CN106237192A - A kind of for compound medicine treating stomachache and preparation method thereof - Google Patents
A kind of for compound medicine treating stomachache and preparation method thereof Download PDFInfo
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- CN106237192A CN106237192A CN201610929839.2A CN201610929839A CN106237192A CN 106237192 A CN106237192 A CN 106237192A CN 201610929839 A CN201610929839 A CN 201610929839A CN 106237192 A CN106237192 A CN 106237192A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention provides a kind of for compound medicine treating stomachache and preparation method thereof, relate to technical field of Chinese medicines.This compound medicine is made up of crude drug, counts by weight, and crude drug includes Rhizoma Smilacis Glabrae, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Fructus Aurantii, Periostracum Cicadae, Poria, the Rhizoma Pinelliae, Fructus Citri Sarcodactylis, Herba Lysimachiae, Bulbus Lilii and Radix Glycyrrhizae.This compound medicine has removing toxic substances dehumidifying, promoting the circulation of QI to relieve pain, the curative effect of soothing the liver stomach invigorating.The preparation method of this compound medicine is: with Radix Glycyrrhizae, Rhizoma Smilacis Glabrae, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Periostracum Cicadae, Poria, the Rhizoma Pinelliae, Bulbus Lilii, Herba Lysimachiae are pulverized to obtain medicated powder, medicated powder ethanol solution carries out at 60～80 DEG C 1～3 time extract, medicinal liquid is obtained after filtration, by medicinal liquid after purification, concentrate drying obtains extractum；Extract the volatile oil of Fructus Citri Sarcodactylis and Fructus Aurantii；Pelletize after extractum, volatile oil are mixed with pharmaceutical excipient, prepare granule, capsule, pill and tablet.This preparation method can improve the amount of active constituents of medicine, reduces the toxic and side effects of medicine.
Description
Technical field
The present invention relates to a kind of technical field of Chinese medicines, and particularly to a kind of compound medicine for treating stomachache and system thereof
Preparation Method.
Background technology
Stomachache is commonly encountered diseases the most clinically, and also known as gastric abscess in motherland's Chinese medicine, it is more common in upper abdomen gastral cavilty portion
Pain is main clinical manifestation, and has the feature such as course of disease length, easily delay and pathogenesis complexity.Live recently as people
Changing and the burst of all kinds of stress event of dietary structure, its annual sickness rate also raises at straight line, the healthy life to patient
Live and cause greatly puzzlement.
The traditional Chinese medical science thinks that liver is in close relations with taste, liver happiness bar reach main catharsis, irritability can catharsis taste mechanism of qi, help stomach internal organs to wear down
Water paddy, helps temper sending up the lucid YANG., stagnation of QI impairing the liver angry if being worried, edema with the liver involved is lost in catharsis, then take advantage of spleen to violate stomach, and taste are received and transported restricted, gas
Machine blocks and causes catharsis, then take advantage of and cause epigastric distending pain.For this disease, modern medicine is many based on nourishing the stomach relieving distension, and in
State's south dampness is heavier, for treating the unsatisfactory curative effect of epigastric distending pain, easily recurring.Majority system Preparation Method does not reaches purification simultaneously
Purpose, side effect is big.
Summary of the invention
It is an object of the invention to provide a kind of compound medicine for treating stomachache, this compound medicine has removing toxic substances and removes
Wet, promoting the circulation of QI to relieve pain, the curative effect of soothing the liver stomach invigorating, be particularly well-suited to the patient that dampness is heavier.
Another object of the present invention is to provide the preparation method of a kind of compound medicine for treating stomachache, this preparation side
Method uses different method for extraction and purification separately to be prepared by the crude drug of different properties, thus improves the amount of active constituents of medicine,
Reduce the toxic and side effects of medicine；This preparation method is workable simultaneously, beneficially industrialized production.
The present invention solves it and technical problem is that and realize by the following technical solutions.
The present invention proposes a kind of compound medicine for treating stomachache, is made up of crude drug, counts by weight, crude drug
Including: Rhizoma Smilacis Glabrae 10～20 parts；The Radix Paeoniae Alba 30～50 parts；Rhizoma Corydalis 10～15 parts；Radix Salviae Miltiorrhizae 10～15 parts；Fructus Aurantii 10～15 parts；Cicadae
Slough off 5～15 parts, Poria 15～30 parts；The Rhizoma Pinelliae 12～15 parts；Fructus Citri Sarcodactylis 12～15 parts；Herba Lysimachiae 15～50 parts；Bulbus Lilii 10～30 parts；
And Radix Glycyrrhizae 6～15 parts.
