CN106237005A - One treats neurasthenic Chinese medicine preparation - Google Patents
One treats neurasthenic Chinese medicine preparation Download PDFInfo
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- CN106237005A CN106237005A CN201610705158.8A CN201610705158A CN106237005A CN 106237005 A CN106237005 A CN 106237005A CN 201610705158 A CN201610705158 A CN 201610705158A CN 106237005 A CN106237005 A CN 106237005A
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Abstract
The present invention provides one to treat neurasthenic Chinese medicine preparation, belong to technical field of Chinese medicines, mainly by Folium Ligustri pubescentis, spend very sweet, Herba Mimosae Pudicae in vain, Herba Crepidis croceae, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk), Semen Nelumbinis, Flos jasmini, Ficus fulva Reinw., Grifola frondosa, Radix berchemiae floribundae, Fructus Mori, Herba Polytrichi, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), Bai Guimu root prepare raw material active component through the ethanol extraction that water carries with volumetric concentration is 70 80%, add pharmaceutically acceptable carrier, be processed into according to the preparation method of conventional Chinese medicine preparation.Chinese medicine preparation of the present invention is according to neurasthenic pathogenesis, selected raw material medicine and proportioning, wherein effective ingredient interaction, Synergistic, play the effects such as purging liver-fire, tranquilizing by nourishing the heart, dispersing the stagnated live-QI to relieve the stagnation of QI, strengthening spleen, tonifying kidney, nourishing YIN and clearing away heat, benefiting QI and nourishing blood, promoting blood circulation to remove obstruction in the collateral, brain healthy altogether, for treating neurasthenia, there is significant curative effect, instant effect, short treating period, cure rate is high, thorough treatment；And mild in medicine property and, safe and reliable, no dependence, have no side effect.
Description
[technical field]
The invention belongs to technical field of Chinese medicines, be specifically related to one and treat neurasthenic Chinese medicine preparation.
[background technology]
Neurasthenia is a kind of neurosis weak based on brain and somatic function, is prone to again tired as spy being prone to excitement
Levy.The cardinal symptom of neurastheniac shows themselves in that often to be felt mental and is short of physical strength, fatiguability, and work efficiency is low, and often
With the physiological function such as emotional symptoms and muscle tone pain, sleep disorder or hypomnesis such as anxiety, worry, irritability
Disorderly symptom, even with minor depressive or anxiety, but exists without organic disease.These symptoms are not to be secondary to physical disease
With brain organic pathological changes, it is not a part for other any mental disorders, but can exist lasting nervous before disease
And stress.Data shows, works, learns hypertonicity and act hurriedly in a messy situation, has a rest and sleep and be irregular, and operating pressure is big, at health
In subhealth state, and feel have burden and offending emotion etc., be to cause neurasthenic main cause.
Western medical treatment neurasthenia relies primarily on the hypnotic sedative dose of symptomatic treatments such as stable, but these medicines in safety and
Dependency aspect existing defects, side effect is bigger, easily forms additive, drug resistance, therefore should not take for a long time.Middle treatment
Treating neurasthenic medicine more, as Cinnabaris is reposed ball, nourishing blood to tranquillize the mind sheet, ZAOREN ANSHEN YE etc., these medicines are to neurasthenia
There is certain curative effect, but majority exists the defects such as onset is slow, DeGrain, Time of Administration length, curative effect are unstable.
[summary of the invention]
In view of problem above, the invention provides one and treat neurasthenic Chinese medicine preparation, this formula of Chinese materia medica preparation section
Learn rationally, there is the merits such as purging liver-fire, tranquilizing by nourishing the heart, dispersing the stagnated live-QI to relieve the stagnation of QI, strengthening spleen, tonifying kidney, nourishing YIN and clearing away heat, benefiting QI and nourishing blood, promoting blood circulation to remove obstruction in the collateral
Effect, and there is good resisting fatigue and Health of brain, the various symptoms caused for treating neurasthenia have significantly
Curative effect, instant effect, short treating period, cure rate is high, thorough treatment；And mild in medicine property and, safe and reliable, no dependence, secondary without any poison
Effect.
For realizing object above, the technical solution adopted in the present invention is as follows:
One treats neurasthenic Chinese medicine preparation, is mainly made up of the raw material of following weight portion: Folium Ligustri pubescentis 10-15 part,
Spend very sweet 6-12 part, Herba Mimosae Pudicae 12-18 part, Herba Crepidis croceae 10-20 part, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 13-17 part, Semen Nelumbinis 10-20 part, element in vain
Fragrant colored 6-12 part, Ficus fulva Reinw. 12-18 part, Grifola frondosa 10-20 part, Radix berchemiae floribundae 13-19 part, Fructus Mori 10-15 part, Herba Polytrichi
8-16 part, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 13-17 part, Bai Guimu root 12-16 part.
