CN106267146A - A kind of external preparation for skin medicine for anti-acne and preparation method thereof - Google Patents

A kind of external preparation for skin medicine for anti-acne and preparation method thereof Download PDF

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CN106267146A
CN106267146A CN201610868618.9A CN201610868618A CN106267146A CN 106267146 A CN106267146 A CN 106267146A CN 201610868618 A CN201610868618 A CN 201610868618A CN 106267146 A CN106267146 A CN 106267146A
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parts
powder
acne
ethanol
raw material
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郭灵医
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/22—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/40—Peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
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    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

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Abstract

The invention discloses a kind of external preparation for skin medicine for anti-acne, including watery component and paste components；Watery component includes the raw material of following parts by weight: ethanol 400 500 parts, hydrogen peroxide 110 120 parts, 59 parts of boric acid water, tannalbin granule 59 parts, compound light-yellow sophora root salicylic acid dissipate 59 parts, Borneolum Syntheticum 59 parts, 0.3 0.7 parts of cefradine powder；Paste components includes the raw material of following parts by weight: 0.3 0.5 parts of chlorphenamine powder, chloramphenicol injection 23 parts, QUMIXIN emulsifiable paste 80 120 parts.The present invention is medicine for external use, little to health side effect, uses the two-in-one use of water cream, short treating period, and cure rate is high.

