CN106265719A - A kind of medical heat clearing away anti-bacterial hydrogel eye sticker and preparation method thereof - Google Patents
A kind of medical heat clearing away anti-bacterial hydrogel eye sticker and preparation method thereof Download PDFInfo
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- CN106265719A CN106265719A CN201610503255.9A CN201610503255A CN106265719A CN 106265719 A CN106265719 A CN 106265719A CN 201610503255 A CN201610503255 A CN 201610503255A CN 106265719 A CN106265719 A CN 106265719A
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- Prior art keywords
- hydrogel
- clearing away
- heat clearing
- medical heat
- eye sticker
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
Abstract
The invention discloses the hydrogel eye plaster that a kind of medical heat clearing away is antibacterial, be made up of polypropylene liner plate, hydrogel, non-woven fabrics and polyvinyl chloride film, for imitative lens type appearance design.Wherein hydrogel is according to mass percentage, including following components: the polyvinyl alcohol of 5 ~ 20%, the polyacrylamide of 0.5 ~ 5%, the chitosan of 0.3 ~ 1.3%, the matrine of 0.2 ~ 1%, the menthol of 0.02 ~ 0.15% and the purified water of 80 ~ 90%.The present invention is with polyvinyl alcohol and polyacrylamide as gel skeleton, to strengthen Swelling Capacity and the breathability of single polyvinyl alcohol hydrogel.Add the antipathogenic compositions such as chitosan, matrine and menthol, strengthen the antibacterial ability of hydrogel.Wherein Chinese medicine ingredients matrine also has heat clearing away, antivirus action, and the interpolation of a small amount of menthol enhances the penetrating power of Chinese medicinal components makes hydrogel have refrigerant sense of touch simultaneously.
Description
Technical field
The present invention relates to a kind of medical treatment and nursing articles for use, be especially a kind of medical heat clearing away anti-bacterial hydrogel eye sticker and preparation thereof
Method.
Background technology
General anesthesia operation patient and degree of depth coma patient lose state owing to being in mind, and eye muscle is lax causes patient to go out
Existing functional hypophasis, thus easily cause exposure keratitis.Clinically, such patient need to be carried out extra eye
Portion nurses, and nursing care mode includes following several: saline gauze covers, smears medicine and surgical adhesive membrane is fixed.Although with upper type
Problem can be alleviated to a certain extent, but still suffer from certain defect.Saline gauze covers and need to be replaced as frequently as avoiding saline to evaporate
And ineffective, and gauze inner surface easily rubs cornea；Smear medicine and there is certain drug side effect, stimulate eyes；Operation
Pad pasting the most easily injures skin, causes skin allergy and hair viscous de-.
In addition, hydrogel eye plaster is also applied to preventing clinical exposure keratitis, and achieves good effect.
As in patent of invention " medical hydrogel eye mask and preparation method thereof " that number of patent application is 201210121029.6, employing includes
Polyvinyl alcohol, polyurethane, collagen, sodium alginate, chitosan have prepared hydrogel eye plaster at interior colloidal stroma and water, for
Eye provides relatively moistening environment.But such eye sticker water content and breathability are relatively poor, antibacterial ability is more weak and needs
Special arrangement is fixed, and is unfavorable for that clinicist operates, and easily causes eye's pressurized and then affect one's power of vision.
The present invention is directed to problem above, it is provided that a kind of medical heat clearing away anti-bacterial hydrogel eye sticker and preparation method thereof.The present invention
In increase the water content of polyvinyl alcohol hydrogel and breathability by introducing the three-dimensional net structure of polyacrylamide, and be conducive to
The slow release of active component, it is provided that lasting antibacterial ability；For the problem without antibacterial ability of POLYPROPYLENE GLYCOL hydrogel, with the addition of
Multiple antimicrobial component including chitosan, matrine and menthol；Matrine as the main active of sophora flavescens ait,
There is good heat clearing away and antivirus action；Being added on of appropriate menthol can improve activity group while avoiding Ocular irritation
The corneal permeability divided, menthol can produce refrigerant sense of touch, improves eye's comfort level；The appearance design of imitative eyeglass, it is not necessary to
Extra fixing device；Polypropylene liner plate can reduce eye's pressurized as backing material, it is to avoid the secondary wound of eye
Evil.
Summary of the invention
The present invention seeks to for problem above, it is provided that a kind of medical heat clearing away anti-bacterial hydrogel eye protector.It is mainly used in
Alleviate that eyes are dry and astringent, itch, acid is swollen, pain, the problem such as shed tears, there is heat clearing away antibacterial action, and eye played physical isolation
With the effect hidden.
