes wheel hub, disk and blade, paddle
Leaf is structure as a whole with disk, and disk is fixed on the lower part of wheel hub.Blade, the thin-wall metal that disk is bend-resistance.Disk and wheel
Hub using rise connect, the connection type of spot welding or bolt fastening.Centre bore is provided in the middle part of disk, under central hole size and wheel hub
The excircle dimension in portion is equipped with.The quantity of blade is two to six, is divided equally in the outside of disk；Plane and circle where blade
Plane where disk is vertical.
Combined type defoaming paddle provided by the invention and the miniature organism reactor that paddle is defoamed using combined type, structure are tight
It gathers, rationally distributed, defoaming paddle and rotating ring retaining ring are effectively increased on the basis of guaranteeing defoaming function using fabricated structure
The coefficient of miniature organism reactor, while structure in tank is simplified, convenient for operation, cleaning, dead angle risk is reduced, it is more preferable full
The foot requirement of microreactor.
It should be noted that above-described embodiment can be freely combined as needed.The above is only of the invention preferred
Embodiment, it is noted that for those skilled in the art, in the premise for not departing from the principle of the invention
Under, several improvements and modifications can also be made, these modifications and embellishments should also be considered as the scope of protection of the present invention.
Claims (6)
1. a kind of combined type defoams paddle characterized by comprising a pair of of blade and retaining ring, the pair of blade are horizontally set on
The geometric center of retaining ring is passed straight through for compressing the outer ring of the retaining ring of mechanical sealing linkage ring, and where the pair of blade.
2. combined type according to claim 1 defoams paddle, it is characterised in that: the lower part of the blade is provided with zigzag knot
The composite structure of structure or flat impeller structure or orthogonal round bar and thin bar.
3. a kind of miniature organism reactor, it is characterised in that: close including tank body, agitating shaft, cover, mechanical sealing linkage ring, machinery
Seal stationary ring and agitating paddle；The mechanical sealing static ring is fixed below cover；Agitating shaft passes through the centre bore of cover, and setting exists
In the inner cavity of tank body；The mechanical sealing linkage ring, mechanical sealing static ring, agitating paddle are arranged on agitating shaft；
Any combined type defoaming paddle of claim 1-2 is additionally provided on agitating shaft；
The lower part of the mechanical sealing linkage ring is arranged in the combined type defoaming paddle, wherein the gear on the combined type defoaming paddle
Press the mechanical sealing linkage ring at the top of circle to realize axial limiting.
4. miniature organism reactor according to claim 3, it is characterised in that: the combined type defoaming paddle is in the stirring
Position on axis is adjustable, to adjust the compression degree to the mechanical sealing linkage ring.
5. miniature organism reactor according to claim 4, it is characterised in that: when combined type defoaming paddle is stirred described
After mixing the position determination on axis, combined type defoaming paddle is fixed on the agitating shaft by holding screw.
6. miniature organism reactor according to claim 4, it is characterised in that: when combined type defoaming paddle is stirred described
It mixes after position on axis determines, by the retaining ring being fixed on the agitating shaft to wearing pin, the combined type is disappeared
Bubble paddle is fixed on the agitating shaft, to fix the crush to the mechanical sealing linkage ring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610643053.4A CN106281978B (en) | 2016-08-08 | 2016-08-08 | A kind of combined type defoaming paddle and the miniature organism reactor using combined type defoaming paddle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610643053.4A CN106281978B (en) | 2016-08-08 | 2016-08-08 | A kind of combined type defoaming paddle and the miniature organism reactor using combined type defoaming paddle |
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| Publication Number | Publication Date |
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| CN106281978A CN106281978A (en) | 2017-01-04 |
| CN106281978B true CN106281978B (en) | 2019-04-09 |
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| CN201610643053.4A Active CN106281978B (en) | 2016-08-08 | 2016-08-08 | A kind of combined type defoaming paddle and the miniature organism reactor using combined type defoaming paddle |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117732399B (en) * | 2023-12-20 | 2024-10-01 | 中国科学院天津工业生物技术研究所 | Stirring type reactor without dynamic seal |
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| CN202139234U (en) * | 2011-06-30 | 2012-02-08 | 虞浩明 | Defoaming stirrer |
| CN102373152A (en) * | 2011-10-18 | 2012-03-14 | 江苏浩特隆搅拌设备有限公司 | Stirrer combination for large-sized fermenting tank |
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| WO2015022852A1 (en) * | 2013-08-13 | 2015-02-19 | 三菱重工環境・化学エンジニアリング株式会社 | Defoaming device |
| CN204981867U (en) * | 2015-09-09 | 2016-01-20 | 雅赛利(台州)制药有限公司 | Defoaming agitator |
| CN105368704A (en) * | 2015-11-27 | 2016-03-02 | 上海日泰医药设备工程有限公司 | Fermentation tank |
| CN205953998U (en) * | 2016-08-08 | 2017-02-15 | 上海国强生化工程装备有限公司 | Modular defoaming paddle and use combination formula defoaming paddle's miniature bioreactor |
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2016
- 2016-08-08 CN CN201610643053.4A patent/CN106281978B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202139234U (en) * | 2011-06-30 | 2012-02-08 | 虞浩明 | Defoaming stirrer |
| CN102373152A (en) * | 2011-10-18 | 2012-03-14 | 江苏浩特隆搅拌设备有限公司 | Stirrer combination for large-sized fermenting tank |
| WO2015022852A1 (en) * | 2013-08-13 | 2015-02-19 | 三菱重工環境・化学エンジニアリング株式会社 | Defoaming device |
| CN203777984U (en) * | 2014-04-02 | 2014-08-20 | 苏梓铭 | Stirring structure and stirring device |
| CN203999610U (en) * | 2014-05-13 | 2014-12-10 | 浙江省天正设计工程有限公司 | A kind of mechanical defoaming device |
| CN204981867U (en) * | 2015-09-09 | 2016-01-20 | 雅赛利(台州)制药有限公司 | Defoaming agitator |
| CN105368704A (en) * | 2015-11-27 | 2016-03-02 | 上海日泰医药设备工程有限公司 | Fermentation tank |
| CN205953998U (en) * | 2016-08-08 | 2017-02-15 | 上海国强生化工程装备有限公司 | Modular defoaming paddle and use combination formula defoaming paddle's miniature bioreactor |
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| CN106281978A (en) | 2017-01-04 |
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