Further, described Chinese medicine preparation is mainly made up of the raw material of following weight portion: Folium Ligustri pubescentis 12-14 part, spend in vain sweet
Honey honey 8-10 part, Herba Mimosae Pudicae 14-16 part, Herba Crepidis croceae 13-17 part, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 14-16 part, Semen Nelumbinis 13-17 part, Flos jasmini 8-
10 parts, Ficus fulva Reinw. 14-16 part, Grifola frondosa 13-17 part, Radix berchemiae floribundae 15-17 part, Fructus Mori 12-14 part, Herba Polytrichi 10-14
Part, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 14-16 part, Bai Guimu root 13-15 part.
Further, described Chinese medicine preparation is mainly made up of the raw material of following weight portion: Folium Ligustri pubescentis 13 parts, spend in vain very sweet
9 parts, Herba Mimosae Pudicae 15 parts, Herba Crepidis croceae 16 parts, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 15 parts, 16 parts of Semen Nelumbinis, Flos jasmini 9 parts, Ficus fulva Reinw. 15 parts, Grifola frondosa
16 parts, Radix berchemiae floribundae 17 parts, Fructus Mori 13 parts, Herba Polytrichi 12 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 15 parts, Bai Guimu root 14 parts.
Further, described Chinese medicine preparation is the active component by described raw material and pharmaceutically acceptable carrier combination,
Required dosage form is made, such as tablet, granule, capsule, syrup, mixture etc. according to the preparation method of conventional Chinese medicine preparation.
Further, the active component of described raw material is that to use water extraction and volumetric concentration be the ethanol extraction of 70-80%
Preparing, concrete preparation method is as follows:
1) described raw material is taken by described weight portion；
2) by Folium Ligustri pubescentis, very sweet, Herba Mimosae Pudicae, Herba Crepidis croceae, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk), Ficus fulva Reinw., Radix berchemiae floribundae, big golden hair are spent in vain
Moss, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) and the Bai Gui wood root disconnected length that is broken to respectively is less than 2cm, then mixes with Semen Nelumbinis, Flos jasmini, Grifola frondosa, Fructus Mori, and
After carry out three water extraction, each amount of water is 6-8 times of raw material gross weight, and extraction time is 1-2h, extracts every time and terminates, mistake
Filter, takes extracting solution, and medicinal residues extract the most next time；After extraction terminates, merge three water extraction gained extracting solution, obtain water extraction
Liquid, remaining medicinal residues retain；
3) after water carries, remaining medicinal residues are again with the alcohol reflux that volumetric concentration is 70-80% three times, each ethanol consumption
For 4-6 times of raw material gross weight, extraction time is 1-2h, extracts every time and terminates, filters, take extracting solution, and medicinal residues then carry out next
Secondary extraction；After extraction terminates, merge three alcohol extraction gained extracting solution, obtain alcohol extract；
4) combining step 2) gained aqueous extract and step 3) gained alcohol extract, to filter, filtrate is condensed into thick paste, to obtain final product
The active component of described raw material.
The pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: lactose, starch, dextrin, Icing Sugar, inorganic salt, microcrystalline Cellulose etc..
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc..
Disintegrating agent: starch, cellulose derivative, carboxymethyl starch sodium, polyvinylpolypyrrolidone etc..
Lubricant: micropowder silica gel, Pulvis Talci, magnesium stearate, Polyethylene Glycol etc..
Cosolvent: water, ethanol, propylene glycol, glycerol, liquid Paraffin, Cera Flava, vegetable oil etc..
Correctives: Mel, stevioside, saccharin sodium etc..
Preservative: benzoic acid and sodium benzoate, sorbic acid, methyl ester, ethyl ester, propyl ester, parabens butyl ester etc..
The processing method of described tablet is: take the active component of described raw material, and addition tablet is commonly used adjuvant and (included dilution
One of agent, wetting agent, binding agent, disintegrating agent, lubricant or whole), it is prepared into Tablets according to conventional production process.
The processing method of described granule is: take the active component of described raw material, and addition granule is commonly used adjuvant and (included dilute
Release one of agent, wetting agent, binding agent, disintegrating agent or whole), it is prepared into granule of the present invention according to conventional production process.