Medical heat clearing away anti-bacterial hydrogel eye sticker involved in the present invention has the feature that
1. the medical heat clearing away anti-bacterial hydrogel eye sticker described in is thin by polypropylene liner plate, hydrogel patch, non-woven fabrics and polrvinyl chloride
Film forms, for imitative lens type appearance design, it is not necessary to uses extra fixing device, convenient operation, is conducive to improving patient comfort.
2. the medical heat clearing away anti-bacterial hydrogel eye sticker described in, is made up of following methods:
(1) prepared by colloid: polyvinyl alcohol, polyacrylamide, chitosan, matrine, menthol are dissolved in proportion in purified water,
Under 90 ~ 100 ° of C, heated and stirred is to being completely dissolved.
(2) fill: after cooling, is circulated into levelling in ready grinding tool by gained colloid.
(3) freezing: hydrogel uses freeze-thaw physical crosslinking method to prepare.By canned product through freezing, solution for several times
Freeze process and obtain medical heat clearing away anti-bacterial hydrogel.
(4) prepared by eye sticker: the hydrogel plaster of gained invests the non-woven fabrics inner surface with ear belting, and non-woven fabrics is arranged
Many places fixing point.The hydrogel Surface mulch polyvinyl chloride film fixed is as sealing coat, to avoid foreign body and hydrogel
Directly contact, increases the ability of prevention foreign object damage.Add polypropylene liner plate as backing material, to avoid hydrogel tension
Fit in eye, to eyes build-up of pressure and unnecessary damage.
(5) sterilizing: above-mentioned hydrogel eye plaster is packed, irradiation sterilization.
3. the medical heat clearing away anti-bacterial hydrogel eye sticker described in, is prepared from by the raw material including following weight portion, raw material weight
Amount and be 100:
Polyvinyl alcohol 5 ~ 20
Polyacrylamide 0.5 ~ 5
Chitosan 0.3-1.3
Matrine 0.2 ~ 1
Menthol 0.02-0.15
Water for injection 80 ~ 90
Preferably, described medical heat clearing away anti-bacterial hydrogel eye sticker, the raw material including following weight portion it is prepared from, raw material weight
With for 100:
Polyvinyl alcohol 9
Polyacrylamide 2.5
Chitosan 0.7
Matrine 0.4
Menthol 0.05
Water for injection 87.35
4. the medical heat clearing away anti-bacterial hydrogel eye sticker described in is by polyvinyl alcohol, polyacrylamide, chitosan, matrine, menthol
Freeze-thaw physical crosslinking method is used to prepare with purified water, it is not necessary to use chemical cross-linking agent, it is to avoid the chemical cross-linking agent used
Eyes are caused secondary injury by residual.
5. the medical heat clearing away anti-bacterial hydrogel eye sticker described in introduces the three-dimensional net structure of polyacrylamide, increases polyethylene
The water content of alcohol hydrogel and breathability, and the slow release of beneficially active component, it is provided that lasting antibacterial ability.
6. the medical heat clearing away anti-bacterial hydrogel eye sticker pin described in the addition of including chitosan, matrine and menthol
Multiple antimicrobial component.
7. the medical heat clearing away anti-bacterial hydrogel eye sticker described in the addition of matrine, has good heat clearing away and antiviral is made
With.
8. the medical heat clearing away anti-bacterial hydrogel eye sticker described in the addition of appropriate menthol, while avoiding Ocular irritation
Can improve the corneal permeability of active component, menthol can produce refrigerant sense of touch, improves eye's comfort level.
9. the medical heat clearing away anti-bacterial hydrogel eye sticker described in can keep relative humidity to be not less than 90%, continues moisturizing 10 h, nothing
Need to frequently change.
10. the pH value of the medical heat clearing away anti-bacterial hydrogel eye sticker described in is maintained between 5.0 ~ 7.5.
The content of beary metal of the medical heat clearing away anti-bacterial hydrogel eye sticker described in 11. is not higher than 10 μ g/g.
The medical heat clearing away irradiated sterilizing of anti-bacterial hydrogel eye sticker described in 12., make product reach aseptic while avoid
The ethylene oxide residue secondary injury to eye.
The cell-cytotoxic reaction of the medical heat clearing away anti-bacterial hydrogel eye sticker described in 13. is not more than 2 grades, anti-without sensitization of skin
Should.
Medical heat clearing away anti-bacterial hydrogel eye sticker described in 14. is without skin wound repair, good biocompatibility.
