CN106248921A - 利用透明质酸评价肾损伤的方法和组合物 - Google Patents

利用透明质酸评价肾损伤的方法和组合物 Download PDF

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Publication number
CN106248921A
CN106248921A CN201610569328.4A CN201610569328A CN106248921A CN 106248921 A CN106248921 A CN 106248921A CN 201610569328 A CN201610569328 A CN 201610569328A CN 106248921 A CN106248921 A CN 106248921A
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CN
China
Prior art keywords
experimenter
concentration
rifle stage
probability
threshold
Prior art date
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Pending
Application number
CN201610569328.4A
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English (en)
Chinese (zh)
Other versions
CN106248921A8 (zh
Inventor
J·安德伯格
J·格雷
P·麦克弗森
K·中村
K·辛巴提
辛巴提
J·A·小凯勒姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Astute Medical Inc
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University of Pittsburgh
Astute Medical Inc
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Filing date
Publication date
Application filed by University of Pittsburgh, Astute Medical Inc filed Critical University of Pittsburgh
Publication of CN106248921A publication Critical patent/CN106248921A/zh
Publication of CN106248921A8 publication Critical patent/CN106248921A8/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
    • G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN201610569328.4A 2010-09-24 2011-09-23 利用透明质酸评价肾损伤的方法和组合物 Pending CN106248921A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38642110P 2010-09-24 2010-09-24
US61/386,421 2010-09-24
CN201180047897.8A CN103189394B (zh) 2010-09-24 2011-09-23 利用透明质酸评价肾损伤的方法和组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201180047897.8A Division CN103189394B (zh) 2010-09-24 2011-09-23 利用透明质酸评价肾损伤的方法和组合物

Publications (2)

Publication Number Publication Date
CN106248921A true CN106248921A (zh) 2016-12-21
CN106248921A8 CN106248921A8 (zh) 2017-07-21

Family

ID=45874188

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201610569328.4A Pending CN106248921A (zh) 2010-09-24 2011-09-23 利用透明质酸评价肾损伤的方法和组合物
CN201180047897.8A Expired - Fee Related CN103189394B (zh) 2010-09-24 2011-09-23 利用透明质酸评价肾损伤的方法和组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201180047897.8A Expired - Fee Related CN103189394B (zh) 2010-09-24 2011-09-23 利用透明质酸评价肾损伤的方法和组合物

Country Status (13)

Country Link
US (1) US20130252264A1 (https=)
EP (1) EP2619231B1 (https=)
JP (1) JP2013541005A (https=)
KR (1) KR20140051099A (https=)
CN (2) CN106248921A (https=)
AU (1) AU2011305197B2 (https=)
BR (1) BR112013006631A2 (https=)
CA (1) CA2813011A1 (https=)
EA (1) EA201390294A1 (https=)
ES (1) ES2619617T3 (https=)
MX (1) MX348303B (https=)
NZ (1) NZ609126A (https=)
WO (1) WO2012040592A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2882767B1 (en) * 2012-08-11 2023-07-12 Astute Medical, Inc. Evaluating renal injury using hyaluronic acid
CN119643878B (zh) * 2024-12-25 2025-07-25 中国人民解放军总医院第一医学中心 一种检测肾脏纤维化相关疾病的生物标志物及其应用

Citations (4)

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WO2009140026A2 (en) * 2008-04-18 2009-11-19 Pharmacophotonics, Llc D/B/A Fast Diagnostics Renal function analysis method and apparatus
WO2010022210A2 (en) * 2008-08-21 2010-02-25 Pxbiosciences Llc Diagnosis and monitoring of renal failure using peptide biomarkers
WO2010025424A1 (en) * 2008-08-28 2010-03-04 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20100081148A1 (en) * 2008-09-26 2010-04-01 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Urinary Biomarkers To Predict Long-Term Dialysis