The processing method of described capsule is: take the active component of described raw material, and addition capsule is commonly used adjuvant and (included dilute
Release one of agent, wetting agent, binding agent, disintegrating agent, lubricant or whole), it is prepared into capsule of the present invention according to conventional production process
Agent.
The processing method of described syrup is: take the active component of described raw material, and addition syrup is commonly used adjuvant and (included rectifying
One of taste agent, preservative, cosolvent or whole), it is prepared into syrup of the present invention according to conventional production process.
The processing method of described mixture is: take the active component of described raw material, and addition mixture is commonly used adjuvant and (included taste masking
One of agent, preservative or whole), it is prepared into mixture of the present invention according to conventional production process.
Using method: for oral administration, each takes the Chinese medicine preparation of the present invention of effective dose 1-2g, three times a day, early, middle and late meal
Half an hour after warm water takes, and within 10 days, is a course for the treatment of, avoids tobacco and wine, pungent, raw and cold, greasy food during medication.
Details as Follows for the used raw material of the present invention:
Folium Ligustri pubescentis: for the leaf of Oleaceae plants Japan Ligustrum groffiae Merr..Bitter in the mouth, micro-sweet, cool in nature.Enter Liver Channel.There is clearing away liver-fire, solution
The effect of pyretic toxicity.
Spend in vain very sweet: for the herb of labiate dracocephalum heterophyllum.Bitter in the mouth, pungent, cold in nature.There is cough-relieving, clearing away liver-fire, dissipate
Effect of pent-up.
Herba Mimosae Pudicae: the herb of pulse family Mimosa plant Herba Mimosae Pudicae.Sweet in the mouth, puckery, cool in nature.There is clearing away heat and promoting diuresis, removing food stagnancy solution
Poison, preventing phlegm from forming and stopping coughing, calmness of calming the nerves, effect of clearing away liver-fire.
Herba Crepidis croceae: slaughter the herb of Radix Crepidis elongatae for feverfew.Bitter in the mouth, cold nature.Have QI invigorating, antitussive is relievingd asthma, clearly
Effect of heat drop fire.
Cratoneuron filicinum (Hedw.) Spruc.(Lolsk): for the plant of Amblystegiaceae Cratoneuron filicinum (Hedw.) Spruc.(Lolsk).Lightly seasoned, micro-puckery, property is put down.Enter heart channel.There is the peace that nourishes heart
Effect of god.
Semen Nelumbinis: for the dry mature seed of nymphaeaceae plant lotus.Sweet in the mouth, puckery, property is put down.Enter spleen, kidney, heart channel.There is spleen reinforcing
Antidiarrheal, kidney tonifying arresting seminal emission, tranquilizing by nourishing the heart, effect of stimulating appetite.
Flos jasmini: for the dry flower of Oleaceae plants Flos jasmini.Bitter in the mouth, property is put down.There are soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain
Effect.
Ficus fulva Reinw.: for the root bark of moraceae plants Ficus fulva Reinw..Sweet in the mouth, property is put down.There is effect of invigorating the spleen and benefiting QI, promoting blood circulation by removing wind.
Grifola frondosa: for the sporophore of On Polyporaceae hen of the woods.Sweet in the mouth, property is put down.Have replenishing QI to invigorate the spleen, qi-restoratives is held up
Positive effect.
Radix berchemiae floribundae: spend more the root of Radix Berchemiae Giraldianae for Rhamnaceae plant.Sweet-bitter flavor, property is put down.Enter spleen, kidney two warp.There is spleen invigorating
QI invigorating, effect of dredge the meridian passage.
Fructus Mori: for the fruit ear of moraceae plants Mulberry.Sweet in the mouth, acid, cold in nature.Enter liver, kidney channel.There is nourishing YIN and benefiting blood, promote the production of body fluid, moisten
Effect of intestinal.
Herba Polytrichi: for the herb of pigeon-wheat section plant Herba Polytrichi.Sweet in the mouth, cold in nature.There is YIN nourishing qi-restoratives, spleen reinforcing, profit
Effect of intestinal.
Cyperus michelianus(L.) Link (Herba Cyperi Micheliani): Cyperaceae Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), with all herbal medicine.Lightly seasoned, pungent, property is put down.The effect there is circulation of qi promoting, nourishing blood.
Bai Guimu root: for the root of moraceae plants Bai Guimu.Sweet in the mouth, light, warm in nature.There is the merit of expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral
Effect.
