CN106238114A - A kind of embedded three-dimensional runner based on PMMA material declines fluidic chip and manufacture method - Google Patents
A kind of embedded three-dimensional runner based on PMMA material declines fluidic chip and manufacture method Download PDFInfo
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- CN106238114A CN106238114A CN201610871264.3A CN201610871264A CN106238114A CN 106238114 A CN106238114 A CN 106238114A CN 201610871264 A CN201610871264 A CN 201610871264A CN 106238114 A CN106238114 A CN 106238114A
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- fluidic chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
Abstract
The present invention relates to a kind of embedded three-dimensional runner based on PMMA material decline fluidic chip and manufacture method.Core concept is that three-dimensional runner carries out sheet stratification process, the fluidic chip that declined by embedded three-dimensional runner is divided into several layers, each layer entity is processed with processing machine, then at each a certain amount of organic solvent of sheet surfaces uniform application, the several lamellas smearing organic solvent are sequentially overlapped from top to bottom the three-dimensional runner of formation, under the effect of temperature and pressure coupling, finally complete the processing of embedded three-dimensional runner.The decline success of making of fluidic chip of this embedded three-dimensional runner makes solution can move along X, Y, Z-direction inside micro-fluidic chip, improve the composite rate of solution and the mixing homogeneity of solution to a great extent, and this embedded three-dimensional runner fluidic chip that declines has the features such as precision is high, intensity is high, cost is relatively low, is suitable for promoting the use of.
Description
Technical field
The invention belongs to micro-fluidic field, be specifically related to the embedded three-dimensional runner of multilamellar and decline fluidic chip and making side
Method.
Background technology
Since the nineties in 20th century, the microflow control technique based on micro-fluidic chip has developed on our times
One of sciemtifec and technical sphere of forefront, owing to can complete mixing and reaction under smaller size smaller, reagent dosage is little, reaction efficiency is high,
Prepare effective, by the extensive concern of scholars.Although the research for micro-fluidic chip presents flourish both at home and abroad
Trend, but due to the micro-fluidic chip processing difficulties of three-dimensional runner, relatively costly, great majority research is all to concentrate on two dimension
Runner micro-fluidic chip, but use the micro-fluidic chip solution of two dimension runner can only carry out the motion of X, Y both direction, thus lead
Cause solution mixing homogeneity relatively low, and the problem such as composite rate is relatively low.
Micro-fluidic chip mainly has active and passive type two kinds, and wherein passive type micro-fluidic chip to pass through the interior of complexity
Portion's structure realizes solution mixing, it is generally required to add in runner, groove, bent angle etc. are two-dimentional or three dimensional structure is mixed to strengthen
Close effect, there is runner length, volume greatly, the problems such as course of reaction is uncontrollable.Active micro-fluidic chip then rely on micro-stirring,
The external energies such as pressure disturbance, acoustic perturbation, electromagnetic distu act on course of reaction.Relative to passive type micro-fluidic chip, main
Dynamic formula micro-fluidic chip flow passage structure is simple, mixing and reaction effect good, be construct at present micro-fluidic chip main method it
One, but the most embedded three-dimensional runner declines, fluidic chip is difficult to.
Runner processing method for micro-fluidic chip is concentrated mainly on method of molding processing microchannel, pressure sintering, swashs at present
Light ablation, soft lithographic, plastics micro shaping method etc., although these processing methods have well for the two-dimentional runner of processed complex
Effect, but three-dimensional runner can not be processed.
Along with 3D printing technique fast development, the making of three-dimensional runner micro-fluidic chip may be used without 3D and print skill
Art, but 3D prints and has a lot of limitation at present.Such as, the chip of processing can not reach the highest intensity and precision, core
The aspects such as using of sheet material is limited, the transparency difference of chip.
In view of the problem existing for current two dimension runner micro-fluidic chip and the limitation of three-dimensional runner facture of microchip
Property, the present invention proposes a kind of microplate layer processing method embedded space multistory three-dimensional runner of making that uses, and this three-dimensional runner uses
Microplate layer processing method, organic solvent and temperature and pressure couple the manufacture method combined, and complete embedded three-dimensional runner and decline stream control
The processing of chip, solves the low mixing efficiency of conventional two-dimensional runner micro-fluidic chip, and uses 3D printing technique processing three-dimensional
The problems such as the intensity of runner micro-fluidic chip, precision and transparency are inadequate.And the one that the present invention proposes is based on PMMA material
Embedded three-dimensional runner decline fluidic chip, use the method that sheet stratification processes, in micro-fluidic chip, not only add driving source,
And solution can also be realized and inside micro-fluidic chip, realize tri-sides of X, Y, Z move upward so that mix and react more
Fully.The most every volume is little, simple in construction, the driving source that is easily integrated can, such as Piezoelectric Driving Micropump, electrostatic drive
Micropump, mechanically driver type Micropump etc..