The present invention proposes the preparation method of a kind of compound medicine for treating stomachache, by Rhizoma Smilacis Glabrae, the Radix Paeoniae Alba, Rhizoma Corydalis,
Radix Salviae Miltiorrhizae, Periostracum Cicadae, Poria, the Rhizoma Pinelliae, Bulbus Lilii, Herba Lysimachiae pulverize to obtain medicated powder, by medicated powder ethanol solution at 60～80 DEG C with Radix Glycyrrhizae
Carry out 1～3 time to extract, obtain medicinal liquid after filtration, medicinal liquid concentrate drying after purification is obtained extractum；Extraction Fructus Citri Sarcodactylis is waved with Fructus Aurantii
Hair oil；Pelletize after extractum, volatile oil are mixed with pharmaceutical excipient, prepare granule, capsule and tablet.
A kind of the providing the benefit that for compound medicine treating stomachache and preparation method thereof of present invention offer: this compound recipe
The prescription rule of Chinese medicine followed by medicine, based on " removing toxic substances dehumidifying, promoting the circulation of QI to relieve pain, soothing the liver stomach invigorating ".
In side, Rhizoma Smilacis Glabrae returns liver, stomach warp, strengthening the spleen and stomach, removing toxic substances, dehumidifying；Radix Paeoniae Alba easing the affected liver, slow liver, yin nourishing and blood vessels, have again slow
The merit of anxious pain relieving, receives the at random of temper, and that holds back irritability throws off restraint horizontal stroke, presses down wood in middle soil, and with Rhizoma Smilacis Glabrae phase 5, one dissipates receipts, dredges gas
Blood, helps Rhizoma Smilacis Glabrae to adjust irritability not hinder vital qi.Hold concurrently invigorate blood circulation with Rhizoma Corydalis, promoting the circulation of QI, pain relieving；Radix Salviae Miltiorrhizae promoting blood circulation, removing blood stasis and relieving pain, with circulation of qi promoting
Medicine share and can strengthen treatment stomachache；Fructus Aurantii, regulating the flow of QI to ease the stomach, relieving distension are except painful abdominal mass；Periostracum Cicadae wind-dispelling heat-dissipating, endogenous wind stopping relieving convulsion；Poria diuretic oozes
Wet, spleen invigorating and in；Rhizoma Pinelliae stopping nausea and vomiting by lowering the adverse flow of QI, drying dampness to eliminate phlegm, dissolving lump and resolving mass；Fructus Citri Sarcodactylis, dispersing the stagnated live-QI to relieve the stagnation of QI, pungent shape is pained, fragrant odour, energy
Spleen invigorating is regulated the flow of vital energy, and middle intestinal stasis relieving；Herba Lysimachiae, dampness removing jaundice eliminating, inducing diuresis for treating stranguria syndrome, removing toxic substances and promoting subsidence of swelling；Bulbus Lilii, nourishing stomach-YIN, clearing away stomach-heat；Radix Glycyrrhizae is good for
Taste, slow liver urgency, coordinating the actions of various ingredients in a prescription；Full side has removing toxic substances dehumidifying, promoting the circulation of QI to relieve pain, the effect of soothing the liver stomach invigorating.
The preparation method of this compound medicine, uses different method for extraction and purification by the separately preparation of the crude drug of different properties
Thus improve the amount of active constituents of medicine, decrease indefinite ingredient in Chinese medicine, thus the poison pair reducing medicine is made
With；Using the curative effect of the compound medicine that this preparation method prepares more preferably, workable, preparation is beneficial to industry metaplasia simultaneously
Produce.
Detailed description of the invention
For making the purpose of the embodiment of the present invention, technical scheme and advantage clearer, below will be in the embodiment of the present invention
Technical scheme be clearly and completely described.In embodiment, unreceipted actual conditions person, builds according to normal condition or manufacturer
The condition of view is carried out.Agents useful for same or instrument unreceipted production firm person, being can be by the commercially available conventional product bought and obtain
Product.
The compound medicine that the embodiment of the present invention is used for treating stomachache below is specifically described.
A kind of compound medicine for treating stomachache that the embodiment of the present invention provides, is made up of crude drug, by weight
Meter, crude drug includes: Rhizoma Smilacis Glabrae 10～20 parts；The Radix Paeoniae Alba 30～50 parts；Rhizoma Corydalis 10～15 parts；Radix Salviae Miltiorrhizae 10～15 parts；Fructus Aurantii 10
～15 parts；Periostracum Cicadae 5～15 parts, Poria 15～30 parts；The Rhizoma Pinelliae 12～15 parts；Fructus Citri Sarcodactylis 12～15 parts；Herba Lysimachiae 15～50 parts；Bulbus Lilii
10～30 parts；And Radix Glycyrrhizae 6～15 parts.
Further, in present pre-ferred embodiments, counting by weight, Rhizoma Smilacis Glabrae is 10 parts；The Radix Paeoniae Alba is 30 parts；Prolong
Rhizoma Corydalis is 15 parts；Radix Salviae Miltiorrhizae is 10 parts；Fructus Aurantii is 10 parts；Periostracum Cicadae is 12 parts, and Poria is 20 parts；The Rhizoma Pinelliae is 15 parts；Fructus Citri Sarcodactylis is 12 parts；
Herba Lysimachiae is 15 parts；Bulbus Lilii is 20 parts；And Radix Glycyrrhizae is 15 parts.
