CN106266037A - A kind of liquid gel and preparation method thereof - Google Patents
A kind of liquid gel and preparation method thereof Download PDFInfo
- Publication number
- CN106266037A CN106266037A CN201610694663.7A CN201610694663A CN106266037A CN 106266037 A CN106266037 A CN 106266037A CN 201610694663 A CN201610694663 A CN 201610694663A CN 106266037 A CN106266037 A CN 106266037A
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- CN
- China
- Prior art keywords
- weight portion
- gel
- purified water
- weight
- chitosan
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
Abstract
A kind of liquid gel and preparation method thereof, it is characterized in that: the composition of this gel includes: chitosan 0.5 2.5 weight portion, hypromellose 0.5 5 weight portion, polyethylene glycol 6000 0.5 6 weight portion, chlorhexidine acetate 0.1 0.3 weight portion, carbomer 0.1 3 weight portion, propylene glycol 0.1 2 weight portion, Semen Crataegi 0.1 3 weight portion, hyalomitome acid 0.2～2 weight portion, miconazole nitrate 0.01 0.5 weight portion, purified water 50 70 weight portion, pH value 5 7.5.Have that side effect is little, good effect, and be not easily caused the advantage that reproductive tract flora is unbalance, can effectively alleviate or cure the state of an illness.
Description
Technical field
The present invention relates to gel rubber material technical field, be specifically related to a kind of liquid gel and preparation method thereof.
Background technology
Along with change and the deterioration of surrounding of philosophy of life, reproductive tract infection increasingly becomes common in women
Disease and frequently-occurring disease.It is mainly to occur at a class infectious disease of female reproductive system, is mainly propagated by sexual approach,
Wherein most commonly seen with vaginitis.And if use oral drug therapy, one to carry out side effect big, and two can not directly act on trouble
Place, curative effect is the most notable；At present, also having use gel rubber material directly to carry out acting on affected part effect, the most rapid-action, curative effect shows
Write, but still there is certain deficiency: such as chemical reagent composition content is big, still has bigger side effect, additionally, also hold
Easily cause vaginal microbial flora unbalance, it is impossible to effectively alleviate or cure the state of an illness.
Summary of the invention
The present invention is directed to the above-mentioned deficiency of prior art, it is provided that a kind of side effect is little, good effect, and is not easily caused reproductive tract
Flora is unbalance, can effectively alleviate or cure the liquid gel of the state of an illness.
In order to solve above-mentioned technical problem, the technical solution used in the present invention is: a kind of liquid gel, the composition of this gel
Including: chitosan 0.5-2.5 weight portion, hypromellose 0.5-5 weight portion, polyethylene glycol 6000 0.5-6 weight portion, vinegar
Acid hibitane 0.1-0.3 weight portion, carbomer 0.1-3 weight portion, propylene glycol 0.1-2 weight portion, Semen Crataegi 0.1-3 weight portion,
Hyalomitome acid 0.2～2 weight portion, miconazole nitrate 0.01-0.5 weight portion, purified water 50-70 weight portion, pH value 5
7.5。
As further preferably, the liquid gel that the present invention is above-mentioned, the composition of this gel includes: chitosan 1-2 weight portion,
Hypromellose 1-4 weight portion, polyethylene glycol 6000 1-3 weight portion, chlorhexidine acetate 0.15-0.25 weight portion, carbomer
0.15-2 weight portion, propylene glycol 0.5-1 weight portion, Semen Crataegi 0.5-2 weight portion, hyalomitome acid 0.5～1.5 weight
Part, miconazole nitrate 0.02-0.3 weight portion, purified water 55-65 weight portion, pH value 5 7.5.
The above-mentioned hyalomitome acid of the present invention is hyaluronate sodium.
The present invention also provides for the preparation method of a kind of aforesaid liquid gel, and preparation process includes:
(1) first dissolve the chitosan in purified water according to formula proportion, abundant swelling rear stand-by；
(2) according to formula proportion, hyalomitome acid is dissolved in purified water, abundant swelling rear stand-by；
(3) by other component mix homogeneously remaining in formula proportion；
(4) solution of step (1)-(3) gained is added in same container, be sufficiently stirred for mixing, regulate pH value 5
7.5 obtain gel products.
