CN102626524A - Chitosan gynaecologic antibacterial gel and preparation method thereof - Google Patents
Chitosan gynaecologic antibacterial gel and preparation method thereof Download PDFInfo
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- CN102626524A CN102626524A CN2012101352545A CN201210135254A CN102626524A CN 102626524 A CN102626524 A CN 102626524A CN 2012101352545 A CN2012101352545 A CN 2012101352545A CN 201210135254 A CN201210135254 A CN 201210135254A CN 102626524 A CN102626524 A CN 102626524A
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- chitosangynaecologicsuppository
- antibacterial gel
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Abstract
The invention discloses chitosan gynaecologic antibacterial gel and a preparation method thereof. The chitosan gynaecologic antibacterial gel contains 20-30 parts of chitosan, 5-15 parts of acetic acid, 40-60 parts of propylene glycol, 50-70 parts of glycerol, 20-40 parts of absolute ethyl alcohol, 0.1-1.0 part of peppermint oil, 0.1-1.0 part of menthol crystal, 0.5-1.5 parts of poloxamer, 2-4 parts of chlorhexidine acetate, 4-8 parts of lauryl alcohol polyoxyethylene ether and 800-900 parts of purified water. The antibacterial gel prepared with the method is good in antibacterial effect and safe and non-toxic to the human body due to the fact that the gel is made of a medical macromolecular material of high density polyethylene.
Description
Technical field
The invention belongs to the pharmaceutical chemistry technical field, be specifically related to Chitosangynaecologicsuppository antibacterial gel and preparation method thereof.
Background technology
" Chitosangynaecologicsuppository antibacterial gel " belongs to the antibiotic and sterilizing product of medical apparatus and instruments II class 6864 medical materials and dressing; List marketing has been for many years at home for like product; Security of products, effectiveness and controllability have obtained the extensive approval of medical institutions, are widely used in the anorectal and the gynaecologic antibiotic antiinflammatory product of medical institutions.
Person skilled on basis with reference to similar products at home and abroad, and through repeatedly producing and checking, according to this equipment registration of the special establishment of its measured result standard, as the Chitosangynaecologicsuppository antibacterial gel produce, check and the foundation of quality control when selling.Gel device is that employing medical macromolecular materials-high density polyethylene (HDPE) is a material, to human body safety non-toxic, National standard.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, Chitosangynaecologicsuppository antibacterial gel and preparation method thereof is provided.
The Chitosangynaecologicsuppository antibacterial gel, fill a prescription as follows:
Chitosan 20--30 part
Acetic acid 5--15 part
Propylene glycol 40--60 part
Glycerol 50--70 part
Dehydrated alcohol 20--40 part
0.1-1.0 parts of Oleum menthae
0.1-1.0 parts of Mentholums
0.5-1.5 parts of poloxamers
Chlorhexidine acetate 2--4 part
Lauryl alcohol polyoxyethylene ether 4--8 part
Purified water 800--900 part
In the present invention; The Chitosangynaecologicsuppository antibacterial gel, optimum formula: 27 parts of chitosans, 10 parts of acetic acid, 50 parts of propylene glycol, 60 parts of glycerol, 30 parts of dehydrated alcohol, 0.5 part of Oleum menthae, 0.5 part of Mentholum, 1 part of poloxamer, 3 parts of chlorhexidine acetate, 6 parts of lauryl alcohol polyoxyethylene ether, 809 parts of purified water.
The method for preparing of Chitosangynaecologicsuppository antibacterial gel may further comprise the steps:
(1), take by weighing 27 parts of chitosans in sterile chamber, add purified water 800--900 part and the dispersion of acetic acid 5--15 part, the gel that fully is swelled into 2--4% is subsequent use;
(2), taking by weighing 0.1-1.0 parts of Oleum menthae, 0.1-1.0 parts of Mentholums, chlorhexidine acetate 2--4 part, poloxamer joins in 20--40 part dehydrated alcohol for 0.5-1.5 parts; Dissolving (heating in case of necessity); Add lauryl alcohol polyoxyethylene ether 4--8 part, propylene glycol 40--60 part, glycerol 50--70 part again; Fully mixing is oil phase altogether, and is subsequent use;
(3), under agitation oil phase is thread and adds in the swelling solution, fully stir, leave standstill the degassing, process gel;
(4), sampling and measuring pH value and content, qualified back fill (4g/ props up), packing promptly gets the Chitosangynaecologicsuppository antibacterial gel.