This compound medicine follows the prescription rule of Chinese medicine, with " removing toxic substances dehumidifying, promoting the circulation of QI to relieve pain, soothing the liver stomach invigorating " is
Main.
In side, Rhizoma Smilacis Glabrae returns liver, stomach warp, strengthening the spleen and stomach, removing toxic substances, dehumidifying, fluent mechanism of qi；Modern pharmacology shows in Rhizoma Smilacis Glabrae
Rhizoma Smilacis Glabrae glycosides can reduce gastric mucosa lipid peroxidation, and free radical resisting damages, and promotes gastric secretion, improves gastric juice pH value, from
And protect gastric mucosa from different perspectives, reduce the generation of ulcer；Secondly, the effective ingredient in Rhizoma Smilacis Glabrae, to gram positive bacteria
All have inhibitory action with gram negative bacteria, its scope of restraining fungi is wide, and bacteriostatic activity is strong；Radix Paeoniae Alba easing the affected liver, slow liver, yin nourishing and blood vessels,
Having again the merit of relieving spasm to stop pain, receive the at random of temper, that holds back irritability throws off restraint horizontal stroke, presses down wood in middle soil, and with Rhizoma Smilacis Glabrae phase 5, one dissipates receipts,
Dredge QI and blood, help Rhizoma Smilacis Glabrae to adjust irritability not hinder vital qi.Rhizoma Corydalis is invigorated blood circulation, promoting the circulation of QI, pain relieving, simultaneously the alcohol extraction thing of Rhizoma Corydalis with
And water extract can suppress the production of helicobacter pylori；Radix Salviae Miltiorrhizae, promoting blood circulation, removing blood stasis and relieving pain, share with qi-activating drug and can strengthen treatment stomach
Bitterly；Periostracum Cicadae wind-dispelling heat-dissipating, endogenous wind stopping relieving convulsion；Poria promoting diuresis to eliminate damp pathogen, spleen invigorating and in；Rhizoma Pinelliae stopping nausea and vomiting by lowering the adverse flow of QI, drying dampness to eliminate phlegm, the painful abdominal mass that disappears dissipates
Knot, the Rhizoma Pinelliae extract can reduce gastric secretion, reduce gastric juice free acidity and total acidity, suppress pepsin activity, protect
Protect gastric mucosa etc.；Fructus Citri Sarcodactylis, dispersing the stagnated live-QI to relieve the stagnation of QI, pungent shape is pained, and fragrant odour can be regulated the flow of vital energy in spleen invigorating, and middle intestinal stasis relieving；Herba Lysimachiae, dampness removing moves back
Huang, inducing diuresis for treating stranguria syndrome, removing toxic substances and promoting subsidence of swelling；Bulbus Lilii, nourishing stomach-YIN, clearing away stomach-heat；Radix Glycyrrhizae strengthening the spleen and stomach, slow liver urgency, coordinating the actions of various ingredients in a prescription.
Further, in present pre-ferred embodiments, the dosage form of compound medicine be decoction, pill, tablet, capsule or
Person's patch.Wherein patch is external preparation.After crude drug is ground or is ground into medicated powder, utilize conventional method, be fabricated to patch.
Patch is affixed on umbilicus, can effectively alleviate gastric abscess；Simultaneously by subcutaneous absorption, without the first pass effect of liver, use patch continuously
Gastric abscess can be treated.
Present invention also offers the preparation method of the above-mentioned compound medicine for treating stomachache, by Rhizoma Smilacis Glabrae, the Radix Paeoniae Alba, Rhizoma Corydalis
Rope, Radix Salviae Miltiorrhizae, Periostracum Cicadae, Poria, the Rhizoma Pinelliae, Bulbus Lilii, Herba Lysimachiae pulverize to obtain medicated powder, by medicated powder ethanol solution at 60～80 DEG C with Radix Glycyrrhizae
Under carry out 1～3 time extract, obtain medicinal liquid after filtration, medicinal liquid concentrate drying after purification obtained extractum；Extract Fructus Citri Sarcodactylis and Fructus Aurantii
Volatile oil, pelletizes after extractum, volatile oil being mixed with pharmaceutical excipient, prepares granule, capsule and tablet.
Preferably, the particle diameter of medicated powder is 80-120 mesh.Further, in present pre-ferred embodiments, use and synchronize to steam
Evaporate extraction and extract the volatile oil of Fructus Citri Sarcodactylis and Fructus Aurantii.Distillation is carried out with extraction simultaneously, compared with traditional method, not only reduces
Step, has saved a large amount of solvent, has also reduced crude drug loss in transfer process.The amount of the volatile oil simultaneously obtained is more
Many.