Summary of the invention
It is an object of the invention to provide a kind of embedded three-dimensional runner based on PMMA material to decline fluidic chip and making
Method, declines fluidic chip processing difficulties, relatively costly solving existing embedded three-dimensional runner, two dimension runner micro-fluidic chip
Composite rate and the relatively low problem of mixing homogeneity.
Embedded three-dimensional runner based on PMMA material of the present invention declines fluidic chip, and this micro-fluidic chip is by several
Lamella, driving source and alignment pin are constituted, and several lamellas are sequentially overlapped the three-dimensional runner of formation from top to bottom, then will be respectively with alignment pin
Individual lamella is fixed into an entirety；
Embedded three-dimensional runner based on PMMA material of the present invention declines fluidic chip, can be in micro-fluidic chip
Portion produces the embedded three-dimensional runner of complexity height, the curved surface three-dimensional runner of multilamellar or other shapes；
Embedded three-dimensional runner based on PMMA material of the present invention declines fluidic chip, and micro-fluidic chip has driving
Source, the most every volume is little, simple in construction, the driving source that is easily integrated can, such as piezoelectric pump drives Micropump, electrostatic drive
Micropump, mechanically driver type Micropump etc..
Embedded three-dimensional runner based on PMMA material of the present invention declines fluidic chip, in the situation having driving source
Under, solution can be internally formed turbulent flow at micro-fluidic chip, and may be implemented in the motion on tri-directions of X, Y, Z.
The technical scheme provided according to the present invention, a kind of embedded three-dimensional runner based on PMMA material declines fluidic chip
Manufacture method, comprises the steps:
1) three-dimensional runner lamellaization is processed: three-dimensional runner is divided into multilamellar, and Design Orientation hole in each lamella；
2) interpolation of organic solvent and temperature and pressure coupling processing: uniform application is a certain amount of organic molten between each lamella
Agent, and alignment pin is installed, the fluidic chip that declined by the embedded three-dimensional runner installing alignment pin is placed in incubator, when temperature reaches
To certain limit, apply corresponding pressure；
Step 1) in the micro-fluidic chip with three-dimensional runner drawn with three-dimensional software is divided into multilamellar after, further according to
The specific features of each lamella processing machine with different cutters processes each layer entity；
Step 2) under conditions of ensureing that PMMA surface material is slightly soluble in the organic solution that sheet interlayer is smeared, process lamella
The organic solvent added can be different organic solvent；
Step 2) in install the three-dimensional runner micro-fluidic chip of alignment pin and should be immediately placed in temperature control box, couple at temperature and pressure
The lower three-dimensional runner micro-fluidic chip of effect with organic solution has been bonded the processing of three-dimensional runner again；
Step 2) in use temperature and pressure to compensate mutually the processing that also can complete complex three-dimensional runner, Qi Zhongwen within the specific limits
Pressure compensation is: if adding temperature height in man-hour, then uses low-pressure, if pressure is high, then uses low temperature.
Accompanying drawing explanation
Fig. 1,2,3 are the isometric view of side of the present invention.
Fig. 4 is the isometric view of present configuration explosive view.
Fig. 5 is the structural blast figure that the present invention removes driving source.
Fig. 6-1,6-2,6-3,6-4,6-5,6-6,6-7 are respectively the lamella 1 front view to lamella 7.
Detailed description of the invention
The concrete structure of the embodiment of the present invention:
With reference to figure (1), figure (2), figure (3), figure (4), figure (5), figure (6), of the present invention based in PMMA material
Embedding three-dimensional runner declines fluidic chip by having valve piezoelectric micropump A (18), having valve piezoelectric micropump B (16), solution inlet Z-direction runner
(17) (1701), Y type solution mixing mouth (405) (406), taphole (10), lamella 1 (1), lamella 2 (2), lamella 3 (3), sheet
Layer 4 (4), lamella 5 (5), lamella 6 (6), lamella 7 (7), alignment pin (8) (801) (802) (803) composition.Wherein there is valve piezoelectric micromotor
Pump B (16) is made up of piezoelectric vibrator (1601) (1605), cantilever beam valve block (1602) (1603) (1604), has valve piezoelectric pump A
(18) it is made up of piezoelectric vibrator (1801) (1805), cantilever beam valve block (1802) (1803) (1804).