It is more readily understood the above-mentioned of the application and other features, aspect and advantage with reference to described further below.
Accompanying drawing explanation
Accompanying drawing is the structural representation of one embodiment of the invention.
Detailed description of the invention
This public affairs can be more easily understood with reference to the detailed description of preferred implementation of the invention below and the embodiment that includes
Open content.Example is served only for explaining the present invention, is not intended to limit the scope of the present invention.Professional and technical personnel in the field
Some nonessential improvement and adjustment that content according to the invention described above is made, still fall within protection scope of the present invention.
Approximation term in specification and claims is used for modifying quantity, represents that the present invention is not limited to this concrete
Quantity, also includes close to this quantity acceptable without causing the part of the correction of the change of relevant basic function.Phase
Answer, modify a numerical value with " about ", " about " etc., mean and the invention is not restricted to this exact numerical.In some example, approximation
Term likely corresponds to detect the precision of the equipment of numerical value.In present specification and claims, scope limits permissible
Combination and/or exchange, these scopes include all subranges contained therebetween if not stated otherwise.
Equivalent, concentration or other value or parameter are preferred with scope, preferred scope or a series of upper limit preferred value and lower limit
During the Range Representation that value limit is walked, this is appreciated that and specifically discloses by any range limit or preferred
All scopes that arbitrary pairing of value and any range lower limit or preferred value is formed, regardless of whether this scope is the most public
Open.Such as, when disclosing scope " l to 5 ", described scope should be interpreted as including scope " 1 to 4 ", " 1 to 3 ", " 1
To 2 ", " 1 to 2 and 4 to 5 ", " 1 to 3 and 5 " etc..When numerical range is described in this article, unless otherwise indicated, otherwise should
Scope is intended to include its end value and all integers within the range and mark.
Additionally, indefinite article " a kind of " before key element of the present invention or component and " one " are to key element or the quantitative requirement of component
(i.e. occurrence number) unrestriction.Therefore " one " or " a kind of " should be read as including one or at least one, and odd number
The key element of form or component also include plural form, unless the obvious purport of described quantity refers to singulative.
It addition, illustrate without other, raw materials used is all commercially available.
Medical heat clearing away anti-bacterial hydrogel eye sticker, as shown in drawings, by polypropylene liner plate, polyvinyl alcohol hydrogel, non-woven fabrics
Form with polyvinyl chloride film, for imitative lens type appearance design.Specific implementation method is as follows:
(1) prepared by colloid: polyvinyl alcohol, polyacrylamide, chitosan, matrine, menthol are dissolved in proportion in purified water,
Under 90 ~ 100 ° of C, heated and stirred is to being completely dissolved.Wherein raw material uses following weight portion to add:
Polyvinyl alcohol 5 ~ 20
Polyacrylamide 0.5 ~ 5
Chitosan 0.3-1.3
Matrine 0.2 ~ 1
Menthol 0.02-0.15
Water for injection 80 ~ 90
Preferably, described medical heat clearing away anti-bacterial hydrogel eye sticker, the raw material including following weight portion it is prepared from, raw material weight
With for 100:
Polyvinyl alcohol 9
Polyacrylamide 2.5
Chitosan 0.7
Matrine 0.4
Menthol 0.05
Water for injection 87.35
(2) fill: after cooling, is circulated into levelling in ready grinding tool by gained colloid.
(3) freezing: hydrogel uses freeze-thaw physical crosslinking method to prepare.By canned product through freezing, solution for several times
Freeze process and obtain polyvinyl alcohol hydrogel.
(4) prepared by eye sticker: the hydrogel plaster of gained invests the non-woven fabrics inner surface with ear belting, and non-woven fabrics is arranged
Many places fixing point.The hydrogel Surface mulch polyvinyl chloride film fixed is as sealing coat, to avoid foreign body and hydrogel
Directly contact, increases the ability of prevention foreign object damage.Additionally, in the present invention, add polypropylene liner plate as backing material,
To avoid hydrogel tension to fit in eye, to eyes build-up of pressure and unnecessary damage.
(5) sterilizing: above-mentioned hydrogel eye plaster is packed, irradiation sterilization.
Polypropylene liner plate and a length of 241 ± 20 cm of polyvinyl chloride film in above-mentioned hydrogel eye plaster, width is 90 ± 10
cm.Wherein a length of 158 ± 20 cm of POLYPROPYLENE GLYCOL hydrogel eye plaster, width is 58 ± 10 cm, for transparent or semitransparent film
Shape, surface is uniform, smooth, clean；Relative humidity is not less than 90%, continues moisturizing 10 h；PH value is between 5.0 ~ 7.5；Heavy metal
Content is not higher than 10 μ g/g；Reach aseptic after irradiated sterilizing；Cell-cytotoxic reaction is not more than 2 grades；Without sensitization of skin reaction and
Without skin wound repair.