Beneficial effect:
The antibacterial gel good anti-bacterial effect of the present invention's preparation, adopting the medical macromolecular materials high density polyethylene (HDPE) is material, to the human body safety non-toxic.
The specific embodiment
Be easy to understand and understand in order to make technological means of the present invention, creation characteristic, workflow, method for using reach purpose and effect,, further set forth the present invention below in conjunction with specific embodiment.
Embodiment 1,
The Chitosangynaecologicsuppository antibacterial gel, fill a prescription as follows:
20 parts of chitosans
5 parts of acetic acid
40 parts of propylene glycol
50 parts of glycerol
20 parts of dehydrated alcohol
0.1 part of Oleum menthae
0.1 part of Mentholum
0.5 part of poloxamer
2 parts of chlorhexidine acetate
4 parts of lauryl alcohol polyoxyethylene ether
800 parts of purified water
The method for preparing of Chitosangynaecologicsuppository antibacterial gel may further comprise the steps:
(1), take by weighing 20 parts of chitosans in sterile chamber, add 800 parts of purified water and 5 parts of dispersions of acetic acid, it is subsequent use fully to be swelled into gel;
(2), taking by weighing 0.1 part of Oleum menthae, 0.1 part of Mentholum, 2 parts of chlorhexidine acetate, poloxamer joins in 20 parts of dehydrated alcohol for 0.5 part; Dissolving (heating in case of necessity); Add 4 parts of lauryl alcohol polyoxyethylene ether, 40 parts of propylene glycol, 50 parts of glycerol again; Fully mixing is oil phase altogether, and is subsequent use;
(3), under agitation oil phase is thread and adds in the swelling solution, fully stir, leave standstill the degassing, process gel;
(4), sampling and measuring pH value and content, qualified back fill, packing promptly gets the Chitosangynaecologicsuppository antibacterial gel.
Embodiment 2,
The Chitosangynaecologicsuppository antibacterial gel, fill a prescription as follows:
27 parts of chitosans
10 parts of acetic acid
50 parts of propylene glycol
60 parts of glycerol
30 parts of dehydrated alcohol
0.5 part of Oleum menthae
0.5 part of Mentholum
1 part of poloxamer
3 parts of chlorhexidine acetate
6 parts of lauryl alcohol polyoxyethylene ether
809 parts of purified water
The method for preparing of Chitosangynaecologicsuppository antibacterial gel may further comprise the steps:
(1), take by weighing chitosan 20--30 part in sterile chamber, add 809 parts of purified water and 10 parts of dispersions of acetic acid, it is subsequent use fully to be swelled into 2.7% gel;
(2), taking by weighing 0.5 part of Oleum menthae, 0.5 part of Mentholum, 3 parts of chlorhexidine acetate, poloxamer joins in 30 parts of dehydrated alcohol for 1 part; Heating for dissolving adds 6 parts of lauryl alcohol polyoxyethylene ether, 50 parts of propylene glycol, 60 parts of glycerol again, fully mixing; Be oil phase altogether, subsequent use;
(3), under agitation oil phase is thread and adds in the swelling solution, fully stir, leave standstill the degassing, process gel;
(4), sampling and measuring pH value and content, qualified back fill, packing promptly gets the Chitosangynaecologicsuppository antibacterial gel.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; The present invention is not restricted to the described embodiments; That describes in the foregoing description and the description just explains principle of the present invention; Under the prerequisite that does not break away from spirit and scope of the invention, the present invention also has various changes and modifications, and these variations and improvement all fall in the scope of the invention that requires protection.The present invention requires protection domain to be defined by appending claims and equivalent thereof.