Advantages of the present invention and beneficial effect:
1. chitosan and miconazole nitrate are used by the present invention first simultaneously, chitosan have broad-spectrum antiseptic, have no drug resistance,
Sterilizing ability is strong and to features such as vagina nonirritants, and side effect is little, uses in conjunction with miconazole nitrate simultaneously, fully improves
Drug effect, because miconazole nitrate is broad-spectrum antifungal medicine, has antibacterial action to multiple fungus, especially candidiasis, to some
Grain-positive bacillus and coccus also have antibacterial action.Its mechanism of action is the synthesis of suppression fungal cell membrane, and affects its generation
Apologize for having done sth. wrong journey.
2. the product of the present invention employs Semen Crataegi and carbomer, it is possible to fully realize the microbial ecological in reproductive tract
Balance and pH are steady, improve the vagina resistance to various pathogenic conditions, and the effectively people of the extraneous antibacterial of prevention or causal organism invades,
Opposing to antibacterial is further up；The HPV of inactivation can be adsorbed by carbomer, parcel excretes, and accelerates rotten to the corn tissue
Quickly repairing and regeneration, promote healing, Semen Crataegi etc. can also improve vagina abnormal flavour, improve vaginal microenvironment, alleviates vagina inflammatory
Reaction, minimizing vaginal secretions amount, be effectively improved vagina cleanness degree, reduce vaginal pH, effectively treat cervicitis, cervical erosion
Deng gynaecopathia.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in more detail, but is not limited only to following example.
Embodiment 1
The composition of this gel includes: chitosan 2 weight portion, hypromellose 2 weight portion, polyethylene glycol 6000 2 weight
Part, chlorhexidine acetate 0.2 weight portion, carbomer 0.15 weight portion, propylene glycol 0.15 weight portion, Semen Crataegi 2 weight portion, hyalomitome
Acid 1.5 weight portion, miconazole nitrate 0.02 weight portion, purified water 55 weight portion, pH value 6.5.
Concrete steps include:
(1) first dissolve the chitosan in purified water according to formula proportion, abundant swelling rear stand-by；
(2) according to formula proportion, hyalomitome acid is dissolved in purified water, abundant swelling rear stand-by；
(3) by other component mix homogeneously remaining in formula proportion；
(4) being added in same container by the solution of step (1)-(3) gained, be sufficiently stirred for mixing, regulation pH value obtains
Gel products.
The water consumption sum of step (1) and (2) is the water consumption of total purified water in gel formula.
Embodiment 2
The composition of this gel includes: chitosan 1.5 weight portion, hypromellose 1 weight portion, polyethylene glycol 6000 1 weight
Amount part, chlorhexidine acetate 0.2 weight portion, carbomer 0.3 weight portion, propylene glycol 0.8 weight portion, Semen Crataegi 1 weight portion, hyalomitome
Acid 1 weight portion, miconazole nitrate 0.025 weight portion, purified water 60 weight portion, pH value 77.
Method is with embodiment 1.
Embodiment 3
The composition of this gel includes: chitosan 2 weight portion, hypromellose 3 weight portion, polyethylene glycol 6000 2.5 weight
Amount part, chlorhexidine acetate 0.20 weight portion, carbomer 0.20 weight portion, propylene glycol 0.6 weight portion, Semen Crataegi 0.6 weight portion, thoroughly
Bright matter acid 1.0 weight portion, miconazole nitrate 0.05 weight portion, purified water 55 weight portion, pH value 6.
Method is with embodiment 1.
Comparative example
Miconazole nitrate in the composition of this gel is removed, and other composition does not changes with embodiment 3, and method is with embodiment 1.
Sample prepared by the embodiment of the present invention, using effect: volunteer is divided into 3 groups, often organizes 80 people.First group
After (test group) volunteer cleans vagina by warm water every night, the gel 3g of Example 1 preparation is coated on labia week
Enclose with vagina inside；Second group (matched group) takes commercially available vaginitis antibacterial gel and compares, each consumption 3g；Often group uses continuously
Carry out after two weeks checking for the first time, second time check after five weeks；It is antibacterial that 3rd group (comparative example group) takes comparative example vaginitis
Gel compares, each consumption 3g；Often group carries out after using two weeks continuously checking for the first time, second time check knot after five weeks
Fruit is shown in Table 1.