Description

A kind of external preparation for skin medicine for anti-acne and preparation method thereof
Technical field
The present invention relates to a kind of external preparation for skin medicine, be specifically related to a kind of external preparation for skin medicine for anti-acne and preparation side thereof Method.
Background technology
Acne, pustule ulcer, eczema, herpes, urticaria, the performance of the pox shape such as allergic rash broadly falls into chronic inflammatory skin Disease, it is probably the many factors such as hypersteatosis, pilosebaceous duct blocking, antibacterial infection and inflammatory reaction and causes , Therapeutic Method, many employing local topical medicines or oral antibiotic treatment the most fast and effectively.
Summary of the invention
For making up the deficiencies in the prior art, the present invention provides outside the skin for anti-acne that a kind of cycle is short, cure rate is high Medication and preparation method thereof.
The present invention is achieved through the following technical solutions:
A kind of external preparation for skin medicine for anti-acne, it is characterized in that and includes watery component and paste components；
Described watery component includes the raw material of following parts by weight: ethanol 400-500 part, hydrogen peroxide 110-120 part, boric acid water 5- 9 parts, tannalbin granule 5-9 part, compound light-yellow sophora root salicylic acid dissipate 5-9 part, Borneolum Syntheticum 5-9 part, cefradine powder 0.3-0.7 part；
Described paste components includes the raw material of following parts by weight: chlorphenamine powder 0.3-0.5 part, chloramphenicol injection 2-3 part, QUMIXIN emulsifiable paste 80-120 part.
The preferred version of the present invention is:
Watery component includes the raw material of following parts by weight: ethanol 425 parts, hydrogen peroxide 113 parts, 7 parts of boric acid water, tannalbin Grain 7 parts, compound light-yellow sophora root salicylic acid dissipate 7 parts, Borneolum Syntheticum 7 parts, 0.5 part of cefradine powder；
Paste components includes the raw material of following parts by weight: 0.4 part of chlorphenamine powder, chloramphenicol injection 2.5 parts, QUMIXIN are newborn Cream 100 parts.
Further, heretofore described ethanol is the ethanol of 75%.
The present invention the preparation method of a kind of external preparation for skin medicine for anti-acne, comprise the following steps:
(1) watery component makes: be sequentially added into ethanol, hydrogen peroxide, boric acid water, compound light-yellow sophora root bigcatkin willow in clean container in order Acid dissipates, fully dissolves after tannalbin granule, Borneolum Syntheticum, cefradine powder and stir；
(2) paste components makes: be sequentially added into chlorphenamine powder, chloramphenicol injection, QUMIXIN in clean container in order Emulsifiable paste, stirs by stirring rod.
The invention has the beneficial effects as follows: the present invention is medicine for external use, little to health side effect, use the two-in-one use of water cream, Short treating period, cure rate is high.
Detailed description of the invention
Embodiment 1
The external preparation for skin medicine for anti-acne of the present embodiment, including watery component and paste components；
Described watery component includes the raw material of following weight: 75% ethanol 470ml, hydrogen peroxide 85ml, boric acid water 5g, tannalbin Granule 5g, compound light-yellow sophora root salicylic acid dissipate 5g, Borneolum Syntheticum 5g, cefradine powder 0.3g；
Described paste components includes the raw material of following weight: chlorphenamine powder 0.3g, chloramphenicol injection 2g, QUMIXIN emulsifiable paste 80g。
The preparation method of the external preparation for skin medicine for anti-acne of the present embodiment, comprises the following steps:
(1) watery component make: be sequentially added in order in clean 1000ml hermetic container ethanol, hydrogen peroxide, boric acid water, Compound light-yellow sophora root salicylic acid dissipates, fully dissolve and rock after tannalbin granule, Borneolum Syntheticum, cefradine powder and be allowed to mix homogeneously i.e. Obtain watery component；
(2) paste components make: be sequentially added in order in clean open-top receptacle chlorphenamine powder, chloramphenicol injection, QUMIXIN emulsifiable paste, stirs by clean stirring rod and i.e. obtains paste components.
Embodiment 2
The external preparation for skin medicine for anti-acne of the present embodiment, including watery component and paste components；
Described watery component includes the raw material of following weight: 75% ethanol 500ml, hydrogen peroxide 100ml, boric acid water 7g, tannalbin Granule 7g, compound light-yellow sophora root salicylic acid dissipate 7g, Borneolum Syntheticum 7g, cefradine powder 0.5g；
Described paste components includes the raw material of following weight: chlorphenamine powder 0.4g, chloramphenicol injection 2.5g, QUMIXIN emulsifiable paste 100g。
The preparation method of the external preparation for skin medicine for anti-acne of the present embodiment, comprises the following steps:
(1) watery component make: be sequentially added in order in clean 1000ml hermetic container ethanol, hydrogen peroxide, boric acid water, Compound light-yellow sophora root salicylic acid dissipates, fully dissolve and rock after tannalbin granule, Borneolum Syntheticum, cefradine powder and be allowed to mix homogeneously i.e. Obtain watery component；
(2) paste components make: be sequentially added in order in clean open-top receptacle chlorphenamine powder, chloramphenicol injection, QUMIXIN emulsifiable paste, stirs by clean stirring rod and i.e. obtains paste components.
Embodiment 3
The external preparation for skin medicine for anti-acne of the present embodiment, including watery component and paste components；
Described watery component includes the raw material of following weight: 75% ethanol 550ml, hydrogen peroxide 120ml, boric acid water 9g, tannalbin Granule 9g, compound light-yellow sophora root salicylic acid dissipate 9g, Borneolum Syntheticum 9g, cefradine powder 0.7g；
Described paste components includes the raw material of following weight: chlorphenamine powder 0.5g, chloramphenicol injection 3g, QUMIXIN emulsifiable paste 120g。
The preparation method of the external preparation for skin medicine for anti-acne of the present embodiment, comprises the following steps:
(1) watery component make: be sequentially added in order in clean 1000ml hermetic container ethanol, hydrogen peroxide, boric acid water, Compound light-yellow sophora root salicylic acid dissipates, fully dissolve and rock after tannalbin granule, Borneolum Syntheticum, cefradine powder and be allowed to mix homogeneously i.e. Obtain watery component；
(2) paste components make: be sequentially added in order in clean open-top receptacle chlorphenamine powder, chloramphenicol injection, QUMIXIN emulsifiable paste, stirs by clean stirring rod and i.e. obtains paste components.
Embodiment 4
Clinical observation
(1) physical data
The present inventor carried out clinical observation and controls 500 example acnes, pustule ulcer, eczema, herpes, urticaria patient in 2003 so far Treat, 15 to 60 years old ages.
(2) Therapeutic Method: with the medicine for external use that embodiment 2 is made, sooner or later spread on affected part every day, 7 days courses for the treatment of, during use first With watery component uniform application to affected part, then repasting with paste components, general two courses for the treatment of can be almost recovered, and can be continuing with Consolidate curative effect the course for the treatment of in case recurring for 1.
(3) efficacy assessment standard
" cure ": symptom all disappears.
" effectively ": symptom significantly reduces.
Engineering noise: after using 2 courses for the treatment of, symptom has no to disappear.
(4) therapeutic effect:
Clinical cure 450 example, accounts for 90%；Effective 39 examples, account for 7.8%；Invalid 11 examples, total effective rate 97.8%.