Claims (3)
1. Chitosangynaecologicsuppository antibacterial gel; It is characterized in that, fill a prescription as follows: chitosan 20--30 part, acetic acid 5--15 part, propylene glycol 40--60 part, glycerol 50--70 part, dehydrated alcohol 20--40 part, 0.1-1.0 parts of Oleum menthae, 0.1-1.0 parts of Mentholums, 0.5-1.5 parts of poloxamers, chlorhexidine acetate 2--4 part, lauryl alcohol polyoxyethylene ether 4--8 part, purified water 800--900 part.
2. Chitosangynaecologicsuppository antibacterial gel according to claim 1; It is characterized in that prescription: 27 parts of chitosans, 10 parts of acetic acid, 50 parts of propylene glycol, 60 parts of glycerol, 30 parts of dehydrated alcohol, 0.5 part of Oleum menthae, 0.5 part of Mentholum, 1 part of poloxamer, 3 parts of chlorhexidine acetate, 6 parts of lauryl alcohol polyoxyethylene ether, 809 parts of purified water.
3. the method for preparing of Chitosangynaecologicsuppository antibacterial gel is characterized in that, may further comprise the steps:
(1), take by weighing 27 parts of chitosans in sterile chamber, add purified water 800--900 part and the dispersion of acetic acid 5--15 part, the gel that fully is swelled into 2--4% is subsequent use;
(2), taking by weighing 0.1-1.0 parts of Oleum menthae, 0.1-1.0 parts of Mentholums, chlorhexidine acetate 2--4 part, poloxamer joins in 20--40 part dehydrated alcohol for 0.5-1.5 parts; Dissolving (heating in case of necessity); Add lauryl alcohol polyoxyethylene ether 4--8 part, propylene glycol 40--60 part, glycerol 50--70 part again; Fully mixing is oil phase altogether, and is subsequent use;
(3), under agitation oil phase is thread and adds in the swelling solution, fully stir, leave standstill the degassing, process gel;
(4), sampling and measuring pH value and content, qualified back fill, packing promptly gets the Chitosangynaecologicsuppository antibacterial gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101352545A CN102626524A (en) | 2012-05-04 | 2012-05-04 | Chitosan gynaecologic antibacterial gel and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101352545A CN102626524A (en) | 2012-05-04 | 2012-05-04 | Chitosan gynaecologic antibacterial gel and preparation method thereof |
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| CN102626524A true CN102626524A (en) | 2012-08-08 |
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| CN2012101352545A Pending CN102626524A (en) | 2012-05-04 | 2012-05-04 | Chitosan gynaecologic antibacterial gel and preparation method thereof |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040728A (en) * | 2013-02-03 | 2013-04-17 | 福州乾正药业有限公司 | Chitosan gel for women as well as preparation method and medical application thereof |
| CN103446180A (en) * | 2013-09-04 | 2013-12-18 | 上海昌颌医药科技有限公司 | Bacterial cellulose-chitosan plural gel as well as preparation method thereof and application thereof in intracorporal treatment |
| CN103463124A (en) * | 2013-09-04 | 2013-12-25 | 上海昌颌医药科技有限公司 | Bacterial cellulose/chitosan composite gel and preparation thereof, and application of composite gel in body surface wound surface healing |
| CN103705535A (en) * | 2013-12-27 | 2014-04-09 | 王东宇 | Gynecological chitosan gel and preparation method thereof |
| CN104630930A (en) * | 2015-02-03 | 2015-05-20 | 湖州市菱湖重兆金辉丝织厂 | Novel spinning solution with hematostatic function and preparation method of novel spinning solution |
| CN106266037A (en) * | 2016-08-19 | 2017-01-04 | 吉安市御美丽健康产业股份有限公司 | A kind of liquid gel and preparation method thereof |