1 liang of table group patient clinical Comparison of therapeutic
| Group | N | Cure | Effective | Invalid | Total effective rate |
| Observation group | 80 | 68 | 10 | 2 | 97.5% |
| Matched group | 80 | 50 | 8 | 22 | 72.5% |
| Comparative example group | 80 | 65 | 8 | 15 | 91.25% |
As can be known from the above table, the gel that prepared by the present invention has cure rate advantage high, eutherapeutic；And chitosan and nitric acid
Miconazole uses simultaneously and uses a kind of difference on effect notable, it was demonstrated that the two uses cure rate higher simultaneously.
Claims (3)
1. a liquid gel, it is characterised in that: the composition of this gel includes: chitosan 0.5-2.5 weight portion, hypromellose
Element 0.5-5 weight portion, polyethylene glycol 6000 0.5-6 weight portion, chlorhexidine acetate 0.1-0.3 weight portion, carbomer 0.1-3 weight
Amount part, propylene glycol 0.1-2 weight portion, Semen Crataegi 0.1-3 weight portion, hyalomitome acid 0.2～2 weight portion, nitric acid miaow health
Azoles 0.01-0.5 weight portion, purified water 50-70 weight portion, pH value 5 7.5.
Liquid gel the most according to claim 1, it is characterised in that: the composition of this gel includes: chitosan 1-2 weight
Part, hypromellose 1-4 weight portion, polyethylene glycol 6000 1-3 weight portion, chlorhexidine acetate 0.15-0.25 weight portion, card
Ripple nurse 0.15-2 weight portion, propylene glycol 0.5-1 weight portion, Semen Crataegi 0.5-2 weight portion, hyalomitome acid 0.5～1.5 weight
Amount part, miconazole nitrate 0.02-0.3 weight portion, purified water 55-65 weight portion, pH value 5 7.5.
3. the preparation method of the liquid gel described in a claim 1 or 2, it is characterised in that: preparation process includes:
(1) first dissolve the chitosan in purified water according to formula proportion, abundant swelling rear stand-by；
(2) according to formula proportion, hyalomitome acid is dissolved in purified water, abundant swelling rear stand-by；
(3) by other component mix homogeneously remaining in formula proportion；
(4) solution of step (1)-(3) gained is added in same container, be sufficiently stirred for mixing, regulation pH value 5 7.5
To gel products.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610694663.7A CN106266037B (en) | 2016-08-19 | 2016-08-19 | Liquid gel and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610694663.7A CN106266037B (en) | 2016-08-19 | 2016-08-19 | Liquid gel and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106266037A true CN106266037A (en) | 2017-01-04 |
| CN106266037B CN106266037B (en) | 2020-09-29 |
Family
ID=57661720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610694663.7A Active CN106266037B (en) | 2016-08-19 | 2016-08-19 | Liquid gel and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106266037B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107080733A (en) * | 2017-04-17 | 2017-08-22 | 滨州医学院附属医院 | A kind of miconazole nitrate chitosan vagina slowly-releasing gel and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050276836A1 (en) * | 1997-06-11 | 2005-12-15 | Michelle Wilson | Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents |
| CN101422448A (en) * | 2008-12-10 | 2009-05-06 | 李海涛 | Miconazole nitrate film and preparation method and pharmacy use thereof |
| CN102626524A (en) * | 2012-05-04 | 2012-08-08 | 江西中兴汉方药业有限公司 | Chitosan gynaecologic antibacterial gel and preparation method thereof |
| CN103316033A (en) * | 2013-07-03 | 2013-09-25 | 康晓飞 | Gel and use thereof |
-
2016
- 2016-08-19 CN CN201610694663.7A patent/CN106266037B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050276836A1 (en) * | 1997-06-11 | 2005-12-15 | Michelle Wilson | Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents |
| CN101422448A (en) * | 2008-12-10 | 2009-05-06 | 李海涛 | Miconazole nitrate film and preparation method and pharmacy use thereof |
| CN102626524A (en) * | 2012-05-04 | 2012-08-08 | 江西中兴汉方药业有限公司 | Chitosan gynaecologic antibacterial gel and preparation method thereof |
| CN103316033A (en) * | 2013-07-03 | 2013-09-25 | 康晓飞 | Gel and use thereof |
Non-Patent Citations (1)
| Title |
|---|
| 陈孝治等: "《药物处方手册》", 30 April 2010, 湖南科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107080733A (en) * | 2017-04-17 | 2017-08-22 | 滨州医学院附属医院 | A kind of miconazole nitrate chitosan vagina slowly-releasing gel and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN106266037B (en) | 2020-09-29 |
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