With reference to figure (1), figure (2), figure (3), figure (4), figure (5), figure (6), to mix two kinds of solution (solution A and solution B),
Driving source is for illustrating the present invention as a example by having valve double series-wound chambers piezoelectric pump.Solution A is through solution inlet Z-direction access road one
(1701), lower entrances passage (602), having valve piezoelectric micropump A (18) cavity of resorption piezoelectric vibrator (1805) and cantilever beam valve block
(1804), under effect, solution is arrived by Z-direction access road two (1901) valve piezoelectric micropump A (18) epicoele, is having valve pressure
Electricity Micropump A (18) epicoele piezoelectric vibrator (1801) and cantilever valve (1802), (1803) effect under solution entered by Z-direction runner
Mouth three (2001) flows to Y type runner (405) and enters embedded three-dimensional runner；B solution is through solution inlet Z-direction runner four simultaneously
(17), lower entrances passage one (601), having valve piezoelectric micropump B (16) cavity of resorption piezoelectric vibrator (1605) and cantilever beam valve block
(1604), under effect, solution is arrived by Z-direction access road five (19) valve piezoelectric micropump B (16) epicoele, is having valve piezoelectricity
Micropump B (16) epicoele piezoelectric vibrator (1601) and cantilever valve (1602), (1603) effect under solution by Z-direction flow channel entry point
Six (20) flow to Y type runner (406) the three-dimensional runner of entrance that crosses with solution A mixes.Mixed solution is at embedded three-dimensional flow
In road, the direction of motion is successively, and mixed solution is through X-direction runner (1201), Z-direction runner (1305), Y-direction runner (15), Z
To runner (1401), Y-direction runner (902), Z-direction runner (14), Y-direction runner (1102), Z-direction runner (1304), X-direction
Runner (1202), Z-direction runner (13), Y-direction runner (1502), Z-direction runner (1402), Y-direction runner (901), Z-direction runner
(1405), Y-direction runner (1101), Z-direction runner (1303), X-direction runner (12), Z-direction runner (1302), Y-direction runner
(1501), Z-direction runner (1403), Y-direction runner (9), Z-direction runner (1404), Y-direction runner (11), Z-direction runner
(1301), eventually passing X-direction runner (1203), complete the mixing of A, B solution, after completing mixing, mixed solution is from mixed solution
Outlet (10) is flowed out.Wherein Z-direction access road one (1701) is to be made up of (102), (202), (302), (402), (502), Z-direction
Access road two (1901) is to be collectively formed by (103), (203), (303), (403), (503), (603), (701), Z-direction entrance
Passage three (2001) is to be collectively formed by (105), (206), (306), Z-direction runner four (17) be by (101), (201), (301),
(401), (501) collectively form, Z-direction runner five (19) be by (104), (204), (304), (404), (504), (604),
(702) collectively forming, Z-direction runner six (20) is to be collectively formed by (106), (205), (305).In three-dimensional runner, Z-direction runner
(1401) being to be collectively formed by (307), (407), (505), Z-direction runner (14) is to be collectively formed by (312), (412), (510),
Z-direction runner (1402) is to be collectively formed by (308), (408), (506), and Z-direction runner (1405) is by (311), (411), (509)
Collectively forming, Z-direction runner (1403) is to be collectively formed by (309), (409), (507), Z-direction runner (1404) be by (310),
(410), (508) collectively form.
The concrete manufacture method of the embodiment of the present invention:
Embedded three-dimensional runner based on PMMA material of the present invention declines fluidic chip, by draw with three-dimensional software
Illustration (1) is seen, further according to the specific features processing machine of each lamella after being divided into multilamellar with the micro-fluidic chip of three-dimensional runner
Process each layer entity and see illustration (5), successively on each lamella uniform application organic solvent such as ethanol or other
Nonpoisonous organic solvent, is sequentially overlaid on together, is then fixed with alignment pin (8), (801), (802), (803).In
Embedding three-dimensional runner declines fluidic chip can be according to the complicated journey of micro-fluidic chip interior three-dimensional runner when carrying out sheet stratification processing
Degree, the lamella of the micro-fluidic chip after using different types of processing machine to process sheet stratification is processed.
