CN106265141A

CN106265141A - A kind of external use skin care composition containing stachyose

Info

Publication number: CN106265141A
Application number: CN201510276814.2A
Authority: CN
Inventors: 徐加英
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-05-27
Filing date: 2015-05-27
Publication date: 2017-01-04

Abstract

The formula of a kind of external use skin care containing stachyose and proportion of composing and make main points.For cosmetic skin-care and cosmetic health product field.There is the effect making coarse skin become exquisiteness, be particularly well-suited to the people that skin of face seems coarse.It is characterized in that the ratio of stachyose and retinol and make main points (heating-up temperature, retention time and oxygen free condition), being used for improving pachylosis, effect is obvious, without any side effects.

Description

A kind of external use skin care composition containing stachyose

Technical field

The present invention relates to cosmetic skin-care and cosmetic health product field, be a kind of external use skin care composition containing stachyose, there is the effect making coarse skin become exquisiteness, be particularly well-suited to the people that skin of face seems coarse.

Background technology

The skincare product sold in the market mainly reaches cosmetology effect by reducing moisture of skin to lose.For the rough skin that seems, your product of current all kinds ofization all cannot make it improve.And the conventional external used medicine that can improve skin coarseness is glucocorticoid, such as fluocinonide ointment contains the external-use antiphlogistic thing of glucocorticoid or derivatives thereof with other.Although the short-period used of this kind of medicine can be obviously improved the roughness of local skin, skin is made to seem fine and smooth glossy, but it is well-known that glucocorticoid has many serious side effect, use can produce drug dependence such as continuously, and local skin horny layer is thinning, then there is atrophy.Therefore dermatologist uses hormones ointment the most prudent, in order to avoid producing above-mentioned side effect along treating dermatosis.And the Ferulic acid of commercial type, its cosmetic result is by innerwear Chinese medicine preparation, is applied to the effective ingredient woods trace of skin of face epithelial cell, and effect pays no attention to phase.Skin of face is coarse can be divided into postpubescence formed and be exposed to sunlight for a long time and gradually form.Both of which is caused by keratodermatitis epithelial cell Developmental and Metabolic Disorder so that keratodermatitis thickens.This compositions, by adding appropriate stachyose and the metabolism of retinol regulation epithelial cell in skin care item, reduces cuticular proliferation rate, reaches horny layer thinning, the effect that skin is fine and smooth.Skincare product in the market there are some add retinol, but owing to not having organic synergism of stachyose, the effect improving skin sophistication is inconspicuous.

Summary of the invention

The purpose of the present invention and inventive principle: provide one to be effectively improved coarse skin, be allowed to become fine and smooth external use skin care.Stachyose is a kind of tetrose, applies in many fields, and China is mainly used in functional health product.External then be applied to the numerous areas such as rubber, environmental protection, biological engineering, organ transplantation.External basic research shows that stachyose can acceptor interaction peaceful with Rameau so that a series of biochemical reactions of this receptor mediation change, and ultimately results in skin epithelial cell horny layer and produces speed and slow down.But stachyose is difficult to percutaneous absorbtion.We have studied the material that multiple assistance stachyose absorbs for this, find that retinol has splendid effect.Preferable, preferably 3%～5% through content effect between 1%-7% of our laboratory observation stachyose.The ratio of corresponding retinol and stachyose is with 1: 50-----1: 800 is the most suitable, stachyose should first be mixed homogeneously with retinol during preparing these skin care item by preferably 1: 100---1: 500. simultaneously, is incubated 30--60 minute under 75--90 degree Celsius of no oxygen existence condition.Then other compound is added.This compositions, by adding appropriate stachyose and the metabolism of retinol regulation epithelial cell in skin care item, reduces cuticular proliferation rate, reaches horny layer thinning, the effect that skin is fine and smooth.

Realize the optimal path of the present invention: this compositions is most widely suited with external.Late frost or skin lotion external can be made.

The positive effect of the present invention: the most not yet find have the cosmetics being obviously improved pachylosis, the compositions of the present invention can fill up market, and this is blank, and does not has the side effect such as allergy, safe and reliable.