Further, in present pre-ferred embodiments, the purification of medicinal liquid uses membrane separation technique, at 25～30 DEG C, across
Film pressure is under 0.20～0.30MPa, is circulated filtration.This is simple to operate, and energy consumption is low, separable be purified into substantial amounts of effectively
Composition, precision is high.
Further, in present pre-ferred embodiments, Fructus Aurantii is the Fructus Aurantii after parched with bran system.The raw Fructus Aurantii property of medicine is violent
Strong, relax by the property of medicine after parched with bran system, the stimulation to stomach reduces.There is spleen benefiting and stimulating the appetite, adjust the five internal organs, effect of the therapeutic method to keep the adverse QI flowing downwards.
Further, in present pre-ferred embodiments, Rhizoma Corydalis is the Rhizoma Corydalis after rice vinegar steams.In Rhizoma Corydalis
Containing multiple alkaloid, wherein dehydrogenation Corydaline is the most effective in cure to gastric and duodenal ulcers, can be combined into salt with acetic acid.By
It is weak acid in vinegar, the alkaloid dissociated can be made to be converted into alkaloid salt and be dissolved in water, easily increased curative effect by soak by water dissolution.
Further, in present pre-ferred embodiments, granule is loaded in enteric capsule shell, make the intestinal of compound medicine
Colloidal sol wafer.Enteric coated capsule can reduce the medicine stimulation to stomach.
Below in conjunction with embodiment, inventive feature and performance are described in further detail.
Embodiment 1
A kind of compound medicine for treating stomachache that the present embodiment provides, the granule that compound medicine is made up of crude drug
Agent, crude drug includes Rhizoma Smilacis Glabrae 10g；Radix Paeoniae Alba 30g；Rhizoma Corydalis 12g；Radix Salviae Miltiorrhizae 10g；Fructus Aurantii 10g；Periostracum Cicadae 15g, Poria 15g；The Rhizoma Pinelliae
15g；Fructus Citri Sarcodactylis 12g；Herba Lysimachiae 15g；Bulbus Lilii 10g；And Radix Glycyrrhizae 10g.
The preparation method of compound medicine is: by Rhizoma Smilacis Glabrae, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Periostracum Cicadae, Poria, the Rhizoma Pinelliae, Bulbus Lilii, gold
Money grass and Radix Glycyrrhizae are pulverized to the medicated powder of 80 mesh, are carried out 1 time by the ethanol solution that medicated powder volume fraction is 60% at 80 DEG C
Extracting, after filtration, merging filtrate obtains medicinal liquid, medicinal liquid uses the method for vapor distillation after purification, and concentrate drying is soaked
Cream；Extract the volatile oil of Fructus Citri Sarcodactylis and Fructus Aurantii, pelletize after extractum, volatile oil are mixed with pharmaceutical excipient, prepare granule.
Embodiment 2
A kind of compound medicine for treating stomachache that the present embodiment provides, the tablet that compound medicine is made up of crude drug,
Crude drug includes Rhizoma Smilacis Glabrae 12g；Radix Paeoniae Alba 40g；Rhizoma Corydalis 15g after vinegar system；Radix Salviae Miltiorrhizae 12g；Fructus Aurantii 12g after parched with bran system；Periostracum Cicadae
10g, Poria 15g；Rhizoma Pinelliae 12g；Fructus Citri Sarcodactylis 15g；Herba Lysimachiae 15g；Bulbus Lilii 15g；And Radix Glycyrrhizae 10g.
The preparation method of compound medicine is: by Rhizoma Smilacis Glabrae, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Periostracum Cicadae, Poria, the Rhizoma Pinelliae, Bulbus Lilii, gold
Money grass and Radix Glycyrrhizae powder are broken to the medicated powder of 90 mesh, carry out 2 times carrying by the ethanol solution that medicated powder volume fraction is 65% at 70 DEG C
Taking, after filtration, merging filtrate obtains medicinal liquid, uses membrane separation technique to be purified medicinal liquid, specifically, at 25 DEG C, and transmembrane pressure
For under 0.20MPa, after being circulated Purification by filtration, concentrate drying obtains extractum；Use synchronize Water distillation extractor extract Fructus Citri Sarcodactylis with
The volatile oil of Fructus Aurantii, pelletizes after extractum, volatile oil being mixed with pharmaceutical excipient, and tabletting obtains the tablet of compound medicine.
Embodiment 3
A kind of compound medicine for treating stomachache that the present embodiment provides, the common glue that compound medicine is made up of crude drug
Wafer, crude drug includes Rhizoma Smilacis Glabrae 15g；Radix Paeoniae Alba 30g；Rhizoma Corydalis 15g；Radix Salviae Miltiorrhizae 10g；Fructus Aurantii 10g after parched with bran system；Periostracum Cicadae 12g,
Poria 20g；Rhizoma Pinelliae 15g；Fructus Citri Sarcodactylis 15g；Herba Lysimachiae 45g；Bulbus Lilii 30g；And Radix Glycyrrhizae 15g.