The micro-fluidic chip installing alignment pin is immediately placed in temperature control box with reference to figure (1), in temperature and pressure coupling with organic
Make embedded three-dimensional runner each lamella of fluidic chip that declines again be bonded under the effect of solvent, complete embedded three-dimensional runner and decline stream
The processing of control chip.During temperature and pressure couple, it is not that the scope to temperature and pressure the most specifically limits ability
Complete the processing of embedded three-dimensional runner, but use temperature and pressure compensation also can complete adding of complex three-dimensional runner within the specific limits
Work, wherein temperature and pressure compensation is: if adding temperature height in man-hour, then uses low-pressure, if pressure is high, then uses low temperature.
Claims (8)
1. embedded three-dimensional runner based on PMMA material declines a fluidic chip, and this micro-fluidic chip is by several lamellas, driving
Source and alignment pin are constituted, and several lamellas are sequentially overlapped the three-dimensional runner of formation from top to bottom, then with alignment pin, each lamella is solid
Surely becoming an entirety, in micro-fluidic chip, solution enters from solution inlet under the effect in the source of driving, through micro-fluidic chip
Interior three-dimensional mixing runner completes mixing and reaction.
Embedded three-dimensional runner based on PMMA material the most according to claim 1 declines fluidic chip, it is characterised in that can
To produce complexity height, the curved surface three-dimensional runner of multilamellar or the embedded three-dimensional flow of other shapes inside micro-fluidic chip
Road.
Embedded three-dimensional runner based on PMMA material the most according to claim 1 declines fluidic chip, it is characterised in that micro-
Fluidic chip has driving source, and solution can move upward in tri-sides of X, Y, Z.
The driving source of micro-fluidic chip the most according to claim 3, it is characterised in that every volume is little, simple in construction, easily
In integrated driving source can, such as Piezoelectric Driving Micropump, electrostatic drive Micropump, Mechanical Driven Micropump etc..
5. an embedded three-dimensional runner based on PMMA material declines the manufacture method of fluidic chip, it is characterised in that use micro-
Lamella processing method makes the embedded three-dimensional runner fluidic chip that declines and comprises the steps:
1) stratification of micro-fluidic chip sheet processes: micro-fluidic chip is divided into multilamellar, and Design Orientation hole in each lamella；
2) interpolation of organic solvent and temperature and pressure coupling processing: a certain amount of organic solvent of uniform application between each lamella, and
And installation alignment pin, the fluidic chip that declined by the embedded three-dimensional runner installing alignment pin is placed in incubator, when temperature reaches one
Determine scope, apply corresponding pressure.
Embedded three-dimensional runner based on PMMA material the most according to claim 5 declines the manufacture method of fluidic chip, its
It is characterised by, after the micro-fluidic chip with three-dimensional runner drawn with three-dimensional software is split several layers, further according to each lamella
The specific features processing machine with different cutters processes each layer entity.
Embedded three-dimensional runner based on PMMA material the most according to claim 5 declines the manufacture method of fluidic chip, its
Being characterised by, the fluidic chip that declined by the embedded three-dimensional runner installing alignment pin is immediately placed in temperature control box, at organic solvent
Each lamella of the lower three-dimensional runner micro-fluidic chip of effect with temperature and pressure coupling has been bonded adding of embedded three-dimensional runner again
Work.
Embedded three-dimensional runner based on PMMA material the most according to claim 5 declines the manufacture method of fluidic chip, its
Be characterised by, step 2) in be not that the scope to temperature and pressure the most specifically limits and just can complete embedded three-dimensional flow
The processing in road, but use temperature and pressure compensation also can complete the processing of complex three-dimensional runner, wherein temperature and pressure compensation within the specific limits
It is: if adding temperature height in man-hour, then use low-pressure, if pressure is high, then use low temperature.
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Cited By (3)
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| CN109926112A (en) * | 2019-04-10 | 2019-06-25 | 中南大学 | The layered manufacturing method of three-dimensional microstructures polymeric micro-fluidic chip |
| CN110624616A (en) * | 2019-10-28 | 2019-12-31 | 西安交通大学 | Three-dimensional microfluidic device and method for high-throughput micro-droplet generation |
| CN111247427A (en) * | 2017-10-19 | 2020-06-05 | Tl基因体科技株式会社 | Cell sorting chip |
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| CN110624616A (en) * | 2019-10-28 | 2019-12-31 | 西安交通大学 | Three-dimensional microfluidic device and method for high-throughput micro-droplet generation |
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Application publication date: 20161221 |