CN106266474A - 用于治疗冠心病的药物 - Google Patents

用于治疗冠心病的药物 Download PDF

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CN106266474A
CN106266474A CN201610749094.1A CN201610749094A CN106266474A CN 106266474 A CN106266474 A CN 106266474A CN 201610749094 A CN201610749094 A CN 201610749094A CN 106266474 A CN106266474 A CN 106266474A
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黄佩丽
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Abstract

本发明公开了一种用于治疗冠心病的药物,主要由下述重量份配比的原料制成:薤白6‑8份、枫香3‑5份、葎叶蛇葡萄3‑5份、山胡椒5‑9份、红花3‑5份、川芎5‑15份、太子参12‑18份、茯苓8‑12份、远志12‑18份、丹参12‑18份、五味子4‑8份、元胡12‑18份、龙骨12‑18份、柏子仁12‑18份。本发明用于治疗冠心病的药物,选取14种天然中药科学配伍,配方简单,各原料药协同作用起到理气活血、通络止痛的效果,见效快,无毒副作用,而且其制备方法简单、服用方便,成本低,有效率达到93.3%以上。

Description

用于治疗冠心病的药物
技术领域
本发明涉及中药,具体是一种用于治疗冠心病的药物。
背景技术
冠心病是冠状动脉粥样硬化性心脏病(coronary atherosclerotic heartdisease)的简称,指由于脂质代谢不正常,血液中的脂质沉着在原本光滑的动脉内膜上,在动脉内膜一些类似粥样的脂类物质堆积而成白色斑块,称为动脉粥样硬化病变。这些斑块渐渐增多造成动脉腔狭窄,使血流受阻,导致心脏缺血,产生心绞痛。主要表现为心绞痛、心律失常、心力衰竭,可能猝死。心电图、心肌酶测定、放射性核素检查和冠状动脉造影能进一步明确诊断。控制血压、血脂、体重和戒烟能有效防止冠心病的发生和发展。
冠心病的主要病因是冠状动脉粥样硬化,但动脉粥样硬化的原因尚不完全清楚,可能是多种因素综合作用的结果。认为本病发生的危险因素有:年龄和性别(45岁以上的男性,55岁以上或者绝经后的女性),家族史(父兄在55岁以前,母亲/姐妹在65岁前死于心脏病),血脂异常(低密度脂蛋白胆固醇LDL-C过高,高密度脂蛋白胆固醇HDL-C过低),高血压,尿糖病,吸烟,超重,肥胖,痛风,不运动,等。发病机制:由于脂质代谢异常,血液中的脂质沉着在原本光滑的动脉内膜上,在动脉内膜一些类似粥样的脂类物质堆积而成白色斑块,这些斑块渐渐增多造成动脉腔狭窄,使血流受阻,导致心脏缺血,产生心绞痛。如果动脉壁上的斑块形成溃疡或破裂,就会形成血栓,使整个血管血流完全中断,发生急性心肌梗死,甚至猝死。冠心病的少见发病机制是冠状动脉痉挛(血管可以没有粥样硬化),产生变异性心绞痛,如果痉挛超过30分钟,也会导致急性心肌梗死(甚至猝死)。
现在多以西药和手术治疗为主,但是副作用较大,且容易复发,不能根治,对患者经济和生理造成一定的负担。而目前的一些中药的治疗效率也不甚理想,治疗周期长,且疗效不显著。
发明内容
本发明的目的是提供一种疗效好、疗程短、成本低、无毒副作用的用于治疗冠心病的药物。
实现本发明目的的技术方案是:
一种用于治疗冠心病的药物,主要由下述重量份配比的原料制成:
薤白6-8份、枫香3-5份、葎叶蛇葡萄3-5份、山胡椒5-9份、红花3-5份、川芎5-15份、太子参12-18份、茯苓8-12份、远志12-18份、丹参12-18份、五味子4-8份、元胡12-18份、龙骨12-18份、柏子仁12-18份。
上述用于治疗冠心病的药物,各原料的最佳重量份配比为:
薤白7份、枫香4份、葎叶蛇葡萄4份、山胡椒7份、红花4份、川芎10份、太子参15份、茯苓10份、远志15份、丹参15份、五味子6份、元胡15份、龙骨15份、柏子仁15份。
所述的原料药材在中药店及市场有售。
本发明药物的制备方法如下:
(1)按重量份配比称取各原料药,将全部原料药粉碎成粗粉,一起混合置于容器中,加入原料量4-6倍浓度为30-60%的乙醇浸渍4-6天后,过滤去渣,滤液减压回收乙醇至无醇味,得浓缩液80-100份,备用;
(2)在步骤(1)制得的浓缩液中加入600-1000份水和0.8-1份山梨酸钾,搅匀、静置20-30h,过滤,得滤液,备用;
(3)另用60-100份蔗糖,加100-120份水煮沸35-45min,过滤,备用;
(4)将步骤(2)和(3)的滤液混合置于容器内,加900-1000份水,冷却后装瓶、密封后进行灭菌处理,制成产品。
本发明中,各原料药的药理、功效如下:
薤白:通阳散结,行气导滞。用于胸痹心痛,脘腹痞满胀痛,泻痢后重。