Claims (4)

1. the external preparation for skin medicine for anti-acne, it is characterised in that: include watery component and paste components；
Described watery component includes the raw material of following parts by weight: ethanol 400-500 part, hydrogen peroxide 110-120 part, boric acid water 5- 9 parts, tannalbin granule 5-9 part, compound light-yellow sophora root salicylic acid dissipate 5-9 part, Borneolum Syntheticum 5-9 part, cefradine powder 0.3-0.7 part；
Described paste components includes the raw material of following parts by weight: chlorphenamine powder 0.3-0.5 part, chloramphenicol injection 2-3 part, QUMIXIN emulsifiable paste 80-120 part.
A kind of external preparation for skin medicine for anti-acne the most according to claim 1, it is characterised in that:
Described watery component includes the raw material of following parts by weight: ethanol 425 parts, hydrogen peroxide 113 parts, 7 parts of boric acid water, tannic acid egg White granule 7 parts, compound light-yellow sophora root salicylic acid dissipate 7 parts, Borneolum Syntheticum 7 parts, 0.5 part of cefradine powder；
Described paste components includes the raw material of following parts by weight: 0.4 part of chlorphenamine powder, chloramphenicol injection 2.5 parts, bent miaow New emulsifiable paste 100 parts.
A kind of external preparation for skin medicine for anti-acne the most according to claim 1 and 2, it is characterised in that: described ethanol is 75% Ethanol.
The preparation method of a kind of external preparation for skin medicine for anti-acne the most according to claim 1 and 2, it is characterised in that: bag Include following steps:
(1) watery component makes: be sequentially added into ethanol, hydrogen peroxide, boric acid water, compound light-yellow sophora root bigcatkin willow in clean container in order Acid dissipates, fully dissolves after tannalbin granule, Borneolum Syntheticum, cefradine powder and stir；
(2) paste components makes: be sequentially added into chlorphenamine powder, chloramphenicol injection, QUMIXIN in clean container in order Emulsifiable paste, stirs by stirring rod.
CN201610868618.9A 2016-09-30 2016-09-30 A kind of external preparation for skin medicine for anti-acne and preparation method thereof Pending CN106267146A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1327827A (en) * 2001-06-21 2001-12-26 贵州宏奇药业有限公司 Exterior-applied medicine for treating dermatopathy
CN105477081A (en) * 2015-12-20 2016-04-13 杜高位 Preparation method of acne removal medicine liquid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1327827A (en) * 2001-06-21 2001-12-26 贵州宏奇药业有限公司 Exterior-applied medicine for treating dermatopathy
CN105477081A (en) * 2015-12-20 2016-04-13 杜高位 Preparation method of acne removal medicine liquid

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
李彪 等: "《新编中医外科学》", 30 November 1999, 人民军医出版社 *
董却非 等: "《实用医院制剂》", 31 July 1982, 重庆出版社 *

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Application publication date: 20170104