The invention provides one and treat neurasthenic Chinese medicine preparation, relative to prior art, there is following useful effect
Really:
The present invention is according to neurasthenic pathogenesis, it then follows the prescriptions principle of the traditional Chinese medical science, carries out dialectical composition of prescription,
Choose Folium Ligustri pubescentis, spend very sweet, Herba Mimosae Pudicae, Herba Crepidis croceae, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk), Semen Nelumbinis, Flos jasmini, Ficus fulva Reinw., Grifola frondosa, Monopterus albus (Zuiew) in vain
Rattan root, Fructus Mori, Herba Polytrichi, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), Bai Guimu root are raw material.Wherein, Folium Ligustri pubescentis, spend very sweet, Herba Mimosae Pudicae in vain, donkey beats
Rolling youngster's grass has purging liver-fire, effects such as calmness of calming the nerves；Cratoneuron filicinum (Hedw.) Spruc.(Lolsk), Semen Nelumbinis, Flos jasmini have tranquilizing by nourishing the heart, dispersing the stagnated live-QI to relieve the stagnation of QI, benefit
The effects such as spleen and tonifying kidney；Ficus fulva Reinw., Grifola frondosa, Radix berchemiae floribundae have the effects such as spleen invigorating, the kidney invigorating, QI invigorating；Fructus Mori, Herba Polytrichi,
Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), Bai Guimu root can nourishing YIN and benefiting blood, promoting blood circulation to remove obstruction in the collateral；The most all medicine compatibilities, wherein effective ingredient interaction, mutually complementation
Fill, Synergistic, play altogether purging liver-fire, tranquilizing by nourishing the heart, dispersing the stagnated live-QI to relieve the stagnation of QI, tonifying speen and tonifying kidney, nourishing YIN and clearing away heat, benefiting QI and nourishing blood, invigorate blood circulation logical
The effects such as network, also have good resisting fatigue and Health of brain, can carry out the body of neurastheniac on the whole
Regulation, and then fundamentally cure neurasthenia, thorough treatment, evident in efficacy, instant effect, short treating period, cure rate is high；And this
Invention Chinese medicine preparation use natural Chinese medicines raw material be prepared from, mild in medicine property and, the intestines and stomach will not be caused stimulation produce bad instead
Should and side effect, no dependence, safe and reliable.
[detailed description of the invention]
The following examples can help those skilled in the art that the present invention is more fully understood, but cannot be with any
Mode limits the present invention.
Embodiment 1
One treats neurasthenic tablet, and concrete manufacture method comprises the following steps:
1) weigh the raw material of following weight portion: Folium Ligustri pubescentis 10 parts, spend in vain very sweet 6 parts, Herba Mimosae Pudicae 12 parts, Herba Crepidis croceae
10 parts, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 13 parts, 10 parts of Semen Nelumbinis, Flos jasmini 6 parts, Ficus fulva Reinw. 12 parts, Grifola frondosa 10 parts, Radix berchemiae floribundae 13 parts, Fructus Mori
10 parts, Herba Polytrichi 8 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 13 parts, Bai Guimu root 12 parts；
2) by Folium Ligustri pubescentis, very sweet, Herba Mimosae Pudicae, Herba Crepidis croceae, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk), Ficus fulva Reinw., Radix berchemiae floribundae, big golden hair are spent in vain
Moss, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) and the Bai Gui wood root disconnected length that is broken to respectively is less than 2cm, then mixes with Semen Nelumbinis, Flos jasmini, Grifola frondosa, Fructus Mori, and
After carry out three water extraction, each amount of water is 6 times of raw material gross weight, and extraction time is 1h, extracts every time and terminates, filters,
Taking extracting solution, medicinal residues extract the most next time；After extraction terminates, merge three water extraction gained extracting solution, obtain aqueous extract,
Remaining medicinal residues retain；
3) after water carries, remaining medicinal residues are again with the alcohol reflux that volumetric concentration is 70% three times, and each ethanol consumption is former
4 times of material gross weight, extraction time is 1h, extracts every time and terminates, filters, take extracting solution, and medicinal residues extract the most next time；Carry
After taking end, merge three alcohol extraction gained extracting solution, obtain alcohol extract；
4) combining step 2) gained aqueous extract and step 3) gained alcohol extract, to filter, filtrate is condensed into thick paste, obtains former
Material active component；
5) to step 4) the raw material active component of gained adds supplementary product starch, ethanol, Pulvis Talci, again through system after mixing
Grain, dry, tabletting, make tablet.