The preparation method of compound medicine is: by Rhizoma Smilacis Glabrae, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Periostracum Cicadae, Poria, the Rhizoma Pinelliae, Bulbus Lilii, gold
Money grass and Radix Glycyrrhizae are pulverized to the medicated powder of 100 mesh, are carried out 3 times by the ethanol solution that medicated powder volume fraction is 60% at 60 DEG C
Extracting, after filtration, merging filtrate obtains medicinal liquid, and medicinal liquid is used supercritical CO2After purification, concentrate drying obtains extractum to extraction；
Use and synchronize Water distillation extractor extraction Fructus Citri Sarcodactylis and the volatile oil of Fructus Aurantii, pelletize after extractum, volatile oil are mixed with pharmaceutical excipient,
Granule is loaded conventional capsule shell and obtains capsule.
Embodiment 4
A kind of compound medicine for treating stomachache that the present embodiment provides, the pill that compound medicine is made up of crude drug,
Crude drug includes Rhizoma Smilacis Glabrae 20g；Radix Paeoniae Alba 40g；Rhizoma Corydalis 15g after vinegar system；Radix Salviae Miltiorrhizae 15g；Fructus Aurantii 15g after parched with bran system；Periostracum Cicadae
5g, Poria 30g；Rhizoma Pinelliae 15g；Fructus Citri Sarcodactylis 12g；Herba Lysimachiae 20g；Bulbus Lilii 15g；And Radix Glycyrrhizae 6g.
The preparation method of compound medicine is: by Rhizoma Smilacis Glabrae, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Periostracum Cicadae, Poria, the Rhizoma Pinelliae, Bulbus Lilii, gold
Money grass and Radix Glycyrrhizae are pulverized to the medicated powder of 90 mesh, by ethanol solution that medicated powder volume fraction is 62% the most successively 75 DEG C with
Carrying out 2 times at 70 DEG C to extract, after filtration, merging filtrate obtains medicinal liquid, uses membrane separation technique to be purified medicinal liquid, specifically,
At 28 DEG C, transmembrane pressure is under 0.30MPa, and after being circulated Purification by filtration, concentrate drying obtains extractum；Use and synchronize distillation extraction
Follow the example of the volatile oil extracting Fructus Citri Sarcodactylis with Fructus Aurantii, pelletize after extractum, volatile oil are mixed with pharmaceutical excipient, add Mel and make ball
Agent.
Embodiment 5
A kind of compound medicine for treating stomachache that the present embodiment provides, the enteric glue that compound medicine is made up of crude drug
Wafer, crude drug includes Rhizoma Smilacis Glabrae 10g；Radix Paeoniae Alba 30g；Rice vinegar steam after Rhizoma Corydalis 15g；Radix Salviae Miltiorrhizae 10g；Fructus Aurantii after parched with bran system
10g；Periostracum Cicadae 12g, Poria 20g；Rhizoma Pinelliae 15g；Fructus Citri Sarcodactylis 12g；Herba Lysimachiae 15g；Bulbus Lilii 20g；And Radix Glycyrrhizae 15g.
The preparation method of compound medicine is: by Rhizoma Smilacis Glabrae, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Periostracum Cicadae, Poria, the Rhizoma Pinelliae, Bulbus Lilii, gold
Money grass and Radix Glycyrrhizae are pulverized to the medicated powder of 95 mesh, by ethanol solution that medicated powder volume fraction is 60% the most successively 80 DEG C,
70 DEG C carry out 3 extractions at 60 DEG C, and after filtration, merging filtrate obtains medicinal liquid, uses membrane separation technique to be purified medicinal liquid,
Specifically, at 30 DEG C, transmembrane pressure is under 0.25MPa, and after being circulated Purification by filtration, concentrate drying obtains extractum；Use same
Step Water distillation extractor extracts the volatile oil of Fructus Citri Sarcodactylis and Fructus Aurantii, makes granule with pharmaceutical excipient after extractum, volatile oil being mixed, will
Granule loading enteric capsule shell obtains enteric coated capsule.
Embodiment 6
A kind of compound medicine for treating stomachache that the present embodiment provides, the decoction that compound medicine is made up of crude drug,
Crude drug includes Rhizoma Smilacis Glabrae 20g；Radix Paeoniae Alba 50g；Rhizoma Corydalis 12g；Radix Salviae Miltiorrhizae 10g；Fructus Aurantii 15g；Periostracum Cicadae 12g, Poria 20g；The Rhizoma Pinelliae
15g；Fructus Citri Sarcodactylis 12g；Herba Lysimachiae 50g；Bulbus Lilii 20g；And Radix Glycyrrhizae 12g.