Embodiment 1
(1) prepared by colloid: polyvinyl alcohol, polyacrylamide, chitosan, matrine, menthol are dissolved in proportion in purified water,
Under 90 ~ 100 ° of C, heated and stirred is to being completely dissolved.It is prepared from by the raw material including following weight portion, raw material weight and be
100:
Polyvinyl alcohol 9
Polyacrylamide 2.5
Chitosan 0.7
Matrine 0.4
Menthol 0.05
Water for injection 87.35
(2) fill: after cooling, is circulated into levelling in ready grinding tool by gained colloid.
(3) freezing: hydrogel uses freeze-thaw physical crosslinking method to prepare.By canned product through 7 freezings, solutions
Freeze process and obtain polyvinyl alcohol hydrogel.
(4) prepared by eye sticker: the hydrogel plaster of gained invests the non-woven fabrics inner surface with ear belting, the water fixed
The said goods, as sealing coat, is then fixed on polypropylene liner plate by gel Surface mulch polyvinyl chloride film.Polrvinyl chloride
Thin film and a length of 232cm of polypropylene liner plate, width 81cm.
(5) sterilizing: packed by above-mentioned hydrogel eye plaster, irradiation sterilization obtains heat clearing away anti-bacterial hydrogel A.
Embodiment 2
(1) prepared by colloid: polyvinyl alcohol, polyacrylamide, chitosan, matrine, menthol are dissolved in proportion in purified water,
Under 90 ~ 100 ° of C, heated and stirred is to being completely dissolved.It is prepared from by the raw material including following weight portion, raw material weight and be
100:
Polyvinyl alcohol 10
Polyacrylamide 3
Chitosan 0.5
Matrine 0.3
Menthol 0.03
Water for injection 86.17
(2) fill: after cooling, is circulated into levelling in ready grinding tool by gained colloid.
(3) freezing: hydrogel uses freeze-thaw physical crosslinking method to prepare.By canned product 8 freezings, defrostings
Process obtains polyvinyl alcohol hydrogel.
(4) prepared by eye sticker: the hydrogel plaster of gained invests the non-woven fabrics inner surface with ear belting, the water fixed
The said goods, as sealing coat, is then fixed on polypropylene liner plate by gel Surface mulch polyvinyl chloride film.Polrvinyl chloride
Thin film and a length of 232 cm of polypropylene liner plate, width 81 cm.
(5) sterilizing: packed by above-mentioned hydrogel eye plaster, irradiation sterilization obtains heat clearing away anti-bacterial hydrogel B.
Embodiment 3
(1) prepared by colloid: polyvinyl alcohol, polyacrylamide, chitosan, matrine, menthol are dissolved in proportion in purified water,
Under 90 ~ 100 ° of C, heated and stirred is to being completely dissolved.It is prepared from by the raw material including following weight portion, raw material weight and be
100:
Polyvinyl alcohol 12
Polyacrylamide 2
Chitosan 0.65
Matrine 0.6
Menthol 0.05
Water for injection 86.7
(2) fill: after cooling, is circulated into levelling in ready grinding tool, grinding tool length 160 cm, width 62 by gained colloid
cm。
(3) freezing: hydrogel uses freeze-thaw physical crosslinking method to prepare.By canned product 9 freezings, defrostings
Process obtains polyvinyl alcohol hydrogel.
(4) prepared by eye sticker: the hydrogel plaster of gained invests the non-woven fabrics inner surface with ear belting, the water fixed
The said goods, as sealing coat, is then fixed on polypropylene liner plate by gel Surface mulch polyvinyl chloride film.Polrvinyl chloride
Thin film and a length of 250 cm of polypropylene liner plate, width 95 cm.
(5) sterilizing: packed by above-mentioned hydrogel eye plaster, irradiation sterilization obtains polyvinyl alcohol hydrogel C.
Embodiment 4
(1) prepared by colloid: polyvinyl alcohol, polyacrylamide, chitosan, matrine, menthol are dissolved in proportion in purified water,
Under 90 ~ 100 ° of C, heated and stirred is to being completely dissolved.It is prepared from by the raw material including following weight portion, raw material weight and be
100:
Polyvinyl alcohol 15
Polyacrylamide 2
Chitosan 0.5
Matrine 0.3
Menthol 0.03
Water for injection 82.17
(2) fill: after cooling, is circulated into levelling in ready grinding tool, grinding tool length 162 cm, width 65 by gained colloid
cm。
(3) freezing: hydrogel uses freeze-thaw physical crosslinking method to prepare.By canned product 7 freezings, defrostings
Process obtains polyvinyl alcohol hydrogel.