Embodiment 2
One treats neurasthenic granule, and concrete manufacture method comprises the following steps:
1) weigh the raw material of following weight portion: Folium Ligustri pubescentis 12 parts, spend in vain very sweet 8 parts, Herba Mimosae Pudicae 14 parts, Herba Crepidis croceae
13 parts, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 14 parts, 13 parts of Semen Nelumbinis, Flos jasmini 8 parts, Ficus fulva Reinw. 14 parts, Grifola frondosa 13 parts, Radix berchemiae floribundae 15 parts, Fructus Mori
12 parts, Herba Polytrichi 10 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 14 parts, Bai Guimu root 13 parts；
2) by Folium Ligustri pubescentis, very sweet, Herba Mimosae Pudicae, Herba Crepidis croceae, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk), Ficus fulva Reinw., Radix berchemiae floribundae, big golden hair are spent in vain
Moss, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) and the Bai Gui wood root disconnected length that is broken to respectively is less than 2cm, then mixes with Semen Nelumbinis, Flos jasmini, Grifola frondosa, Fructus Mori, and
After carry out three water extraction, each amount of water is 7 times of raw material gross weight, and extraction time is 1.5h, extracts every time and terminates, mistake
Filter, takes extracting solution, and medicinal residues extract the most next time；After extraction terminates, merge three water extraction gained extracting solution, obtain water extraction
Liquid, remaining medicinal residues retain；
3) after water carries, remaining medicinal residues are again with the alcohol reflux that volumetric concentration is 75% three times, and each ethanol consumption is former
5 times of material gross weight, extraction time is 1.5h, extracts every time and terminates, filters, take extracting solution, and medicinal residues extract the most next time；
After extraction terminates, merge three alcohol extraction gained extracting solution, obtain alcohol extract；
4) combining step 2) gained aqueous extract and step 3) gained alcohol extract, to filter, filtrate is condensed into thick paste, obtains former
Material active component；
5) to step 4) the raw material active component of gained adds supplementary product starch, dextrin, stevioside, again through system after mixing
Grain, dry, granulate, subpackage, make granule.
Embodiment 3
One treats neurasthenic capsule, and concrete manufacture method comprises the following steps:
1) weigh the raw material of following weight portion: Folium Ligustri pubescentis 13 parts, spend in vain very sweet 9 parts, Herba Mimosae Pudicae 15 parts, Herba Crepidis croceae
16 parts, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 15 parts, 16 parts of Semen Nelumbinis, Flos jasmini 9 parts, Ficus fulva Reinw. 15 parts, Grifola frondosa 16 parts, Radix berchemiae floribundae 17 parts, Fructus Mori
13 parts, Herba Polytrichi 12 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 15 parts, Bai Guimu root 14 parts；
2) by Folium Ligustri pubescentis, very sweet, Herba Mimosae Pudicae, Herba Crepidis croceae, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk), Ficus fulva Reinw., Radix berchemiae floribundae, big golden hair are spent in vain
Moss, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) and the Bai Gui wood root disconnected length that is broken to respectively is less than 2cm, then mixes with Semen Nelumbinis, Flos jasmini, Grifola frondosa, Fructus Mori, and
After carry out three water extraction, each amount of water is 8 times of raw material gross weight, and extraction time is 2h, extracts every time and terminates, filters,
Taking extracting solution, medicinal residues extract the most next time；After extraction terminates, merge three water extraction gained extracting solution, obtain aqueous extract,
Remaining medicinal residues retain；
3) after water carries, remaining medicinal residues are again with the alcohol reflux that volumetric concentration is 80% three times, and each ethanol consumption is former
6 times of material gross weight, extraction time is 2h, extracts every time and terminates, filters, take extracting solution, and medicinal residues extract the most next time；Carry
After taking end, merge three alcohol extraction gained extracting solution, obtain alcohol extract；
4) combining step 2) gained aqueous extract and step 3) gained alcohol extract, to filter, filtrate is condensed into thick paste, obtains former
Material active component；
5) to step 4) the raw material active component of gained adds supplementary product starch, ethanol, microcrystalline Cellulose, magnesium stearate,
After mixing again through granulation, granulate, be packed in capsule shells, make capsule.