The preparation method of compound medicine is: by broken for above-mentioned raw materials medicated powder, and mixing is with after the water soaking 30 minutes of 3 times amount, pan-fried
Boil, obtain decoction.
Comparative example 1
The medicine of the treatment stomachache that this comparative example provides is made up of the crude drug of following weight proportion:
Radix Bupleuri 3.33 parts, Radix Paeoniae Rubra 4 parts, Fructus Aurantii Immaturus 3 parts, the Radix Aucklandiae 2 parts, Radix Salviae Miltiorrhizae 3.33 parts, Rhizoma Corydalis 3 parts, Rhizoma Curcumae 2 parts, Rhizoma Coptidis 3
Part, Fructus Evodiae 1 part, Radix Et Rhizoma Rhei 1 part, Radix Codonopsis 4 parts, and 1 part of Radix Glycyrrhizae.
Crude drug is prepared as decoction.
Test example 1 animal experiment
1, Animal Model
SD rat 100, male and female half and half, body weight (200 ± 20) g.
Stomachache (chronic non-atrophic gastritis) modeling step is as follows:
1. gavage: include ethanol and NaTDC two kinds, ethanol gavage 2 times a week, NaTDC gavage every day.②
Freely drink: ammonia is made into 2 concentration, gives respectively in different time sections.The ammonia of 0.05wt% was i.e. given at the 1st～6 week,
The ammonia giving 0.1wt% on 7th～12 week.3. irregular diet: odd-numbered day fasting, even-numbered days enough feedings.
Three step co-operation, 12 Zhou Houke are successfully established SD rat stomachache (chronic non-atrophic gastritis).
2, packet and medicine feed
Choose and be successfully established the SD rat 80 of stomachache and only weigh, labelling, it is randomly divided into 8 groups, often group 10, the most corresponding empty
White matched group, embodiment 1～6 and comparative example 1, male and female half and half, blank group starts through gavage for second day after modeling
0.85wt% sodium chloride.The warm water of compound medicine same volume embodiment 1～5 provided dissolves and (makes concentration be all 2g/
And the decoction (making its concentration is 2g/ml) of comparative example 1 and embodiment 6 is by 1ml/100g gavage rat ml),.
3, histological examination
Cut rat stomach focus and surrounding tissue, fix with the formalin that volume fraction is 10%, be dehydrated according to routine,
Paraffin embedding, 5 μ m thick, carry out hematoxylin-eosin staining, Ali Xinlan-periodic acid snow husband's Albert'stain Albert, every rat group respectively
Knit 3 sections of making, extract 1 the random observation of 5 visuals field inflammatory cell number, new vessels number under high power microscope, keep in mind
Mean values, the results are shown in Table 1.
4, NO detection
Detect serum NO level by nitrate reductase method, specifically illustrate that step is carried out by test kit, the results are shown in Table 2.
5, result and analysis
Table 1. each lesion tissue inflammatory cell number, new vessels number compare (n=10, X ± S)
Note: compared with blank group, * p < 0.05, * * p < 0.01.
Can obtain according to table 1: the focus inflammatory cell number of the rat of the compound medicine using embodiment 1～6 to provide is than blank
The inflammatory cell number of matched group and comparative example 1 is few, and new vessels number is many, and the treatment of the compound medicine that embodiment 1～6 provides is described
Effect is good.And compared with blank group, have significant difference (p < 0.05, p < 0.01).
Table 2.NO level compares (n=10, X ± S)
| Group | NO(μmol/L) |
| Blank group | 4.98±1.22 |
| Embodiment 1 | 6.54±1.86* |
| Embodiment 2 | 7.02±1.96* |
| Embodiment 3 | 6.85±2.05** |
| Embodiment 4 | 7.36±2.12** |
| Embodiment 5 | 8.24±2.45** |
| Embodiment 6 | 6.04±1.75* |
| Comparative example 1 | 5.47±1.56* |
Note: compared with blank group, * p < 0.05, * * p < 0.01.
According to table 2: use the Serum concentration of NO of rat of the compound medicine that embodiment 1～6 provides than matched group and right
The NO concentration of ratio 1 is big, illustrates that the therapeutic effect of the compound medicine that embodiment 1～6 provides is good.And compared with blank group,
There is significant difference (p < 0.05, p < 0.01).
Test example 2 clinical trial
1, case is selected in
Patient 350 example as object of study, wherein average course of disease (3.6 ± 0.9) year.Inclusion criteria: true through gastroscopy
Examine, and meet in " new Chinese medicine guideline of clinical investigations " about the criterion having a stomachache；It is classified as 7 groups, often group 50
Patient, respectively corresponding embodiment 1～6 and comparative example 1, the physical data such as each the group sex of patient, stadium compares, and difference is without statistics
Learn meaning (p > 0.05).