(4) prepared by eye sticker: the hydrogel plaster of gained invests the non-woven fabrics inner surface with ear belting, the water fixed
The said goods, as sealing coat, is then fixed on polypropylene liner plate by gel Surface mulch polyvinyl chloride film.Polrvinyl chloride
Thin film and a length of 255 cm of polypropylene liner plate, width 97 cm.
(5) sterilizing: packed by above-mentioned hydrogel eye plaster, irradiation sterilization obtains polyvinyl alcohol hydrogel D.
Embodiment 5
(1) prepared by colloid: polyvinyl alcohol, polyacrylamide, chitosan, matrine, menthol are dissolved in proportion in purified water,
Under 90 ~ 100 ° of C, heated and stirred is to being completely dissolved.It is prepared from by the raw material including following weight portion, raw material weight and be
100:
Polyvinyl alcohol 8
Polyacrylamide 4
Chitosan 0.8
Matrine 0.3
Menthol 0.04
Water for injection 86.86
(2) fill: after cooling, is circulated into levelling in ready grinding tool, grinding tool length 142 cm, width 49 by gained colloid
cm。
(3) freezing: hydrogel uses freeze-thaw physical crosslinking method to prepare.By canned product 7 freezings, defrostings
Process obtains polyvinyl alcohol hydrogel.
(4) prepared by eye sticker: the hydrogel plaster of gained invests the non-woven fabrics inner surface with ear belting, the water fixed
The said goods, as sealing coat, is then fixed on polypropylene liner plate by gel Surface mulch polyvinyl chloride film.Polrvinyl chloride
Thin film and a length of 230 cm of polypropylene liner plate, width 88 cm.
(5) sterilizing: packed by above-mentioned hydrogel eye plaster, irradiation sterilization obtains polyvinyl alcohol hydrogel E.
Embodiment 6
(1) prepared by colloid: polyvinyl alcohol, polyacrylamide, chitosan, matrine, menthol are dissolved in proportion in purified water,
Under 90 ~ 100 ° of C, heated and stirred is to being completely dissolved.It is prepared from by the raw material including following weight portion, raw material weight and be
100:
Polyvinyl alcohol 6
Polyacrylamide 5
Chitosan 1.1
Matrine 0.85
Menthol 0.05
Water for injection 87
(2) fill: after cooling, is circulated into levelling in ready grinding tool, grinding tool length 146 cm, width by gained colloid
51cm。
(3) freezing: hydrogel uses freeze-thaw physical crosslinking method to prepare.By canned product 8 freezings, defrostings
Process obtains polyvinyl alcohol hydrogel.
(4) prepared by eye sticker: the hydrogel plaster of gained invests the non-woven fabrics inner surface with ear belting, the water fixed
The said goods, as sealing coat, is then fixed on polypropylene liner plate by gel Surface mulch polyvinyl chloride film.Polrvinyl chloride
Thin film and a length of 233cm of polypropylene liner plate, width 91cm.
(5) sterilizing: packed by above-mentioned hydrogel eye plaster, irradiation sterilization obtains polyvinyl alcohol hydrogel F.
Embodiment 7
(1) prepared by colloid: polyvinyl alcohol, polyacrylamide, chitosan, matrine, menthol are dissolved in proportion in purified water,
Under 90 ~ 100 ° of C, heated and stirred is to being completely dissolved.It is prepared from by the raw material including following weight portion, raw material weight and be
100:
Polyvinyl alcohol 11
Polyacrylamide 2.5
Chitosan 0.6
Matrine 0.35
Menthol 0.05
Water for injection 85.5
(2) fill: after cooling, is circulated into levelling in ready grinding tool, grinding tool length 147cm, width by gained colloid
56cm。
(3) freezing: hydrogel uses freeze-thaw physical crosslinking method to prepare.By canned product 7 freezings, defrostings
Process obtains polyvinyl alcohol hydrogel.
(4) prepared by eye sticker: the hydrogel plaster of gained invests the non-woven fabrics inner surface with ear belting, the water fixed
The said goods, as sealing coat, is then fixed on polypropylene liner plate by gel Surface mulch polyvinyl chloride film.Polrvinyl chloride
Thin film and a length of 237cm of polypropylene liner plate, width 94cm.