枫香:又名枫香树,能解毒止痛,止血生肌,有祛风除湿,通络活血功效。
葎叶蛇葡萄:根皮入药,能消炎解毒、活血散瘀,祛风除湿。
山胡椒:温中散寒。治中风不语,心腹冷痛。
红花:又称草红花。活血通经,散瘀止痛,有助于治经闭、痛经、恶露不行、胸痹心痛、瘀滞腹痛、胸胁刺痛、跌打损伤、疮疡肿痛疗效。
川芎:行气开郁,法风燥湿,活血止痛。治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。
太子参:具有益气健脾,生津润肺之功效。常用于脾虚体倦,食欲不振,病后虚弱,气阴不足,自汗日渴,肺燥干咳。
茯苓:利水渗湿,健脾,宁心。用于水肿尿少,痰饮眩悸,脾虚食少,便溏泄泻,心神不安,惊悸失眠。
远志:具有安神益智、祛痰、消肿的功能,用于心肾不交引起的失眠多梦、健忘惊悸,神志恍惚,咳痰不爽,疮疡肿毒,乳房肿痛。
丹参:具有活血祛瘀,通经止痛,清心除烦,凉血消痈之功效。用于胸痹心痛,脘腹胁痛,瘕瘕积聚,热痹疼痛,心烦不眠,月经不调,痛经经闭,疮疡肿痛。
五味子:具有收敛固涩,益气生津,补肾宁心之功效。常用于久嗽虚喘,梦遗滑精,遗尿尿频,久泻不止,自汗盗汗,津伤口渴,内热消渴,心悸失眠。
元胡:有活血散瘀,理气止痛的功能。用于全身各部气滞血瘀之痛,痛经,经闭,症瘕,产后瘀阻,跌扑损伤,疝气作痛。
龙骨:重镇安神镇惊安神,敛汗固精,止血涩肠,生肌敛疮。治惊痫癫狂,怔忡健忘,失眠多梦,自汗盗汗,遗精淋浊,吐衄便血,崩漏带下,泻痢脱肛,溃疡久不收口。
柏子仁:具有养心安神,润肠通便,止汗的功效。用于阴血不足,虚烦失眠,心悸怔忡,肠燥便秘,阴虚盗汗。
本发明用于治疗冠心病的药物,选取14种天然中药科学配伍,配方简单,各原料药协同作用起到理气活血、通络止痛的效果,见效快,无毒副作用,而且其制备方法简单、服用方便,成本低。
具体实施方式
下面结合实施例对本发明内容作进一步的说明,但不是对本发明的限定。
实施例1
一种用于治疗冠心病的药物,主要由下述重量份配比的原料制成:
薤白6kg、枫香3kg、葎叶蛇葡萄3kg、山胡椒5kg、红花3kg、川芎5kg、太子参12kg、茯苓8kg、远志12kg、丹参12kg、五味子4kg、元胡12kg、龙骨12kg、柏子仁12kg。
本发明药物的制备方法如下:
(1)按重量份配比称取各原料药,将全部原料药粉碎成粗粉,一起混合置于容器中,加入原料量4倍浓度为30%的乙醇浸渍4天后,过滤去渣,滤液减压回收乙醇至无醇味,得浓缩液80kg,备用;
(2)在步骤(1)制得的浓缩液中加入600kg水和0.8kg山梨酸钾,搅匀、静置20h,过滤,得滤液,备用;
(3)另用60kg蔗糖,加100kg水煮沸35min,过滤,备用;
(4)将步骤(2)和(3)的滤液混合置于容器内,加900kg水,冷却后装瓶、密封后进行灭菌处理,制成产品。
实施例2
一种用于治疗冠心病的药物,主要由下述重量份配比的原料制成:
薤白7kg、枫香4kg、葎叶蛇葡萄4kg、山胡椒7kg、红花4kg、川芎10kg、太子参15kg、茯苓10kg、远志15kg、丹参15kg、五味子6kg、元胡15kg、龙骨15kg、柏子仁15kg。
本发明药物的制备方法如下:
(1)按重量份配比称取各原料药,将全部原料药粉碎成粗粉,一起混合置于容器中,加入原料量5倍浓度为45%的乙醇浸渍5后,过滤去渣,滤液减压回收乙醇至无醇味,得浓缩液90kg,备用;
(2)在步骤(1)制得的浓缩液中加入800kg水和0.9kg山梨酸钾,搅匀、静置25h,过滤,得滤液,备用;
(3)另用80kg蔗糖,加110kg水煮沸40min,过滤,备用;
(4)将步骤(2)和(3)的滤液混合置于容器内,加950kg水,冷却后装瓶、密封后进行灭菌处理,制成产品。
实施例3
一种用于治疗冠心病的药物,主要由下述重量份配比的原料制成:
薤白8份、枫香5kg、葎叶蛇葡萄5kg、山胡椒9kg、红花5kg、川芎15kg、太子参18kg、茯苓12kg、远志18kg、丹参18kg、五味子8kg、元胡18kg、龙骨18kg、柏子仁18kg。
本发明药物的制备方法如下:
(1)按重量份配比称取各原料药,将全部原料药粉碎成粗粉,一起混合置于容器中,加入原料量6倍浓度为60%的乙醇浸渍6天后,过滤去渣,滤液减压回收乙醇至无醇味,得浓缩液100kg,备用;
(2)在步骤(1)制得的浓缩液中加入1000kg水和1kg山梨酸钾,搅匀、静置30h,过滤,得滤液,备用;
(3)另用100kg蔗糖,加120kg水煮沸45min,过滤,备用;
(4)将步骤(2)和(3)的滤液混合置于容器内,加1000kg水,冷却后装瓶、密封后进行灭菌处理,制成产品。
为了进一步证明本发明中药的临床疗效,选择收治患者中的150例,对本发明药物的疗效进行临床观察。年龄50-70岁,随机分为3组,每组为50例,分别为实验组1-3组。
实验组1-3组分别服用实施例1-3的药物,每日3次,每次内服5g,10天为一个疗程,连续服用2个疗程。其中显效139例,有效140例,治愈136例,无效10例,治愈率90.7%,有效率93.3%。