2, Therapeutic Method
Patient is administered orally embodiment 1～6 and the compound medicine that provides of comparative example 1 respectively.Three times a day, 4 days courses for the treatment of.
3, curative effect determinate standard
Cure: substantially without stomachache and related symptoms, follow up a case by regular visits to have no recurrence half a year, and x-ray canel barium meal contrast examination, gastroscopy etc. are not
See exception.
Effective: stomachache and related symptoms have significantly alleviation, follow up a case by regular visits to have no recurrence half a year, and mainly check that prompting has substantially
Recover.
Effective: stomachache and related symptoms have taken a turn for the better, even during following up a case by regular visits to have outbreak, but pain alleviates earlier above, mainly checks
Close with before treatment.
Invalid: stomachache symptom, mainly inspection are unchanged, have increased the weight of.
Each group result of the test is shown in Table 3.
4, result and analysis
Table 3 clinical efficacy result table (example)
| Group | Cure | Effective | Effectively | Invalid | Total effective rate (%) |
| Embodiment 1 | 40 | 2 | 4 | 4 | 92% |
| Embodiment 2 | 41 | 4 | 3 | 2 | 96% |
| Embodiment 3 | 41 | 3 | 3 | 3 | 94% |
| Embodiment 4 | 42 | 5 | 2 | 1 | 98% |
| Embodiment 5 | 45 | 3 | 2 | 0 | 100% |
| Embodiment 6 | 39 | 1 | 4 | 6 | 88% |
| Comparative example 1 | 35 | 2 | 4 | 9 | 82% |
Obtain according to table 3: the total effective rate of the patient of the compound medicine using embodiment 1～6 to provide is more corresponding than matched group
The total effective rate of patient is high, illustrates that the therapeutic effect of the compound medicine that embodiment 1～6 provides is good.
Model case 1
Make pottery certain, female, 62 years old, epigastric distending pain 10 years, increase the weight of 7 days, companion feels sick, big ferry institute Gastroscope Diagnosis: chronic non-wither
Contracting gastritis, is in hospital out-patient treatment through multiple hospitals, and its effect is the best.Examine and see: gastral cavilty distension pain, feel sick, red tongue, thick fur
Greasy, xerostomia.Tcm diagnosis: stomachache.The compound medicine being used for treating stomachache using the embodiment of the present invention 5 to provide obtained effect after 8 days.
Model case 2
Beam, female, 56 years old, epigastric distending pain 8 years, increase the weight of 6 days, companion feels sick, certain institute's Gastroscope Diagnosis: chronic non-atrophic stomach
Inflammation, treats through multiple hospitals, and its effect is the best.Examine and see: gastral cavilty distension pain, singultus, red tongue, yellowish fur, bitter taste.The traditional Chinese medical science is examined
Disconnected: stomachache.The compound medicine being used for treating stomachache using the embodiment of the present invention 2 to provide obtained effect after 7 days.
Model case 3
Lee, man, 50 years old, epigastric distending pain 6 years, increase the weight of 6 days, companion feels sick, certain institute's Gastroscope Diagnosis: chronic non-atrophic stomach
Inflammation, B ultrasonic: cholecystitis, it to be in hospital out-patient treatment through multiple hospitals, its effect is the best.Examine and see: gastral cavilty distension pain, feel sick, red tongue, tongue
Thick and greasy fur, xerostomia.Tcm diagnosis: stomachache, gallbladder-distention.Use the compound medicine 6 for treating stomachache that the embodiment of the present invention 3 provides
Effect is obtained after it.
Model case 4
Pu, man, 58 years old, epigastric distending pain 9 years, increase the weight of 5 days, companion feels sick, certain institute's Gastroscope Diagnosis: chronic non-atrophic stomach
Inflammation, is in hospital out-patient treatment through multiple hospitals, and its effect is the best.Examining and see: gastral cavilty distension pain, feel sick, red tongue, thick fur is greasy.The traditional Chinese medical science
Diagnosis: stomachache.The compound medicine being used for treating stomachache using the embodiment of the present invention 4 to provide obtained effect after 7 days.
Embodiments described above is a part of embodiment of the present invention rather than whole embodiments.The reality of the present invention
The detailed description executing example is not intended to limit the scope of claimed invention, but is merely representative of the selected enforcement of the present invention
Example.Based on the embodiment in the present invention, those of ordinary skill in the art are obtained under not making creative work premise
Every other embodiment, broadly falls into the scope of protection of the invention.
Claims (10)
1. the compound medicine being used for treating stomachache, it is characterised in that be made up of crude drug, count by weight, described former
Material medicine includes: Rhizoma Smilacis Glabrae 10～20 parts；The Radix Paeoniae Alba 30～50 parts；Rhizoma Corydalis 10～15 parts；Radix Salviae Miltiorrhizae 10～15 parts；Fructus Aurantii 10～15
Part；Periostracum Cicadae 5～15 parts, Poria 15～30 parts；The Rhizoma Pinelliae 12～15 parts；Fructus Citri Sarcodactylis 12～15 parts；Herba Lysimachiae 15～50 parts；Bulbus Lilii 10～
30 parts；And Radix Glycyrrhizae 6～15 parts.