Embodiment 4
One treats neurasthenic syrup, and concrete manufacture method is:
1) weigh the material medicine of following weight portion: Folium Ligustri pubescentis 14 parts, spend very sweet 10 parts in vain, Herba Mimosae Pudicae 16 parts, donkey beat
Rolling youngster grass 17 parts, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 16 parts, 17 parts of Semen Nelumbinis, Flos jasmini 10 parts, Ficus fulva Reinw. 16 parts, Grifola frondosa 17 parts, Radix berchemiae floribundae 17 parts,
Fructus Mori 14 parts, Herba Polytrichi 14 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 16 parts, Bai Guimu root 15 parts；
2) by Folium Ligustri pubescentis, very sweet, Herba Mimosae Pudicae, Herba Crepidis croceae, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk), Ficus fulva Reinw., Radix berchemiae floribundae, big golden hair are spent in vain
Moss, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) and the Bai Gui wood root disconnected length that is broken to respectively is less than 2cm, then mixes with Semen Nelumbinis, Flos jasmini, Grifola frondosa, Fructus Mori, and
After carry out three water extraction, each amount of water is respectively 8 times of raw material gross weight, 7 times, 6 times, extraction time be respectively 2h,
1.5h, 1h, extract every time and terminate, filter, take extracting solution, and medicinal residues extract the most next time；After extraction terminates, merge and carry for three times
Taking gained extracting solution, obtain aqueous extract, remaining medicinal residues retain；
3) after water carries, remaining medicinal residues are again with the alcohol reflux that volumetric concentration is 75% three times, and each ethanol consumption is respectively
For 6 times, 5 times, 4 times of raw material gross weight, extraction time is respectively 2h, 1.5h, 1h, extracts every time and terminates, filters, take extraction
Liquid, medicinal residues extract the most next time；After extraction terminates, merge three alcohol extraction gained extracting solution, obtain alcohol extract；
4) combining step 2) gained aqueous extract and step 3) gained alcohol extract, to filter, filtrate is condensed into thick paste, obtains former
Material active component；
5) to step 4) the raw material active component of gained adds adjuvant sucrose, Mel, potassium sorbate, water, after mixing, add
Work makes syrup.
Embodiment 5
One treats neurasthenic mixture, and concrete manufacture method is:
1) weigh the material medicine of following weight portion: Folium Ligustri pubescentis 15 parts, spend very sweet 12 parts in vain, Herba Mimosae Pudicae 18 parts, donkey beat
Rolling youngster grass 20 parts, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 17 parts, 20 parts of Semen Nelumbinis, Flos jasmini 12 parts, Ficus fulva Reinw. 18 parts, Grifola frondosa 20 parts, Radix berchemiae floribundae 19 parts,
Fructus Mori 15 parts, Herba Polytrichi 16 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 17 parts, Bai Guimu root 16 parts；
2) by Folium Ligustri pubescentis, very sweet, Herba Mimosae Pudicae, Herba Crepidis croceae, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk), Ficus fulva Reinw., Radix berchemiae floribundae, big golden hair are spent in vain
Moss, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) and the Bai Gui wood root disconnected length that is broken to respectively is less than 2cm, then mixes with Semen Nelumbinis, Flos jasmini, Grifola frondosa, Fructus Mori, and
After carry out three water extraction, each amount of water is respectively 8 times of raw material gross weight, 7 times, 6 times, extraction time be respectively 2h,
1.5h, 1h, extract every time and terminate, filter, take extracting solution, and medicinal residues extract the most next time；After extraction terminates, merge three water
Extracting gained extracting solution, obtain aqueous extract, remaining medicinal residues retain；
3) after water carries, remaining medicinal residues use alcohol reflux three times again, and the volumetric concentration of ethanol the most used is respectively
80%, 75%, 70%, ethanol consumption is respectively 6 times of raw material gross weight, 5 times, 4 times, extraction time be respectively 2h, 1.5h,
1h, extracts every time and terminates, filter, take extracting solution, and medicinal residues extract the most next time；After extraction terminates, merge three alcohol extractions
Gained extracting solution, obtains alcohol extract；
4) combining step 2) gained aqueous extract and step 3) gained alcohol extract, to filter, filtrate is condensed into thick paste, obtains former
Material active component；
5) to step 4) the raw material active component of gained adds adjuvant sucrose, ethyl ester, water, potassium sorbate, after mixing, add
Work makes mixture.
Clinical observation is added up:
1, the object of observation:
Select neurastheniac 240 example made a definite diagnosis to carry out clinical observation, be randomly divided into treatment group and matched group two groups, control
Treatment group 120 example, wherein male 58 example, women 62 example, age 17-40 year, 33.8 years old mean age, the shortest person of the course of disease 3 months,
Elder 6 years；Matched group 120 example, wherein male 57 example, women 63 example, in age 17-40 year, 33.9 years old mean age, the course of disease is the shortest
Person 4 months, elder 6 years.Treatment group and the sex of two groups of cases of matched group, age, the course of disease, degrees of symptoms basic
Cause, without significant difference, there is comparability.