(5) sterilizing: packed by above-mentioned hydrogel eye plaster, irradiation sterilization obtains polyvinyl alcohol hydrogel G.
Embodiment 8
(1) prepared by colloid: polyvinyl alcohol, polyacrylamide, chitosan, matrine, menthol are dissolved in proportion in purified water,
Under 90 ~ 100 ° of C, heated and stirred is to being completely dissolved.It is prepared from by the raw material including following weight portion, raw material weight and be
100:
Polyvinyl alcohol 9
Polyacrylamide 3.5
Chitosan 1
Matrine 0.3
Menthol 0.03
Water for injection 86.17
(2) fill: after cooling, is circulated into levelling in ready grinding tool, grinding tool length 152cm, width by gained colloid
59cm。
(3) freezing: hydrogel uses freeze-thaw physical crosslinking method to prepare.By canned product 9 freezings, defrostings
Process obtains polyvinyl alcohol hydrogel.
(4) prepared by eye sticker: the hydrogel plaster of gained invests the non-woven fabrics inner surface with ear belting, the water fixed
The said goods, as sealing coat, is then fixed on polypropylene liner plate by gel Surface mulch polyvinyl chloride film.Polrvinyl chloride
Thin film and a length of 239cm of polypropylene liner plate, width 97cm.
(5) sterilizing: packed by above-mentioned hydrogel eye plaster, irradiation sterilization obtains polyvinyl alcohol hydrogel H.
Reference examples 1
By polyvinyl alcohol during 1:9 is dissolved in purified water in proportion, under 95 ° of C, heated and stirred is to being completely dissolved, and adds plasticizer, friendship
Connection agent, pours in grinding tool after cooling deaeration.Obtained hydrogel is fixed on non-woven fabrics, after using ethylene oxide sterilizing is
Obtain polyvinyl alcohol hydrogel eye sticker.
Method of testing
The performance indications of Dispoable medical hydrogel eye plaster need according to clinical practice and formulate, and biological, chemical property is mainly joined
Examine the Pharmacopoeia of the People's Republic of China (version two in 2010), GB/T 14233.1-2008, GB/T16886.5-2003, GB/
The pertinent regulations of T16886.10-2005 and formulate.
(1) outward appearance.With visual observation, differentiate with feel, olfactory sensation.
(2) size.Use universal or special gage measuring.
(3) moisture retention.Temperature be 25 ± 2 ° of C, humidity be under 45 ~ 70% environment, eye sticker is covered in taper bottleneck, use
Its space humidity data of the probe measurement of hygronom, start after 30min to observe, and every 1h records once.
(4) acid-base value.
A. prepared by detection liquid: weighing 6 g hydrogels, impregnated in deionized water, sample with the mass ratio of deionized water is
1:40, extracts 24 h under conditions of 37 ± 1 ° of C, is separated with liquid by sample, be cooled to room temperature, as detection liquid.
B. test: take detection liquid, be measured with pH meter.
(5) content of beary metal.The methods experiment specified by 5.6.1 in GB/T 14233.1-2008.
(6) aseptic.The Pharmacopoeia of the People's Republic of China (version two in 2010) annex " Sterility Test " is tested.?
Take 11 products less, take each packaging apart with sterile working, take two 1cm × 3cm battens at each product different parts, respectively
It is seeded to THIOGLYCOLLIC ACID salt broth (often pipe loading amount 15mL) and improvement Martin's culture medium (often pipe loading amount 10mL).Positive right
It is separately added into the staphylococcus aureus less than 100 cfu to THIOGLYCOLLIC ACID salt broth, Candida albicans to changing according to group
Fine horse fourth culture medium, 48h ~ 72h cultivated by positive control pipe.Using culture medium as negative control group.Container containing culture medium is by rule
Fixed temperature is cultivated 14 days, and THIOGLYCOLLIC ACID salt broth is put 30 ~ 35 ° of C and cultivated, and improvement Martin's culture medium is put 23 ~ 28 ° of C and cultivated.
During cultivation, negative control group must not have bacteria growing, sample sets culture medium all to clarify, though or showing muddiness but through confirming aseptic life
Long, then product is aseptic.
(7) cytotoxicity.Take eye sticker by 1.25 cm2The ratio of/mL, prepares under 37 ± 1 ° of C, 24h ± 2h extracting conditions
Experimental liquid, extraction medium: cell culture fluid.Take experimental liquid by the mtt assay test of regulation in GB/T16886.5-2003.