Compound medicine for treating stomachache the most according to claim 1, it is characterised in that count by weight, described
Rhizoma Smilacis Glabrae is 10 parts；The described Radix Paeoniae Alba is 30 parts；Described Rhizoma Corydalis is 15 parts；Described Radix Salviae Miltiorrhizae is 10 parts；Described Fructus Aurantii is 10 parts；Institute
Stating Periostracum Cicadae is 12 parts, and described Poria is 20 parts；The described Rhizoma Pinelliae is 15 parts；Described Fructus Citri Sarcodactylis is 12 parts；Described Herba Lysimachiae is 15 parts；Institute
Stating Bulbus Lilii is 20 parts；And described Radix Glycyrrhizae is 15 parts.
Compound medicine for treating stomachache the most according to claim 1, it is characterised in that the dosage form of described compound medicine
For decoction, pill, tablet, capsule or patch.
4. the preparation method being used for as claimed in claim 1 treating the compound medicine of stomachache, it is characterised in that by described
Rhizoma Smilacis Glabrae, the described Radix Paeoniae Alba, described Rhizoma Corydalis, described Radix Salviae Miltiorrhizae, described Periostracum Cicadae, described Poria, the described Rhizoma Pinelliae, described Bulbus Lilii, described
Herba Lysimachiae and described Radix Glycyrrhizae pulverize to obtain medicated powder, described medicated powder ethanol solution carries out at 60～80 DEG C 1～3 time and extracts, mistake
Obtaining medicinal liquid after filter, by described medicinal liquid after purification, concentrate drying obtains extractum；Extract the volatilization of described Fructus Citri Sarcodactylis and described Fructus Aurantii
Oil；Make granule after described extractum, described volatile oil being mixed with pharmaceutical excipient, prepare granule, capsule, pill or sheet
Agent.
The preparation method of the compound medicine for treating stomachache the most according to claim 4, it is characterised in that described medicated powder
Particle diameter be 80-120 mesh.
The preparation method of the compound medicine for treating stomachache the most according to claim 4, it is characterised in that use and synchronize
Water distillation extractor extracts the volatile oil of described Fructus Citri Sarcodactylis and described Fructus Aurantii.
The preparation method of the compound medicine for treating stomachache the most according to claim 4, it is characterised in that described medicinal liquid
Purification use membrane separation technique, at 25～30 DEG C, transmembrane pressure is under 0.20～0.30MPa, is circulated filtration.
The preparation method of the compound medicine for treating stomachache the most according to claim 4, it is characterised in that described Fructus Aurantii
For the Fructus Aurantii after parched with bran system.
The preparation method of the compound medicine for treating stomachache the most according to claim 4, it is characterised in that described Rhizoma Corydalis
Rope is the Rhizoma Corydalis after rice vinegar steams.
10. according to the preparation method of the compound medicine for treating stomachache described in claim 4～9 any one, its feature
It is, described granule is loaded in enteric capsule shell, makes the enteric coated capsule of described compound medicine.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167921A (en) * | 2007-11-07 | 2008-04-30 | 北京中科雍和医药技术有限公司 | Medicinal composition for treating stomachache and preparation process thereof |
| CN105079722A (en) * | 2015-09-25 | 2015-11-25 | 刘瑞云 | Medicine for treating stomachache |
| CN105435102A (en) * | 2015-12-16 | 2016-03-30 | 郑州仁宏医药科技有限公司 | Traditional Chinese medicine for treating gastritis stomachache |
| CN105521472A (en) * | 2015-12-22 | 2016-04-27 | 卢倩 | Stomachache-treating traditional Chinese medicine composition |
-
2016
- 2016-10-31 CN CN201610929839.2A patent/CN106237192A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167921A (en) * | 2007-11-07 | 2008-04-30 | 北京中科雍和医药技术有限公司 | Medicinal composition for treating stomachache and preparation process thereof |
| CN105079722A (en) * | 2015-09-25 | 2015-11-25 | 刘瑞云 | Medicine for treating stomachache |
| CN105435102A (en) * | 2015-12-16 | 2016-03-30 | 郑州仁宏医药科技有限公司 | Traditional Chinese medicine for treating gastritis stomachache |
| CN105521472A (en) * | 2015-12-22 | 2016-04-27 | 卢倩 | Stomachache-treating traditional Chinese medicine composition |
Non-Patent Citations (1)
| Title |
|---|
| 洪婷等: "加味柴芍六君汤治疗慢性非萎缩性胃炎（脾虚肝郁型）60例", 《江西中医药》 * |
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