2, diagnostic criteria:
Formulate with reference to " Chinese Spirit disease classification schemes and diagnostic criteria (CCMD-2-R) " relevant criterion.Neurastheniac
Spirit is easily excited, mental and be short of physical strength, and fatiguability is often accompanied by the emotional symptoms such as anxiety, worry and irritability, and muscle is tight
The physiological dysfunction symptoms such as extensional pain and sleep disorder, and described symptom is not the disease being secondary to body or brain, before disease
Lasting nervous or compression of nerves can be there is.
3, medication and observational technique:
Treatment group: for oral administration, each takes the Chinese medicine preparation of the present invention of effective dose 1-2g, three times a day, early, middle and late after meal
Half an hour, warm water took, and within 10 days, was 1 course for the treatment of, can fully recover 2-4 the course for the treatment of, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.Medication
Period avoids tobacco and wine, pungent, raw and cold, greasy food.
Matched group: take the neurasthenic endo-medicine of commercially available treatment (such as amitriptyline sheet), carry out according to taking explanation
Take, during treatment, avoid tobacco and wine, pungent, raw and cold, greasy food.
4, treatment standard:
1. cure: being emotionally stable, symptom is wholly absent；
The most effective: the physiological functions such as sleep are recovered substantially, emotion slightly fluctuates；
The most effective: the physiological functions such as sleep have been recovered, emotion slightly fluctuates；
The most invalid: psychology and physiological signs are unchanged.
5, observed result and analysis
Respectively treatment group and matched group case being carried out clinical observation, acquired results is as shown in table 1 below:
Table 1 clinical observation result
| Cure | Effective | Effectively | Invalid | Total effective rate | |
| Treatment group | 50 examples | 34 examples | 26 examples | 10 examples | 91.7% |
| Matched group | 37 examples | 31 examples | 20 examples | 32 examples | 72% |
By upper table 1 it can be seen that 120 example neurastheniacs for the treatment of group, Chinese medicine preparation of the present invention is used to treat,
Wherein, cure 50 examples, account for total number of persons 41.7%；Effective 34 examples, account for total number of persons 28.3%；Effective 26 examples, account for total number of persons 21.7%；
Invalid 10 examples, account for total number of persons 8.3%；Total effective rate reaches 91.7%.And matched group 120 example neurastheniac, use commercially available controlling
Treat neurasthenic medicine to treat, cure 37 examples, account for total number of persons 30.8%；Effective 31 examples, account for total number of persons 25.8%；Effectively
20 examples, account for total number of persons 16.7%；Invalid 32 examples, account for total number of persons 26.7%；Total effective rate is 73.3%.Two groups of contrasts understand, and control
The treatment group employing Chinese medicine preparation of the present invention neurasthenic cure rate for the treatment of and total effective rate are obviously higher than matched group, and are treating
During have no untoward reaction, evident in efficacy, cure rate is high.
Model case:
Case 1: Huang, female, 32 years old, suffers from neurasthenia and has a surplus for 1 year.Cardinal symptom: all day is dizzy, and evening, difficulty entered
Sleep, dreaming often and waking easily, can not concentrate one's energy daytime, hypomnesis, bradykinesia, susceptible to lose temper due to restlessness, lassitude.Used once
Various ways is treated, and poor effect has a strong impact on routine work, life.Take Chinese medicine preparation of the present invention afterwards to treat, 1
After the individual course for the treatment of, all diseases alleviate；Continuing to take 2 courses for the treatment of, neurasthenic various diseases all disappear, it is thus achieved that recovery from illness.
Case 2: Zheng, man, 39 years old, suffers from neurasthenia and has a surplus for 2 years.Cardinal symptom: insomnia, dizzy, working nothing
Essence beat adopt, hypomnesis, tired asthenia, spiritual atrophy, susceptible to lose temper due to restlessness.Took multi-medicament treatment once, the most to no effect.
Taking Chinese medicine preparation of the present invention after being introduced to treat, after 1 course for the treatment of, above-mentioned symptom is alleviated；Continue to take 3 courses for the treatment of,
Above-mentioned disease all disappears, and all recover normal, follows up a case by regular visits to the state of an illness without recurrence.