(8) hypersensitive.Take eye sticker by 1.25 cm2The ratio of/mL, makes under 37 ± 1 ° of C, 24h ± 2h extracting conditions
Standby experimental liquid, extraction medium uses normal saline.Take experimental liquid by the method test of regulation in GB/T16886.10-2005.
(9) skin irritation.Take eye sticker by 1.25 cm2The ratio of/mL, makes under 37 ± 1 ° of C, 24h ± 2h extracting conditions
Standby experimental liquid, extraction medium uses normal saline.Take experimental liquid by the method test of regulation in GB/T16886.10-2005.
Table 1: the property list of product
Aforesaid example is merely illustrative, for explaining some features of the feature of the disclosure.Appended claim is intended to
Require the widest scope that it is contemplated that, and embodiments as presented herein is only the group according to all possible embodiment
The explanation of the embodiment of the selection closed.Therefore, the purpose of applicant is that appended claim is not by the spy of the explanation present invention
The selectional restriction of the example levied.And the progress in science and technology will be formed due to language performance inaccurate reason and not by mesh
Possible equivalent or the son of front consideration are replaced, and these changes also should be interpreted in the conceived case by appended right
Require to cover.
Claims (9)
1. medical heat clearing away anti-bacterial hydrogel eye sticker and preparation method thereof, it is characterised in that: by polypropylene liner plate, hydrogel plaster
Sheet, non-woven fabrics and polyvinyl chloride film composition, for imitative lens type appearance design.
Medical heat clearing away anti-bacterial hydrogel eye sticker the most according to claim 1, is made up of following methods:
(1) prepared by colloid: polyvinyl alcohol, polyacrylamide, chitosan, matrine, menthol are dissolved in proportion in purified water,
Under 90 ~ 100 ° of C, heated and stirred is to being completely dissolved；
(2) fill: after cooling, is circulated into levelling in ready grinding tool by gained colloid；
(3) freezing: hydrogel uses freeze-thaw physical crosslinking method to prepare；
Canned product is processed through freezing, defrosting for several times and obtains medical heat clearing away anti-bacterial hydrogel；
(4) prepared by eye sticker: the hydrogel plaster of gained invests the non-woven fabrics inner surface with ear belting, and non-woven fabrics arranges many places
Fixing point, the hydrogel Surface mulch polyvinyl chloride film fixed is as sealing coat, to avoid the direct of foreign body and hydrogel
Contact, increases the ability of prevention foreign object damage, adds polypropylene liner plate as backing material, to avoid hydrogel tension to fit
In eye, to eyes build-up of pressure and unnecessary damage；
(5) sterilizing: above-mentioned hydrogel eye plaster is packed, irradiation sterilization.
Medical heat clearing away anti-bacterial hydrogel eye sticker the most according to claim 2, it is characterised in that: by including following weight portion
Raw material is prepared from, raw material weight and be 100:
Polyvinyl alcohol 5 ~ 20
Polyacrylamide 0.5 ~ 5
Chitosan 0.3-1.3
Matrine 0.2 ~ 1
Menthol 0.02-0.15
Water for injection 80 ~ 90
Preferably, described medical heat clearing away anti-bacterial hydrogel eye sticker, the raw material including following weight portion it is prepared from, raw material weight
With for 100:
Polyvinyl alcohol 9
Polyacrylamide 2.5
Chitosan 0.7
Matrine 0.4
Menthol 0.05
Water for injection 87.35.
Medical heat clearing away anti-bacterial hydrogel eye sticker the most according to claim 2, it is characterised in that: described polypropylene liner plate by
The polypropylene meeting YY/T 0242 standard is made, a length of 241 ± 20 cm, and width is 90 ± 10cm.
Medical heat clearing away anti-bacterial hydrogel eye sticker the most according to claim 2, it is characterised in that: described non-woven fabrics uses symbol
The non-woven fabrics of conjunction FZ/T 64005-2011 health light weight nonwovens standard adds deeply with ear band to be made.
Medical heat clearing away anti-bacterial hydrogel eye sticker the most according to claim 2, it is characterised in that: described polyvinyl chloride film
Being made up of the polyvinyl chloride film meeting GB15593-1995 standard, a length of 241 ± 20cm, width is 90 ± 10cm.
Medical heat clearing away anti-bacterial hydrogel eye sticker the most according to claim 2, it is characterised in that: hydrogel eye plaster is a length of
158cm ± 20cm, width is 58 ± 10cm.