Below in conjunction with preferred embodiment, the present invention will be further described.

Late frost formula (percentage by weight)

Retinol 0.002%

Stachyose 2%

Squalane 20%

Liquid paraffin 15%

Glycerol 15%

Vaseline 10%

It is 100% that pure water adds to total amount

Make main points: first mixed homogeneously with retinol by stachyose, there is bar 75--90 degree Celsius of no oxygen

It is incubated 30--60 minute under part.Then add other compound, finally add water to scheduled volume.Mixed

Close uniformly.

Experiment 1: the personnel coarse to 40 skin of face test.Employing double-blind method is tested, i.e. establishment officer and subjects does not knows that who uses containing the formula (representing with A) of stachyose, and who uses control formula without stachyose (, represent with B).(, in addition to without stachyose, other component ratio is the most identical for this B formula, and stachyose part is substituted by extra equal proportion vaseline).20 people use this formula late frost, other 20 people use outward appearance and pack identical protective skin cream, open code name code again and know that who uses A or B formula, then classified statistics curative effect after experiment terminates after finishing effect assessment.Efficacy determination method and result: late frost is slept front washed and is applied to left side face, continuously with 3 months by experimenter.Respectively left side face is taken a picture before and after use, skin degree of improvement is visually evaluated.

It will be clear that A formula has the extraordinary effect improving skin coarseness, hence it is evident that improvement rate reaches 80%, B formula then only has 5%, and both have highly significant difference (p ＜ 0.001).Illustrate that A formula has the effect improving skin coarseness.

Late frost curative effect

Curative effect A formula (20 people) B formula (20 people) is obviously improved 16 (80%) 1 (5%) has improvement 2 (10%) 4 (20%) without improving 2 (10%) 15 (75%).

Skin lotion formula (percentage by weight)

Making main points:

First stachyose is mixed homogeneously with retinol, under 75--90 degree Celsius of no oxygen existence condition, be incubated 30--60 minute.Then add other compound, finally add water to scheduled volume.Mix homogeneously.

Retinol 0.025%

Stachyose 5%

Squalane 20%

Liquid paraffin 15%

Glycerol 15%

Spermol 2.5%

70% sorbitol solution 3%

Vaseline 10%

Pure water-add to total amount is 100%

Experiment 2: the personnel coarse to 40 skin of face test.Employing double-blind method is tested, i.e. establishment officer and subjects does not knows that who uses containing the formula (representing with A1) of stachyose, and who uses control formula without stachyose (, represent with B1).(, in addition to without stachyose, other component ratio is the most identical for this B1 formula, and stachyose part is substituted by extra equal proportion vaseline).20 people use this formula skin lotion, other 20 people use outward appearance and pack identical cold cream, open code name code again and know that who uses A1 or B1 formula, then classified statistics curative effect after experiment terminates after finishing effect assessment.

Efficacy determination method and result: experimenter is by skin lotion every day twice, and washed is applied to left side face, continuously with 3 months, every day 2 times.Respectively left side face is taken a picture before and after experiment, skin degree of improvement is visually evaluated.

It will be clear that A1 formula has the extraordinary effect improving skin coarseness, hence it is evident that improvement rate reaches 90%, B1 formula then only has 10%, and both have highly significant difference (p ＜ 0.001).Illustrate that A1 formula has the effect improving skin coarseness.

Skin lotion curative effect

Curative effect A1 formula (20 people) B1 formula (20 people) is obviously improved 18 (90%) 2 (10%) have improvement 1 (5%) 1 (5%) without improving 1 (5%) 17 (85%).

Claims

1. the external use skin care composition formula being used for improving pachylosis.

2. it is characterized in that: said composition contains stachyose, and the ratio of stachyose and retinol is 800: 1～50: 1, as 500: 1～100: 1 better.

Composite formula the most according to claim 1, in making, stachyose should individually be mixed homogeneously with retinol, and should heat under anaerobic, and temperature is 75～90 degrees Celsius, and holding time is 30～60 minutes.