Although, the present invention is described in detail the most with a general description of the specific embodiments, but
On the basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (6)
1. treat neurasthenic Chinese medicine preparation for one kind, it is characterised in that described Chinese medicine preparation mainly former by following weight portion
Material is made: Folium Ligustri pubescentis 10-15 part, spend very sweet 6-12 part, Herba Mimosae Pudicae 12-18 part, Herba Crepidis croceae 10-20 part, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) in vain
13-17 part, Semen Nelumbinis 10-20 part, Flos jasmini 6-12 part, Ficus fulva Reinw. 12-18 part, Grifola frondosa 10-20 part, Radix berchemiae floribundae 13-19 part,
Fructus Mori 10-15 part, Herba Polytrichi 8-16 part, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 13-17 part, Bai Guimu root 12-16 part.
2. as claimed in claim 1 treat neurasthenic Chinese medicine preparation, it is characterised in that described Chinese medicine preparation mainly by with
The raw material of lower weight portion is made: Folium Ligustri pubescentis 12-14 part, spend very sweet 8-10 part, Herba Mimosae Pudicae 14-16 part, Herba Crepidis croceae 13-in vain
17 parts, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 14-16 part, Semen Nelumbinis 13-17 part, Flos jasmini 8-10 part, Ficus fulva Reinw. 14-16 part, Grifola frondosa 13-17 part, Monopterus albus (Zuiew)
Rattan root 15-17 part, Fructus Mori 12-14 part, Herba Polytrichi 10-14 part, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 14-16 part, Bai Guimu root 13-15 part.
3. as claimed in claim 2 treat neurasthenic Chinese medicine preparation, it is characterised in that described Chinese medicine preparation mainly by with
The raw material of lower weight portion is made: Folium Ligustri pubescentis 13 parts, spend in vain very sweet 9 parts, Herba Mimosae Pudicae 15 parts, Herba Crepidis croceae 16 parts, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk)
15 parts, 16 parts of Semen Nelumbinis, Flos jasmini 9 parts, Ficus fulva Reinw. 15 parts, Grifola frondosa 16 parts, Radix berchemiae floribundae 17 parts, Fructus Mori 13 parts, big golden hair
Moss 12 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 15 parts, Bai Guimu root 14 parts.
4. the neurasthenic Chinese medicine preparation for the treatment of as described in claim 1-3 is arbitrary, its characteristic is: described Chinese medicine preparation is
By the active component of described raw material and pharmaceutically acceptable carrier combination, according to the preparation method processing system of conventional Chinese medicine preparation
Become.
5. the neurasthenic Chinese medicine preparation for the treatment of as claimed in claim 4, it is characterised in that: the active component of described raw material is
Use water to carry to prepare with the ethanol extraction that volumetric concentration is 70-80%.
6. the neurasthenic Chinese medicine preparation for the treatment of as claimed in claim 5, it is characterised in that the active component of described raw material is
Prepare by the following method:
1) described raw material is taken by described weight portion；
2) by Folium Ligustri pubescentis, spend in vain very sweet, Herba Mimosae Pudicae, Herba Crepidis croceae, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk), Ficus fulva Reinw., Radix berchemiae floribundae, Herba Polytrichi,
Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) and the Bai Gui wood root disconnected length that is broken to respectively is less than 2cm, then mixes with Semen Nelumbinis, Flos jasmini, Grifola frondosa, Fructus Mori, then
Carrying out three water extraction, each amount of water is 6-8 times of raw material gross weight, and extraction time is 1-2h, extracts every time and terminates, mistake
Filter, takes extracting solution, and medicinal residues extract the most next time；After extraction terminates, merge three water extraction gained extracting solution, obtain water extraction
Liquid, remaining medicinal residues retain；
3) after water carries, remaining medicinal residues are again with the alcohol reflux that volumetric concentration is 70-80% three times, and each ethanol consumption is former
4-6 times of material gross weight, extraction time is 1-2h, extracts every time and terminates, filters, take extracting solution, and medicinal residues carry the most next time
Take；After extraction terminates, merge three alcohol extraction gained extracting solution, obtain alcohol extract；
4) combining step 2) gained aqueous extract and step 3) gained alcohol extract, to filter, filtrate is condensed into thick paste, obtains described
The active component of raw material.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547598A (en) * | 2015-02-09 | 2015-04-29 | 张继振 | Traditional Chinese medicine preparation for treating neurasthenia and preparation method thereof |
| CN105106547A (en) * | 2015-09-27 | 2015-12-02 | 南京晶云化工有限公司 | Pharmaceutic preparation for treating neurasthenia |
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2016
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547598A (en) * | 2015-02-09 | 2015-04-29 | 张继振 | Traditional Chinese medicine preparation for treating neurasthenia and preparation method thereof |
| CN105106547A (en) * | 2015-09-27 | 2015-12-02 | 南京晶云化工有限公司 | Pharmaceutic preparation for treating neurasthenia |
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