Medical heat clearing away anti-bacterial hydrogel eye sticker the most according to claim 2, it is characterised in that: described POLYPROPYLENE GLYCOL meets
The Pharmacopoeia of the People's Republic of China (version in 2010) standard.
Medical heat clearing away anti-bacterial hydrogel eye sticker the most according to claim 2, it is characterised in that: described purified water meets
The Pharmacopoeia of the People's Republic of China (version in 2010) standard.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110403920A (en) * | 2019-08-26 | 2019-11-05 | 江苏远恒药业有限公司 | Dispoable medical hydrogel eye plaster |
| CN116036154A (en) * | 2023-01-13 | 2023-05-02 | 青岛大学 | Water supplementing, mite removing and bacteria inhibiting hydrogel eye mask and preparation method and application thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101518481A (en) * | 2009-03-20 | 2009-09-02 | 都本立 | Medical moisturized eye paste and method for preparing same |
| CN201978189U (en) * | 2010-12-30 | 2011-09-21 | 江西宜信堂医疗科技有限公司 | Eye protecting paster |
| CN102370697A (en) * | 2011-10-27 | 2012-03-14 | 吴克 | Care cream for acute/chronic eczema and dermatitis |
| WO2013102234A1 (en) * | 2012-01-06 | 2013-07-11 | Ubs Ultimate Relief Pty Ltd | Formulation and method for treatment of pain and/or inflammation associated with a skin condition |
| CN103446618A (en) * | 2013-09-16 | 2013-12-18 | 河南科高辐射化工科技有限公司 | Antibacterial hydrogel wound coating film and wound paste prepared by using coating film |
| CN103494668A (en) * | 2013-09-30 | 2014-01-08 | 长沙海润生物技术有限公司 | Medical hydrogel moisturizing eye care mask and preparation method thereof |
| CN103893157A (en) * | 2014-04-09 | 2014-07-02 | 山东赛克赛斯药业科技有限公司 | Hydrogel eye protective pad dressing and preparation method thereof |
| CN104274383A (en) * | 2013-07-03 | 2015-01-14 | 郑州市新视明科技工程有限公司 | Composition for promoting skin compliance and active ingredient absorption of eye wet compressing agent |
| CN205234755U (en) * | 2015-11-10 | 2016-05-18 | 李学军 | Medical eyeshield subsides |
-
2016
- 2016-06-30 CN CN201610503255.9A patent/CN106265719A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101518481A (en) * | 2009-03-20 | 2009-09-02 | 都本立 | Medical moisturized eye paste and method for preparing same |
| CN201978189U (en) * | 2010-12-30 | 2011-09-21 | 江西宜信堂医疗科技有限公司 | Eye protecting paster |
| CN102370697A (en) * | 2011-10-27 | 2012-03-14 | 吴克 | Care cream for acute/chronic eczema and dermatitis |
| WO2013102234A1 (en) * | 2012-01-06 | 2013-07-11 | Ubs Ultimate Relief Pty Ltd | Formulation and method for treatment of pain and/or inflammation associated with a skin condition |
| CN104274383A (en) * | 2013-07-03 | 2015-01-14 | 郑州市新视明科技工程有限公司 | Composition for promoting skin compliance and active ingredient absorption of eye wet compressing agent |
| CN103446618A (en) * | 2013-09-16 | 2013-12-18 | 河南科高辐射化工科技有限公司 | Antibacterial hydrogel wound coating film and wound paste prepared by using coating film |
| CN103494668A (en) * | 2013-09-30 | 2014-01-08 | 长沙海润生物技术有限公司 | Medical hydrogel moisturizing eye care mask and preparation method thereof |
| CN103893157A (en) * | 2014-04-09 | 2014-07-02 | 山东赛克赛斯药业科技有限公司 | Hydrogel eye protective pad dressing and preparation method thereof |
| CN205234755U (en) * | 2015-11-10 | 2016-05-18 | 李学军 | Medical eyeshield subsides |
Non-Patent Citations (1)
| Title |
|---|
| 李云霞等: "薄荷醇手性拆分的研究进展", 《香料香精化妆品》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110403920A (en) * | 2019-08-26 | 2019-11-05 | 江苏远恒药业有限公司 | Dispoable medical hydrogel eye plaster |
| CN110403920B (en) * | 2019-08-26 | 2022-12-02 | 江苏远恒药业有限公司 | Disposable medical hydrogel eye patch |
| CN116036154A (en) * | 2023-01-13 | 2023-05-02 | 青岛大学 | Water supplementing, mite removing and bacteria inhibiting hydrogel eye mask and preparation method and application thereof |
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Application publication date: 20170104 |