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US5939272A (en) 1989-01-10 1999-08-17 Biosite Diagnostics Incorporated Non-competitive threshold ligand-receptor assays
US5028535A (en) 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
US5922615A (en) 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
CA2072758A1 (en) 1990-09-14 1992-03-15 Kenneth Francis Buechler Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays
US5955377A (en) 1991-02-11 1999-09-21 Biostar, Inc. Methods and kits for the amplification of thin film based assays
AU1772992A (en) 1991-04-10 1992-11-17 Biosite Diagnostics Incorporated Crosstalk inhibitors and their uses
JP3290988B2 (ja) 1991-04-11 2002-06-10 バイオサイト・ダイアグノスティックス・インコーポレイテッド 多重リガンドを同時検出する新規接合体及び検定法
US6143576A (en) 1992-05-21 2000-11-07 Biosite Diagnostics, Inc. Non-porous diagnostic devices for the controlled movement of reagents
US5885527A (en) 1992-05-21 1999-03-23 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membrances
US5494829A (en) 1992-07-31 1996-02-27 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference
US5824799A (en) 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
US6113855A (en) 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
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JP2004208693A (ja) * 2002-12-17 2004-07-29 Sanyo Chem Ind Ltd 抗ヒアルロン酸抗体、これを含む試薬キット、抗ヒアルロン酸抗体の製造法及びヒアルロン酸の測定法
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CN102369293B (zh) * 2009-02-06 2014-05-28 阿斯图特医药公司 肾损伤和肾衰竭的诊断及预后
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009140026A2 (en) * 2008-04-18 2009-11-19 Pharmacophotonics, Llc D/B/A Fast Diagnostics Renal function analysis method and apparatus
WO2010022210A2 (en) * 2008-08-21 2010-02-25 Pxbiosciences Llc Diagnosis and monitoring of renal failure using peptide biomarkers
WO2010025424A1 (en) * 2008-08-28 2010-03-04 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20100081148A1 (en) * 2008-09-26 2010-04-01 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Urinary Biomarkers To Predict Long-Term Dialysis

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BIHORAC,A等: "Incidence, Clinical Predictors, Genomics, and Outcome of Acute Kidney Injury Among Trauma Patients", 《ANNALS OF SURGERY》 *
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沈文清等: "慢性肾脏病患者血清和尿透明质酸、Ⅲ型前胶原、Ⅳ型胶原及层粘连蛋白的变化及其临床意义", 《临床医学》 *
陈文清: "肾脏疾病的生化学诊断及进展", 《安徽卫生职业技术学院学报》 *

Also Published As

Publication number Publication date
MX2013003204A (es) 2013-06-05
US20130252264A1 (en) 2013-09-26
KR20140051099A (ko) 2014-04-30
CN106248921A8 (zh) 2017-07-21
AU2011305197B2 (en) 2015-06-11
AU2011305197A1 (en) 2013-05-02
WO2012040592A1 (en) 2012-03-29
EP2619231A4 (en) 2014-04-30
JP2013541005A (ja) 2013-11-07
CN103189394A (zh) 2013-07-03
MX348303B (es) 2017-06-06
ES2619617T3 (es) 2017-06-26
NZ609126A (en) 2015-05-29
EA201390294A1 (ru) 2013-09-30
BR112013006631A2 (pt) 2017-10-24
CN103189394B (zh) 2016-08-17
EP2619231B1 (en) 2016-12-21
CA2813011A1 (en) 2012-03-29
EP2619231A1 (en) 2013-07-31

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CI01 Publication of corrected invention patent application

Correction item: Inventor

Correct: Anderberg Joseph|Gray Jeff|Mcpherson Paul|Nakamura Kevin|Kampf James Patrick|Singbartl Kai|Kellum John A. Jr.

False: Anderberg Joseph|Gray Jeff|Mcpherson Paul|Nakamura Kevin|Singbartl Kai|Xin Bati|Kellum John A. Jr.

Number: 51

Volume: 32

CI02 Correction of invention patent application

Correction item: Inventor

Correct: Anderberg Joseph|Gray Jeff|Mcpherson Paul|Nakamura Kevin|Kampf James Patrick|Singbartl Kai|Kellum John A. Jr.

False: Anderberg Joseph|Gray Jeff|Mcpherson Paul|Nakamura Kevin|Singbartl Kai|Xin Bati|Kellum John A. Jr.

Number: 51

Page: The title page

Volume: 32

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