Claims (7)

1.一种用于治疗冠心病的药物,其特征是:主要由下述重量份配比的原料制成:
薤白6-8份、枫香3-5份、葎叶蛇葡萄3-5份、山胡椒5-9份、红花3-5份、川芎5-15份、太子参12-18份、茯苓8-12份、远志12-18份、丹参12-18份、五味子4-8份、元胡12-18份、龙骨12-18份、柏子仁12-18份。
2.根据权利要求1所述的用于治疗冠心病的药物,其特征是:各原料的重量份配比为:
薤白7份、枫香4份、葎叶蛇葡萄4份、山胡椒7份、红花4份、川芎10份、太子参15份、茯苓10份、远志15份、丹参15份、五味子6份、元胡15份、龙骨15份、柏子仁15份。
3.根据权利要求1所述的用于治疗冠心病的药物的制备方法,其特征是:具体步骤如下:
(1)按重量份配比称取各原料药,将全部原料药粉碎成粗粉,一起混合置于容器中,加入原料量4-6倍的乙醇浸渍4-6天后,过滤去渣,滤液减压回收乙醇至无醇味,得浓缩液80-100份,备用;
(2)在步骤(1)制得的浓缩液中加入水和山梨酸钾,搅匀、静置20-30h,过滤,得滤液,备用;
(3)另用蔗糖,加水煮沸35-45min,过滤,备用;
(4)将步骤(2)和(3)的滤液混合置于容器内,加水,冷却后装瓶、密封后进行灭菌处理,制成产品。
4.根据权利要求3所述的用于治疗冠心病的药物的制备方法,其特征是:所述步骤(1)中加入的乙醇的浓度为30-60%。
5.根据权利要求3所述的用于治疗冠心病的药物的制备方法,其特征是:所述步骤(2)中水的加入量为600-1000份,山梨酸钾的加入量为0.8-1份。
6.根据权利要求3所述的用于治疗冠心病的药物的制备方法,其特征是:所述步骤(3)中的蔗糖的量为60-100份,水的量为100-120份。
7.根据权利要求3所述的用于治疗冠心病的药物的制备方法,其特征是:所述步骤(4)中水的加入量为900-1000份。
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CN107096000A (zh) * 2017-05-26 2017-08-29 蒋田英 一种治疗冠心病的药物

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CN105168804A (zh) * 2015-10-12 2015-12-23 谢桂斌 用于治疗心肌梗塞的中药组合物
CN105213778A (zh) * 2015-11-09 2016-01-06 谢桂斌 用于治疗冠心病的中药

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Publication number Priority date Publication date Assignee Title
CN105168804A (zh) * 2015-10-12 2015-12-23 谢桂斌 用于治疗心肌梗塞的中药组合物
CN105213778A (zh) * 2015-11-09 2016-01-06 谢桂斌 用于治疗冠心病的中药

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107096000A (zh) * 2017-05-26 2017-08-29 蒋田英 一种治疗冠心病的药物

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