| CN107184641A (en) * | 2017-05-23 | 2017-09-22 | 刘羽 | A kind of gynecological antimicrobial gel recipe and preparation method thereof |
| CN108904780A (en) * | 2018-08-24 | 2018-11-30 | 湖南金朋医疗器械有限公司 | A kind of gynaecological gel and preparation method thereof |
| CN109771545A (en) * | 2019-03-14 | 2019-05-21 | 盛荣秋实生物技术(广州)有限公司 | A kind of temperature sensitive bacteriostatic gel of intelligence |
| CN110934147A (en) * | 2018-09-25 | 2020-03-31 | 上海利康消毒高科技有限公司 | Medical ultrasonic disinfection coupling agent and preparation method thereof |
| CN114129592A (en) * | 2021-12-06 | 2022-03-04 | 郑州大学第一附属医院 | Disinfection gel for obstetrics and gynecology department and preparation method thereof |
| CN114870066A (en) * | 2022-04-21 | 2022-08-09 | 田耿家 | Functional dressing for treating chronic wound surface, preparation and preparation method thereof |
-
2012
- 2012-05-04 CN CN2012101352545A patent/CN102626524A/en active Pending
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040728A (en) * | 2013-02-03 | 2013-04-17 | 福州乾正药业有限公司 | Chitosan gel for women as well as preparation method and medical application thereof |
| CN103446180A (en) * | 2013-09-04 | 2013-12-18 | 上海昌颌医药科技有限公司 | Bacterial cellulose-chitosan plural gel as well as preparation method thereof and application thereof in intracorporal treatment |
| CN103463124A (en) * | 2013-09-04 | 2013-12-25 | 上海昌颌医药科技有限公司 | Bacterial cellulose/chitosan composite gel and preparation thereof, and application of composite gel in body surface wound surface healing |
| CN103446180B (en) * | 2013-09-04 | 2015-09-30 | 上海昌颌医药科技有限公司 | The application of a kind of Bacterial cellulose chitosan plural gel and preparation and interior therapeutic |
| CN103463124B (en) * | 2013-09-04 | 2016-01-13 | 上海昌颌医药科技有限公司 | A kind of Bacterial cellulose chitosan plural gel and preparation thereof and the surface wound application of healing |
| CN103705535A (en) * | 2013-12-27 | 2014-04-09 | 王东宇 | Gynecological chitosan gel and preparation method thereof |
| CN104630930A (en) * | 2015-02-03 | 2015-05-20 | 湖州市菱湖重兆金辉丝织厂 | Novel spinning solution with hematostatic function and preparation method of novel spinning solution |
| CN106266037B (en) * | 2016-08-19 | 2020-09-29 | 吉安市御美丽健康产业股份有限公司 | Liquid gel and preparation method thereof |
| CN106266037A (en) * | 2016-08-19 | 2017-01-04 | 吉安市御美丽健康产业股份有限公司 | A kind of liquid gel and preparation method thereof |
| CN107184641A (en) * | 2017-05-23 | 2017-09-22 | 刘羽 | A kind of gynecological antimicrobial gel recipe and preparation method thereof |
| CN108904780A (en) * | 2018-08-24 | 2018-11-30 | 湖南金朋医疗器械有限公司 | A kind of gynaecological gel and preparation method thereof |
| CN108904780B (en) * | 2018-08-24 | 2022-03-15 | 湖南金朋医疗器械有限公司 | Gynecological gel and preparation method thereof |
| CN110934147A (en) * | 2018-09-25 | 2020-03-31 | 上海利康消毒高科技有限公司 | Medical ultrasonic disinfection coupling agent and preparation method thereof |
| CN109771545A (en) * | 2019-03-14 | 2019-05-21 | 盛荣秋实生物技术(广州)有限公司 | A kind of temperature sensitive bacteriostatic gel of intelligence |
| CN114129592A (en) * | 2021-12-06 | 2022-03-04 | 郑州大学第一附属医院 | Disinfection gel for obstetrics and gynecology department and preparation method thereof |
| CN114129592B (en) * | 2021-12-06 | 2023-03-10 | 郑州大学第一附属医院 | Disinfecting gel for obstetrics and gynecology department and preparation method thereof |
| CN114870066A (en) * | 2022-04-21 | 2022-08-09 | 田耿家 | Functional dressing for treating chronic wound surface, preparation and preparation method thereof |
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| C06 | Publication | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120808 |